Regulation of gene-activation pathways by PIAS proteins in the immune system (Q28264801)

Nature Reviews Immunology

Europe PubMed Central

title

Regulation of gene-activation pathways by PIAS proteins in the immune system (English)

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author name string

Ke Shuai

series ordinal

1

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Bin Liu

series ordinal

2

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language of work or name

English

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publication date

August 2005

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published in

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volume

5

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page(s)

593-605

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issue

8

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cites work

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Inhibition of Stat1-mediated gene activation by PIAS1

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SAP - a putative DNA-binding motif involved in chromosomal organization

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PIASy, a nuclear matrix-associated SUMO E3 ligase, represses LEF1 activity by sequestration into nuclear bodies

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NMR structure of the N-terminal domain of SUMO ligase PIAS1 and its interaction with tumor suppressor p53 and A/T-rich DNA oligomers

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A signature motif in transcriptional co-activators mediates binding to nuclear receptors

21 April 2017

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A transcriptional corepressor of Stat1 with an essential LXXLL signature motif

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Distinct effects of PIAS proteins on androgen-mediated gene activation in prostate cancer cells

21 April 2017

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The ‘PINIT’ motif, of a newly identified conserved domain of the PIAS protein family, is essential for nuclear retention of PIAS3L

21 April 2017

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Protein inhibitor of activated STAT Y (PIASy) and a splice variant lacking exon 6 enhance sumoylation but are not essential for embryogenesis and adult life

21 April 2017

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Covalent modification of p73alpha by SUMO-1. Two-hybrid screening with p73 identifies novel SUMO-1-interacting proteins and a SUMO-1 interaction motif

21 April 2017

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Distinct roles of the NH2- and COOH-terminal domains of the protein inhibitor of activated signal transducer and activator of transcription (STAT) 1 (PIAS1) in cytokine-induced PIAS1-Stat1 interaction

21 April 2017

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Physical and functional interactions of histone deacetylase 3 with TFII-I family proteins and PIASxbeta

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PIASx is a transcriptional co-repressor of signal transducer and activator of transcription 4

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An E3-like factor that promotes SUMO conjugation to the yeast septins

21 April 2017

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PIAS1 and PIASxalpha function as SUMO-E3 ligases toward androgen receptor and repress androgen receptor-dependent transcription

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PIAS proteins promote SUMO-1 conjugation to STAT1

21 April 2017

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Activation of Smad transcriptional activity by protein inhibitor of activated STAT3 (PIAS3)

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The T cell protein tyrosine phosphatase is a negative regulator of janus family kinases 1 and 3

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Identification of a nuclear Stat1 protein tyrosine phosphatase

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Zimp encodes a homologue of mouse Miz1 and PIAS3 and is an essential gene in Drosophila melanogaster

21 April 2017

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A Drosophila PIAS homologue negatively regulates stat92E

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Phosphorylation meets ubiquitination: the control of NF-[kappa]B activity

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PIAS3 suppresses NF-kappaB-mediated transcription by interacting with the p65/RelA subunit

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Smad-dependent and Smad-independent pathways in TGF-beta family signalling

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Regulation of transforming growth factor-beta signaling by protein inhibitor of activated STAT, PIASy through Smad3

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Transforming Growth Factor-β-mediated Signaling via the p38 MAP Kinase Pathway Activates Smad-dependent Transcription through SUMO-1 Modification of Smad4

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p53, the cellular gatekeeper for growth and division

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Activation of p53 by protein inhibitor of activated Stat1 (PIAS1)

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Members of the PIAS family act as SUMO ligases for c-Jun and p53 and repress p53 activity

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Involvement of PIAS1 in the sumoylation of tumor suppressor p53

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The ubiquitin-protein ligase Itch regulates p73 stability

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PIAS-1 is a checkpoint regulator which affects exit from G1 and G2 by sumoylation of p73

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Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53

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Sumoylation of Mdm2 by protein inhibitor of activated STAT (PIAS) and RanBP2 enzymes

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SUMO modification of a novel MAR-binding protein, SATB2, modulates immunoglobulin mu gene expression

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A new role for the STAT3 inhibitor, PIAS3: a repressor of microphthalmia transcription factor

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C/EBPepsilon is a myeloid-specific activator of cytokine, chemokine, and macrophage-colony-stimulating factor receptor genes

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Macrophage functional maturation and cytokine production are impaired in C/EBP epsilon-deficient mice

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Protein partners of C/EBPepsilon

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Association of the nucleocapsid protein of the Seoul and Hantaan hantaviruses with small ubiquitin-like modifier-1-related molecules

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RAD6-dependent DNA repair is linked to modification of PCNA by ubiquitin and SUMO.

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Polymeric chains of SUMO-2 and SUMO-3 are conjugated to protein substrates by SAE1/SAE2 and Ubc9.

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The nucleoporin RanBP2 has SUMO1 E3 ligase activity

21 April 2017

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The zinc finger protein Gfi-1 can enhance STAT3 signaling by interacting with the STAT3 inhibitor PIAS3

21 April 2017

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ATBF1 enhances the suppression of STAT3 signaling by interaction with PIAS3

21 April 2017

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PIAS3 induces SUMO-1 modification and transcriptional repression of IRF-1

21 April 2017

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Repression of the Transactivating Capacity of the Oncoprotein PLAG1 by SUMOylation

21 April 2017

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Stats: transcriptional control and biological impact

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Protein modification by SUMO

21 April 2017

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STATs and gene regulation

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The two NF-kappaB activation pathways and their role in innate and adaptive immunity

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Signalling pathways of the TNF superfamily: a double-edged sword

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SUMO--nonclassical ubiquitin

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SUMO-1 conjugation in vivo requires both a consensus modification motif and nuclear targeting

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Regulation of JAK-STAT signalling in the immune system

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The IKK NF-kappa B system: a treasure trove for drug development

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Smads as transcriptional co-modulators

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Development of TGF-beta signalling inhibitors for cancer therapy

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Impaired response to interferon-alpha/beta and lethal viral disease in human STAT1 deficiency

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The STAT family of proteins in cytokine signaling

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Modulation of STAT signaling by STAT-interacting proteins

31 March 2020

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A new RING for SUMO: wrestling transcriptional responses into nuclear bodies with PIAS family E3 SUMO ligases

31 March 2020

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PIAS/SUMO: new partners in transcriptional regulation.

31 March 2020

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SAF-Box, a conserved protein domain that specifically recognizes scaffold attachment region DNA.

31 March 2020

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The CoRNR motif controls the recruitment of corepressors by nuclear hormone receptors

31 March 2020

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Functional analyses of an LXXLL motif in nuclear receptor corepressor (N-CoR).

31 March 2020

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RING finger proteins: mediators of ubiquitin ligase activity

31 March 2020

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PIAS proteins modulate transcription factors by functioning as SUMO-1 ligases.

31 March 2020

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Negative regulation of NF-kappaB signaling by PIAS1.

31 March 2020

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PIAS1 selectively inhibits interferon-inducible genes and is important in innate immunity.

31 March 2020

1 reference

Repression of Smad transcriptional activity by PIASy, an inhibitor of activated STAT.

31 March 2020

1 reference

PIASy-mediated repression of the androgen receptor is independent of sumoylation

31 March 2020

1 reference

SUMO modification of STAT1 and its role in PIAS-mediated inhibition of gene activation

31 March 2020

1 reference

SUMO-1 conjugation selectively modulates STAT1-mediated gene responses

31 March 2020

1 reference

The Drosophila Su(var)2-10 locus regulates chromosome structure and function and encodes a member of the PIAS protein family

31 March 2020

1 reference

PIASy-deficient mice display modest defects in IFN and Wnt signaling

31 March 2020

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Rel/NF-kappa B and I kappa B proteins: an overview

31 March 2020

1 reference

Sumoylation of Smad4, the Common Smad Mediator of Transforming Growth Factor-β Family Signaling

31 March 2020

1 reference

Regulation of Smad4 sumoylation and transforming growth factor-beta signaling by protein inhibitor of activated STAT1.

31 March 2020

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Negative regulation of Smad2 by PIASy is required for proper Xenopus mesoderm formation.

31 March 2020

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Functional regulation of p73 and p63: development and cancer

31 March 2020

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p53 leans on its siblings

31 March 2020

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p53: traffic cop at the crossroads of DNA repair and recombination

31 March 2020

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p73, the "assistant" guardian of the genome?

31 March 2020

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Signaling to p53: breaking the MDM2-p53 circuit

31 March 2020

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Regulating the p53 system through ubiquitination

31 March 2020

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Role played by microphthalmia transcription factor phosphorylation and its Zip domain in its transcriptional inhibition by PIAS3

31 March 2020

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Interplay between MITF, PIAS3, and STAT3 in mast cells and melanocytes

31 March 2020

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Impaired granulopoiesis, myelodysplasia, and early lethality in CCAAT/enhancer binding protein epsilon-deficient mice.

31 March 2020

1 reference

Repression and coactivation of CCAAT/enhancer-binding protein epsilon by sumoylation and protein inhibitor of activated STATx proteins

31 March 2020

1 reference

Post-translational modification of Rta of Epstein-Barr virus by SUMO-1.

31 March 2020

1 reference

PIAS1 enhances SUMO-1 modification and the transactivation activity of the major immediate-early IE2 protein of human cytomegalovirus

31 March 2020

1 reference

Proteins of the PIAS family enhance the sumoylation of the papillomavirus E1 protein.

31 March 2020

1 reference

Versatile protein tag, SUMO: its enzymology and biological function

31 March 2020

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Intracellular targeting of proteins by sumoylation

31 March 2020

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The intranuclear prolactin/cyclophilin B complex as a transcriptional inducer

31 March 2020

1 reference

PIASy represses TRIF-induced ISRE and NF-kappaB activation but not apoptosis.

31 March 2020

1 reference