Prolyl hydroxylase 3 (PHD3) is essential for hypoxic regulation of neutrophilic inflammation in humans and mice (Q41984558)

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22 January 2020

title

Prolyl hydroxylase 3 (PHD3) is essential for hypoxic regulation of neutrophilic inflammation in humans and mice (English)

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22 January 2020

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Cormac T Taylor

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Randall S. Johnson

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Peter J. Ratcliffe

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22 January 2020

Sarah Walmsley

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Edwin R Chilvers

2

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Roger Thompson

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Helen M Marriott

5

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David H Dockrell

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22 January 2020

Chris Pugh

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Peter Carmeliet

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22 January 2020

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Selina Parmar

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22 January 2020

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Moira K B Whyte

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22 January 2020

author name string

Kathryn Vaughan

4

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22 January 2020

Lisa C Parker

6

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Gary Shaw

7

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22 January 2020

Martin Schneider

9

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Marta Milo

12

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Patrick H Maxwell

17

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22 January 2020

language of work or name

English

0 references

publication date

7 February 2011

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Journal of Clinical Investigation

22 January 2020

published in

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22 January 2020

volume

121

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22 January 2020

page(s)

1053-1063

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22 January 2020

issue

3

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Loss of prolyl hydroxylase-1 protects against colitis through reduced epithelial cell apoptosis and increased barrier function

22 January 2020

cites work

1 reference

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Prolyl hydroxylases 2 and 3 act in gliomas as protective negative feedback regulators of hypoxia-inducible factors

5 June 2018

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Control of cyclin D1 and breast tumorigenesis by the EglN2 prolyl hydroxylase

5 June 2018

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Oxygen sensing by metazoans: the central role of the HIF hydroxylase pathway

5 June 2018

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CD47 deficiency protects mice from lipopolysaccharide-induced acute lung injury and Escherichia coli pneumonia

5 June 2018

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The kinesin KIF1Bbeta acts downstream from EglN3 to induce apoptosis and is a potential 1p36 tumor suppressor

5 June 2018

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Abnormal sympathoadrenal development and systemic hypotension in PHD3-/- mice

5 June 2018

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Pyrin, product of the MEFV locus, interacts with the proapoptotic protein, Siva

5 June 2018

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An endoplasmic reticulum transmembrane prolyl 4-hydroxylase is induced by hypoxia and acts on hypoxia-inducible factor alpha

5 June 2018

1 reference

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Prolyl hydroxylase-1 negatively regulates IkappaB kinase-beta, giving insight into hypoxia-induced NFkappaB activity

5 June 2018

1 reference

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Bim and Bad mediate imatinib-induced killing of Bcr/Abl+ leukemic cells, and resistance due to their loss is overcome by a BH3 mimetic.

5 June 2018

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Cyclin-dependent kinase inhibitors enhance the resolution of inflammation by promoting inflammatory cell apoptosis

5 June 2018

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Concordant regulation of gene expression by hypoxia and 2-oxoglutarate-dependent dioxygenase inhibition: the role of HIF-1alpha, HIF-2alpha, and other pathways

5 June 2018

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The involvement of the apoptosis-modulating proteins ERK 1/2, Bcl-xL and Bax in the resolution of acute inflammation in vivo

5 June 2018

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Synergistic effect of Nod1 and Nod2 agonists with toll-like receptor agonists on human dendritic cells to generate interleukin-12 and T helper type 1 cells

5 June 2018

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Neuronal apoptosis linked to EglN3 prolyl hydroxylase and familial pheochromocytoma genes: developmental culling and cancer

5 June 2018

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Hypoxia-induced neutrophil survival is mediated by HIF-1alpha-dependent NF-kappaB activity

5 June 2018

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Differential function of the prolyl hydroxylases PHD1, PHD2, and PHD3 in the regulation of hypoxia-inducible factor

5 June 2018

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Granulocyte-macrophage colony-stimulating factor (GM-CSF) induces antiapoptotic and proapoptotic signals in acute myeloid leukemia

5 June 2018

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HIF-1alpha is essential for myeloid cell-mediated inflammation

5 June 2018

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5 June 2018

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Cellular adaptation to hypoxia: O2-sensing protein hydroxylases, hypoxia-inducible transcription factors, and O2-regulated gene expression

5 June 2018

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5 June 2018

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5 June 2018

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A conserved family of prolyl-4-hydroxylases that modify HIF

5 June 2018

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C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation

5 June 2018

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5 June 2018

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5 June 2018

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5 June 2018

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5 June 2018

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5 June 2018

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5 June 2018

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5 June 2018

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18 August 2018

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18 August 2018

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HIF-1alpha expression regulates the bactericidal capacity of phagocytes

18 August 2018

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Caspase-1-deficient mice have delayed neutrophil apoptosis and a prolonged inflammatory response to lipopolysaccharide-induced acute lung injury.

18 August 2018

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Involvement of a ferroprotein sensor in hypoxia-mediated inhibition of neutrophil apoptosis

18 August 2018

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BCL-2 family expression in human neutrophils during delayed and accelerated apoptosis.

18 August 2018

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Toll-like receptor (TLR)2 and TLR4 in human peripheral blood granulocytes: a critical role for monocytes in leukocyte lipopolysaccharide responses

18 August 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21317538

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Hypoxia prolongs neutrophil survival in vitro

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21317538

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Oxygen-dependent ATF-4 stability is mediated by the PHD3 oxygen sensor

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21317538

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1172/JCI43273

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21317538%20AND%20SRC:MED&resulttype=core&format=json

22 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21317538%20AND%20SRC:MED&resulttype=core&format=json

22 January 2020

1 reference