Tie1 controls angiopoietin function in vascular remodeling and inflammation (Q30805233)

19 August 2017

Tie1 controls angiopoietin function in vascular remodeling and inflammation (English)

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microvasculature remodeling

19 August 2017

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13

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26 June 2017

Breanna Allen

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Tomas Strandin

object named as

Tomas Strandin

11

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Kari Alitalo

object named as

Kari Alitalo

16

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Antti Vaheri

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object named as

Antti Vaheri

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19 August 2017

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Gabriela D'Amico

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Anita Lampinen

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Marja Lohela

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19 August 2017

Emilia A Korhonen

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Hemant Giri

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19 August 2017

Andrey Anisimov

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19 August 2017

Minah Kim

5

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19 August 2017

Shentong Fang

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19 August 2017

Tuomas J Sipilä

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Gou Young Koh

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Donald M McDonald

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Pipsa Saharinen

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19 August 2017

language of work or name

English

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publication date

22 August 2016

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Journal of Clinical Investigation

19 August 2017

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126

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9

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3495-3510

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describes a project that uses

19 August 2017

ImageJ

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11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC5004934/fullTextXML

inferred from PubMed Central ID database lookup

cites work

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21 June 2018

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21 June 2018

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21 June 2018

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Effects of angiopoietin-2-blocking antibody on endothelial cell-cell junctions and lung metastasis

21 June 2018

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The molecular balance between receptor tyrosine kinases Tie1 and Tie2 is dynamically controlled by VEGF and TNFα and regulates angiopoietin signalling

21 June 2018

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Angiopoietin-1 is essential in mouse vasculature during development and in response to injury

21 June 2018

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Tie1 attenuation reduces murine atherosclerosis in a dose-dependent and shear stress-specific manner

21 June 2018

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21 June 2018

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21 June 2018

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Tie1-Tie2 interactions mediate functional differences between angiopoietin ligands

21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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Regulated proteolytic processing of Tie1 modulates ligand responsiveness of the receptor-tyrosine kinase Tie2.

21 June 2018

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Activation of the orphan endothelial receptor Tie1 modifies Tie2-mediated intracellular signaling and cell survival

21 June 2018

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Angiopoietin-2 functions as an autocrine protective factor in stressed endothelial cells

21 June 2018

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Excess circulating angiopoietin-2 may contribute to pulmonary vascular leak in sepsis in humans

21 June 2018

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Stable interaction between alpha5beta1 integrin and Tie2 tyrosine kinase receptor regulates endothelial cell response to Ang-1.

21 June 2018

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Multiple angiopoietin recombinant proteins activate the Tie1 receptor tyrosine kinase and promote its interaction with Tie2

21 June 2018

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Microvascular patterning is controlled by fine-tuning the Akt signal

21 June 2018

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Angiopoietin-1 modulates endothelial cell function and gene expression via the transcription factor FKHR (FOXO1).

21 June 2018

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COMP-Ang1: a designed angiopoietin-1 variant with nonleaky angiogenic activity

21 June 2018

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Angiopoietin-2 causes pericyte dropout in the normal retina: evidence for involvement in diabetic retinopathy.

21 June 2018

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21 June 2018

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The endothelial receptor tyrosine kinase Tie1 activates phosphatidylinositol 3-kinase and Akt to inhibit apoptosis.

21 June 2018

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Biological action of angiopoietin-2 in a fibrin matrix model of angiogenesis is associated with activation of Tie2.

21 June 2018

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Conditional transgene expression in endothelial cells.

21 June 2018

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TIE1 and TIE2 receptor tyrosine kinases inversely regulate embryonic angiogenesis by the mechanism of intussusceptive microvascular growth

21 June 2018

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Angiopoietin-2, a natural antagonist for Tie2 that disrupts in vivo angiogenesis

21 June 2018

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Isolation of angiopoietin-1, a ligand for the TIE2 receptor, by secretion-trap expression cloning

21 June 2018

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The receptor tyrosine kinase TIE is required for integrity and survival of vascular endothelial cells.

21 June 2018

1 reference

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tek, a novel tyrosine kinase gene located on mouse chromosome 4, is expressed in endothelial cells and their presumptive precursors

21 June 2018

1 reference

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Enhanced expression of the tie receptor tyrosine kinase in endothelial cells during neovascularization

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5004934

A novel endothelial cell surface receptor tyrosine kinase with extracellular epidermal growth factor homology domains

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5004934

Lung-targeted RNA interference against angiopoietin-2 ameliorates multiple organ dysfunction and death in sepsis.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5004934

Genetic dissection of tie pathway in mouse lymphatic maturation and valve development.

25 November 2018

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Angiopoietin 2 induces pericyte apoptosis via α3β1 integrin signaling in diabetic retinopathy.

25 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5004934

Angiopoietin-2 inhibition prevents transplant ischemia-reperfusion injury and chronic rejection in rat cardiac allografts.

25 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5004934

The flow dependency of Tie2 expression in endotoxemia.

25 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5004934

Acute administration of recombinant Angiopoietin-1 ameliorates multiple-organ dysfunction syndrome and improves survival in murine sepsis.

25 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5004934

Loss of endothelial Tie1 receptor impairs lymphatic vessel development-brief report

25 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5004934

A designed angiopoietin-2 variant, pentameric COMP-Ang2, strongly activates Tie2 receptor and stimulates angiogenesis.

25 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5004934

Suppression of Tie-1 in endothelial cells in vitro induces a change in the genome-wide expression profile reflecting an inflammatory function

25 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5004934

Regulation of angiopoietin expression by bacterial lipopolysaccharide.

25 November 2018

1 reference

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Efficient, inducible Cre-recombinase activation in vascular endothelium.

25 November 2018

1 reference

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Cell-based angiopoietin-1 gene therapy for acute lung injury.

25 November 2018

1 reference

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Long-term and sustained COMP-Ang1 induces long-lasting vascular enlargement and enhanced blood flow.

25 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5004934

Bidirectional transmembrane signaling by cytoplasmic domain separation in integrins

25 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5004934

Angiopoietin-2 is required for postnatal angiogenesis and lymphatic patterning, and only the latter role is rescued by Angiopoietin-1.

25 November 2018

1 reference

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Imaging sites of receptor dephosphorylation by PTP1B on the surface of the endoplasmic reticulum

25 November 2018

1 reference

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Interaction of the TEK and TIE receptor tyrosine kinases during cardiovascular development.

25 November 2018

1 reference

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The new Tie-1 monoclonal antibodies detect angiogenesis in metastatic malignancies

25 November 2018

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12 December 2020

In vivo actions of angiopoietins on quiescent and remodeling blood and lymphatic vessels in mouse airways and skin

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12 December 2020

Angiopoietin-1 guides directional angiogenesis through integrin αvβ5 signaling for recovery of ischemic retinopathy.

1 reference

12 December 2020

Endothelial Cell-Derived Angiopoietin-2 Controls Liver Regeneration as a Spatiotemporal Rheostat

1 reference

12 December 2020

Enhanced expression of the tie receptor tyrosine kinase mesenger RNA in the vascular endothelium of metastatic melanomas

1 reference

12 December 2020

Imaging protein interactions by FRET microscopy: FLIM measurements

1 reference

12 December 2020

Inflammatory cytokines and vascular endothelial growth factor stimulate the release of soluble tie receptor from human endothelial cells via metalloprotease activation

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12 December 2020

Identifiers

DOI

10.1172/JCI84923

1 reference

19 August 2017

1 reference

19 August 2017

1 reference