BIM expression in treatment-naive cancers predicts responsiveness to kinase inhibitors. (Q35588268)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22145099%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

title

BIM expression in treatment-naive cancers predicts responsiveness to kinase inhibitors (English)

1 reference

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17 January 2020

3

1 reference

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17 January 2020

Euiheon Chung

6

1 reference

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17 January 2020

Joao Incio

7

1 reference

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17 January 2020

Henry Leonidas Gómez

16

1 reference

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17 January 2020

21

Rakesh K Jain

1 reference

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17 January 2020

4

Lecia V Sequist

1 reference

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17 January 2020

20

Dora Dias-Santagata

1 reference

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17 January 2020

22

Jeffrey A Engelman

1 reference

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17 January 2020

2

Ryan B Corcoran

1 reference

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17 January 2020

11

Alona Muzikansky

1 reference

17 January 2020

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10

Youngchul Song

1 reference

17 January 2020

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12

Eugene Lifshits

1 reference

17 January 2020

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Anthony C Faber

1

1 reference

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17 January 2020

Belinda A Waltman

5

1 reference

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17 January 2020

Subba R Digumarthy

8

1 reference

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17 January 2020

Sarah F Pollack

9

1 reference

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17 January 2020

Sylvie Roberge

13

1 reference

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17 January 2020

Erik J Coffman

14

1 reference

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17 January 2020

Cyril H Benes

15

1 reference

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17 January 2020

José Baselga

17

1 reference

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17 January 2020

Carlos L Arteaga

18

1 reference

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17 January 2020

Miguel N Rivera

19

1 reference

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17 January 2020

publication date

22 July 2011

1 reference

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17 January 2020

1 reference

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17 January 2020

volume

1

1 reference

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17 January 2020

issue

4

1 reference

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17 January 2020

page(s)

352-365

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22145099%20AND%20SRC:MED&resulttype=core&format=json

BIM is a prognostic biomarker for early prednisolone response in pediatric acute lymphoblastic leukemia.

17 January 2020

cites work

1 reference

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27 July 2018

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Inhibition of Mutated, Activated BRAF in Metastatic Melanoma

27 July 2018

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Reversion of epigenetically mediated BIM silencing overcomes chemoresistance in Burkitt lymphoma.

27 July 2018

1 reference

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Clinical benefit of lapatinib-based therapy in patients with human epidermal growth factor receptor 2-positive breast tumors coexpressing the truncated p95HER2 receptor.

27 July 2018

1 reference

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Differences underlying EGFR and HER2 oncogene addiction

27 July 2018

1 reference

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Preexistence and clonal selection of MET amplification in EGFR mutant NSCLC.

27 July 2018

1 reference

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Specific apoptosis induction by the dual PI3K/mTor inhibitor NVP-BEZ235 in HER2 amplified and PIK3CA mutant breast cancer cells

27 July 2018

1 reference

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Detection of BRAF mutations in the tumour and serum of patients enrolled in the AZD6244 (ARRY-142886) advanced melanoma phase II study.

27 July 2018

1 reference

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The BH3-only protein Bim plays a critical role in leukemia cell death triggered by concomitant inhibition of the PI3K/Akt and MEK/ERK1/2 pathways

27 July 2018

1 reference

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Clinical features and outcome of patients with non-small-cell lung cancer who harbor EML4-ALK

27 July 2018

1 reference

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PUMA mediates EGFR tyrosine kinase inhibitor-induced apoptosis in head and neck cancer cells

27 July 2018

1 reference

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PI3K-dependent cross-talk interactions converge with Ras as quantifiable inputs integrated by Erk

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3229203

Treatment of B-RAF mutant human tumor cells with a MEK inhibitor requires Bim and is enhanced by a BH3 mimetic

27 July 2018

1 reference

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BAX activation is initiated at a novel interaction site

27 July 2018

1 reference

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Colorectal cancer cells with the BRAF(V600E) mutation are addicted to the ERK1/2 pathway for growth factor-independent survival and repression of BIM.

27 July 2018

1 reference

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Differential impact of fibroblasts on the efficient cell death of lung cancer cells induced by paclitaxel and cisplatin

27 July 2018

1 reference

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ABT-263: a potent and orally bioavailable Bcl-2 family inhibitor

27 July 2018

1 reference

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Lymphoproliferative disease and autoimmunity in mice with increased miR-17-92 expression in lymphocytes

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3229203

Sorafenib induces apoptosis of AML cells via Bim-mediated activation of the intrinsic apoptotic pathway.

27 July 2018

1 reference

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Gefitinib-induced killing of NSCLC cell lines expressing mutant EGFR requires BIM and can be enhanced by BH3 mimetics

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3229203

BIM mediates EGFR tyrosine kinase inhibitor-induced apoptosis in lung cancers with oncogenic EGFR mutations

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3229203

Induction of BIM is essential for apoptosis triggered by EGFR kinase inhibitors in mutant EGFR-dependent lung adenocarcinomas

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3229203

MET amplification leads to gefitinib resistance in lung cancer by activating ERBB3 signaling

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3229203

Apoptosis initiated when BH3 ligands engage multiple Bcl-2 homologs, not Bax or Bak

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3229203

Inhibition of phosphatidylinositol 3-kinase-mediated glucose metabolism coincides with resveratrol-induced cell cycle arrest in human diffuse large B-cell lymphomas

27 July 2018

1 reference

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Targeting ADAM-mediated ligand cleavage to inhibit HER3 and EGFR pathways in non-small cell lung cancer

27 July 2018

1 reference

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Mitochondria primed by death signals determine cellular addiction to antiapoptotic BCL-2 family members

27 July 2018

1 reference

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Differential effects of gefitinib and cetuximab on non-small-cell lung cancers bearing epidermal growth factor receptor mutations

27 July 2018

1 reference

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Enhanced cytotoxicity induced by gefitinib and specific inhibitors of the Ras or phosphatidyl inositol-3 kinase pathways in non-small cell lung cancer cells.

27 July 2018

1 reference

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ErbB-3 mediates phosphoinositide 3-kinase activity in gefitinib-sensitive non-small cell lung cancer cell lines

27 July 2018

1 reference

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Select clinical trials of erlotinib (OSI-774) in non-small-cell lung cancer with emphasis on phase III outcomes.

27 July 2018

1 reference

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BimEL is an important determinant for induction of anoikis sensitivity by mitogen-activated protein/extracellular signal-regulated kinase kinase inhibitors.

27 July 2018

1 reference

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Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib

27 July 2018

1 reference

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Activation of the ERK1/2 signaling pathway promotes phosphorylation and proteasome-dependent degradation of the BH3-only protein, Bim.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3229203

Role of ERK-BIM and STAT3-survivin signaling pathways in ALK inhibitor-induced apoptosis in EML4-ALK-positive lung cancer

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3229203

Chemoradiotherapy and gefitinib in stage III non-small cell lung cancer with epidermal growth factor receptor and KRAS mutation analysis: cancer and leukemia group B (CALEB) 30106, a CALGB-stratified phase II trial

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3229203

Epigenetic silencing of BIM in glucocorticoid poor-responsive pediatric acute lymphoblastic leukemia, and its reversal by histone deacetylase inhibition.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3229203

Rapid targeted mutational analysis of human tumours: a clinical platform to guide personalized cancer medicine

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3229203

Differential induction of apoptosis in HER2 and EGFR addicted cancers following PI3K inhibition.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3229203

Epigenetic down-regulation of BIM expression is associated with reduced optimal responses to imatinib treatment in chronic myeloid leukaemia.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3229203

Efficacy and safety of lapatinib as first-line therapy for ErbB2-amplified locally advanced or metastatic breast cancer

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3229203

First-line gefitinib in patients with advanced non-small-cell lung cancer harboring somatic EGFR mutations

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3229203

Inhibition of cyclin-dependent kinase-2 induces apoptosis in human diffuse large B-cell lymphomas

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3229203

Proapoptotic BH3-only BCL-2 family protein BIM connects death signaling from epidermal growth factor receptor inhibition to the mitochondrion

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3229203

Downregulation of Bim by brain-derived neurotrophic factor activation of TrkB protects neuroblastoma cells from paclitaxel but not etoposide or cisplatin-induced cell death.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3229203

Epidermal growth factor receptor mutations and gene amplification in non-small-cell lung cancer: molecular analysis of the IDEAL/INTACT gefitinib trials

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3229203

Roles of Bim in apoptosis of normal and Bcr-Abl-expressing hematopoietic progenitors

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3229203

Tumor response to chemotherapy: The validity and reproducibility of RECIST guidelines in NSCLC patients1

26 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22145099

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Regulated targeting of Bax and Bak to intracellular membranes during apoptosis

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22145099

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1158/2159-8290.CD-11-0106

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22145099%20AND%20SRC:MED&resulttype=core&format=json

release_otwx6rovezejzpacqxgitgexxi

17 January 2020

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/otwx6rovezejzpacqxgitgexxi

mapped directly with Wikidata item

24 November 2022

based on heuristic

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22145099%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

1 reference