An endoplasmic reticulum transmembrane prolyl 4-hydroxylase is induced by hypoxia and acts on hypoxia-inducible factor alpha (Q40088306)

17 September 2017

An endoplasmic reticulum transmembrane prolyl 4-hydroxylase is induced by hypoxia and acts on hypoxia-inducible factor alpha (English)

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17 September 2017

endoplasmic reticulum

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hypoxia

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transmembrane protein

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8

Johanna Myllyharju

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17 September 2017

Peppi Koivunen

1

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17 September 2017

Päivi Tiainen

2

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17 September 2017

Jaana Hyvärinen

3

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17 September 2017

Kim E Williams

4

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17 September 2017

Raija Sormunen

5

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17 September 2017

Stephen J Klaus

6

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17 September 2017

Kari I Kivirikko

7

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17 September 2017

language of work or name

English

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publication date

27 August 2007

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Journal of Biological Chemistry

17 September 2017

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17 September 2017

282

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17 September 2017

30544-30552

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17 September 2017

42

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Prolyl 4-hydroxylases, the key enzymes of collagen biosynthesis

17 September 2017

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https://api.crossref.org/works/10.1074%2FJBC.M704988200

Collagens, modifying enzymes and their mutations in humans, flies and worms

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M704988200

Targeting HIF-1 for cancer therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704988200

Oxygen sensing by HIF hydroxylases

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M704988200

Dioxygenases as O2-dependent regulators of the hypoxic response pathway

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M704988200

Proline hydroxylation and gene expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704988200

Identification and characterization of a third human, rat, and mouse collagen prolyl 4-hydroxylase isoenzyme

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704988200

Cloning of a novel prolyl 4-hydroxylase subunit expressed in the fibrous cap of human atherosclerotic plaque.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704988200

HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704988200

Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704988200

A conserved family of prolyl-4-hydroxylases that modify HIF

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704988200

C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704988200

Biochemical purification and pharmacological inhibition of a mammalian prolyl hydroxylase acting on hypoxia-inducible factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704988200

Characterization of the iron- and 2-oxoglutarate-binding sites of human prolyl 4-hydroxylase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704988200

Overexpression of PH-4, a novel putative proline 4-hydroxylase, modulates activity of hypoxia-inducible transcription factors

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704988200

The length of peptide substrates has a marked effect on hydroxylation by the hypoxia-inducible factor prolyl 4-hydroxylases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704988200

Differential function of the prolyl hydroxylases PHD1, PHD2, and PHD3 in the regulation of hypoxia-inducible factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704988200

Structural studies on 2-oxoglutarate oxygenases and related double-stranded beta-helix fold proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704988200

Cellular oxygen sensing: Crystal structure of hypoxia-inducible factor prolyl hydroxylase (PHD2)

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704988200

Identification of a novel proline-rich peptide-binding domain in prolyl 4-hydroxylase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704988200

The peptide-substrate-binding domain of human collagen prolyl 4-hydroxylases. Backbone assignments, secondary structure, and binding of proline-rich peptides

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704988200

The peptide-substrate-binding domain of collagen prolyl 4-hydroxylases is a tetratricopeptide repeat domain with functional aromatic residues

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704988200

Effect of desferrioxamine and metals on the hydroxylases in the oxygen sensing pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704988200

Characterization of three fragments that constitute the monomers of the human lysyl hydroxylase isoenzymes 1-3. The 30-kDa N-terminal fragment is not required for lysyl hydroxylase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704988200

Characterization of the human prolyl 4-hydroxylases that modify the hypoxia-inducible factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704988200

Cloning and characterization of a low molecular weight prolyl 4-hydroxylase from Arabidopsis thaliana. Effective hydroxylation of proline-rich, collagen-like, and hypoxia-inducible transcription factor alpha-like peptides

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704988200

Leu-574 of HIF-1alpha is essential for the von Hippel-Lindau (VHL)-mediated degradation pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704988200

Many amino acid substitutions in a hypoxia-inducible transcription factor (HIF)-1alpha-like peptide cause only minor changes in its hydroxylation by the HIF prolyl 4-hydroxylases: substitution of 3,4-dehydroproline or azetidine-2-carboxylic acid for

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704988200

Sequence determinants in hypoxia-inducible factor-1alpha for hydroxylation by the prolyl hydroxylases PHD1, PHD2, and PHD3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704988200

Intracellular localisation of human HIF-1 alpha hydroxylases: implications for oxygen sensing

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704988200

A Fenton reaction at the endoplasmic reticulum is involved in the redox control of hypoxia-inducible gene expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704988200

Peroxisomal localization of hypoxia-inducible factors and hypoxia-inducible factor regulatory hydroxylases in primary rat hepatocytes exposed to hypoxia-reoxygenation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704988200

HIF prolyl-hydroxylase 2 is the key oxygen sensor setting low steady-state levels of HIF-1alpha in normoxia

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704988200

HIF hydroxylation and cellular oxygen sensing

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704988200

von Hippel-Lindau protein binds hyperphosphorylated large subunit of RNA polymerase II through a proline hydroxylation motif and targets it for ubiquitination

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704988200

Prolyl hydroxylase-1 negatively regulates IkappaB kinase-beta, giving insight into hypoxia-induced NFkappaB activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704988200

Posttranslational hydroxylation of ankyrin repeats in IkappaB proteins by the hypoxia-inducible factor (HIF) asparaginyl hydroxylase, factor inhibiting HIF (FIH)

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704988200

21 January 2018

Identifiers

DOI

10.1074/JBC.M704988200

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17 September 2017

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