The tyrosine phosphatase PTPN22 discriminates weak self peptides from strong agonist TCR signals (Q42013527)

15 October 2017

The tyrosine phosphatase PTPN22 discriminates weak self peptides from strong agonist TCR signals (English)

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15 October 2017

2

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15 October 2017

Vicky L Morrison

3

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Rose Zamoyska

object named as

Rose Zamoyska

series ordinal

4

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Robert Salmond

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1

object named as

Robert J Salmond

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PMCID

4148831

15 October 2017

language of work or name

English

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publication date

10 August 2014

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15 October 2017

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15 October 2017

15

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15 October 2017

875-883

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15 October 2017

9

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https://scigraph.springernature.com/pub.10.1038/ni.2958

15 October 2017

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Tyrosine phosphatase PTPN22: multifunctional regulator of immune signaling, development, and disease.

5 June 2018

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Human autoimmunity after lymphocyte depletion is caused by homeostatic T-cell proliferation

5 June 2018

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Interferon regulatory factor 4 sustains CD8(+) T cell expansion and effector differentiation

5 June 2018

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The transcription factor IRF4 is essential for TCR affinity-mediated metabolic programming and clonal expansion of T cells

5 June 2018

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The transcription factor Interferon Regulatory Factor 4 is required for the generation of protective effector CD8+ T cells

5 June 2018

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A disease-associated PTPN22 variant promotes systemic autoimmunity in murine models

5 June 2018

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TCPTP regulates SFK and STAT3 signaling and is lost in triple-negative breast cancers.

5 June 2018

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Alemtuzumab versus interferon beta 1a as first-line treatment for patients with relapsing-remitting multiple sclerosis: a randomised controlled phase 3 trial

5 June 2018

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5 June 2018

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Transcriptional control of effector and memory CD8+ T cell differentiation

5 June 2018

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Autoreactive T cells bypass negative selection and respond to self-antigen stimulation during infection.

5 June 2018

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Protein tyrosine phosphatases in lymphocyte activation and autoimmunity

5 June 2018

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Protein kinase D isoforms are dispensable for integrin-mediated lymphocyte adhesion and homing to lymphoid tissues

5 June 2018

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The transcription factor Myc controls metabolic reprogramming upon T lymphocyte activation

5 June 2018

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T cell protein tyrosine phosphatase attenuates T cell signaling to maintain tolerance in mice

5 June 2018

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Unraveling the functional implications of GWAS: how T cell protein tyrosine phosphatase drives autoimmune disease.

5 June 2018

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Normal T cell homeostasis: the conversion of naive cells into memory-phenotype cells

5 June 2018

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Detecting shared pathogenesis from the shared genetics of immune-related diseases

5 June 2018

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Thymic selection threshold defined by compartmentalization of Ras/MAPK signalling

5 June 2018

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Altered peptide ligands induce delayed CD8-T cell receptor interaction--a role for CD8 in distinguishing antigen quality

5 June 2018

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Identification of substrates of human protein-tyrosine phosphatase PTPN22

5 June 2018

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Effector and memory CD8+ T cell fate coupled by T-bet and eomesodermin

5 June 2018

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Regulation of mature T cell homeostasis

5 June 2018

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Homeostatic expansion of T cells during immune insufficiency generates autoimmunity.

5 June 2018

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PEST domain-enriched tyrosine phosphatase (PEP) regulation of effector/memory T cells

5 June 2018

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Antigen-driven effector CD8 T cell function regulated by T-bet

5 June 2018

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Enumeration, phenotyping, and identification of activation events in conjugates between T cells and antigen-presenting cells by flow cytometry

5 June 2018

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Rare, structurally homologous self-peptides promote thymocyte positive selection

5 June 2018

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Rap1A positively regulates T cells via integrin activation rather than inhibiting lymphocyte signaling

5 June 2018

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How alpha beta T cells deal with induced TCR alpha ablation

5 June 2018

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Homeostatic expansion and phenotypic conversion of naïve T cells in response to self peptide/MHC ligands

5 June 2018

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Low-affinity ligands for the TCR drive proliferation of mature CD8+ T cells in lymphopenic hosts

5 June 2018

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T cell receptor antagonist peptides induce positive selection

5 June 2018

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Activation of human peripheral blood T lymphocytes by pharmacological induction of protein-tyrosine phosphorylation

5 June 2018

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Lack of the phosphatase PTPN22 increases adhesion of murine regulatory T cells to improve their immunosuppressive function.

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4148831

The autoimmune disease-associated PTPN22 variant promotes calpain-mediated Lyp/Pep degradation associated with lymphocyte and dendritic cell hyperresponsiveness.

17 August 2018

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Selective expression of the Cre recombinase in late-stage thymocytes using the distal promoter of the Lck gene.

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4148831

Generation of CD8 T cell memory is regulated by IL-12.

17 August 2018

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FNI.2958

PTPN2 attenuates T-cell lymphopenia-induced proliferation

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FNI.2958

Cutting edge: CD4 and CD8 T cells are intrinsically different in their proliferative responses

21 January 2018

1 reference

12 December 2020

Involvement of p21ras activation in T cell CD69 expression

1 reference

12 December 2020

Recent immune status determines the source of antigens that drive homeostatic T cell expansion

1 reference

12 December 2020

Lymphopenia-induced spontaneous T-cell proliferation as a cofactor for autoimmune disease development

1 reference

12 December 2020

Identifiers

DOI

10.1038/NI.2958

1 reference

Dimensions Publication ID

15 October 2017

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0 references

1 reference

15 October 2017

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