Epithelial-to-mesenchymal transition antagonizes response to targeted therapies in lung cancer by suppressing BIM. (Q45070526)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29051323%20AND%20SRC:MED&resulttype=core&format=json

7 April 2020

title

Epithelial-to-Mesenchymal Transition Antagonizes Response to Targeted Therapies in Lung Cancer by Suppressing BIM (English)

1 reference

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7 April 2020

3

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7 April 2020

Konstantinos V Floros

7

1 reference

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7 April 2020

Yotam Drier

11

1 reference

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7 April 2020

Mikhail G Dozmorov

25

1 reference

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7 April 2020

Hiromichi Ebi

28

1 reference

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7 April 2020

27

Bradley Bernstein

1 reference

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7 April 2020

26

Lecia V Sequist

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7 April 2020

author name string

Kyung-A Song

1

1 reference

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7 April 2020

Matthew J Niederst

2

1 reference

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7 April 2020

Aaron N Hata

4

1 reference

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7 April 2020

Hidenori Kitai

5

1 reference

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7 April 2020

Jungoh Ham

6

1 reference

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7 April 2020

Mark A Hicks

8

1 reference

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7 April 2020

Haichuan Hu

9

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7 April 2020

Hillary E Mulvey

10

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7 April 2020

Daniel A R Heisey

12

1 reference

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7 April 2020

Mark T Hughes

13

1 reference

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7 April 2020

Neha U Patel

14

1 reference

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7 April 2020

Shawn Gillepsie

17

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7 April 2020

Hannah L Archibald

18

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7 April 2020

Maria Gomez-Caraballo

19

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Tara J Nulton

20

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Zofia Piotrowska

22

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7 April 2020

Sinem E Sahingur

23

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7 April 2020

Shirley M Taylor

24

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7 April 2020

Jeffrey A Engelman

29

1 reference

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7 April 2020

Anthony C Faber

30

1 reference

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7 April 2020

Elizabeth L Lockerman

15

1 reference

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7 April 2020

Angel Garcia

16

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7 April 2020

Brad E Windle

21

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7 April 2020

language of work or name

English

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publication date

19 October 2017

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7 April 2020

published in

Clinical Cancer Research

1 reference

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7 April 2020

volume

24

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7 April 2020

page(s)

197-208

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7 April 2020

issue

1

1 reference

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ZEB1 drives epithelial-to-mesenchymal transition in lung cancer

7 April 2020

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1 reference

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A genetic cell context-dependent role for ZEB1 in lung cancer.

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Epithelial-to-Mesenchymal Transition Defines Feedback Activation of Receptor Tyrosine Kinase Signaling Induced by MEK Inhibition in KRAS-Mutant Lung Cancer

27 August 2018

1 reference

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Exploitation of the Apoptosis-Primed State of MYCN-Amplified Neuroblastoma to Develop a Potent and Specific Targeted Therapy Combination

27 August 2018

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Tumor cells can follow distinct evolutionary paths to become resistant to epidermal growth factor receptor inhibition

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BIM and mTOR expression levels predict outcome to erlotinib in EGFR-mutant non-small-cell lung cancer

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Detection of Enhancer-Associated Rearrangements Reveals Mechanisms of Oncogene Dysregulation in B-cell Lymphoma

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27 August 2018

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Assessment of ABT-263 activity across a cancer cell line collection leads to a potent combination therapy for small-cell lung cancer.

27 August 2018

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Drug-induced death signaling strategy rapidly predicts cancer response to chemotherapy.

27 August 2018

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27 August 2018

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27 August 2018

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AXL inhibition sensitizes mesenchymal cancer cells to antimitotic drugs

27 August 2018

1 reference

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ATM-mediated stabilization of ZEB1 promotes DNA damage response and radioresistance through CHK1.

27 August 2018

1 reference

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Improved vectors and genome-wide libraries for CRISPR screening

27 August 2018

1 reference

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Clinical profiling of BCL-2 family members in the setting of BRAF inhibition offers a rationale for targeting de novo resistance using BH3 mimetics

27 August 2018

1 reference

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Failure to induce apoptosis via BCL-2 family proteins underlies lack of efficacy of combined MEK and PI3K inhibitors for KRAS-mutant lung cancers

27 August 2018

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Epithelial-mesenchymal Transition---A Hallmark of Breast Cancer Metastasis

27 August 2018

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The impact of EGFR T790M mutations and BIM mRNA expression on outcome in patients with EGFR-mutant NSCLC treated with erlotinib or chemotherapy in the randomized phase III EURTAC trial

27 August 2018

1 reference

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Epithelial-to-mesenchymal transition rewires the molecular path to PI3K-dependent proliferation

27 August 2018

1 reference

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mTOR inhibition specifically sensitizes colorectal cancers with KRAS or BRAF mutations to BCL-2/BCL-XL inhibition by suppressing MCL-1.

27 August 2018

1 reference

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Epithelial-mesenchymal plasticity in carcinoma metastasis

27 August 2018

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Epithelial-mesenchymal transition leads to crizotinib resistance in H2228 lung cancer cells with EML4-ALK translocation

27 August 2018

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Notch-1 contributes to epidermal growth factor receptor tyrosine kinase inhibitor acquired resistance in non-small cell lung cancer in vitro and in vivo

27 August 2018

1 reference

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27 August 2018

1 reference

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PUMA and BIM are required for oncogene inactivation-induced apoptosis.

27 August 2018

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EGFR-TKI resistance due to BIM polymorphism can be circumvented in combination with HDAC inhibition.

27 August 2018

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Synthetic lethal interaction of combined BCL-XL and MEK inhibition promotes tumor regressions in KRAS mutant cancer models

27 August 2018

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An epithelial-mesenchymal transition gene signature predicts resistance to EGFR and PI3K inhibitors and identifies Axl as a therapeutic target for overcoming EGFR inhibitor resistance

27 August 2018

1 reference

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Activation of the AXL kinase causes resistance to EGFR-targeted therapy in lung cancer

27 August 2018

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The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity

27 August 2018

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A common BIM deletion polymorphism mediates intrinsic resistance and inferior responses to tyrosine kinase inhibitors in cancer

27 August 2018

1 reference

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Erlotinib versus standard chemotherapy as first-line treatment for European patients with advanced EGFR mutation-positive non-small-cell lung cancer (EURTAC): a multicentre, open-label, randomised phase 3 trial

27 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5959009

BIM expression in treatment-naive cancers predicts responsiveness to kinase inhibitors.

27 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5959009

Receptor tyrosine kinases exert dominant control over PI3K signaling in human KRAS mutant colorectal cancers

27 August 2018

1 reference

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Epithelial to mesenchymal transition in an epidermal growth factor receptor-mutant lung cancer cell line with acquired resistance to erlotinib

27 August 2018

1 reference

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Genotypic and histological evolution of lung cancers acquiring resistance to EGFR inhibitors

27 August 2018

1 reference

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PTEN loss confers BRAF inhibitor resistance to melanoma cells through the suppression of BIM expression

27 August 2018

1 reference

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Clinical and molecular evidences of epithelial to mesenchymal transition in acquired resistance to EGFR-TKIs

27 August 2018

1 reference

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ZEB1-responsive genes in non-small cell lung cancer

27 August 2018

1 reference

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Apoptosis induction by MEK inhibition in human lung cancer cells is mediated by Bim

27 August 2018

1 reference

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EMT, cancer stem cells and drug resistance: an emerging axis of evil in the war on cancer

27 August 2018

1 reference

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Differential induction of apoptosis in HER2 and EGFR addicted cancers following PI3K inhibition.

27 August 2018

1 reference

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Epithelial to mesenchymal transition contributes to drug resistance in pancreatic cancer

27 August 2018

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Ultrafast and memory-efficient alignment of short DNA sequences to the human genome

27 August 2018

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Model-based analysis of ChIP-Seq (MACS)

27 August 2018

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Kinase switching in mesenchymal-like non-small cell lung cancer lines contributes to EGFR inhibitor resistance through pathway redundancy

27 August 2018

1 reference

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First-line gefitinib in patients with advanced non-small-cell lung cancer harboring somatic EGFR mutations

27 August 2018

1 reference

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Proapoptotic BH3-only BCL-2 family protein BIM connects death signaling from epidermal growth factor receptor inhibition to the mitochondrion

27 August 2018

1 reference

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ERK1/2-dependent phosphorylation of BimEL promotes its rapid dissociation from Mcl-1 and Bcl-xL

27 August 2018

1 reference

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The transcription factor ZEB1 (deltaEF1) promotes tumour cell dedifferentiation by repressing master regulators of epithelial polarity

27 August 2018

1 reference

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Structural insights into the degradation of Mcl-1 induced by BH3 domains

27 August 2018

1 reference

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Restoring E-cadherin expression increases sensitivity to epidermal growth factor receptor inhibitors in lung cancer cell lines.

27 August 2018

1 reference

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ONCOMINE: a cancer microarray database and integrated data-mining platform

27 August 2018

1 reference

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Snail induction of epithelial to mesenchymal transition in tumor cells is accompanied by MUC1 repression and ZEB1 expression

27 August 2018

1 reference

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Analytical Performance of a 15-Gene Prognostic Assay for Early-Stage Non–Small-Cell Lung Carcinoma Using RNA-Stabilized Tissue

27 August 2018

1 reference

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10.1158/1078-0432.CCR-17-1577

1 December 2018

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29051323%20AND%20SRC:MED&resulttype=core&format=json

7 April 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29051323%20AND%20SRC:MED&resulttype=core&format=json

7 April 2020

1 reference