Immunity to CRISPR Cas9 and Cas12a therapeutics (Q45873745)

17 December 2017

title

Immunity to CRISPR Cas9 and Cas12a therapeutics (English)

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17 December 2017

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Wei Leong Chew

1

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17 December 2017

publication date

30 October 2017

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17 December 2017

Wiley interdisciplinary reviews. Systems biology and medicine

published in

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17 December 2017

volume

10

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17 December 2017

issue

1

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17 December 2017

A Programmable Dual-RNA-Guided DNA Endonuclease in Adaptive Bacterial Immunity

cites work

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Cas9-crRNA ribonucleoprotein complex mediates specific DNA cleavage for adaptive immunity in bacteria

21 January 2018

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Multiplex genome engineering using CRISPR/Cas systems

21 January 2018

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RNA-guided human genome engineering via Cas9

21 January 2018

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Cpf1 is a single RNA-guided endonuclease of a class 2 CRISPR-Cas system

21 January 2018

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Genome-wide analysis reveals specificities of Cpf1 endonucleases in human cells.

21 January 2018

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Genome-wide specificities of CRISPR-Cas Cpf1 nucleases in human cells.

21 January 2018

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In vivo high-throughput profiling of CRISPR-Cpf1 activity

21 January 2018

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Cas9 as a versatile tool for engineering biology

21 January 2018

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Biology and Applications of CRISPR Systems: Harnessing Nature's Toolbox for Genome Engineering

21 January 2018

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CRISPR-Based Technologies for the Manipulation of Eukaryotic Genomes

21 January 2018

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Cornerstones of CRISPR-Cas in drug discovery and therapy

21 January 2018

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Genome editing. The new frontier of genome engineering with CRISPR-Cas9

21 January 2018

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Applications of CRISPR technologies in research and beyond

21 January 2018

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Next stop for the CRISPR revolution: RNA-guided epigenetic regulators

21 January 2018

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Beyond editing: repurposing CRISPR-Cas9 for precision genome regulation and interrogation

21 January 2018

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CRISPR-Cas systems for editing, regulating and targeting genomes

21 January 2018

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Applications of CRISPR Genome Engineering in Cell Biology

21 January 2018

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Non-viral delivery of genome-editing nucleases for gene therapy

21 January 2018

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The unsung heroes of CRISPR.

21 January 2018

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21 January 2018

The Heroes of CRISPR.

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Genome editing at the crossroads of delivery, specificity, and fidelity

21 January 2018

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CRISPR/Cas9 in Genome Editing and Beyond

21 January 2018

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A guide to genome engineering with programmable nucleases

21 January 2018

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On the Origin of CRISPR-Cas Technology: From Prokaryotes to Mammals.

21 January 2018

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Therapeutic genome editing: prospects and challenges

21 January 2018

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Genome editing in cardiovascular diseases

21 January 2018

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Refining strategies to translate genome editing to the clinic

21 January 2018

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21 January 2018

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Therapeutic genome engineering via CRISPR-Cas systems

21 January 2018

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Genome-editing Technologies for Gene and Cell Therapy

21 January 2018

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Methods for Optimizing CRISPR-Cas9 Genome Editing Specificity

21 January 2018

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Creating and evaluating accurate CRISPR-Cas9 scalpels for genomic surgery

21 January 2018

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Defining and improving the genome-wide specificities of CRISPR-Cas9 nucleases

21 January 2018

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In Vivo Delivery of CRISPR/Cas9 for Therapeutic Gene Editing: Progress and Challenges

21 January 2018

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Future of rAAV Gene Therapy: Platform for RNAi, Gene Editing, and Beyond

21 January 2018

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Engineering Delivery Vehicles for Genome Editing.

21 January 2018

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AAV Vectorization of DSB-mediated Gene Editing Technologies

21 January 2018

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In Vivo Delivery Systems for Therapeutic Genome Editing

21 January 2018

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Materials and methods for delivery of biological drugs

21 January 2018

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Chemical Biology Approaches to Genome Editing: Understanding, Controlling, and Delivering Programmable Nucleases

21 January 2018

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Delivery and Specificity of CRISPR-Cas9 Genome Editing Technologies for Human Gene Therapy.

21 January 2018

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CRISPR genome engineering and viral gene delivery: a case of mutual attraction

21 January 2018

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Challenges in CRISPR/CAS9 Delivery: Potential Roles of Nonviral Vectors.

21 January 2018

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Delivery and therapeutic applications of gene editing technologies ZFNs, TALENs, and CRISPR/Cas9.

21 January 2018

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Therapeutic gene editing: delivery and regulatory perspectives

21 January 2018

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Classification and evolution of type II CRISPR-Cas systems

21 January 2018

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Protein length in eukaryotic and prokaryotic proteomes

21 January 2018

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Unravelling the structural and mechanistic basis of CRISPR-Cas systems

21 January 2018

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CRISPR-Cas immunity in prokaryotes

21 January 2018

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An updated evolutionary classification of CRISPR-Cas systems

21 January 2018

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Diverse evolutionary roots and mechanistic variations of the CRISPR-Cas systems

21 January 2018

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Structures and mechanisms of CRISPR RNA-guided effector nucleases

21 January 2018

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Diversity and evolution of class 2 CRISPR-Cas systems

21 January 2018

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CRISPR-Cas9 Structures and Mechanisms

21 January 2018

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In vivo genome editing using Staphylococcus aureus Cas9

21 January 2018

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In vivo genome editing with a small Cas9 orthologue derived from Campylobacter jejuni

21 January 2018

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The complex and evolving story of T cell activation to AAV vector-encoded transgene products

21 January 2018

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Pre-Clinical Assessment of Immune Responses to Adeno-Associated Virus (AAV) Vectors

21 January 2018

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Impact of AAV Capsid-Specific T-Cell Responses on Design and Outcome of Clinical Gene Transfer Trials with Recombinant Adeno-Associated Viral Vectors: An Evolving Controversy.

21 January 2018

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Viral Vectors for Gene Therapy: Translational and Clinical Outlook

21 January 2018

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Therapeutic in vivo gene transfer for genetic disease using AAV: progress and challenges

21 January 2018

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Cellular and humoral immune responses to adenoviral vectors containing factor IX gene: tolerization of factor IX and vector antigens allows for long-term expression

21 January 2018

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Immunology of gene therapy with adenoviral vectors in mouse skeletal muscle.

21 January 2018

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FK506 immunosuppression to control the immune reactions triggered by first-generation adenovirus-mediated gene transfer

21 January 2018

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Cellular immune response to adenoviral vector infected cells does not require de novo viral gene expression: implications for gene therapy.

21 January 2018

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Immunity to adenovirus and adeno-associated viral vectors: implications for gene therapy

21 January 2018

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Efficient gene editing in adult mouse livers via adenoviral delivery of CRISPR/Cas9.

21 January 2018

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Adenovirus-Mediated Somatic Genome Editing of Pten by CRISPR/Cas9 in Mouse Liver in Spite of Cas9-Specific Immune Responses.

21 January 2018

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Modeling invasive lobular breast carcinoma by CRISPR/Cas9-mediated somatic genome editing of the mammary gland

21 January 2018

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CRISPR/Cas9-mediated somatic correction of a novel coagulator factor IX gene mutation ameliorates hemophilia in mouse

21 January 2018

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Recombinant adeno-associated virus for muscle directed gene therapy

21 January 2018

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Gene delivery to skeletal muscle results in sustained expression and systemic delivery of a therapeutic protein

21 January 2018

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Immune responses to adenovirus and adeno-associated virus in humans.

21 January 2018

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Differential activation of innate immune responses by adenovirus and adeno-associated virus vectors

21 January 2018

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Immune response following intraocular delivery of recombinant viral vectors

21 January 2018

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Safety and efficacy of gene transfer for Leber's congenital amaurosis

21 January 2018

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Adenovirus-associated virus vector-mediated gene transfer in hemophilia B

21 January 2018

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CRISPR/Cas9-mediated genome engineering: an adeno-associated viral (AAV) vector toolbox

21 January 2018

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A multifunctional AAV-CRISPR-Cas9 and its host response

21 January 2018

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A dual AAV system enables the Cas9-mediated correction of a metabolic liver disease in newborn mice

21 January 2018

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Therapeutic genome editing by combined viral and non-viral delivery of CRISPR system components in vivo

21 January 2018

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Somatic genome editing with CRISPR/Cas9 generates and corrects a metabolic disease

21 January 2018

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In vivo genome editing via CRISPR/Cas9 mediated homology-independent targeted integration

21 January 2018

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CRISPR-Cas9 Targeting of PCSK9 in Human Hepatocytes In Vivo-Brief Report

21 January 2018

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Nrl knockdown by AAV-delivered CRISPR/Cas9 prevents retinal degeneration in mice

21 January 2018

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AAV-Mediated CRISPR/Cas Gene Editing of Retinal Cells In Vivo.

21 January 2018

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CRISPR/Cas9-Mediated Genome Editing as a Therapeutic Approach for Leber Congenital Amaurosis 10.

21 January 2018

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In vivo gene editing in dystrophic mouse muscle and muscle stem cells

21 January 2018

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In vivo genome editing improves muscle function in a mouse model of Duchenne muscular dystrophy.

21 January 2018

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Postnatal genome editing partially restores dystrophin expression in a mouse model of muscular dystrophy.

21 January 2018

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A mouse model for adult cardiac-specific gene deletion with CRISPR/Cas9

21 January 2018

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Genome editing with CRISPR/Cas9 in postnatal mice corrects PRKAG2 cardiac syndrome.

21 January 2018

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Muscle-specific CRISPR/Cas9 dystrophin gene editing ameliorates pathophysiology in a mouse model for Duchenne muscular dystrophy

21 January 2018

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Prevention of Muscle Wasting by CRISPR/Cas9-mediated Disruption of Myostatin In Vivo.

21 January 2018

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CRISPR-Cas9 knockin mice for genome editing and cancer modeling

21 January 2018

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In vivo interrogation of gene function in the mammalian brain using CRISPR-Cas9

21 January 2018

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Multiplex gene editing by CRISPR-Cpf1 using a single crRNA array

21 January 2018

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CRISPR/Cas9 Editing of the Mutant Huntingtin Allele In Vitro and In Vivo

21 January 2018

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Successful transduction of liver in hemophilia by AAV-Factor IX and limitations imposed by the host immune response

21 January 2018

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AAV-1-mediated gene transfer to skeletal muscle in humans results in dose-dependent activation of capsid-specific T cells

21 January 2018

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Immune responses to AAV in clinical trials

21 January 2018

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Nucleic acid sensing at the interface between innate and adaptive immunity in vaccination

21 January 2018

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21 January 2018

Immune sensing of DNA

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Guide RNA functional modules direct Cas9 activity and orthogonality

21 January 2018

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Kinetics of the CRISPR-Cas9 effector complex assembly and the role of 3'-terminal segment of guide RNA.

21 January 2018

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CRISPRscan: designing highly efficient sgRNAs for CRISPR-Cas9 targeting in vivo

21 January 2018

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Chemically modified guide RNAs enhance CRISPR-Cas genome editing in human primary cells

21 January 2018

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CRISPR-Cas9 nuclear dynamics and target recognition in living cells.

21 January 2018

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Programmable RNA Tracking in Live Cells with CRISPR/Cas9.

21 January 2018

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Unbiased detection of off-target cleavage by CRISPR-Cas9 and TALENs using integrase-defective lentiviral vectors.

21 January 2018

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GUIDE-seq enables genome-wide profiling of off-target cleavage by CRISPR-Cas nucleases

21 January 2018

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Suppression of RNA recognition by Toll-like receptors: the impact of nucleoside modification and the evolutionary origin of RNA

21 January 2018

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Innate Immune Responses to AAV Vectors

21 January 2018

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Gene disruption by cell-penetrating peptide-mediated delivery of Cas9 protein and guide RNA.

21 January 2018

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Efficient genome editing in the mouse brain by local delivery of engineered Cas9 ribonucleoprotein complexes.

21 January 2018

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Cationic lipid-mediated delivery of proteins enables efficient protein-based genome editing in vitro and in vivo

21 January 2018

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Efficient delivery of genome-editing proteins using bioreducible lipid nanoparticles.

21 January 2018

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Highly efficient RNA-guided genome editing in human cells via delivery of purified Cas9 ribonucleoproteins

21 January 2018

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Enhanced homology-directed human genome engineering by controlled timing of CRISPR/Cas9 delivery

21 January 2018

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Generation of knock-in primary human T cells using Cas9 ribonucleoproteins.

21 January 2018

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Efficient delivery of nuclease proteins for genome editing in human stem cells and primary cells

21 January 2018

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Highly efficient RNA-guided base editing in mouse embryos.

21 January 2018

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Targeted gene knock-in by homology-directed genome editing using Cas9 ribonucleoprotein and AAV donor delivery

21 January 2018

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Targeted mutagenesis in mice by electroporation of Cpf1 ribonucleoproteins.

21 January 2018

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Post-translational modifications in the context of therapeutic proteins

21 January 2018

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DNA Damage Response and Immune Defense: Links and Mechanisms

21 January 2018

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Identification and characterization of essential genes in the human genome.

21 January 2018

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CRISPR Screens Provide a Comprehensive Assessment of Cancer Vulnerabilities but Generate False-Positive Hits for Highly Amplified Genomic Regions.

21 January 2018

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Genomic Copy Number Dictates a Gene-Independent Cell Response to CRISPR/Cas9 Targeting

21 January 2018

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CpG-depleted adeno-associated virus vectors evade immune detection.

21 January 2018

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Therapeutic targeting of innate immunity with Toll-like receptor agonists and antagonists

21 January 2018

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Vaccinia virus encodes a soluble type I interferon receptor of novel structure and broad species specificity

21 January 2018

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Vaccinia virus B18R gene encodes a type I interferon-binding protein that blocks interferon alpha transmembrane signaling

21 January 2018

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Highly efficient reprogramming to pluripotency and directed differentiation of human cells with synthetic modified mRNA.

21 January 2018

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A direct estimate of the human alphabeta T cell receptor diversity

21 January 2018

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Comprehensive assessment of T-cell receptor beta-chain diversity in alphabeta T cells

21 January 2018

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Diversity and clonal selection in the human T-cell repertoire

21 January 2018

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CDR3 loop flexibility contributes to the degeneracy of TCR recognition

21 January 2018

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A T cell receptor CDR3beta loop undergoes conformational changes of unprecedented magnitude upon binding to a peptide/MHC class I complex

21 January 2018

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Understanding the structural dynamics of TCR-pMHC complex interactions.

21 January 2018

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In-depth determination and analysis of the human paired heavy- and light-chain antibody repertoire

21 January 2018

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Comprehensive analysis of cancer-associated somatic mutations in class I HLA genes

21 January 2018

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Nine major HLA class I supertypes account for the vast preponderance of HLA-A and -B polymorphism

21 January 2018

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HLA class I supertypes: a revised and updated classification

21 January 2018

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Functional classification of class II human leukocyte antigen (HLA) molecules reveals seven different supertypes and a surprising degree of repertoire sharing across supertypes

21 January 2018

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T-cell dependent immunogenicity of protein therapeutics: Preclinical assessment and mitigation

21 January 2018

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Design and engineering of deimmunized biotherapeutics.

21 January 2018

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Technologies for MHC class I immunoproteomics

21 January 2018

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Towards a systems understanding of MHC class I and MHC class II antigen presentation.

21 January 2018

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Recent advances in antigen processing and presentation

21 January 2018

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Discovering protective CD8 T cell epitopes--no single immunologic property predicts it!

21 January 2018

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Peptide binding predictions for HLA DR, DP and DQ molecules

21 January 2018

1 reference

NetMHCIIpan-3.0, a common pan-specific MHC class II prediction method including all three human MHC class II isotypes, HLA-DR, HLA-DP and HLA-DQ.

21 January 2018

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NetMHCpan-3.0; improved prediction of binding to MHC class I molecules integrating information from multiple receptor and peptide length datasets

21 January 2018

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Defining CD8+ T cell determinants during human viral infection in populations of Asian ethnicity.

21 January 2018

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Mass Spectrometry Profiling of HLA-Associated Peptidomes in Mono-allelic Cells Enables More Accurate Epitope Prediction

21 January 2018

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A large fraction of HLA class I ligands are proteasome-generated spliced peptides.

21 January 2018

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Beyond model antigens: high-dimensional methods for the analysis of antigen-specific T cells

21 January 2018

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Writ large: Genomic dissection of the effect of cellular environment on immune response

21 January 2018

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Deconstructing the Peptide-MHC Specificity of T Cell Recognition

21 January 2018

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Benchmarking B cell epitope prediction: underperformance of existing methods

21 January 2018

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Reliable B cell epitope predictions: impacts of method development and improved benchmarking

21 January 2018

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ElliPro: a new structure-based tool for the prediction of antibody epitopes

21 January 2018

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Antibody-protein interactions: benchmark datasets and prediction tools evaluation

21 January 2018

1 reference

Removal of B cell epitopes as a practical approach for reducing the immunogenicity of foreign protein-based therapeutics

21 January 2018

1 reference

Reduction of the inhibitory antibody response to human factor VIII in hemophilia A mice by mutagenesis of the A2 domain B-cell epitope

21 January 2018

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Recombinant immunotoxin against B-cell malignancies with no immunogenicity in mice by removal of B-cell epitopes.

21 January 2018

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Recombinant immunotoxin engineered for low immunogenicity and antigenicity by identifying and silencing human B-cell epitopes

21 January 2018

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Recombinant immunotoxin for cancer treatment with low immunogenicity by identification and silencing of human T-cell epitopes

21 January 2018

1 reference

Enhancing the Clinical Potential of AAV Vectors by Capsid Engineering to Evade Pre-Existing Immunity

21 January 2018

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Directed evolution of novel adeno-associated viruses for therapeutic gene delivery.

21 January 2018

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DNA shuffling of adeno-associated virus yields functionally diverse viral progeny

21 January 2018

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Directed evolution of adeno-associated virus yields enhanced gene delivery vectors

21 January 2018

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In Silico Reconstruction of the Viral Evolutionary Lineage Yields a Potent Gene Therapy Vector

21 January 2018

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Development of Patient-specific AAV Vectors After Neutralizing Antibody Selection for Enhanced Muscle Gene Transfer

21 January 2018

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Rationally engineered therapeutic proteins with reduced immunogenicity.

21 January 2018

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Therapeutic enzyme deimmunization by combinatorial T-cell epitope removal using neutral drift

21 January 2018

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Elimination of an immunodominant CD4+ T cell epitope in human IFN-beta does not result in an in vivo response directed at the subdominant epitope

21 January 2018

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Enhancement of the CD8+ T cell response to a subdominant epitope of respiratory syncytial virus by deletion of an immunodominant epitope

21 January 2018

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Removing T-cell epitopes with computational protein design.

21 January 2018

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Protein deimmunization via structure-based design enables efficient epitope deletion at high mutational loads

21 January 2018

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Mapping the Pareto optimal design space for a functionally deimmunized biotherapeutic candidate

21 January 2018

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Broadening the targeting range of Staphylococcus aureus CRISPR-Cas9 by modifying PAM recognition

21 January 2018

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Engineered CRISPR-Cas9 nucleases with altered PAM specificities

21 January 2018

1 reference

Induction of immune tolerance to coagulation factor IX antigen by in vivo hepatic gene transfer

21 January 2018

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Hepatic T cells and liver tolerance

21 January 2018

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The site of primary T cell activation is a determinant of the balance between intrahepatic tolerance and immunity

21 January 2018

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Induction and role of regulatory CD4+CD25+ T cells in tolerance to the transgene product following hepatic in vivo gene transfer

21 January 2018

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The liver as a lymphoid organ

21 January 2018

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Antigen-presenting cell function in the tolerogenic liver environment.

21 January 2018

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Immune tolerance: what is unique about the liver

21 January 2018

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How tolerogenic dendritic cells induce regulatory T cells

21 January 2018

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Immune surveillance by the liver

21 January 2018

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The Balance between CD8+ T Cell-Mediated Clearance of AAV-Encoded Antigen in the Liver and Tolerance Is Dependent on the Vector Dose

21 January 2018

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Efficient presentation of exogenous antigen by liver endothelial cells to CD8+ T cells results in antigen-specific T-cell tolerance

21 January 2018

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Hepatic regulatory T cells and Kupffer cells are crucial mediators of systemic T cell tolerance to antigens targeting murine liver.

21 January 2018

1 reference

Copackaged AAV9 Vectors Promote Simultaneous Immune Tolerance and Phenotypic Correction of Pompe Disease

21 January 2018

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Lack of immunotoxicity after regional intravenous (RI) delivery of rAAV to nonhuman primate skeletal muscle

21 January 2018

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A dystrophic muscle broadens the contribution and activation of immune cells reacting to rAAV gene transfer

21 January 2018

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Factors influencing cross-presentation of non-self antigens expressed from recombinant adeno-associated virus vectors

21 January 2018

1 reference

Immunogenicity of porcine circovirus type 2 capsid protein targeting to different subcellular compartments

21 January 2018

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Genome editing with Cas9 in adult mice corrects a disease mutation and phenotype.

21 January 2018

1 reference

Engineering adeno-associated viruses for clinical gene therapy

21 January 2018

1 reference

E Pluribus Unum: 50 Years of Research, Millions of Viruses, and One Goal--Tailored Acceleration of AAV Evolution

21 January 2018

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Tailoring the AAV vector capsid for gene therapy.

21 January 2018

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CRISPR-based self-cleaving mechanism for controllable gene delivery in human cells

21 January 2018

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A general strategy to construct small molecule biosensors in eukaryotes

21 January 2018

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Chemical and Biophysical Modulation of Cas9 for Tunable Genome Engineering

21 January 2018

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Regulatory and Exhausted T Cell Responses to AAV Capsid.

21 January 2018

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Activation of natural regulatory T cells by IgG Fc-derived peptide "Tregitopes"

21 January 2018

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Human Treg responses allow sustained recombinant adeno-associated virus-mediated transgene expression

21 January 2018

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Transgene regulation using the tetracycline-inducible TetR-KRAB system after AAV-mediated gene transfer in rodents and nonhuman primates

21 January 2018

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Lack of an immune response against the tetracycline-dependent transactivator correlates with long-term doxycycline-regulated transgene expression in nonhuman primates after intramuscular injection of recombinant adeno-associated virus

21 January 2018

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Proteasome inhibitors decrease AAV2 capsid derived peptide epitope presentation on MHC class I following transduction.

21 January 2018

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Engineered AAV vector minimizes in vivo targeting of transduced hepatocytes by capsid-specific CD8+ T cells.

21 January 2018

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Inhibition of ubiquitin/proteasome-dependent protein degradation by the Gly-Ala repeat domain of the Epstein-Barr virus nuclear antigen 1.

21 January 2018

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Inhibition of antigen processing by the internal repeat region of the Epstein-Barr virus nuclear antigen-1.

21 January 2018

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A minimal glycine-alanine repeat prevents the interaction of ubiquitinated I kappaB alpha with the proteasome: a new mechanism for selective inhibition of proteolysis

21 January 2018

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Inhibition of proteasomal degradation by the gly-Ala repeat of Epstein-Barr virus is influenced by the length of the repeat and the strength of the degradation signal

21 January 2018

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Creation of immune 'stealth' genes for gene therapy through fusion with the Gly-Ala repeat of EBNA-1.

21 January 2018

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Viral subversion of the immune system

21 January 2018

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Giving CD4+ T cells the slip: viral interference with MHC class II-restricted antigen processing and presentation.

21 January 2018

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Viral interference with antigen presentation

21 January 2018

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An integrated encyclopedia of DNA elements in the human genome

21 January 2018

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Reprogramming metabolic pathways in vivo with CRISPR/Cas9 genome editing to treat hereditary tyrosinaemia

21 January 2018

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CRISPR-mediated Genome Editing Restores Dystrophin Expression and Function in mdx Mice

21 January 2018

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Immune response to full-length dystrophin delivered to Dmd muscle by a high-capacity adenoviral vector

21 January 2018

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Effects of immunosuppression on circulating adeno-associated virus capsid-specific T cells in humans

21 January 2018

1 reference

Discovery and Functional Characterization of Diverse Class 2 CRISPR-Cas Systems

21 January 2018

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C2c2 is a single-component programmable RNA-guided RNA-targeting CRISPR effector

21 January 2018

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PAM-Dependent Target DNA Recognition and Cleavage by C2c1 CRISPR-Cas Endonuclease

21 January 2018

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New CRISPR-Cas systems from uncultivated microbes.

21 January 2018

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Two distinct RNase activities of CRISPR-C2c2 enable guide-RNA processing and RNA detection

21 January 2018

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Cas13b Is a Type VI-B CRISPR-Associated RNA-Guided RNase Differentially Regulated by Accessory Proteins Csx27 and Csx28.

21 January 2018

1 reference

Argonaute proteins: functional insights and emerging roles

21 January 2018

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The evolutionary journey of Argonaute proteins

21 January 2018

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DNA-guided genome editing using the Natronobacterium gregoryi Argonaute

21 January 2018

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High-throughput functional genomics using CRISPR-Cas9.

21 January 2018

1 reference

Brave new epigenomes: the dawn of epigenetic engineering

21 January 2018

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Comparison of Cas9 activators in multiple species

21 January 2018

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Editing the epigenome: technologies for programmable transcription and epigenetic modulation

21 January 2018

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Transcriptional regulation with CRISPR-Cas9: principles, advances, and applications

21 January 2018

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From profiles to function in epigenomics.

21 January 2018

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Elimination of Toxic Microsatellite Repeat Expansion RNA by RNA-Targeting Cas9.

21 January 2018

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Programmable editing of a target base in genomic DNA without double-stranded DNA cleavage

21 January 2018

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Targeted nucleotide editing using hybrid prokaryotic and vertebrate adaptive immune systems.

21 January 2018

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Engineering and optimising deaminase fusions for genome editing

21 January 2018

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Directed evolution using dCas9-targeted somatic hypermutation in mammalian cells.

21 January 2018

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Targeted AID-mediated mutagenesis (TAM) enables efficient genomic diversification in mammalian cells

21 January 2018

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Increasing the genome-targeting scope and precision of base editing with engineered Cas9-cytidine deaminase fusions

21 January 2018

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CRISPR germline engineering--the community speaks

21 January 2018

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Human germ line editing-roles and responsibilities

21 January 2018

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The morality and ethics governing CRISPR-Cas9 patents in China.

21 January 2018

1 reference

Don’t edit the human germ line

21 January 2018

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Genome editing of the germline: broadening the discussion

21 January 2018

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Biotechnology. A prudent path forward for genomic engineering and germline gene modification

21 January 2018

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The societal opportunities and challenges of genome editing

21 January 2018

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The ethics of publishing human germline research

21 January 2018

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The Public and the Gene-Editing Revolution.

21 January 2018

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Toward Responsible Human Genome Editing

21 January 2018

1 reference

CRISPR/Cas9-mediated gene editing in human tripronuclear zygotes

21 January 2018

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Correction of a pathogenic gene mutation in human embryos

21 January 2018

1 reference

A Genome-wide CRISPR Screen in Primary Immune Cells to Dissect Regulatory Networks

21 January 2018

1 reference

Continuous genetic recording with self-targeting CRISPR-Cas in human cells.

21 January 2018

1 reference

Genetic dissection of Flaviviridae host factors through genome-scale CRISPR screens

21 January 2018

1 reference

Genetic dissection of mammalian ERAD through comparative haploid and CRISPR forward genetic screens

21 January 2018

1 reference

Dissecting Immune Circuits by Linking CRISPR-Pooled Screens with Single-Cell RNA-Seq

21 January 2018

1 reference

Perturb-Seq: Dissecting Molecular Circuits with Scalable Single-Cell RNA Profiling of Pooled Genetic Screens

21 January 2018

1 reference

Pooled CRISPR screening with single-cell transcriptome readout

21 January 2018

1 reference

Targeting a CAR to the TRAC locus with CRISPR/Cas9 enhances tumour rejection.

21 January 2018

1 reference

The immune epitope database (IEDB) 3.0.

21 January 2018

1 reference

Crystal Structure of Cas9 in Complex with Guide RNA and Target DNA

21 January 2018

1 reference

Crystal Structure of Staphylococcus aureus Cas9

21 January 2018

1 reference

Crystal Structure of the Minimal Cas9 from Campylobacter jejuni Reveals the Molecular Diversity in the CRISPR-Cas9 Systems.

21 January 2018

1 reference

The crystal structure of Cpf1 in complex with CRISPR RNA

21 January 2018

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Crystal Structure of Cpf1 in Complex with Guide RNA and Target DNA

21 January 2018

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21 January 2018

Identifiers

DOI

10.1002/WSBM.1408

1 reference

17 December 2017

PubMed ID

29083112

1 reference

17 December 2017