The Orphan Receptor Tie1 Controls Angiogenesis and Vascular Remodeling by Differentially Regulating Tie2 in Tip and Stalk Cells. (Q40567745)

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23 February 2020

title

The Orphan Receptor Tie1 Controls Angiogenesis and Vascular Remodeling by Differentially Regulating Tie2 in Tip and Stalk Cells (English)

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microvasculature remodeling

23 February 2020

main subject

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1

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23 February 2020

Andrew V Benest

9

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23 February 2020

Carmen Ruiz De Almodovar

14

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23 February 2020

Hellmut G Augustin

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23 February 2020

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Hans-Reimer Rodewald

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23 February 2020

author name string

Silvia La Porta

2

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23 February 2020

Annika Budnik

3

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23 February 2020

Katrin Busch

4

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23 February 2020

Junhao Hu

5

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23 February 2020

Nathalie Tisch

6

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23 February 2020

Claudia Korn

7

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23 February 2020

Aida Freire Valls

8

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Dorothee Terhardt

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23 February 2020

Xianghu Qu

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23 February 2020

H Scott Baldwin

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23 February 2020

Ralf H Adams

12

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23 February 2020

language of work or name

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3 September 2015

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23 February 2020

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23 February 2020

volume

12

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issue

11

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23 February 2020

page(s)

1761-1773

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Inflammatory cytokines and vascular endothelial growth factor stimulate the release of soluble tie receptor from human endothelial cells via metalloprotease activation

23 February 2020

cites work

1 reference

12 December 2020

Tie-1-directed expression of Cre recombinase in endothelial cells of embryoid bodies and transgenic mice

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12 December 2020

Cre reporter strains produced by targeted insertion of EYFP and ECFP into the ROSA26 locus

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Codon-improved Cre recombinase (iCre) expression in the mouse

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The endothelial receptor tyrosine kinase Tie1 activates phosphatidylinositol 3-kinase and Akt to inhibit apoptosis.

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Vascular endothelial growth factor modulates the Tie-2:Tie-1 receptor complex.

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12 December 2020

Angiopoietin-2 displays VEGF-dependent modulation of capillary structure and endothelial cell survival in vivo

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12 December 2020

A fluorescent Tie1 reporter allows monitoring of vascular development and endothelial cell isolation from transgenic mouse embryos

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12 December 2020

VEGF guides angiogenic sprouting utilizing endothelial tip cell filopodia

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12 December 2020

Transcriptional and post‐translation regulation of the Tiel receptor by fluid shear stress changes in vascular endothelial cells

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12 December 2020

Specific Induction of tie1 Promoter by Disturbed Flow in Atherosclerosis-Prone Vascular Niches and Flow-Obstructing Pathologies

1 reference

12 December 2020

How do endothelial cells orientate?

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12 December 2020

Multiple angiopoietin recombinant proteins activate the Tie1 receptor tyrosine kinase and promote its interaction with Tie2

1 reference

12 December 2020

Integration of flow-dependent endothelial phenotypes by Kruppel-like factor 2

1 reference

12 December 2020

Systemic overexpression of angiopoietin-2 promotes tumor microvessel regression and inhibits angiogenesis and tumor growth

1 reference

12 December 2020

Activation of the orphan endothelial receptor Tie1 modifies Tie2-mediated intracellular signaling and cell survival

1 reference

12 December 2020

Angiopoietins assemble distinct Tie2 signalling complexes in endothelial cell-cell and cell-matrix contacts

1 reference

12 December 2020

Differential function of Tie2 at cell-cell contacts and cell-substratum contacts regulated by angiopoietin-1

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12 December 2020

Heterozygous deficiency of PHD2 restores tumor oxygenation and inhibits metastasis via endothelial normalization

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12 December 2020

Angiogenesis: a team effort coordinated by notch.

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12 December 2020

Angiopoietin 2 is a partial agonist/antagonist of Tie2 signaling in the endothelium

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Control of vascular morphogenesis and homeostasis through the angiopoietin-Tie system

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12 December 2020

VEGF and Notch signaling: the yin and yang of angiogenic sprouting

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Loss of endothelial Tie1 receptor impairs lymphatic vessel development-brief report

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12 December 2020

Effects of angiopoietins-1 and -2 on the receptor tyrosine kinase Tie2 are differentially regulated at the endothelial cell surface

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12 December 2020

Abnormal embryonic lymphatic vessel development in Tie1 hypomorphic mice

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12 December 2020

Tie1-Tie2 interactions mediate functional differences between angiopoietin ligands

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12 December 2020

Ephrin-B2 controls VEGF-induced angiogenesis and lymphangiogenesis

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12 December 2020

Identification and functional analysis of endothelial tip cell-enriched genes

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12 December 2020

Endothelial cells dynamically compete for the tip cell position during angiogenic sprouting

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12 December 2020

Tie1 attenuation reduces murine atherosclerosis in a dose-dependent and shear stress-specific manner

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12 December 2020

Molecular control of endothelial cell behaviour during blood vessel morphogenesis

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12 December 2020

Basic and therapeutic aspects of angiogenesis

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12 December 2020

Angiogenic morphogenesis driven by dynamic and heterogeneous collective endothelial cell movement.

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12 December 2020

The molecular balance between receptor tyrosine kinases Tie1 and Tie2 is dynamically controlled by VEGF and TNFα and regulates angiopoietin signalling

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12 December 2020

Angiopoietin-2 differentially regulates angiogenesis through TIE2 and integrin signaling

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12 December 2020

Angiopoietin-2 functions as a Tie2 agonist in tumor models, where it limits the effects of VEGF inhibition

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12 December 2020

Angiopoietin-2: an attractive target for improved antiangiogenic tumor therapy

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12 December 2020

Endocytosis of receptor tyrosine kinases

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12 December 2020

Tie1 deletion inhibits tumor growth and improves angiopoietin antagonist therapy

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12 December 2020

The role of differential VE-cadherin dynamics in cell rearrangement during angiogenesis.

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12 December 2020

Endothelial cell-derived non-canonical Wnt ligands control vascular pruning in angiogenesis.

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12 December 2020

Host genetic diversity enables Ebola hemorrhagic fever pathogenesis and resistance

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12 December 2020

Mechanisms of Vessel Pruning and Regression.

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12 December 2020

Distinct roles of the receptor tyrosine kinases Tie-1 and Tie-2 in blood vessel formation

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12 December 2020

Endothelial-specific gene expression directed by the tie gene promoter in vivo.

1 reference

12 December 2020

Dominant-negative and targeted null mutations in the endothelial receptor tyrosine kinase, tek, reveal a critical role in vasculogenesis of the embryo

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12 December 2020

The receptor tyrosine kinase TIE is required for integrity and survival of vascular endothelial cells.

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12 December 2020

The endothelial receptor tyrosine kinase tie-1 is upregulated by hypoxia and vascular endothelial growth factor.

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12 December 2020

Analysis of blood vessel maturation processes during cyclic ovarian angiogenesis.

1 reference

12 December 2020

10.1016/J.CELREP.2015.08.024

Identifiers

DOI

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23 February 2020

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23 February 2020

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