cGAS produces a 2'-5'-linked cyclic dinucleotide second messenger that activates STING. (Q34084866)

30 July 2017

cGAS produces a 2'-5'-linked cyclic dinucleotide second messenger that activates STING. (English)

1 reference

2'-O,5'-O-((adenosine-3'-O,5'-O-diyl)bisphosphinico)guanosine

30 July 2017

1 reference

c[G(2',5')pA(3',5')p](2-)

ChEBI release 2020-05-28

1 reference

ChEBI release 2020-05-28

ChEBI ID

78318

1 reference

ChEBI release 2020-05-28

7

1 reference

30 July 2017

6

Ingo Röhl

1 reference

30 July 2017

9

Veit Hornung

1 reference

30 July 2017

1

Andrea Ablasser

1 reference

30 July 2017

Marion Goldeck

2

1 reference

30 July 2017

Taner Cavlar

3

1 reference

30 July 2017

Tobias Deimling

4

1 reference

30 July 2017

Gregor Witte

5

1 reference

30 July 2017

Janos Ludwig

8

1 reference

30 July 2017

language of work or name

English

0 references

publication date

30 May 2013

1 reference

30 July 2017

1 reference

30 July 2017

498

1 reference

30 July 2017

380-384

1 reference

30 July 2017

7454

1 reference

https://scigraph.springernature.com/pub.10.1038/nature12306

30 July 2017

0 references

cites work

The innate immune DNA sensor cGAS produces a noncanonical cyclic dinucleotide that activates human STING

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4143541

Cyclic [G(2′,5′)pA(3′,5′)p] Is the Metazoan Second Messenger Produced by DNA-Activated Cyclic GMP-AMP Synthase

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4143541

Species-specific detection of the antiviral small-molecule compound CMA by STING

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4143541

Mouse, but not human STING, binds and signals in response to the vascular disrupting agent 5,6-dimethylxanthenone-4-acetic acid

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4143541

Cyclic GMP-AMP synthase is a cytosolic DNA sensor that activates the type I interferon pathway

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4143541

Cyclic GMP-AMP is an endogenous second messenger in innate immune signaling by cytosolic DNA

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4143541

STING manifests self DNA-dependent inflammatory disease

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4143541

Crystal structures of STING protein reveal basis for recognition of cyclic di-GMP

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4143541

The structural basis for the sensing and binding of cyclic di-GMP by STING

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4143541

Structure of STING bound to cyclic di-GMP reveals the mechanism of cyclic dinucleotide recognition by the immune system

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4143541

Structural Analysis of the STING Adaptor Protein Reveals a Hydrophobic Dimer Interface and Mode of Cyclic di-GMP Binding

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4143541

Coordinated regulation of accessory genetic elements produces cyclic di-nucleotides for V. cholerae virulence

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4143541

Autoimmunity initiates in nonhematopoietic cells and progresses via lymphocytes in an interferon-dependent autoimmune disease

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4143541

STING is a direct innate immune sensor of cyclic di-GMP

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4143541

The oligoadenylate synthetase family: an ancient protein family with multiple antiviral activities

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4143541

One-flask syntheses of c-di-GMP and the [Rp,Rp] and [Rp,Sp] thiophosphate analogues

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4143541

Intracellular DNA recognition

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4143541

STING regulates intracellular DNA-mediated, type I interferon-dependent innate immunity

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4143541

ERIS, an endoplasmic reticulum IFN stimulator, activates innate immune signaling through dimerization

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4143541

The adaptor protein MITA links virus-sensing receptors to IRF3 transcription factor activation

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4143541

STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4143541

MPYS, a novel membrane tetraspanner, is associated with major histocompatibility complex class II and mediates transduction of apoptotic signals

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4143541

pEF-BOS, a powerful mammalian expression vector

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4143541

Enzymatic synthesis of c-di-GMP using a thermophilic diguanylate cyclase

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4143541

28 October 2018

Identifiers

DOI

10.1038/NATURE12306

1 reference

Dimensions Publication ID

30 July 2017

1008735526

0 references

Fatcat ID

release_tsmy7otpjfcerm2iqsk3w3he5q

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/tsmy7otpjfcerm2iqsk3w3he5q

mapped directly with Wikidata item

24 November 2022

based on heuristic

PMCID

4143541

1 reference

30 July 2017

1 reference