cGAS-cGAMP-STING: The three musketeers of cytosolic DNA sensing and signaling (Q38972881)

8 September 2017

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title

cGAS-cGAMP-STING: The three musketeers of cytosolic DNA sensing and signaling (English)

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8 September 2017

Jianli Tao

1

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author name string

Xiang Zhou

series ordinal

2

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8 September 2017

Zhengfan Jiang

series ordinal

3

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8 September 2017

language of work or name

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5 October 2016

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8 September 2017

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8 September 2017

68

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8 September 2017

11

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8 September 2017

858-870

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Pattern recognition receptors and inflammation

8 September 2017

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Innate immune sensing and signaling of cytosolic nucleic acids

21 January 2018

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Nucleic acid driven sterile inflammation

21 January 2018

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The cGAS-cGAMP-STING pathway of cytosolic DNA sensing and signaling

21 January 2018

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DNA makes RNA makes innate immunity.

21 January 2018

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Regulation of inflammasome signaling

21 January 2018

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A Toll-like receptor recognizes bacterial DNA

21 January 2018

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RNA polymerase III detects cytosolic DNA and induces type I interferons through the RIG-I pathway

21 January 2018

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RIG-I-dependent sensing of poly(dA:dT) through the induction of an RNA polymerase III-transcribed RNA intermediate

21 January 2018

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DAI (DLM-1/ZBP1) is a cytosolic DNA sensor and an activator of innate immune response

21 January 2018

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The helicase DDX41 senses intracellular DNA mediated by the adaptor STING in dendritic cells

21 January 2018

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DNA-PK is a DNA sensor for IRF-3-dependent innate immunity.

21 January 2018

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DNA damage sensor MRE11 recognizes cytosolic double-stranded DNA and induces type I interferon by regulating STING trafficking

21 January 2018

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STING recognition of cytoplasmic DNA instigates cellular defense

21 January 2018

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Sox2 functions as a sequence-specific DNA sensor in neutrophils to initiate innate immunity against microbial infection

21 January 2018

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PQBP1 Is a Proximal Sensor of the cGAS-Dependent Innate Response to HIV-1.

21 January 2018

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IFI16 is an innate immune sensor for intracellular DNA

21 January 2018

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Cyclic GMP-AMP synthase is a cytosolic DNA sensor that activates the type I interferon pathway

21 January 2018

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Cyclic GMP-AMP is an endogenous second messenger in innate immune signaling by cytosolic DNA

21 January 2018

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Structure of Human cGAS Reveals a Conserved Family of Second-Messenger Enzymes in Innate Immunity

21 January 2018

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Sequence-specific activation of the DNA sensor cGAS by Y-form DNA structures as found in primary HIV-1 cDNA

21 January 2018

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Cytosolic RNA:DNA hybrids activate the cGAS-STING axis

21 January 2018

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Genome-wide DNA hypomethylation and RNA:DNA hybrid accumulation in Aicardi-Goutières syndrome

21 January 2018

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Cyclic [G(2′,5′)pA(3′,5′)p] Is the Metazoan Second Messenger Produced by DNA-Activated Cyclic GMP-AMP Synthase

21 January 2018

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Structural mechanism of cytosolic DNA sensing by cGAS

21 January 2018

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Structural biology of innate immunity

21 January 2018

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Cyclic GMP-AMP Synthase Is Activated by Double-Stranded DNA-Induced Oligomerization

21 January 2018

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The Cytosolic DNA Sensor cGAS Forms an Oligomeric Complex with DNA and Undergoes Switch-like Conformational Changes in the Activation Loop

21 January 2018

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cGAS dimerization entangles DNA recognition

21 January 2018

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Crosstalk between the cGAS DNA sensor and Beclin-1 autophagy protein shapes innate antimicrobial immune responses

21 January 2018

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Akt Kinase-Mediated Checkpoint of cGAS DNA Sensing Pathway

21 January 2018

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Glutamylation of the DNA sensor cGAS regulates its binding and synthase activity in antiviral immunity

21 January 2018

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Cyclic dinucleotides trigger ULK1 (ATG1) phosphorylation of STING to prevent sustained innate immune signaling

21 January 2018

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Hydrolysis of 2'3'-cGAMP by ENPP1 and design of nonhydrolyzable analogs

21 January 2018

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iRhom2 is essential for innate immunity to DNA viruses by mediating trafficking and stability of the adaptor STING.

21 January 2018

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STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling

21 January 2018

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The ER-associated protein ZDHHC1 is a positive regulator of DNA virus-triggered, MITA/STING-dependent innate immune signaling

21 January 2018

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The E3 ubiquitin ligase AMFR and INSIG1 bridge the activation of TBK1 kinase by modifying the adaptor STING.

21 January 2018

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RNF26 temporally regulates virus-triggered type I interferon induction by two distinct mechanisms

21 January 2018

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The ubiquitin ligase TRIM56 regulates innate immune responses to intracellular double-stranded DNA

21 January 2018

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TRIM32 protein modulates type I interferon induction and cellular antiviral response by targeting MITA/STING protein for K63-linked ubiquitination

21 January 2018

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The ubiquitin ligase RNF5 regulates antiviral responses by mediating degradation of the adaptor protein MITA

21 January 2018

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TRIM30α Is a Negative-Feedback Regulator of the Intracellular DNA and DNA Virus-Triggered Response by Targeting STING

21 January 2018

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NLRX1 Sequesters STING to Negatively Regulate the Interferon Response, Thereby Facilitating the Replication of HIV-1 and DNA Viruses.

21 January 2018

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Atg9a controls dsDNA-driven dynamic translocation of STING and the innate immune response

21 January 2018

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S6K-STING interaction regulates cytosolic DNA-mediated activation of the transcription factor IRF3.

21 January 2018

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Phosphorylation of innate immune adaptor proteins MAVS, STING, and TRIF induces IRF3 activation

21 January 2018

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PPM1A regulates antiviral signaling by antagonizing TBK1-mediated STING phosphorylation and aggregation

21 January 2018

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Activation of STAT6 by STING is critical for antiviral innate immunity

21 January 2018

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Positive feedback regulation of type I IFN production by the IFN-inducible DNA sensor cGAS

21 January 2018

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Positive feedback regulation of type I interferon by the interferon-stimulated gene STING.

21 January 2018

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Pan-viral specificity of IFN-induced genes reveals new roles for cGAS in innate immunity

21 January 2018

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OAS proteins and cGAS: unifying concepts in sensing and responding to cytosolic nucleic acids

21 January 2018

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Overlapping Patterns of Rapid Evolution in the Nucleic Acid Sensors cGAS and OAS1 Suggest a Common Mechanism of Pathogen Antagonism and Escape

21 January 2018

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cGAS produces a 2'-5'-linked cyclic dinucleotide second messenger that activates STING.

21 January 2018

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The innate immune DNA sensor cGAS produces a noncanonical cyclic dinucleotide that activates human STING

21 January 2018

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Cyclic GMP-AMP Containing Mixed Phosphodiester Linkages Is An Endogenous High-Affinity Ligand for STING

21 January 2018

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Cyclic (di)nucleotides: the common language shared by microbe and host.

21 January 2018

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Pivotal roles of cGAS-cGAMP signaling in antiviral defense and immune adjuvant effects

21 January 2018

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Cyclic GMP-AMP displays mucosal adjuvant activity in mice

21 January 2018

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Natural STING Agonist as an "Ideal" Adjuvant for Cutaneous Vaccination.

21 January 2018

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Cell intrinsic immunity spreads to bystander cells via the intercellular transfer of cGAMP.

21 January 2018

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Carcinoma-astrocyte gap junctions promote brain metastasis by cGAMP transfer

21 January 2018

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Viruses transfer the antiviral second messenger cGAMP between cells

21 January 2018

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Transmission of innate immune signaling by packaging of cGAMP in viral particles

21 January 2018

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Identification of ectonucleotide pyrophosphatase/phosphodiesterase 3 (ENPP3) as a regulator of N-acetylglucosaminyltransferase GnT-IX (GnT-Vb).

21 January 2018

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Activation of cyclic GMP-AMP synthase by self-DNA causes autoimmune diseases

21 January 2018

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cGMP-AMP synthase paves the way to autoimmunity

21 January 2018

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Coordinated regulation of accessory genetic elements produces cyclic di-nucleotides for V. cholerae virulence

21 January 2018

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Identification and characterization of phosphodiesterases that specifically degrade 3'3'-cyclic GMP-AMP

21 January 2018

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V-cGAPs: attenuators of 3'3'-cGAMP signaling

21 January 2018

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GEMM-I riboswitches from Geobacter sense the bacterial second messenger cyclic AMP-GMP

21 January 2018

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Control of bacterial exoelectrogenesis by c-AMP-GMP.

21 January 2018

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Hybrid promiscuous (Hypr) GGDEF enzymes produce cyclic AMP-GMP (3', 3'-cGAMP)

21 January 2018

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Ancient Origin of cGAS-STING Reveals Mechanism of Universal 2',3' cGAMP Signaling

21 January 2018

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Molecular basis for the specific recognition of the metazoan cyclic GMP-AMP by the innate immune adaptor protein STING.

21 January 2018

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Direct Activation of STING in the Tumor Microenvironment Leads to Potent and Systemic Tumor Regression and Immunity

21 January 2018

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STING agonist formulated cancer vaccines can cure established tumors resistant to PD-1 blockade

21 January 2018

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Structure-guided reprogramming of human cGAS dinucleotide linkage specificity

21 January 2018

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Structural biochemistry of a Vibrio cholerae dinucleotide cyclase reveals cyclase activity regulation by folates

21 January 2018

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Crystal structure of the novel di-nucleotide cyclase from Vibrio cholerae (DncV) responsible for synthesizing a hybrid cyclic GMP-AMP.

21 January 2018

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STING regulates intracellular DNA-mediated, type I interferon-dependent innate immunity

21 January 2018

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The adaptor protein MITA links virus-sensing receptors to IRF3 transcription factor activation

21 January 2018

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MPYS, a novel membrane tetraspanner, is associated with major histocompatibility complex class II and mediates transduction of apoptotic signals

21 January 2018

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ERIS, an endoplasmic reticulum IFN stimulator, activates innate immune signaling through dimerization

21 January 2018

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STING is a direct innate immune sensor of cyclic di-GMP

21 January 2018

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STING specifies IRF3 phosphorylation by TBK1 in the cytosolic DNA signaling pathway

21 January 2018

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The structural basis for the sensing and binding of cyclic di-GMP by STING

21 January 2018

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Structural Analysis of the STING Adaptor Protein Reveals a Hydrophobic Dimer Interface and Mode of Cyclic di-GMP Binding

21 January 2018

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Crystal structures of STING protein reveal basis for recognition of cyclic di-GMP

21 January 2018

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Structure of STING bound to cyclic di-GMP reveals the mechanism of cyclic dinucleotide recognition by the immune system

21 January 2018

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Cyclic di-GMP sensing via the innate immune signaling protein STING

21 January 2018

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Rat and human STINGs profile similarly towards anticancer/antiviral compounds

21 January 2018

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Structure-Function Analysis of STING Activation by c[G(2′,5′)pA(3′,5′)p] and Targeting by Antiviral DMXAA

21 January 2018

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Cutting Edge: Novel Tmem173 Allele Reveals Importance of STING N Terminus in Trafficking and Type I IFN Production

21 January 2018

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DNA tumor virus oncogenes antagonize the cGAS-STING DNA-sensing pathway

21 January 2018

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Ligand-induced Ordering of the C-terminal Tail Primes STING for Phosphorylation by TBK1

21 January 2018

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MITA/STING: a central and multifaceted mediator in innate immune response

21 January 2018

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Single nucleotide polymorphisms of human STING can affect innate immune response to cyclic dinucleotides

21 January 2018

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The N-ethyl-N-nitrosourea-induced Goldenticket mouse mutant reveals an essential function of Sting in the in vivo interferon response to Listeria monocytogenes and cyclic dinucleotides

21 January 2018

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Molecular evolutionary and structural analysis of the cytosolic DNA sensor cGAS and STING

21 January 2018

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Cyclic di-nucleotide signaling enters the eukaryote domain.

21 January 2018

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Modulation of the cGAS-STING DNA sensing pathway by gammaherpesviruses

21 January 2018

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Adenovirus detection by the cGAS/STING/TBK1 DNA sensing cascade

21 January 2018

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E2 proteins of high risk human papillomaviruses down-modulate STING and IFN-κ transcription in keratinocytes

21 January 2018

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cGAS Senses Human Cytomegalovirus and Induces Type I Interferon Responses in Human Monocyte-Derived Cells

21 January 2018

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Cyclic GMP-AMP synthase is an innate immune sensor of HIV and other retroviruses

21 January 2018

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Mitochondrial DNA stress primes the antiviral innate immune response

21 January 2018

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Apoptotic caspases prevent the induction of type I interferons by mitochondrial DNA.

21 January 2018

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Apoptotic caspases suppress mtDNA-induced STING-mediated type I IFN production

21 January 2018

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Viral evasion of DNA-stimulated innate immune responses

21 January 2018

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Innate immune evasion strategies of DNA and RNA viruses

21 January 2018

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The expanding regulatory network of STING-mediated signaling

21 January 2018

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Inhibition of cGAS DNA Sensing by a Herpesvirus Virion Protein

21 January 2018

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Cytoplasmic isoforms of Kaposi sarcoma herpesvirus LANA recruit and antagonize the innate immune DNA sensor cGAS

21 January 2018

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Hepatitis B virus polymerase disrupts K63-linked ubiquitination of STING to block innate cytosolic DNA-sensing pathways

21 January 2018

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Hepatitis C Virus NS4B Can Suppress STING Accumulation To Evade Innate Immune Responses

21 January 2018

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STING: infection, inflammation and cancer

21 January 2018

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DENV inhibits type I IFN production in infected cells by cleaving human STING

21 January 2018

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Influenza A virus targets a cGAS-independent STING pathway that controls enveloped RNA viruses.

21 January 2018

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Cyclic dinucleotide (c-di-GMP, c-di-AMP, and cGAMP) signalings have come of age to be inhibited by small molecules.

21 January 2018

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Listeria monocytogenes induces IFNβ expression through an IFI16-, cGAS- and STING-dependent pathway

21 January 2018

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Cyclic GMP-AMP Synthase Is an Innate Immune DNA Sensor for Mycobacterium tuberculosis

21 January 2018

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The Cytosolic Sensor cGAS Detects Mycobacterium tuberculosis DNA to Induce Type I Interferons and Activate Autophagy

21 January 2018

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Extracellular M. tuberculosis DNA targets bacteria for autophagy by activating the host DNA-sensing pathway

21 January 2018

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cGAS and Ifi204 cooperate to produce type I IFNs in response to Francisella infection

21 January 2018

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The DNA sensor, cyclic GMP-AMP synthase, is essential for induction of IFN-β during Chlamydia trachomatis infection.

21 January 2018

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STING-dependent recognition of cyclic di-AMP mediates type I interferon responses during Chlamydia trachomatis infection.

21 January 2018

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Stimulator of IFN gene is critical for induction of IFN-beta during Chlamydia muridarum infection

21 January 2018

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Age-enhanced endoplasmic reticulum stress contributes to increased Atg9A inhibition of STING-mediated IFN-β production during Streptococcus pneumoniae infection

21 January 2018

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Type I Interferon Induction by Neisseria gonorrhoeae: Dual Requirement of Cyclic GMP-AMP Synthase and Toll-like Receptor 4.

21 January 2018

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c-di-AMP secreted by intracellular Listeria monocytogenes activates a host type I interferon response

21 January 2018

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A bacterial cyclic dinucleotide activates the cytosolic surveillance pathway and mediates innate resistance to tuberculosis.

21 January 2018

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For Better or Worse: Cytosolic DNA Sensing during Intracellular Bacterial Infection Induces Potent Innate Immune Responses.

21 January 2018

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Mycobacterium tuberculosis activates the DNA-dependent cytosolic surveillance pathway within macrophages

21 January 2018

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STING-dependent type I IFN production inhibits cell-mediated immunity to Listeria monocytogenes

21 January 2018

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Type I interferon promotes cell-to-cell spread of Listeria monocytogenes.

21 January 2018

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STING Activation by Translocation from the ER Is Associated with Infection and Autoinflammatory Disease

21 January 2018

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Inflammatory clearance of apoptotic remnants in systemic lupus erythematosus (SLE).

21 January 2018

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DNase 1 and systemic lupus erythematosus

21 January 2018

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Autoinflammation by endogenous DNA.

21 January 2018

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STING manifests self DNA-dependent inflammatory disease

21 January 2018

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Trex1 prevents cell-intrinsic initiation of autoimmunity

21 January 2018

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Intrinsic self-DNA triggers inflammatory disease dependent on STING.

21 January 2018

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Cutting Edge: cGAS Is Required for Lethal Autoimmune Disease in the Trex1-Deficient Mouse Model of Aicardi-Goutières Syndrome

21 January 2018

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Ribonuclease H2 mutations induce a cGAS/STING-dependent innate immune response

21 January 2018

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Inherited STING-activating mutation underlies a familial inflammatory syndrome with lupus-like manifestations

21 January 2018

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Activated STING in a vascular and pulmonary syndrome

21 January 2018

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Single amino acid change in STING leads to constitutive active signaling

21 January 2018

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Familial chilblain lupus due to a gain-of-function mutation in STING.

21 January 2018

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Old Dogs, New Tricks: Monogenic Autoinflammatory Disease Unleashed

21 January 2018

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Activation of STING requires palmitoylation at the Golgi.

21 January 2018

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21 January 2018

DNA sensing unchained

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The role of cGAS in innate immunity and beyond

21 January 2018

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Cutting edge: Antimalarial drugs inhibit IFN-β production through blockade of cyclic GMP-AMP synthase-DNA interaction

21 January 2018

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The STING pathway and the T cell-inflamed tumor microenvironment

21 January 2018

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Type I interferons in anticancer immunity

21 January 2018

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The DNA Structure-Specific Endonuclease MUS81 Mediates DNA Sensor STING-Dependent Host Rejection of Prostate Cancer Cells.

21 January 2018

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STING-Dependent Cytosolic DNA Sensing Promotes Radiation-Induced Type I Interferon-Dependent Antitumor Immunity in Immunogenic Tumors.

21 January 2018

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STING-dependent cytosolic DNA sensing mediates innate immune recognition of immunogenic tumors.

21 January 2018

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CD47 blockade triggers T cell-mediated destruction of immunogenic tumors

21 January 2018

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STING activation of tumor endothelial cells initiates spontaneous and therapeutic antitumor immunity

21 January 2018

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Antitumor Activity of cGAMP via Stimulation of cGAS-cGAMP-STING-IRF3 Mediated Innate Immune Response

21 January 2018

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STING Pathway Activation Stimulates Potent Immunity against Acute Myeloid Leukemia

21 January 2018

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Agonist-Mediated Activation of STING Induces Apoptosis in Malignant B Cells

21 January 2018

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Cyclic dinucleotides modulate human T-cell response through monocyte cell death.

21 January 2018

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Deregulation of STING Signaling in Colorectal Carcinoma Constrains DNA Damage Responses and Correlates With Tumorigenesis

21 January 2018

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Structural basis for concerted recruitment and activation of IRF-3 by innate immune adaptor proteins.

21 January 2018

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Antagonism of the STING Pathway via Activation of the AIM2 Inflammasome by Intracellular DNA.

21 January 2018

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The AIM2-like Receptors Are Dispensable for the Interferon Response to Intracellular DNA.

21 January 2018

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cGAS-STING Signaling Regulates Initial Innate Control of Cytomegalovirus Infection

21 January 2018

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21 January 2018

Identifiers

DOI

10.1002/IUB.1566

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release_gisec2ruojhejcl3bymxqvennu

8 September 2017

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Fatcat

https://api.fatcat.wiki/v0/release/gisec2ruojhejcl3bymxqvennu

mapped directly with Wikidata item

24 November 2022

based on heuristic

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