Protein deimmunization via structure-based design enables efficient epitope deletion at high mutational loads (Q30371474)

3 October 2017

Protein deimmunization via structure-based design enables efficient epitope deletion at high mutational loads (English)

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3 October 2017

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2

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1 June 2020

4

Chris Bailey-Kellogg

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1 June 2020

author name string

Regina S Salvat

series ordinal

1

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25655032%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

Alexandra Bishop

series ordinal

3

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25655032%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

Karl E Griswold

series ordinal

5

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1 June 2020

publication date

23 February 2015

1 reference

Biotechnology and Bioengineering

3 October 2017

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25655032%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

volume

112

1 reference

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1 June 2020

issue

7

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1 June 2020

page(s)

1306-1318

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Mapping the Pareto optimal design space for a functionally deimmunized biotherapeutic candidate

1 June 2020

cites work

1 reference

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Computationally driven deletion of broadly distributed T cell epitopes in a biotherapeutic candidate.

3 June 2018

1 reference

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Removing T-cell epitopes with computational protein design.

3 June 2018

1 reference

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Recombinant immunotoxin for cancer treatment with low immunogenicity by identification and silencing of human T-cell epitopes

3 June 2018

1 reference

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A high throughput MHC II binding assay for quantitative analysis of peptide epitopes.

3 June 2018

1 reference

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Evaluating the immunogenicity of protein drugs by applying in vitro MHC binding data and the immune epitope database and analysis resource

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4452428

Structure-guided deimmunization of therapeutic proteins

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4452428

Structure-based redesign of proteins for minimal T-cell epitope content

3 June 2018

1 reference

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Identification and elimination of an immunodominant T-cell epitope in recombinant immunotoxins based on Pseudomonas exotoxin A.

3 June 2018

1 reference

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Design and analysis of immune-evading enzymes for ADEPT therapy.

3 June 2018

1 reference

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Protein design using continuous rotamers

3 June 2018

1 reference

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Effect of HLA DR epitope de-immunization of Factor VIII in vitro and in vivo.

3 June 2018

1 reference

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A divide-and-conquer approach to determine the Pareto frontier for optimization of protein engineering experiments

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4452428

Immunogenicity of protein therapeutics: The key causes, consequences and challenges

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4452428

Immunogenicity of biotherapeutics in the context of developing biosimilars and biobetters

3 June 2018

1 reference

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Therapeutic enzyme deimmunization by combinatorial T-cell epitope removal using neutral drift

3 June 2018

1 reference

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MHC class II epitope predictive algorithms.

3 June 2018

1 reference

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The immunogenicity of humanized and fully human antibodies: residual immunogenicity resides in the CDR regions

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4452428

Optimization algorithms for functional deimmunization of therapeutic proteins

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4452428

Prediction of immunogenicity of therapeutic proteins: validity of computational tools

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4452428

Engineering and biological characterization of VB6-845, an anti-EpCAM immunotoxin containing a T-cell epitope-depleted variant of the plant toxin bouganin

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4452428

Understanding the focused CD4 T cell response to antigen and pathogenic organisms

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4452428

A systematic assessment of MHC class II peptide binding predictions and evaluation of a consensus approach

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4452428

Progress towards a genome-derived, epitope-driven vaccine for latent TB infection

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4452428

Immunogenicity of protein therapeutics

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4452428

Progress in computational protein design

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4452428

Prediction of MHC class II binding affinity using SMM-align, a novel stabilization matrix alignment method

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4452428

Comparison of multiple Amber force fields and development of improved protein backbone parameters

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4452428

Antibiotic-refractory Lyme arthritis is associated with HLA-DR molecules that bind a Borrelia burgdorferi peptide

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4452428

A beta-lactamase with reduced immunogenicity for the targeted delivery of chemotherapeutics using antibody-directed enzyme prodrug therapy

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4452428

Cell biology of antigen processing in vitro and in vivo

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4452428

The Pfam protein families database

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4452428

The relationship between predicted peptide-MHC class II affinity and T-cell activation in a HLA-DRbeta1*0401 transgenic mouse model

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4452428

The HLA molecules DQA1*0501/B1*0201 and DQA1*0301/B1*0302 share an extensive overlap in peptide binding specificity

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4452428

Bioequivalence and the immunogenicity of biopharmaceuticals

3 June 2018

1 reference

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The penultimate rotamer library

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4452428

Several common HLA-DR types share largely overlapping peptide binding repertoires

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4452428

Immunodominance of a low-affinity major histocompatibility complex-binding myelin basic protein epitope (residues 111-129) in HLA-DR4 (B1*0401) subjects is associated with a restricted T cell receptor repertoire

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4452428

Oligopeptide biases in protein sequences and their use in predicting protein coding regions in nucleotide sequences

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4452428

What's fueling the biotech engine-2012 to 2013.

3 June 2018

1 reference

The use of differential scanning fluorimetry to detect ligand interactions that promote protein stability

21 January 2018

1 reference

Optimization of therapeutic proteins to delete T-cell epitopes while maintaining beneficial residue interactions

21 January 2018

1 reference

ProPred: prediction of HLA-DR binding sites.

21 January 2018

1 reference

Semianalytical treatment of solvation for molecular mechanics and dynamics

21 January 2018

1 reference

Generation of tissue-specific and promiscuous HLA ligand databases using DNA microarrays and virtual HLA class II matrices

21 January 2018

1 reference

Elimination of an immunodominant CD4+ T cell epitope in human IFN-beta does not result in an in vivo response directed at the subdominant epitope

21 January 2018

1 reference

Recombinant staphylokinase variants with altered immunoreactivity. I: Construction and characterization

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25655032

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

The immunogenicity of therapeutic proteins

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25655032

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1002/BIT.25554

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25655032%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25655032%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

1 reference