STAT3 targeting by polyphenols: Novel therapeutic strategy for melanoma. (Q39023307)

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28 March 2020

review article

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title

STAT3 targeting by polyphenols: Novel therapeutic strategy for melanoma (English)

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28 March 2020

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2

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28 March 2020

Mohammad Abdollahi

4

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28 March 2020

Saeideh Momtaz

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28 March 2020

Luca Rastrelli

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28 March 2020

author name string

Faheem Maqbool

3

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28 March 2020

Seyed Mohammad Nabavi

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28 March 2020

publication date

29 November 2016

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28 March 2020

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28 March 2020

volume

43

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28 March 2020

page(s)

347-370

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28 March 2020

issue

3

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Curcumin as "Curecumin": from kitchen to clinic.

28 March 2020

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Downregulation of tumor necrosis factor and other proinflammatory biomarkers by polyphenols

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Flavonoids inhibit cell growth and induce apoptosis in B16 melanoma 4A5 cells

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Resveratrol is a potent inducer of apoptosis in human melanoma cells

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Resveratrol induces cell-cycle disruption and apoptosis in chemoresistant B16 melanoma

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Cancer chemoprevention and chemotherapy: dietary polyphenols and signalling pathways

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Anti-angiogenic effects of resveratrol mediated by decreased VEGF and increased TSP1 expression in melanoma-endothelial cell co-culture

21 January 2018

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Radiosensitization of melanoma cells through combined inhibition of protein regulators of cell survival

21 January 2018

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Genetic factors in chronic inflammation: single nucleotide polymorphisms in the STAT-JAK pathway, susceptibility to DNA damage and Crohn's disease in a New Zealand population.

21 January 2018

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Identification of a Stat gene that functions in Drosophila development.

21 January 2018

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Structure, function, and regulation of STAT proteins

21 January 2018

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Role of STATs as downstream signal transducers in Src family kinase-mediated tumorigenesis

21 January 2018

1 reference

p42/p44 MAPK-mediated Stat3Ser727 phosphorylation is required for progestin-induced full activation of Stat3 and breast cancer growth

21 January 2018

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Stat3 dimerization regulated by reversible acetylation of a single lysine residue

21 January 2018

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Targeted disruption of the mouse Stat3 gene leads to early embryonic lethality

21 January 2018

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STAT3 activation is sufficient to maintain an undifferentiated state of mouse embryonic stem cells

21 January 2018

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STAT3 regulates cytokine-mediated generation of inflammatory helper T cells

21 January 2018

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STAT3 signaling and the hyper-IgE syndrome

21 January 2018

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Signal transducer and activator of transcription 3 is required for the oncogenic effects of non-small-cell lung cancer-associated mutations of the epidermal growth factor receptor

21 January 2018

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Signal transducers and activators of transcription (STATs): Novel targets of chemopreventive and chemotherapeutic drugs

21 January 2018

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Active Stat3 is required for survival of human squamous cell carcinoma cells in serum-free conditions

21 January 2018

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Acetylated STAT3 is crucial for methylation of tumor-suppressor gene promoters and inhibition by resveratrol results in demethylation.

21 January 2018

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Stat3 is a negative regulator of intestinal tumor progression in Apc(Min) mice

21 January 2018

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Molecular cloning of APRF, a novel IFN-stimulated gene factor 3 p91-related transcription factor involved in the gp130-mediated signaling pathway

21 January 2018

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P210 and P190(BCR/ABL) induce the tyrosine phosphorylation and DNA binding activity of multiple specific STAT family members

21 January 2018

1 reference

Enhanced DNA-binding activity of a Stat3-related protein in cells transformed by the Src oncoprotein

21 January 2018

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STAT3 serine phosphorylation by ERK-dependent and -independent pathways negatively modulates its tyrosine phosphorylation

21 January 2018

1 reference

Protein kinase C delta associates with and phosphorylates Stat3 in an interleukin-6-dependent manner

21 January 2018

1 reference

STAT3 regulates Nemo-like kinase by mediating its interaction with IL-6-stimulated TGFbeta-activated kinase 1 for STAT3 Ser-727 phosphorylation

21 January 2018

1 reference

Requirement for Ras/Rac1-mediated p38 and c-Jun N-terminal kinase signaling in Stat3 transcriptional activity induced by the Src oncoprotein

21 January 2018

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Turning off signal transducer and activator of transcription (STAT): the negative regulation of STAT signaling

21 January 2018

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Structural and evolutionary relationships among protein tyrosine phosphatase domains

21 January 2018

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Protein tyrosine phosphatases in signal transduction.

21 January 2018

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CD45 is a JAK phosphatase and negatively regulates cytokine receptor signalling

21 January 2018

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Ptpn11/Shp2 acts as a tumor suppressor in hepatocellular carcinogenesis

21 January 2018

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Loss of SHP1 enhances JAK3/STAT3 signaling and decreases proteosome degradation of JAK3 and NPM-ALK in ALK+ anaplastic large-cell lymphoma

21 January 2018

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Regulation of angiotensin II-induced phosphorylation of STAT3 in vascular smooth muscle cells

21 January 2018

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LMW-PTP associates and dephosphorylates STAT5 interacting with its C-terminal domain

21 January 2018

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PIASx is a transcriptional co-repressor of signal transducer and activator of transcription 4

21 January 2018

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Specific inhibition of Stat3 signal transduction by PIAS3

21 January 2018

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A transcriptional corepressor of Stat1 with an essential LXXLL signature motif

21 January 2018

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Inhibition of Stat1-mediated gene activation by PIAS1

21 January 2018

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Modulation of STAT signaling by STAT-interacting proteins

21 January 2018

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Regulation of gene-activation pathways by PIAS proteins in the immune system

21 January 2018

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A new RING for SUMO: wrestling transcriptional responses into nuclear bodies with PIAS family E3 SUMO ligases

21 January 2018

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A new protein containing an SH2 domain that inhibits JAK kinases

21 January 2018

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Structure and function of a new STAT-induced STAT inhibitor

21 January 2018

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A family of cytokine-inducible inhibitors of signalling

21 January 2018

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SOCS regulation of the JAK/STAT signalling pathway

21 January 2018

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The conserved SOCS box motif in suppressors of cytokine signaling binds to elongins B and C and may couple bound proteins to proteasomal degradation

21 January 2018

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STAT3: a multifaceted oncogene

21 January 2018

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Stat3 activation by Src induces specific gene regulation and is required for cell transformation

21 January 2018

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STAT3 activation is required for interleukin-6 induced transformation in tumor-promotion sensitive mouse skin epithelial cells

21 January 2018

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Role of STAT3 in in vitro transformation triggered by TRK oncogenes

21 January 2018

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Activation of signal transducer and activator of transcription 3 by oncogenic RET/PTC (rearranged in transformation/papillary thyroid carcinoma) tyrosine kinase: roles in specific gene regulation and cellular transformation

21 January 2018

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Activation of Stat3 transcription factor by Herpesvirus saimiri STP-A oncoprotein

21 January 2018

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Stat3 is required for full neoplastic transformation by the Simian Virus 40 large tumor antigen

21 January 2018

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Activation of STAT3 by the Hepatitis C Virus Core Protein Leads to Cellular Transformation

21 January 2018

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STAT3 as a central mediator of neoplastic cellular transformation

21 January 2018

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c-Myc target genes involved in cell growth, apoptosis, and metabolism

21 January 2018

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Synergistic roles for Pim-1 and c-Myc in STAT3-mediated cell cycle progression and antiapoptosis.

21 January 2018

1 reference

STAT3-mediated transcription of Bcl-2, Mcl-1 and c-IAP2 prevents apoptosis in polyamine-depleted cells

21 January 2018

1 reference

Role of Stat3 in regulating p53 expression and function

21 January 2018

1 reference

Suppression of epithelial apoptosis and delayed mammary gland involution in mice with a conditional knockout of Stat3.

21 January 2018

1 reference

Identification of a PTEN-regulated STAT3 brain tumor suppressor pathway

21 January 2018

1 reference

Overexpression of phosphorylated-STAT3 correlated with the invasion and metastasis of cutaneous squamous cell carcinoma

21 January 2018

1 reference

RNA interference-mediated signal transducers and activators of transcription 3 gene silencing inhibits invasion and metastasis of human pancreatic cancer cells

21 January 2018

1 reference

STAT3 knockdown reduces pancreatic cancer cell invasiveness and matrix metalloproteinase-7 expression in nude mice

21 January 2018

1 reference

Stat3 activation regulates the expression of matrix metalloproteinase-2 and tumor invasion and metastasis.

21 January 2018

1 reference

Requirement of matrix metalloproteinase-9 for the transformation of human mammary epithelial cells by Stat3-C.

21 January 2018

1 reference

Requirement of STAT3 activation for maximal collagenase-1 (MMP-1) induction by epidermal growth factor and malignant characteristics in T24 bladder cancer cells.

21 January 2018

1 reference

Keratinocyte-specific ablation of Stat3 exhibits impaired skin remodeling, but does not affect skin morphogenesis

21 January 2018

1 reference

Activated signal transducer and activator of transcription (STAT) 3: localization in focal adhesions and function in ovarian cancer cell motility

21 January 2018

1 reference

Stat3 regulates microtubules by antagonizing the depolymerization activity of stathmin

21 January 2018

1 reference

A role of STAT3 in Rho GTPase-regulated cell migration and proliferation

21 January 2018

1 reference

Constitutively activated Stat3 induces tumorigenesis and enhances cell motility of prostate epithelial cells through integrin beta 6

21 January 2018

1 reference

The tumor cell-host organ interface in the early onset of metastatic organ colonisation

21 January 2018

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Metastasis: from dissemination to organ-specific colonization

21 January 2018

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Regulation of the innate and adaptive immune responses by Stat-3 signaling in tumor cells

21 January 2018

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Vascular endothelial growth factor is a potential tumour angiogenesis factor in human gliomas in vivo.

21 January 2018

1 reference

STAT3: a critical transcription activator in angiogenesis.

21 January 2018

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Constitutive Stat3 activity up-regulates VEGF expression and tumor angiogenesis

21 January 2018

1 reference

Targeting Stat3 blocks both HIF-1 and VEGF expression induced by multiple oncogenic growth signaling pathways

21 January 2018

1 reference

Nuclear translocation of phosphorylated STAT3 is essential for vascular endothelial growth factor-induced human dermal microvascular endothelial cell migration and tube formation.

21 January 2018

1 reference

Targeting HIF-1 for cancer therapy

21 January 2018

1 reference

Hypoxia-inducible factor-1alpha enhances haptoglobin gene expression by improving binding of STAT3 to the promoter

21 January 2018

1 reference

The function of Stat3 in tumor cells and their microenvironment

21 January 2018

1 reference

Inactivation of Stat3 in tumor cells: releasing a brake on immune responses against cancer?

21 January 2018

1 reference

Tumour escape from immune surveillance through dendritic cell inactivation

21 January 2018

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Immunosuppressive networks in the tumour environment and their therapeutic relevance

21 January 2018

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Crosstalk between cancer and immune cells: role of STAT3 in the tumour microenvironment.

21 January 2018

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Roles of activated Src and Stat3 signaling in melanoma tumor cell growth

21 January 2018

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Butein downregulates phorbol 12-myristate 13-acetate-induced COX-2 transcriptional activity in cancerous and non-cancerous breast cells

21 January 2018

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Butein ameliorates renal concentrating ability in cisplatin-induced acute renal failure in rats

21 January 2018

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Potential of butein, a tetrahydroxychalcone to obliterate cancer.

21 January 2018

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Butein suppresses constitutive and inducible signal transducer and activator of transcription (STAT) 3 activation and STAT3-regulated gene products through the induction of a protein tyrosine phosphatase SHP-1.

21 January 2018

1 reference

2',4',6'-Tris(methoxymethoxy) chalcone attenuates hepatic stellate cell proliferation by a heme oxygenase-dependent pathway.

21 January 2018

1 reference

Targeting signal-transducer-and-activator-of-transcription-3 for prevention and therapy of cancer: modern target but ancient solution

21 January 2018

1 reference

Licochalcone A is a potent inhibitor of TEL-Jak2-mediated transformation through the specific inhibition of Stat3 activation

21 January 2018

1 reference

Cardamonin suppresses nitric oxide production via blocking the IFN-γ/STAT pathway in endotoxin-challenged peritoneal macrophages of ICR mice

21 January 2018

1 reference

Enhanced sensitivity of human oral tumours to the flavonol, morin, during cancer progression: involvement of the Akt and stress kinase pathways.

21 January 2018

1 reference

Morin inhibits STAT3 tyrosine 705 phosphorylation in tumor cells through activation of protein tyrosine phosphatase SHP1.

21 January 2018

1 reference

Molecular mechanisms underlying anticancer effects of myricetin

21 January 2018

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Myricetin directly targets JAK1 to inhibit cell transformation

21 January 2018

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Multi-targeted therapy of cancer by genistein

21 January 2018

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Natural products with therapeutic potential in melanoma metastasis.

21 January 2018

1 reference

The specific role of isoflavones in reducing prostate cancer risk

21 January 2018

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Genistein protects pancreatic beta cells against cytokine-mediated toxicity

21 January 2018

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Green tea polyphenols: biology and therapeutic implications in cancer

21 January 2018

1 reference

Epigallocatechin gallate and mitochondria-A story of life and death

21 January 2018

1 reference

Epigallocatechin-3-gallate decreases VEGF production in head and neck and breast carcinoma cells by inhibiting EGFR-related pathways of signal transduction.

21 January 2018

1 reference

Inhibition of STAT3/cyclinD1 pathway promotes chemotherapeutic sensitivity of colorectal caner.

21 January 2018

1 reference

Bioactive compounds or metabolites from black raspberries modulate T lymphocyte proliferation, myeloid cell differentiation and Jak/STAT signaling

21 January 2018

1 reference

Procyanidin B2 3,3(″)-di-O-gallate, a biologically active constituent of grape seed extract, induces apoptosis in human prostate cancer cells via targeting NF-κB, Stat3, and AP1 transcription factors

21 January 2018

1 reference

A critical role of luteolin-induced reactive oxygen species in blockage of tumor necrosis factor-activated nuclear factor-kappaB pathway and sensitization of apoptosis in lung cancer cells

21 January 2018

1 reference

Luteolin promotes degradation in signal transducer and activator of transcription 3 in human hepatoma cells: an implication for the antitumor potential of flavonoids

21 January 2018

1 reference

Luteolin induces carcinoma cell apoptosis through binding Hsp90 to suppress constitutive activation of STAT3.

21 January 2018

1 reference

Diet-derived polyphenols inhibit angiogenesis by modulating the interleukin-6/STAT3 pathway.

21 January 2018

1 reference

Capsaicin is a novel blocker of constitutive and interleukin-6-inducible STAT3 activation

21 January 2018

1 reference

Isolation and purification of baicalein, wogonin and oroxylin A from the medicinal plant Scutellaria baicalensis by high-speed counter-current chromatography

21 January 2018

1 reference

Oroxylin A induces autophagy in human malignant glioma cells via the mTOR-STAT3-Notch signaling pathway

21 January 2018

1 reference

Bone marrow microenvironment confers imatinib resistance to chronic myelogenous leukemia and oroxylin A reverses the resistance by suppressing Stat3 pathway

21 January 2018

1 reference

Honokiol inhibits signal transducer and activator of transcription-3 signaling, proliferation, and survival of hepatocellular carcinoma cells via the protein tyrosine phosphatase SHP-1.

21 January 2018

1 reference

Constitutive activation of JAK1 in Src-transformed cells

21 January 2018

1 reference

Honokiol inhibits epithelial-mesenchymal transition in breast cancer cells by targeting signal transducer and activator of transcription 3/Zeb1/E-cadherin axis

21 January 2018

1 reference

Calpain/SHP-1 interaction by honokiol dampening peritoneal dissemination of gastric cancer in nu/nu mice

21 January 2018

1 reference

Quercetin exerts anti-melanoma activities and inhibits STAT3 signaling

21 January 2018

1 reference

A potential role for resveratrol as a radiation sensitizer for melanoma treatment

21 January 2018

1 reference

Resveratrol sensitizes melanomas to TRAIL through modulation of antiapoptotic gene expression

21 January 2018

1 reference

Inhibition of the STAT3 signaling pathway contributes to apigenin-mediated anti-metastatic effect in melanoma.

21 January 2018

1 reference

Curcumin induces proapoptotic effects against human melanoma cells and modulates the cellular response to immunotherapeutic cytokines

21 January 2018

1 reference

An anticancer effect of curcumin mediated by down-regulating phosphatase of regenerating liver-3 expression on highly metastatic melanoma cells

21 January 2018

1 reference

The small molecule curcumin analog FLLL32 induces apoptosis in melanoma cells via STAT3 inhibition and retains the cellular response to cytokines with anti-tumor activity

21 January 2018

1 reference

Silibinin inhibits inflammatory and angiogenic attributes in photocarcinogenesis in SKH-1 hairless mice.

21 January 2018

1 reference

Quercetin: potentials in the prevention and therapy of disease

21 January 2018

1 reference

Role of quercetin as an alternative for obesity treatment: you are what you eat!

21 January 2018

1 reference

A critical review of the data related to the safety of quercetin and lack of evidence of in vivo toxicity, including lack of genotoxic/carcinogenic properties

21 January 2018

1 reference

Late type apoptosis and apoptosis free lethal effect of quercetin in human melanoma

21 January 2018

1 reference

Quercetin inhibits the invasion of murine melanoma B16-BL6 cells by decreasing pro-MMP-9 via the PKC pathway

21 January 2018

1 reference

Protective effect of quercetin on aroclor 1254-induced oxidative damage in cultured chicken spermatogonial cells

21 January 2018

1 reference

Quercetin abrogates chemoresistance in melanoma cells by modulating deltaNp73.

21 January 2018

1 reference

Quercetin abrogates IL-6/STAT3 signaling and inhibits glioblastoma cell line growth and migration

21 January 2018

1 reference

Natural products as a gold mine for arthritis treatment.

21 January 2018

1 reference

Resveratrol and Alzheimer's Disease: Mechanistic Insights

21 January 2018

1 reference

Resveratrol and the mitochondria: From triggering the intrinsic apoptotic pathway to inducing mitochondrial biogenesis, a mechanistic view

21 January 2018

1 reference

Resveratrol as a Potential Therapeutic Candidate for the Treatment and Management of Alzheimer's Disease

21 January 2018

1 reference

Resveratrol addiction: to die or not to die.

21 January 2018

1 reference

Resveratrol as a chemopreventive agent: a promising molecule for fighting cancer

21 January 2018

1 reference

High absorption but very low bioavailability of oral resveratrol in humans

21 January 2018

1 reference

Multiple molecular targets of resveratrol: Anti-carcinogenic mechanisms

21 January 2018

1 reference

Cancer chemopreventive activity of resveratrol, a natural product derived from grapes

21 January 2018

1 reference

Resveratrol inhibits Src and Stat3 signaling and induces the apoptosis of malignant cells containing activated Stat3 protein

21 January 2018

1 reference

NF-kappaB activation in melanoma

21 January 2018

1 reference

Death receptors and melanoma resistance to apoptosis

21 January 2018

1 reference

Resveratrol inhibits proliferation, induces apoptosis, and overcomes chemoresistance through down-regulation of STAT3 and nuclear factor-kappaB-regulated antiapoptotic and cell survival gene products in human multiple myeloma cells.

21 January 2018

1 reference

Resveratrol suppresses tumorigenicity and enhances radiosensitivity in primary glioblastoma tumor initiating cells by inhibiting the STAT3 axis.

21 January 2018

1 reference

IL-18 production downstream of the Nlrp3 inflammasome confers protection against colorectal tumor formation

21 January 2018

1 reference

Sequential treatment by ionizing radiation and sodium arsenite dramatically accelerates TRAIL-mediated apoptosis of human melanoma cells.

21 January 2018

1 reference

A neuroprotective herbal mixture inhibits caspase-3-independent apoptosis in retinal ganglion cells.

21 January 2018

1 reference

Apigenin: a promising molecule for cancer prevention

21 January 2018

1 reference

Flavonoids inhibit melanoma lung metastasis by impairing tumor cells endothelium interactions

21 January 2018

1 reference

Apigenin inhibits HGF-promoted invasive growth and metastasis involving blocking PI3K/Akt pathway and beta 4 integrin function in MDA-MB-231 breast cancer cells

21 January 2018

1 reference

Induction of caspase-dependent extrinsic apoptosis by apigenin through inhibition of signal transducer and activator of transcription 3 (STAT3) signalling in HER2-overexpressing BT-474 breast cancer cells.

21 January 2018

1 reference

Cytotoxicity of apigenin on leukemia cell lines: implications for prevention and therapy

21 January 2018

1 reference

Phase II trial of curcumin in patients with advanced pancreatic cancer

21 January 2018

1 reference

Enhanced anti-tumor activity of a new curcumin-related compound against melanoma and neuroblastoma cells

21 January 2018

1 reference

Curcumin: getting back to the roots.

21 January 2018

1 reference

Curcumin (diferuloylmethane) down-regulates the constitutive activation of nuclear factor-kappa B and IkappaBalpha kinase in human multiple myeloma cells, leading to suppression of proliferation and induction of apoptosis

21 January 2018

1 reference

Curcumin induces cell-arrest and apoptosis in association with the inhibition of constitutively active NF-kappaB and STAT3 pathways in Hodgkin's lymphoma cells

21 January 2018

1 reference

Curcumin inhibits constitutive STAT3 phosphorylation in human pancreatic cancer cell lines and downregulation of survivin/BIRC5 gene expression

21 January 2018

1 reference

Lysophosphatidic acid induces STAT3 phosphorylation and ovarian cancer cell motility: their inhibition by curcumin.

21 January 2018

1 reference

Targeting constitutive and interleukin-6-inducible signal transducers and activators of transcription 3 pathway in head and neck squamous cell carcinoma cells by curcumin (diferuloylmethane).

21 January 2018

1 reference

Novel STAT3 phosphorylation inhibitors exhibit potent growth-suppressive activity in pancreatic and breast cancer cells

21 January 2018

1 reference

Dietary curcumin attenuates glioma growth in a syngeneic mouse model by inhibition of the JAK1,2/STAT3 signaling pathway

21 January 2018

1 reference

Structurally modified curcumin analogs inhibit STAT3 phosphorylation and promote apoptosis of human renal cell carcinoma and melanoma cell lines

21 January 2018

1 reference

The novel curcumin analog FLLL32 decreases STAT3 DNA binding activity and expression, and induces apoptosis in osteosarcoma cell lines

21 January 2018

1 reference

Milk thistle nomenclature: why it matters in cancer research and pharmacokinetic studies

21 January 2018

1 reference

Silibinin and STAT3: A natural way of targeting transcription factors for cancer therapy

21 January 2018

1 reference

Antimetastatic efficacy of silibinin: molecular mechanisms and therapeutic potential against cancer

21 January 2018

1 reference

Prostate cancer prevention by silibinin

21 January 2018

1 reference

Mechanisms and preclinical efficacy of silibinin in preventing skin cancer.

21 January 2018

1 reference

Multitargeted therapy of cancer by silymarin

21 January 2018

1 reference

Silibinin suppresses growth of human prostate carcinoma PC-3 orthotopic xenograft via activation of extracellular signal-regulated kinase 1/2 and inhibition of signal transducers and activators of transcription signaling

21 January 2018

1 reference

Silibinin inhibits constitutive activation of Stat3, and causes caspase activation and apoptotic death of human prostate carcinoma DU145 cells

21 January 2018

1 reference

Growth inhibition and regression of lung tumors by silibinin: modulation of angiogenesis by macrophage-associated cytokines and nuclear factor-kappaB and signal transducers and activators of transcription 3.

21 January 2018

1 reference

Melanogenesis inhibitors from the desert plant Anastatica hierochuntica in B16 melanoma cells

21 January 2018

1 reference

131. The constitution of oroxylin-A, a yellow colouring matter from the root-bark of Oroxylum indicum, vent

21 January 2018

1 reference

Polyphenol/peptide binding and precipitation

21 January 2018

1 reference

21 January 2018

Identifiers

DOI

10.1002/BIOF.1345

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27896891%20AND%20SRC:MED&resulttype=core&format=json

28 March 2020

1 reference