Applications of CRISPR technologies in research and beyond (Q34539796)

2 August 2017

Applications of CRISPR technologies in research and beyond (English)

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2 August 2017

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2

Jennifer A Doudna

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2 August 2017

Rodolphe Barrangou

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publication date

8 September 2016

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2 August 2017

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2 August 2017

34

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2 August 2017

9

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2 August 2017

933-941

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https://scigraph.springernature.com/pub.10.1038/nbt.3659

2 August 2017

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21 January 2018

CRISPR, the disruptor

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Phage response to CRISPR-encoded resistance in Streptococcus thermophilus

21 January 2018

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Diversity, activity, and evolution of CRISPR loci in Streptococcus thermophilus

21 January 2018

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Short motif sequences determine the targets of the prokaryotic CRISPR defence system

21 January 2018

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Structural basis of PAM-dependent target DNA recognition by the Cas9 endonuclease

21 January 2018

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Mechanism of substrate selection by a highly specific CRISPR endoribonuclease

21 January 2018

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Systematic analysis of CRISPR-Cas9 mismatch tolerance reveals low levels of off-target activity

21 January 2018

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Direct observation of R-loop formation by single RNA-guided Cas9 and Cascade effector complexes.

21 January 2018

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The CRISPR/Cas bacterial immune system cleaves bacteriophage and plasmid DNA

21 January 2018

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Dynamics of CRISPR-Cas9 genome interrogation in living cells

21 January 2018

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Conformational control of DNA target cleavage by CRISPR-Cas9.

21 January 2018

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ZFN, TALEN, and CRISPR/Cas-based methods for genome engineering

21 January 2018

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Group II introns: mobile ribozymes that invade DNA.

21 January 2018

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Genome editing. The new frontier of genome engineering with CRISPR-Cas9

21 January 2018

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RNA events. Cas9 targeting and the CRISPR revolution

21 January 2018

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DNA repair and genome maintenance in Bacillus subtilis

21 January 2018

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Alternative end-joining mechanisms: a historical perspective

21 January 2018

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Alternative-NHEJ is a mechanistically distinct pathway of mammalian chromosome break repair

21 January 2018

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MMEJ-assisted gene knock-in using TALENs and CRISPR-Cas9 with the PITCh systems.

21 January 2018

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Development and applications of CRISPR-Cas9 for genome engineering

21 January 2018

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CRISPR-Cas systems for editing, regulating and targeting genomes

21 January 2018

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Dimeric CRISPR RNA-Guided FokI-dCas9 Nucleases Directed by Truncated gRNAs for Highly Specific Genome Editing

21 January 2018

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Dimeric CRISPR RNA-guided FokI nucleases for highly specific genome editing

21 January 2018

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Improving CRISPR-Cas nuclease specificity using truncated guide RNAs

21 January 2018

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CAS9 transcriptional activators for target specificity screening and paired nickases for cooperative genome engineering

21 January 2018

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Genome editing using Cas9 nickases

21 January 2018

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Genome engineering using the CRISPR-Cas9 system

21 January 2018

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Cpf1 is a single RNA-guided endonuclease of a class 2 CRISPR-Cas system

21 January 2018

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Discovery and Functional Characterization of Diverse Class 2 CRISPR-Cas Systems

21 January 2018

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Genome-Scale CRISPR-Mediated Control of Gene Repression and Activation

21 January 2018

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CRISPR-mediated modular RNA-guided regulation of transcription in eukaryotes

21 January 2018

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CRISPR interference (CRISPRi) for sequence-specific control of gene expression

21 January 2018

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Repurposing CRISPR as an RNA-guided platform for sequence-specific control of gene expression

21 January 2018

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Dynamic imaging of genomic loci in living human cells by an optimized CRISPR/Cas system

21 January 2018

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Multiplexed labeling of genomic loci with dCas9 and engineered sgRNAs using CRISPRainbow.

21 January 2018

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Epigenome editing by a CRISPR-Cas9-based acetyltransferase activates genes from promoters and enhancers.

21 January 2018

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Functional annotation of native enhancers with a Cas9-histone demethylase fusion.

21 January 2018

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Enabling functional genomics with genome engineering

21 January 2018

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Guide RNA functional modules direct Cas9 activity and orthogonality

21 January 2018

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Orthogonal Cas9 proteins for RNA-guided gene regulation and editing

21 January 2018

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Phylogeny of Cas9 determines functional exchangeability of dual-RNA and Cas9 among orthologous type II CRISPR-Cas systems

21 January 2018

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Orthogonal gene knockout and activation with a catalytically active Cas9 nuclease

21 January 2018

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Chemically modified guide RNAs enhance CRISPR-Cas genome editing in human primary cells

21 January 2018

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Streptococcus thermophilus CRISPR-Cas9 Systems Enable Specific Editing of the Human Genome

21 January 2018

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Crystal Structure of Cas9 in Complex with Guide RNA and Target DNA

21 January 2018

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In Vitro Reconstitution and Crystallization of Cas9 Endonuclease Bound to a Guide RNA and a DNA Target

21 January 2018

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In vitro enzymology of Cas9.

21 January 2018

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Structures of Cas9 Endonucleases Reveal RNA-Mediated Conformational Activation

21 January 2018

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Engineered CRISPR-Cas9 nucleases with altered PAM specificities

21 January 2018

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The structural biology of CRISPR-Cas systems

21 January 2018

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STRUCTURAL BIOLOGY. A Cas9-guide RNA complex preorganized for target DNA recognition

21 January 2018

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Crystal Structure of Cpf1 in Complex with Guide RNA and Target DNA

21 January 2018

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The crystal structure of Cpf1 in complex with CRISPR RNA

21 January 2018

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Rationally engineered Cas9 nucleases with improved specificity

21 January 2018

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High-fidelity CRISPR-Cas9 nucleases with no detectable genome-wide off-target effects.

21 January 2018

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Identifying and Visualizing Functional PAM Diversity across CRISPR-Cas Systems

21 January 2018

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Rational design of a split-Cas9 enzyme complex

21 January 2018

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A split-Cas9 architecture for inducible genome editing and transcription modulation

21 January 2018

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Enhancing homology-directed genome editing by catalytically active and inactive CRISPR-Cas9 using asymmetric donor DNA.

21 January 2018

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DNA-binding-domain fusions enhance the targeting range and precision of Cas9.

21 January 2018

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Photoactivatable CRISPR-Cas9 for optogenetic genome editing

21 January 2018

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CRISPR-Cas9-based photoactivatable transcription system.

21 January 2018

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Inducible in vivo genome editing with CRISPR-Cas9

21 January 2018

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Increasing the efficiency of precise genome editing with CRISPR-Cas9 by inhibition of nonhomologous end joining

21 January 2018

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Increasing the efficiency of homology-directed repair for CRISPR-Cas9-induced precise gene editing in mammalian cells.

21 January 2018

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High-throughput functional genomics using CRISPR-Cas9.

21 January 2018

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Small molecules enhance CRISPR genome editing in pluripotent stem cells.

21 January 2018

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Advances in CRISPR-Cas9 genome engineering: lessons learned from RNA interference

21 January 2018

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Genome-wide CRISPR screen in a mouse model of tumor growth and metastasis

21 January 2018

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Next-generation libraries for robust RNA interference-based genome-wide screens.

21 January 2018

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Functional genetics for all: engineered nucleases, CRISPR and the gene editing revolution

21 January 2018

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Functional genomics platform for pooled screening and generation of mammalian genetic interaction maps

21 January 2018

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Adapting CRISPR/Cas9 for functional genomics screens.

21 January 2018

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Genetic screens in human cells using the CRISPR-Cas9 system

21 January 2018

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Genome-wide recessive genetic screening in mammalian cells with a lentiviral CRISPR-guide RNA library

21 January 2018

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Genome-scale transcriptional activation by an engineered CRISPR-Cas9 complex

21 January 2018

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Identification and characterization of essential genes in the human genome.

21 January 2018

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CRISPR knockout screening outperforms shRNA and CRISPRi in identifying essential genes.

21 January 2018

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Identification of potential drug targets for tuberous sclerosis complex by synthetic screens combining CRISPR-based knockouts with RNAi

21 January 2018

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A Genome-wide CRISPR Screen in Primary Immune Cells to Dissect Regulatory Networks

21 January 2018

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High-Resolution CRISPR Screens Reveal Fitness Genes and Genotype-Specific Cancer Liabilities.

21 January 2018

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CRISPR/Cas9 somatic multiplex-mutagenesis for high-throughput functional cancer genomics in mice

21 January 2018

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Functional genetic screens for enhancer elements in the human genome using CRISPR-Cas9.

21 January 2018

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High-throughput mapping of regulatory DNA.

21 January 2018

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Tailored Pig Models for Preclinical Efficacy and Safety Testing of Targeted Therapies

21 January 2018

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Genome-wide inactivation of porcine endogenous retroviruses (PERVs).

21 January 2018

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Generation of gene-modified cynomolgus monkey via Cas9/RNA-mediated gene targeting in one-cell embryos.

21 January 2018

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Unraveling the potential of CRISPR-Cas9 for gene therapy

21 January 2018

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Functional Gene Correction for Cystic Fibrosis in Lung Epithelial Cells Generated from Patient iPSCs

21 January 2018

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Correction of a genetic disease in mouse via use of CRISPR-Cas9.

21 January 2018

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Prevention of muscular dystrophy in mice by CRISPR/Cas9-mediated editing of germline DNA

21 January 2018

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Fanconi anemia gene editing by the CRISPR/Cas9 system

21 January 2018

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In vivo genome editing improves muscle function in a mouse model of Duchenne muscular dystrophy.

21 January 2018

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Postnatal genome editing partially restores dystrophin expression in a mouse model of muscular dystrophy.

21 January 2018

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In vivo gene editing in dystrophic mouse muscle and muscle stem cells

21 January 2018

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Genome editing with Cas9 in adult mice corrects a disease mutation and phenotype.

21 January 2018

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Permanent alteration of PCSK9 with in vivo CRISPR-Cas9 genome editing

21 January 2018

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In Vivo CRISPR/Cas9 Gene Editing Corrects Retinal Dystrophy in the S334ter-3 Rat Model of Autosomal Dominant Retinitis Pigmentosa

21 January 2018

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Modelling kidney disease with CRISPR-mutant kidney organoids derived from human pluripotent epiblast spheroids

21 January 2018

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CRISPR/Cas9-mediated heterozygous knockout of the autism gene CHD8 and characterization of its transcriptional networks in neurodevelopment

21 January 2018

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Applications of CRISPR-Cas systems in neuroscience

21 January 2018

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In vivo interrogation of gene function in the mammalian brain using CRISPR-Cas9

21 January 2018

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CRISPR/Cas9-Mediated Genome Editing of Epigenetic Factors for Cancer Therapy.

21 January 2018

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CRISPR-mediated direct mutation of cancer genes in the mouse liver

21 January 2018

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Adenovirus-Mediated Somatic Genome Editing of Pten by CRISPR/Cas9 in Mouse Liver in Spite of Cas9-Specific Immune Responses.

21 January 2018

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Genome engineering using Adeno-Associated Virus (AAV).

21 January 2018

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Generation of knock-in primary human T cells using Cas9 ribonucleoproteins.

21 January 2018

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Cationic lipid-mediated delivery of proteins enables efficient protein-based genome editing in vitro and in vivo

21 January 2018

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TALEN- and CRISPR/Cas9-Mediated Gene Editing in Human Pluripotent Stem Cells Using Lipid-Based Transfection.

21 January 2018

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High Efficiency, Homology-Directed Genome Editing in Caenorhabditis elegans Using CRISPR-Cas9 Ribonucleoprotein Complexes.

21 January 2018

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DNA-free genome editing in plants with preassembled CRISPR-Cas9 ribonucleoproteins

21 January 2018

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Highly efficient RNA-guided genome editing in human cells via delivery of purified Cas9 ribonucleoproteins

21 January 2018

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Self-assembled DNA nanoclews for the efficient delivery of CRISPR-Cas9 for genome editing.

21 January 2018

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A CRISPR design for next-generation antimicrobials

21 January 2018

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Programmable removal of bacterial strains by use of genome-targeting CRISPR-Cas systems

21 January 2018

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Exploiting CRISPR-Cas nucleases to produce sequence-specific antimicrobials

21 January 2018

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Sequence-specific antimicrobials using efficiently delivered RNA-guided nucleases.

21 January 2018

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Cas3 is a single-stranded DNA nuclease and ATP-dependent helicase in the CRISPR/Cas immune system

21 January 2018

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In vitro reconstitution of Cascade-mediated CRISPR immunity in Streptococcus thermophilus.

21 January 2018

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RNA-directed gene editing specifically eradicates latent and prevents new HIV-1 infection.

21 January 2018

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Inhibition of HIV-1 infection of primary CD4+ T-cells by gene editing of CCR5 using adenovirus-delivered CRISPR/Cas9.

21 January 2018

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CCR5 gene disruption via lentiviral vectors expressing Cas9 and single guided RNA renders cells resistant to HIV-1 infection

21 January 2018

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Seamless modification of wild-type induced pluripotent stem cells to the natural CCR5Δ32 mutation confers resistance to HIV infection

21 January 2018

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Efficient human immunodeficiency virus (HIV-1) infection of cells lacking PDZD8

21 January 2018

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Use of the CRISPR/Cas9 system as an intracellular defense against HIV-1 infection in human cells

21 January 2018

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Genome editing of CXCR4 by CRISPR/cas9 confers cells resistant to HIV-1 infection.

21 January 2018

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RNA-guided endonuclease provides a therapeutic strategy to cure latent herpesviridae infection

21 January 2018

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Inactivation of the human papillomavirus E6 or E7 gene in cervical carcinoma cells by using a bacterial CRISPR/Cas RNA-guided endonuclease.

21 January 2018

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Targeting hepatitis B virus cccDNA by CRISPR/Cas9 nuclease efficiently inhibits viral replication.

21 January 2018

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Suppression of hepatitis B virus DNA accumulation in chronically infected cells using a bacterial CRISPR/Cas RNA-guided DNA endonuclease

21 January 2018

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Bacterial CRISPR/Cas DNA endonucleases: A revolutionary technology that could dramatically impact viral research and treatment

21 January 2018

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Inhibition of hepatitis B virus by the CRISPR/Cas9 system via targeting the conserved regions of the viral genome

21 January 2018

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CRISPR/Cas9 cleavage of viral DNA efficiently suppresses hepatitis B virus

21 January 2018

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Dual gRNAs guided CRISPR/Cas9 system inhibits hepatitis B virus replication

21 January 2018

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The CRISPR/Cas9 System Facilitates Clearance of the Intrahepatic HBV Templates In Vivo

21 January 2018

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Harnessing the clustered regularly interspaced short palindromic repeat (CRISPR)/CRISPR-associated Cas9 system to disrupt the hepatitis B virus

21 January 2018

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Gene-edited pigs are protected from porcine reproductive and respiratory syndrome virus

21 January 2018

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Production of Human Albumin in Pigs Through CRISPR/Cas9-Mediated Knockin of Human cDNA into Swine Albumin Locus in the Zygotes

21 January 2018

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Editing plant genomes with CRISPR/Cas9.

21 January 2018

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Targeted Mutagenesis, Precise Gene Editing, and Site-Specific Gene Insertion in Maize Using Cas9 and Guide RNA.

21 January 2018

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Cas9-Guide RNA Directed Genome Editing in Soybean.

21 January 2018

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Efficient Virus-Mediated Genome Editing in Plants Using the CRISPR/Cas9 System

21 January 2018

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Gene-edited CRISPR mushroom escapes US regulation.

21 January 2018

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CRISPR-Based Technologies and the Future of Food Science

21 January 2018

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Harnessing CRISPR-Cas systems for bacterial genome editing

21 January 2018

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Genomic impact of CRISPR immunization against bacteriophages

21 January 2018

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CRISPR: new horizons in phage resistance and strain identification

21 January 2018

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CRISPR-Cas9-assisted recombineering in Lactobacillus reuteri

21 January 2018

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Precision genome engineering in lactic acid bacteria

21 January 2018

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Exploiting CRISPR-Cas immune systems for genome editing in bacteria

21 January 2018

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Selection of chromosomal DNA libraries using a multiplex CRISPR system

21 January 2018

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CRISPR-based screening of genomic island excision events in bacteria

21 January 2018

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Molecular recordings by directed CRISPR spacer acquisition

21 January 2018

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Concerning RNA-guided gene drives for the alteration of wild populations

21 January 2018

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Highly efficient Cas9-mediated gene drive for population modification of the malaria vector mosquito Anopheles stephensi

21 January 2018

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Safeguarding CRISPR-Cas9 gene drives in yeast

21 January 2018

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A CRISPR-Cas9 gene drive system targeting female reproduction in the malaria mosquito vector Anopheles gambiae

21 January 2018

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Discovery of cancer drug targets by CRISPR-Cas9 screening of protein domains

21 January 2018

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Efficient generation of genetically distinct pigs in a single pregnancy using multiplexed single-guide RNA and carbohydrate selection.

21 January 2018

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Functional repair of CFTR by CRISPR/Cas9 in intestinal stem cell organoids of cystic fibrosis patients

21 January 2018

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Multiplex CRISPR/Cas9-based genome editing for correction of dystrophin mutations that cause Duchenne muscular dystrophy.

21 January 2018

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Functional disruption of the dystrophin gene in rhesus monkey using CRISPR/Cas9.

21 January 2018

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Improved hematopoietic differentiation efficiency of gene-corrected beta-thalassemia induced pluripotent stem cells by CRISPR/Cas9 system

21 January 2018

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Seamless gene correction of β-thalassemia mutations in patient-specific iPSCs using CRISPR/Cas9 and piggyBac

21 January 2018

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Both TALENs and CRISPR/Cas9 directly target the HBB IVS2-654 (C > T) mutation in β-thalassemia-derived iPSCs

21 January 2018

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Naïve Induced Pluripotent Stem Cells Generated From β-Thalassemia Fibroblasts Allow Efficient Gene Correction With CRISPR/Cas9.

21 January 2018

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CRISPR germline engineering--the community speaks

21 January 2018

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Biotechnology. A prudent path forward for genomic engineering and germline gene modification

21 January 2018

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Annotation and Classification of CRISPR-Cas Systems.

21 January 2018

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Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies

21 January 2018

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Crystal Structure of Staphylococcus aureus Cas9

21 January 2018

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In vivo genome editing using Staphylococcus aureus Cas9

21 January 2018

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CRISPR/Cas9-mediated gene editing in human tripronuclear zygotes

21 January 2018

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Characterization of human induced pluripotent stem cell-derived retinal pigment epithelium cell sheets aiming for clinical application.

21 January 2018

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From Genomics to Gene Therapy: Induced Pluripotent Stem Cells Meet Genome Editing

21 January 2018

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Genomic engineering and the future of medicine

21 January 2018

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CRISPR-based adaptive and heritable immunity in prokaryotes

21 January 2018

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CRISPR-Cas immunity in prokaryotes

21 January 2018

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The Bacterial Origins of the CRISPR Genome-Editing Revolution

21 January 2018

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CRISPR-Cas systems: Prokaryotes upgrade to adaptive immunity

21 January 2018

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CRISPR Provides Acquired Resistance Against Viruses in Prokaryotes

21 January 2018

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Small CRISPR RNAs guide antiviral defense in prokaryotes

21 January 2018

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CRISPR interference limits horizontal gene transfer in staphylococci by targeting DNA

21 January 2018

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RNA-guided RNA cleavage by a CRISPR RNA-Cas protein complex

21 January 2018

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Cas9-crRNA ribonucleoprotein complex mediates specific DNA cleavage for adaptive immunity in bacteria

21 January 2018

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A Programmable Dual-RNA-Guided DNA Endonuclease in Adaptive Bacterial Immunity

21 January 2018

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CRISPR RNA maturation by trans-encoded small RNA and host factor RNase III

21 January 2018

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RNA-mediated programmable DNA cleavage.

21 January 2018

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RNA-guided human genome engineering via Cas9

21 January 2018

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Multiplex genome engineering using CRISPR/Cas systems

21 January 2018

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RNA-guided editing of bacterial genomes using CRISPR-Cas systems

21 January 2018

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Targeted genome engineering in human cells with the Cas9 RNA-guided endonuclease

21 January 2018

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Efficient genome editing in zebrafish using a CRISPR-Cas system

21 January 2018

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RNA-programmed genome editing in human cells

21 January 2018

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Expanding the Biologist's Toolkit with CRISPR-Cas9

21 January 2018

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MAGeCK enables robust identification of essential genes from genome-scale CRISPR/Cas9 knockout screens

21 January 2018

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12 December 2020

ASXL1 mutation correction by CRISPR/Cas9 restores gene function in leukemia cells and increases survival in mouse xenografts.

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12 December 2020

Production of hornless dairy cattle from genome-edited cell lines.

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12 December 2020

Disruption of human papillomavirus 16 E6 gene by clustered regularly interspaced short palindromic repeat/Cas system in human cervical cancer cells

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12 December 2020

Enhanced homology-directed human genome engineering by controlled timing of CRISPR/Cas9 delivery

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12 December 2020

Next biotech plants: new traits, crops, developers and technologies for addressing global challenges

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12 December 2020

Synthetic CRISPR RNA-Cas9-guided genome editing in human cells

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12 December 2020

Disruption of HPV16-E7 by CRISPR/Cas system induces apoptosis and growth inhibition in HPV16 positive human cervical cancer cells

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12 December 2020

Challenges facing European agriculture and possible biotechnological solutions

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7 January 2021

inferred from DOI database lookup

Estimating the biotech sector's contribution to the US economy

1 reference

9 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1038/NBT.3659

Identifiers

DOI

10.1038/NBT.3659

1 reference

2 August 2017

1 reference

PubMed ID

27606440