Neurodegenerative diseases: a decade of discoveries paves the way for therapeutic breakthroughs (Q35906130)

11 August 2017

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title

Neurodegenerative diseases: a decade of discoveries paves the way for therapeutic breakthroughs (English)

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11 August 2017

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2

John Q Trojanowski

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11 August 2017

Mark S Forman

1

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11 August 2017

Virginia M-Y Lee

series ordinal

3

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11 August 2017

language of work or name

English

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publication date

1 October 2004

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11 August 2017

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11 August 2017

10

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11 August 2017

10

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11 August 2017

1055-1063

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https://scigraph.springernature.com/pub.10.1038/nm1113

11 August 2017

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cites work

Alzheimer's disease: Initial report of the purification and characterization of a novel cerebrovascular amyloid protein

1 reference

7 January 2021

A68: a major subunit of paired helical filaments and derivatized forms of normal Tau.

1 reference

7 January 2021

Alpha-synuclein in Lewy bodies

1 reference

7 January 2021

Novel proteinaceous infectious particles cause scrapie

1 reference

7 January 2021

Alzheimer Disease in the US Population

1 reference

7 January 2021

Number of dementia sufferers in Europe between the years 2000 and 2050.

1 reference

7 January 2021

Molecular chaperones in the cytosol: from nascent chain to folded protein

1 reference

7 January 2021

Early-onset Alzheimer's disease caused by mutations at codon 717 of the beta-amyloid precursor protein gene

1 reference

7 January 2021

Familial Alzheimer's disease in kindreds with missense mutations in a gene on chromosome 1 related to the Alzheimer's disease type 3 gene

1 reference

7 January 2021

Candidate gene for the chromosome 1 familial Alzheimer's disease locus

1 reference

7 January 2021

Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease

1 reference

7 January 2021

Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease

1 reference

7 January 2021

The presenilins in Alzheimer's disease--proteolysis holds the key.

1 reference

7 January 2021

Mutant genes in familial Alzheimer's disease and transgenic models

1 reference

7 January 2021

Aph-1, Pen-2, and Nicastrin with Presenilin generate an active gamma-Secretase complex

1 reference

7 January 2021

The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics

1 reference

7 January 2021

Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families

1 reference

7 January 2021

Lack of apolipoprotein E dramatically reduces amyloid beta-peptide deposition.

1 reference

7 January 2021

Apolipoprotein E and cholesterol metabolism in the pathogenesis and treatment of Alzheimer's disease

1 reference

7 January 2021

Alzheimer's disease: the cholesterol connection

1 reference

7 January 2021

New frontiers in Alzheimer's disease genetics

1 reference

7 January 2021

A subset of NSAIDs lower amyloidogenic Abeta42 independently of cyclooxygenase activity

1 reference

7 January 2021

Nonsteroidal anti-inflammatory drug use and the risk for Alzheimer's disease: dissecting the epidemiological evidence

1 reference

7 January 2021

Transgenic animal models of Alzheimer's disease and related disorders: histopathology, behavior and therapy.

1 reference

7 January 2021

Human neurodegenerative disease modeling using Drosophila.

1 reference

7 January 2021

Formation of neurofibrillary tangles in P301l tau transgenic mice induced by Abeta 42 fibrils

1 reference

7 January 2021

Enhanced neurofibrillary degeneration in transgenic mice expressing mutant tau and APP.

1 reference

7 January 2021

Abeta immunotherapy leads to clearance of early, but not late, hyperphosphorylated tau aggregates via the proteasome

1 reference

7 January 2021

Immunotherapeutic Approaches to Alzheimer's Disease

1 reference

7 January 2021

Neurodegenerative tauopathies

1 reference

7 January 2021

Association of missense and 5'-splice-site mutations in tau with the inherited dementia FTDP-17

1 reference

7 January 2021

Tau is a candidate gene for chromosome 17 frontotemporal dementia

1 reference

7 January 2021

Mutation in the tau gene in familial multiple system tauopathy with presenile dementia

1 reference

7 January 2021

Regulated phosphorylation and dephosphorylation of tau protein: effects on microtubule interaction, intracellular trafficking and neurodegeneration

1 reference

7 January 2021

Fibrillogenesis of tau: insights from tau missense mutations in FTDP-17.

1 reference

7 January 2021

Tauopathy in Drosophila: neurodegeneration without neurofibrillary tangles

1 reference

7 January 2021

Initiation and Synergistic Fibrillization of Tau and Alpha-Synuclein

1 reference

7 January 2021

Alpha-synuclein and neurodegenerative diseases

1 reference

7 January 2021

Mutation in the alpha-synuclein gene identified in families with Parkinson's disease

1 reference

7 January 2021

Ala30Pro mutation in the gene encoding alpha-synuclein in Parkinson's disease

1 reference

7 January 2021

alpha-Synuclein locus triplication causes Parkinson's disease

1 reference

7 January 2021

The new mutation, E46K, of alpha-synuclein causes Parkinson and Lewy body dementia

1 reference

7 January 2021

Chronic systemic pesticide exposure reproduces features of Parkinson's disease

1 reference

7 January 2021

Oxidative modifications of alpha-synuclein.

1 reference

7 January 2021

The role of alpha-synuclein in Parkinson's disease: insights from animal models

1 reference

7 January 2021

Pharmacological prevention of Parkinson disease in Drosophila.

1 reference

7 January 2021

Chaperone suppression of alpha-synuclein toxicity in a Drosophila model for Parkinson's disease

1 reference

7 January 2021

Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism

1 reference

7 January 2021

The ubiquitin pathway in Parkinson's disease.

1 reference

7 January 2021

Are ubiquitination pathways central to Parkinson's disease?

1 reference

7 January 2021

Mutations in the DJ-1 gene associated with autosomal recessive early-onset parkinsonism

1 reference

7 January 2021

Hereditary early-onset Parkinson's disease caused by mutations in PINK1

1 reference

7 January 2021

Glutamine repeats and neurodegeneration

1 reference

7 January 2021

Androgen receptor gene mutations in X-linked spinal and bulbar muscular atrophy

1 reference

7 January 2021

Huntingtin-encoded polyglutamine expansions form amyloid-like protein aggregates in vitro and in vivo

1 reference

7 January 2021

Expanding our understanding of polyglutamine diseases through mouse models

1 reference

7 January 2021

Ataxin-1 with an expanded glutamine tract alters nuclear matrix-associated structures

1 reference

7 January 2021

Intranuclear neuronal inclusions: a common pathogenic mechanism for glutamine-repeat neurodegenerative diseases?

1 reference

7 January 2021

Chaperoning brain degeneration

1 reference

7 January 2021

Polyglutamine pathogenesis: emergence of unifying mechanisms for Huntington's disease and related disorders

1 reference

7 January 2021

Mechanisms of cell death in polyglutamine expansion diseases

1 reference

7 January 2021

Impairment of the ubiquitin-proteasome system by protein aggregation

1 reference

7 January 2021

Polyglutamines placed into context

1 reference

7 January 2021

Are amyotrophic lateral sclerosis patients cognitively normal?

1 reference

7 January 2021

Unraveling the mechanisms involved in motor neuron degeneration in ALS

1 reference

7 January 2021

A gene encoding a putative GTPase regulator is mutated in familial amyotrophic lateral sclerosis 2

1 reference

7 January 2021

The gene encoding alsin, a protein with three guanine-nucleotide exchange factor domains, is mutated in a form of recessive amyotrophic lateral sclerosis

1 reference

7 January 2021

Mutant dynactin in motor neuron disease.

1 reference

7 January 2021

Mutations in dynein link motor neuron degeneration to defects in retrograde transport

1 reference

7 January 2021

Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis

1 reference

7 January 2021

Amyotrophic lateral sclerosis. unfolding the toxicity of the misfolded

1 reference

7 January 2021

Aggregation and Motor Neuron Toxicity of an ALS-Linked SOD1 Mutant Independent from Wild-Type SOD1

1 reference

7 January 2021

Wild-Type Nonneuronal Cells Extend Survival of SOD1 Mutant Motor Neurons in ALS Mice

1 reference

7 January 2021

Prion Protein Biology

1 reference

7 January 2021

Variant Creutzfeldt-Jakob disease.

1 reference

7 January 2021

Transmissible spongiform encephalopathies.

1 reference

7 January 2021

Cell-free formation of protease-resistant prion protein.

1 reference

7 January 2021

PrP knock-out and PrP transgenic mice in prion research

1 reference

7 January 2021

Prion propagation in mice expressing human and chimeric PrP transgenes implicates the interaction of cellular PrP with another protein

1 reference

7 January 2021

BSE and prions: uncertainties about the agent

1 reference

7 January 2021

Synthetic mammalian prions

1 reference

7 January 2021

Drug therapy in human and experimental transmissible spongiform encephalopathy

1 reference

7 January 2021

Prions as protein-based genetic elements

1 reference

7 January 2021

Protein-only transmission of three yeast prion strains.

1 reference

7 January 2021

Conformational variations in an infectious protein determine prion strain differences

1 reference

7 January 2021

Neuropathology of cognitively normal elderly.

1 reference

7 January 2021

Specific spatial learning deficits become severe with age in beta -amyloid precursor protein transgenic mice that harbor diffuse beta -amyloid deposits but do not form plaques

1 reference

7 January 2021

Protofibrils, pores, fibrils, and neurodegeneration: separating the responsible protein aggregates from the innocent bystanders

1 reference

7 January 2021

Nuclear inclusions in glutamine repeat disorders: are they pernicious, coincidental, or beneficial?

1 reference

7 January 2021

Ataxin-1 nuclear localization and aggregation: role in polyglutamine-induced disease in SCA1 transgenic mice.

1 reference

7 January 2021

Neurotoxicity and neurodegeneration when PrP accumulates in the cytosol

1 reference

7 January 2021

Tau blocks traffic of organelles, neurofilaments, and APP vesicles in neurons and enhances oxidative stress

1 reference

7 January 2021

Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo

1 reference

7 January 2021

Accelerated in vitro fibril formation by a mutant alpha-synuclein linked to early-onset Parkinson disease.

1 reference

7 January 2021

Toxic proteins in neurodegenerative disease

1 reference

7 January 2021

Folding proteins in fatal ways

1 reference

7 January 2021

Mechanisms of neurodegenerative disorders: Part 1: protein aggregates.

1 reference

7 January 2021

Toxicity of familial ALS-linked SOD1 mutants from selective recruitment to spinal mitochondria.

1 reference

7 January 2021

Amyotrophic lateral sclerosis-associated SOD1 mutant proteins bind and aggregate with Bcl-2 in spinal cord mitochondria

1 reference

7 January 2021

Genotype-phenotype correlations in FTDP-17: does form follow function?

1 reference

7 January 2021

Identifiers

DOI

10.1038/NM1113

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Dimensions Publication ID

11 August 2017

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