Discriminating self from non-self in nucleic acid sensing (Q38907820)

7 September 2017

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title

Discriminating self from non-self in nucleic acid sensing (English)

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7 September 2017

Gunther Hartmann

2

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Martin Schlee

series ordinal

1

object named as

Martin Schlee

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PubMed ID

27455396

7 September 2017

language of work or name

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25 July 2016

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Nature Reviews Immunology

7 September 2017

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7 September 2017

16

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7 September 2017

9

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7 September 2017

566-580

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Translating nucleic acid-sensing pathways into therapies

7 September 2017

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2016.78

Nucleic acid driven sterile inflammation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2016.78

Innate immune sensing and signaling of cytosolic nucleic acids

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2016.78

Recognition of nucleic acids by pattern-recognition receptors and its relevance in autoimmunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2016.78

Cytosolic surveillance and antiviral immunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2016.78

Nucleic acid sensing at the interface between innate and adaptive immunity in vaccination

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2016.78

Recognition of viral nucleic acids in innate immunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2016.78

Targeting the viral Achilles' heel: recognition of 5'-triphosphate RNA in innate anti-viral defence

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2016.78

Turning tumors into vaccines: co-opting the innate immune system

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2016.78

Renaissance of mammalian endogenous RNAi

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2016.78

Reciprocal inhibition between intracellular antiviral signaling and the RNAi machinery in mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2016.78

The RNA sensor RIG-I dually functions as an innate sensor and direct antiviral factor for hepatitis B virus

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2016.78

Influenza virus adaptation PB2-627K modulates nucleocapsid inhibition by the pathogen sensor RIG-I.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2016.78

Protein kinase PKR amplification of interferon β induction occurs through initiation factor eIF-2α-mediated translational control

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2016.78

Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2016.78

Innate antiviral responses by means of TLR7-mediated recognition of single-stranded RNA

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2016.78

Species-specific recognition of single-stranded RNA via toll-like receptor 7 and 8

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2016.78

Sequence-specific potent induction of IFN-alpha by short interfering RNA in plasmacytoid dendritic cells through TLR7

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2016.78

Subcellular localization of Toll-like receptor 3 in human dendritic cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2016.78

The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2016.78

Helicases in Antiviral Immunity: Dual Properties as Sensors and Effectors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2016.78

Master sensors of pathogenic RNA - RIG-I like receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2016.78

A novel mitochondrial MAVS/Caspase-8 platform links RNA virus-induced innate antiviral signaling to Bax/Bak-independent apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2016.78

IPS-1 differentially induces TRAIL, BCL2, BIRC3 and PRKCE in type I interferons-dependent and -independent anticancer activity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2016.78

Targeting the cytosolic innate immune receptors RIG-I and MDA5 effectively counteracts cancer cell heterogeneity in glioblastoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2016.78

Viral apoptosis is induced by IRF-3-mediated activation of Bax

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2016.78

The mitochondrial antiviral protein MAVS associates with NLRP3 and regulates its inflammasome activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2016.78

The adaptor MAVS promotes NLRP3 mitochondrial localization and inflammasome activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2016.78

Cytosolic double-stranded RNA activates the NLRP3 inflammasome via MAVS-induced membrane permeabilization and K+ efflux

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2016.78

Recognition of RNA virus by RIG-I results in activation of CARD9 and inflammasome signaling for interleukin 1 beta production

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2016.78

Type I IFN triggers RIG-I/TLR3/NLRP3-dependent inflammasome activation in influenza A virus infected cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2016.78

Regulation of protein synthesis: Activation by double-stranded RNA of a protein kinase that phosphorylates eukaryotic initiation factor 2

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2016.78

2'-O methylation of the viral mRNA cap evades host restriction by IFIT family members

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2016.78

IFIT1 is an antiviral protein that recognizes 5'-triphosphate RNA

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2016.78

Structural basis for viral 5'-PPP-RNA recognition by human IFIT proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2016.78

Sequestration by IFIT1 impairs translation of 2'O-unmethylated capped RNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2016.78

Inhibition of translation by IFIT family members is determined by their ability to interact selectively with the 5'-terminal regions of cap0-, cap1- and 5'ppp- mRNAs

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2016.78

Isolation of two interferon-induced translational inhibitors: a protein kinase and an oligo-isoadenylate synthetase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2016.78

Synthesis of low molecular weight inhibitor of protein synthesis with enzyme from interferon-treated cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2016.78

Expression cloning of 2-5A-dependent RNAase: a uniquely regulated mediator of interferon action

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2016.78

An RNA editor, adenosine deaminase acting on double-stranded RNA (ADAR1).

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2016.78

Enhancement of replication of RNA viruses by ADAR1 via RNA editing and inhibition of RNA-activated protein kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2016.78

Double-stranded RNA is produced by positive-strand RNA viruses and DNA viruses but not in detectable amounts by negative-strand RNA viruses

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2016.78

Essential role of mda-5 in type I IFN responses to polyriboinosinic:polyribocytidylic acid and encephalomyocarditis picornavirus

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2016.78

Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2016.78

Length-dependent recognition of double-stranded ribonucleic acids by retinoic acid-inducible gene-I and melanoma differentiation-associated gene 5

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2016.78

Antiviral immunity via RIG-I-mediated recognition of RNA bearing 5'-diphosphates

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2016.78

The TLR3 signaling complex forms by cooperative receptor dimerization

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2016.78

Short-interfering RNAs induce retinal degeneration via TLR3 and IRF3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2016.78

Toll-like receptor (TLR) 3 immune modulation by unformulated small interfering RNA or DNA and the role of CD14 (in TLR-mediated effects).

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2016.78

Toll-like receptor 3 recognizes incomplete stem structures in single-stranded viral RNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2016.78

Structural basis for dsRNA recognition, filament formation, and antiviral signal activation by MDA5

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2016.78

RNA editing by ADAR1 prevents MDA5 sensing of endogenous dsRNA as nonself

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2016.78

Isoforms of RNA-Editing Enzyme ADAR1 Independently Control Nucleic Acid Sensor MDA5-Driven Autoimmunity and Multi-organ Development.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2016.78

Activation of IFN-β expression by a viral mRNA through RNase L and MDA5

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2016.78

In vivo ligands of MDA5 and RIG-I in measles virus-infected cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2016.78

mda-5, but not RIG-I, is a common target for paramyxovirus V proteins.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2016.78

In Vivo RNAi Screening Identifies MDA5 as a Significant Contributor to the Cellular Defense against Influenza A Virus

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2016.78

Molecular mechanism of signal perception and integration by the innate immune sensor retinoic acid-inducible gene-I (RIG-I).

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2016.78

Interactions between double-stranded RNA regulators and the protein kinase DAI

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2016.78

Selection of molecular structure and delivery of RNA oligonucleotides to activate TLR7 versus TLR8 and to induce high amounts of IL-12p70 in primary human monocytes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2016.78

Toll-like receptor 8 senses degradation products of single-stranded RNA

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2016.78

Guanosine and its modified derivatives are endogenous ligands for TLR7.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2016.78

Innate immunity induced by composition-dependent RIG-I recognition of hepatitis C virus RNA

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2016.78

The influence of CpG and UpA dinucleotide frequencies on RNA virus replication and characterization of the innate cellular pathways underlying virus attenuation and enhanced replication.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2016.78

RNA virus attenuation by codon pair deoptimisation is an artefact of increases in CpG/UpA dinucleotide frequencies.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2016.78

A structural basis for discriminating between self and nonself double-stranded RNAs in mammalian cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2016.78

5'-Triphosphate RNA is the ligand for RIG-I

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2016.78

Recognition of 5' triphosphate by RIG-I helicase requires short blunt double-stranded RNA as contained in panhandle of negative-strand virus

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2016.78

The thermodynamic basis for viral RNA detection by the RIG-I innate immune sensor

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2016.78

Unpaired 5' ppp-nucleotides, as found in arenavirus double-stranded RNA panhandles, are not recognized by RIG-I

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2016.78

Structural and functional insights into 5′-ppp RNA pattern recognition by the innate immune receptor RIG-I

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2016.78

The RIG-I ATPase domain structure reveals insights into ATP-dependent antiviral signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2016.78

Structural basis of RNA recognition and activation by innate immune receptor RIG-I

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2016.78

Structural Insights into RNA Recognition by RIG-I

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2016.78

Structural basis for the activation of innate immune pattern-recognition receptor RIG-I by viral RNA

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2016.78

Defining the functional determinants for RNA surveillance by RIG-I

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2016.78

Identification of host cytosolic sensors and bacterial factors regulating the type I interferon response to Legionella pneumophila

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2016.78

RIG-I detects infection with live Listeria by sensing secreted bacterial nucleic acids

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2016.78

RIG-I detects triphosphorylated RNA of Listeria monocytogenes during infection in non-immune cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2016.78

Sendai virus defective-interfering genomes and the activation of interferon-beta

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2016.78

5'-triphosphate-dependent activation of PKR by RNAs with short stem-loops

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2016.78

Bacterial RNA: An Underestimated Stimulus for Innate Immune Responses

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2016.78

Suppression of RNA recognition by Toll-like receptors: the impact of nucleoside modification and the evolutionary origin of RNA

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2016.78

Modifications in small interfering RNA that separate immunostimulation from RNA interference

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2016.78

A Conserved Histidine in the RNA Sensor RIG-I Controls Immune Tolerance to N1-2'O-Methylated Self RNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2016.78

Structural basis for m7G recognition and 2'-O-methyl discrimination in capped RNAs by the innate immune receptor RIG-I.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2016.78

Ribose 2'-O-methylation provides a molecular signature for the distinction of self and non-self mRNA dependent on the RNA sensor Mda5.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2016.78

Innate immune restriction and antagonism of viral RNA lacking 2׳-O methylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2016.78

A viral RNA structural element alters host recognition of nonself RNA

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2016.78

Processing of Genome 5′ Termini as a Strategy of Negative-Strand RNA Viruses to Avoid RIG-I-Dependent Interferon Induction

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2016.78

Mismatches in the Influenza A Virus RNA Panhandle Prevent Retinoic Acid-Inducible Gene I (RIG-I) Sensing by Impairing RNA/RIG-I Complex Formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2016.78

Nucleic acid-sensing Toll-like receptors are essential for the control of endogenous retrovirus viremia and ERV-induced tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2016.78

Small self-RNA generated by RNase L amplifies antiviral innate immunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2016.78

RETRACTED: The unfolded protein response element IRE1α senses bacterial proteins invading the ER to activate RIG-I and innate immune signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2016.78

The SKIV2L RNA exosome limits activation of the RIG-I-like receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2016.78

A Toll-like receptor recognizes bacterial DNA

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2016.78

AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2016.78

AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2016.78

An orthogonal proteomic-genomic screen identifies AIM2 as a cytoplasmic DNA sensor for the inflammasome

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2016.78

The AIM2 inflammasome is essential for host defense against cytosolic bacteria and DNA viruses

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2016.78

IFI16 acts as a nuclear pathogen sensor to induce the inflammasome in response to Kaposi Sarcoma-associated herpesvirus infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2016.78

IFI16 DNA sensor is required for death of lymphoid CD4 T cells abortively infected with HIV

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2016.78

IFI16 senses DNA forms of the lentiviral replication cycle and controls HIV-1 replication.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2016.78

Rad50-CARD9 interactions link cytosolic DNA sensing to IL-1β production

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2016.78

A Toll-like receptor-independent antiviral response induced by double-stranded B-form DNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2016.78

RIG-I-dependent sensing of poly(dA:dT) through the induction of an RNA polymerase III-transcribed RNA intermediate

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2016.78

RNA polymerase III detects cytosolic DNA and induces type I interferons through the RIG-I pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2016.78

Recognition of cytosolic DNA activates an IRF3-dependent innate immune response

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2016.78

Activation and regulation of DNA-driven immune responses

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2016.78

STING regulates intracellular DNA-mediated, type I interferon-dependent innate immunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2016.78

The adaptor protein MITA links virus-sensing receptors to IRF3 transcription factor activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2016.78

The N-ethyl-N-nitrosourea-induced Goldenticket mouse mutant reveals an essential function of Sting in the in vivo interferon response to Listeria monocytogenes and cyclic dinucleotides

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2016.78

STING is a direct innate immune sensor of cyclic di-GMP

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2016.78

Cyclic GMP-AMP synthase is a cytosolic DNA sensor that activates the type I interferon pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2016.78

Cyclic GMP-AMP is an endogenous second messenger in innate immune signaling by cytosolic DNA

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2016.78

Cyclic [G(2′,5′)pA(3′,5′)p] Is the Metazoan Second Messenger Produced by DNA-Activated Cyclic GMP-AMP Synthase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2016.78

cGAS produces a 2'-5'-linked cyclic dinucleotide second messenger that activates STING.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2016.78

Structural mechanism of cytosolic DNA sensing by cGAS

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2016.78

Structural and Functional Analyses of DNA-Sensing and Immune Activation by Human cGAS

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2016.78

Structure of Human cGAS Reveals a Conserved Family of Second-Messenger Enzymes in Innate Immunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2016.78

Cyclic GMP-AMP synthase is an innate immune sensor of HIV and other retroviruses

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2016.78

The Cytosolic DNA Sensor cGAS Forms an Oligomeric Complex with DNA and Undergoes Switch-like Conformational Changes in the Activation Loop

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2016.78

Cyclic GMP-AMP Synthase Is Activated by Double-Stranded DNA-Induced Oligomerization

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2016.78

Pivotal roles of cGAS-cGAMP signaling in antiviral defense and immune adjuvant effects

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2016.78

Adenovirus detection by the cGAS/STING/TBK1 DNA sensing cascade

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2016.78

The capsids of HIV-1 and HIV-2 determine immune detection of the viral cDNA by the innate sensor cGAS in dendritic cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2016.78

HIV-1 evades innate immune recognition through specific cofactor recruitment

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2016.78

Sequence-specific activation of the DNA sensor cGAS by Y-form DNA structures as found in primary HIV-1 cDNA

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2016.78

IFI16 is an innate immune sensor for intracellular DNA

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2016.78

IFI16: At the interphase between innate DNA sensing and genome regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2016.78

BRCA1 Regulates IFI16 Mediated Nuclear Innate Sensing of Herpes Viral DNA and Subsequent Induction of the Innate Inflammasome and Interferon-β Responses

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2016.78

DNA-PK is a DNA sensor for IRF-3-dependent innate immunity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2016.78

PQBP1 Is a Proximal Sensor of the cGAS-Dependent Innate Response to HIV-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2016.78

Structures of the HIN Domain:DNA Complexes Reveal Ligand Binding and Activation Mechanisms of the AIM2 Inflammasome and IFI16 Receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2016.78

Potent Cell-Intrinsic Immune Responses in Dendritic Cells Facilitate HIV-1-Specific T Cell Immunity in HIV-1 Elite Controllers

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2016.78

CpG motifs in bacterial DNA trigger direct B-cell activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2016.78

Mechanism and function of a newly identified CpG DNA motif in human primary B cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2016.78

Higher activation of TLR9 in plasmacytoid dendritic cells by microbial DNA compared with self-DNA based on CpG-specific recognition of phosphodiester DNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2016.78

RNA:DNA hybrids are a novel molecular pattern sensed by TLR9.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2016.78

Cytosolic RNA:DNA hybrids activate the cGAS-STING axis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2016.78

Oxidative damage of DNA confers resistance to cytosolic nuclease TREX1 degradation and potentiates STING-dependent immune sensing

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2016.78

Features of systemic lupus erythematosus in Dnase1-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2016.78

Dnase2a deficiency uncovers lysosomal clearance of damaged nuclear DNA via autophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2016.78

Lethal anemia caused by interferon-beta produced in mouse embryos carrying undigested DNA

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2016.78

Cutting edge: AIM2 and endosomal TLRs differentially regulate arthritis and autoantibody production in DNase II-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2016.78

AIM2 Drives Joint Inflammation in a Self-DNA Triggered Model of Chronic Polyarthritis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2016.78

Trex1 prevents cell-intrinsic initiation of autoimmunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2016.78

Activation of cyclic GMP-AMP synthase by self-DNA causes autoimmune diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2016.78

TREX1 deficiency triggers cell-autonomous immunity in a cGAS-dependent manner.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2016.78

Cutting Edge: cGAS Is Required for Lethal Autoimmune Disease in the Trex1-Deficient Mouse Model of Aicardi-Goutières Syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2016.78

Inflammasome activation in response to dead cells and their metabolites

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2016.78

Characterization of human disease phenotypes associated with mutations in TREX1, RNASEH2A, RNASEH2B, RNASEH2C, SAMHD1, ADAR, and IFIH1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2016.78

ATP hydrolysis by the viral RNA sensor RIG-I prevents unintentional recognition of self-RNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2016.78

Activated STING in a vascular and pulmonary syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2016.78

Identification of loss of function mutations in human genes encoding RIG-I and MDA5: implications for resistance to type I diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2016.78

Association of IFIH1 rs1990760 polymorphism with susceptibility to autoimmune diseases: a meta-analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2016.78

Role of DNA/RNA sensors and contribution to autoimmunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2016.78

Mitochondrial antiviral signaling protein (MAVS) monitors commensal bacteria and induces an immune response that prevents experimental colitis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2016.78

Rig-I-/- mice develop colitis associated with downregulation of G alpha i2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2016.78

Chronic polyarthritis caused by mammalian DNA that escapes from degradation in macrophages

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2016.78

Foreign nucleic acids as the stimulus to make interferon

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2016.78

Sequence-dependent stimulation of the mammalian innate immune response by synthetic siRNA

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2016.78

DNase II-dependent DNA digestion is required for DNA sensing by TLR9

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2016.78

An enteric virus can replace the beneficial function of commensal bacteria

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2016.78

Structural requirements of double-stranded RNA for the activation of 2‘,5‘-oligo(A) polymerase and protein kinase of interferon-treated HeLa cells

31 March 2020

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/27455396

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Proapoptotic signaling induced by RIG-I and MDA-5 results in type I interferon-independent apoptosis in human melanoma cells.

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/27455396

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/NRI.2016.78

1 reference

7 September 2017

1 reference

PubMed ID

27455396