Context-dependent functions of angiopoietin 2 are determined by the endothelial phosphatase VEPTP. (Q47846359)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29358379%20AND%20SRC:MED&resulttype=core&format=json

9 April 2020

title

Context-dependent functions of angiopoietin 2 are determined by the endothelial phosphatase VEPTP (English)

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9 April 2020

1

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9 April 2020

Benjamin R Thomson

2

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9 April 2020

Isabel Anna Carota

4

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9 April 2020

Tuncer Onay

6

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9 April 2020

Jing Jin

15

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9 April 2020

12

Aris N Economides

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9 April 2020

8

Asish K Ghosh

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9 April 2020

author name string

Stefan Heinen

3

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9 April 2020

Shinji Yamaguchi

5

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9 April 2020

Pan Liu

7

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9 April 2020

Chengjin Li

9

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9 April 2020

Vera Eremina

10

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9 April 2020

Young-Kwon Hong

11

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9 April 2020

Kevin G Peters

14

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9 April 2020

Susan E Quaggin

16

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9 April 2020

Dietmar Vestweber

13

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9 April 2020

language of work or name

English

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publication date

22 January 2018

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Proceedings of the National Academy of Sciences of the United States of America

9 April 2020

published in

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9 April 2020

volume

115

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9 April 2020

page(s)

1298-1303

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9 April 2020

issue

6

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Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International

9 April 2020

copyright license

start time

22 January 2018

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

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cites work

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Angiopoietin receptor Tie2 is required for vein specification and maintenance via regulating COUP-TFII

22 May 2018

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22 May 2018

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22 May 2018

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22 May 2018

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22 May 2018

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22 May 2018

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Angiopoietin-2-induced blood-brain barrier compromise and increased stroke size are rescued by VE-PTP-dependent restoration of Tie2 signaling

22 May 2018

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Interfering with VE-PTP stabilizes endothelial junctions in vivo via Tie-2 in the absence of VE-cadherin

22 May 2018

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The Orphan Receptor Tie1 Controls Angiogenesis and Vascular Remodeling by Differentially Regulating Tie2 in Tip and Stalk Cells.

22 May 2018

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Hematopoietic stem and progenitor cells regulate the regeneration of their niche by secreting Angiopoietin-1

22 May 2018

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22 May 2018

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Molecular controls of lymphatic VEGFR3 signaling

22 May 2018

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A lymphatic defect causes ocular hypertension and glaucoma in mice

22 May 2018

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Targeting VE-PTP activates TIE2 and stabilizes the ocular vasculature

22 May 2018

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The tyrosine phosphatase PTPN22 discriminates weak self peptides from strong agonist TCR signals

22 May 2018

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Angiopoietin 2 regulates the transformation and integrity of lymphatic endothelial cell junctions

22 May 2018

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Tie1 deletion inhibits tumor growth and improves angiopoietin antagonist therapy

22 May 2018

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22 May 2018

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The complex role of angiopoietin-2 in the angiopoietin-tie signaling pathway

22 May 2018

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Regulation of TCR signalling by tyrosine phosphatases: from immune homeostasis to autoimmunity

22 May 2018

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Angiopoietin-2 differentially regulates angiogenesis through TIE2 and integrin signaling

22 May 2018

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Angiopoietin-1 is essential in mouse vasculature during development and in response to injury

22 May 2018

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A tissue-specific atlas of mouse protein phosphorylation and expression

22 May 2018

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Visualization of lymphatic vessels by Prox1-promoter directed GFP reporter in a bacterial artificial chromosome-based transgenic mouse

22 May 2018

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Cell signaling by receptor tyrosine kinases

22 May 2018

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Lymphatic endothelial cell sphingosine kinase activity is required for lymphocyte egress and lymphatic patterning

22 May 2018

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Control of vascular morphogenesis and homeostasis through the angiopoietin-Tie system

22 May 2018

1 reference

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Defective remodeling and maturation of the lymphatic vasculature in Angiopoietin-2 deficient mice.

22 May 2018

1 reference

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Differential function of Tie2 at cell-cell contacts and cell-substratum contacts regulated by angiopoietin-1

22 May 2018

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Angiopoietins assemble distinct Tie2 signalling complexes in endothelial cell-cell and cell-matrix contacts

22 May 2018

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Vascular endothelial tyrosine phosphatase (VE-PTP)-null mice undergo vasculogenesis but die embryonically because of defects in angiogenesis

22 May 2018

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Differential response of lymphatic, venous and arterial endothelial cells to angiopoietin-1 and angiopoietin-2.

22 May 2018

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Angiopoietin-2 functions as an autocrine protective factor in stressed endothelial cells

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5819405

Crystal structures of the Tie2 receptor ectodomain and the angiopoietin-2-Tie2 complex

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5819405

Vascular endothelial cell-specific phosphotyrosine phosphatase (VE-PTP) activity is required for blood vessel development

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5819405

Excess circulating angiopoietin-2 may contribute to pulmonary vascular leak in sepsis in humans

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5819405

Oligomerization and multimerization are critical for angiopoietin-1 to bind and phosphorylate Tie2.

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5819405

A unique autophosphorylation site on Tie2/Tek mediates Dok-R phosphotyrosine binding domain binding and function

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5819405

Angiopoietin-2 at high concentration can enhance endothelial cell survival through the phosphatidylinositol 3'-kinase/Akt signal transduction pathway

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5819405

Functional interaction of vascular endothelial-protein-tyrosine phosphatase with the angiopoietin receptor Tie-2

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5819405

Identification of Tek/Tie2 binding partners. Binding to a multifunctional docking site mediates cell survival and migration

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5819405

Tyrosine 1101 of Tie2 is the major site of association of p85 and is required for activation of phosphatidylinositol 3-kinase and Akt

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5819405

Angiopoietin-2, a natural antagonist for Tie2 that disrupts in vivo angiogenesis

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5819405

Vascular dysmorphogenesis caused by an activating mutation in the receptor tyrosine kinase TIE2

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5819405

Requisite role of angiopoietin-1, a ligand for the TIE2 receptor, during embryonic angiogenesis

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5819405

Tie-1 and tie-2 define another class of putative receptor tyrosine kinase genes expressed in early embryonic vascular system

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5819405

Dominant-negative and targeted null mutations in the endothelial receptor tyrosine kinase, tek, reveal a critical role in vasculogenesis of the embryo

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5819405

Distinct roles of the receptor tyrosine kinases Tie-1 and Tie-2 in blood vessel formation

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5819405

Normalization of Tumor Vessels by Tie2 Activation and Ang2 Inhibition Enhances Drug Delivery and Produces a Favorable Tumor Microenvironment.

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5819405

Genetic dissection of tie pathway in mouse lymphatic maturation and valve development.

14 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5819405

Loss of endothelial Tie1 receptor impairs lymphatic vessel development-brief report

14 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5819405

A designed angiopoietin-2 variant, pentameric COMP-Ang2, strongly activates Tie2 receptor and stimulates angiogenesis.

14 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5819405

Angiopoietin-1 prevents VEGF-induced endothelial permeability by sequestering Src through mDia.

14 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5819405

Angiopoietin-2 sensitizes endothelial cells to TNF-alpha and has a crucial role in the induction of inflammation.

14 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5819405

The Tie-2 ligand angiopoietin-2 is stored in and rapidly released upon stimulation from endothelial cell Weibel-Palade bodies

14 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5819405

Angiopoietin-2 is required for postnatal angiogenesis and lymphatic patterning, and only the latter role is rescued by Angiopoietin-1.

14 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5819405

14 August 2018

Identifiers

DOI

10.1073/PNAS.1714446115

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29358379%20AND%20SRC:MED&resulttype=core&format=json

9 April 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29358379%20AND%20SRC:MED&resulttype=core&format=json

9 April 2020

1 reference