Translating nucleic acid-sensing pathways into therapies (Q38570333)

4 September 2017

Translating nucleic acid-sensing pathways into therapies (English)

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4 September 2017

2

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4 September 2017

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Tobias Junt

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author name string

Tobias Junt

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1

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4 September 2017

21 August 2015

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Nature Reviews Immunology

4 September 2017

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4 September 2017

15

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4 September 2017

9

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4 September 2017

529-544

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Type I interferons (alpha/beta) in immunity and autoimmunity

4 September 2017

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The impact of the interferon-lambda family on the innate and adaptive immune response to viral infections

31 March 2020

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Interferon-stimulated genes: a complex web of host defenses

31 March 2020

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Innate recognition of viruses

31 March 2020

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2 methylate or not 2 methylate: viral evasion of the type I interferon response.

31 March 2020

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Gene-targeted mice lacking the Trex1 (DNase III) 3'-->5' DNA exonuclease develop inflammatory myocarditis

31 March 2020

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Lethal anemia caused by interferon-beta produced in mouse embryos carrying undigested DNA

31 March 2020

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Intrinsic self-DNA triggers inflammatory disease dependent on STING.

31 March 2020

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Apoptotic caspases prevent the induction of type I interferons by mitochondrial DNA.

31 March 2020

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Dnase2a deficiency uncovers lysosomal clearance of damaged nuclear DNA via autophagy

31 March 2020

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DNase II-dependent DNA digestion is required for DNA sensing by TLR9

31 March 2020

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Cutting Edge: DNase II deficiency prevents activation of autoreactive B cells by double-stranded DNA endogenous ligands

31 March 2020

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STING-dependent cytosolic DNA sensing mediates innate immune recognition of immunogenic tumors.

31 March 2020

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Plasmacytoid dendritic cells sense self-DNA coupled with antimicrobial peptide

31 March 2020

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Induction of interferon-alpha production in plasmacytoid dendritic cells by immune complexes containing nucleic acid released by necrotic or late apoptotic cells and lupus IgG.

31 March 2020

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Activation of the type I interferon system in primary Sjögren's syndrome: a possible etiopathogenic mechanism

31 March 2020

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Intracellular toll-like receptors

31 March 2020

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Toll-like receptor 8 senses degradation products of single-stranded RNA

31 March 2020

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Structural basis of CpG and inhibitory DNA recognition by Toll-like receptor 9

31 March 2020

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SnapShot: nucleic acid immune sensors, part 1.

31 March 2020

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5'-Triphosphate RNA is the ligand for RIG-I

31 March 2020

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Antiviral immunity via RIG-I-mediated recognition of RNA bearing 5'-diphosphates

31 March 2020

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Length-dependent recognition of double-stranded ribonucleic acids by retinoic acid-inducible gene-I and melanoma differentiation-associated gene 5

31 March 2020

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Activation of MDA5 requires higher-order RNA structures generated during virus infection

31 March 2020

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MAVS forms functional prion-like aggregates to activate and propagate antiviral innate immune response

31 March 2020

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Cyclic GMP-AMP synthase is a cytosolic DNA sensor that activates the type I interferon pathway

31 March 2020

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Cyclic GMP-AMP is an endogenous second messenger in innate immune signaling by cytosolic DNA

31 March 2020

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Cyclic [G(2′,5′)pA(3′,5′)p] Is the Metazoan Second Messenger Produced by DNA-Activated Cyclic GMP-AMP Synthase

31 March 2020

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STING is a direct innate immune sensor of cyclic di-GMP

31 March 2020

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MPYS is required for IFN response factor 3 activation and type I IFN production in the response of cultured phagocytes to bacterial second messengers cyclic-di-AMP and cyclic-di-GMP.

31 March 2020

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Phosphorylation of innate immune adaptor proteins MAVS, STING, and TRIF induces IRF3 activation

31 March 2020

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Activation and regulation of the inflammasomes

31 March 2020

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Toll receptor agonist therapy of skin cancer and cutaneous T-cell lymphoma

31 March 2020

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Programming the magnitude and persistence of antibody responses with innate immunity

31 March 2020

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Protective T cell immunity in mice following protein-TLR7/8 agonist-conjugate immunization requires aggregation, type I IFN, and multiple DC subsets.

31 March 2020

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Adjuvant-carrying synthetic vaccine particles augment the immune response to encapsulated antigen and exhibit strong local immune activation without inducing systemic cytokine release.

31 March 2020

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Dendritic cell-targeted vaccines--hope or hype?

31 March 2020

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Inducers of interferon and host resistance. II. Multistranded synthetic polynucleotide complexes

31 March 2020

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Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3

31 March 2020

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Essential role of mda-5 in type I IFN responses to polyriboinosinic:polyribocytidylic acid and encephalomyocarditis picornavirus

31 March 2020

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Synthetic double-stranded RNA induces innate immune responses similar to a live viral vaccine in humans

31 March 2020

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A double-blind, placebo-controlled, randomized, clinical trial of the TLR-3 agonist rintatolimod in severe cases of chronic fatigue syndrome

31 March 2020

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Small anti-viral compounds activate immune cells via the TLR7 MyD88-dependent signaling pathway

31 March 2020

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DMXAA: an antivascular agent with multiple host responses

31 March 2020

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Randomized phase III placebo-controlled trial of carboplatin and paclitaxel with or without the vascular disrupting agent vadimezan (ASA404) in advanced non-small-cell lung cancer

31 March 2020

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Mouse, but not human STING, binds and signals in response to the vascular disrupting agent 5,6-dimethylxanthenone-4-acetic acid

31 March 2020

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Binding-pocket and lid-region substitutions render human STING sensitive to the species-specific drug DMXAA.

31 March 2020

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Bacterial c-di-GMP is an immunostimulatory molecule

31 March 2020

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Rationale, progress and development of vaccines utilizing STING-activating cyclic dinucleotide adjuvants

31 March 2020

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Structure-Function Analysis of STING Activation by c[G(2′,5′)pA(3′,5′)p] and Targeting by Antiviral DMXAA

31 March 2020

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Pivotal roles of cGAS-cGAMP signaling in antiviral defense and immune adjuvant effects

31 March 2020

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CpG motifs in bacterial DNA trigger direct B-cell activation

31 March 2020

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Clinical evaluation of CpG oligonucleotides as adjuvants for vaccines targeting infectious diseases and cancer

31 March 2020

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Isoflavone agonists of IRF-3 dependent signaling have antiviral activity against RNA viruses

31 March 2020

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Structural and functional insights into 5′-ppp RNA pattern recognition by the innate immune receptor RIG-I

31 March 2020

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Recognition of 5' triphosphate by RIG-I helicase requires short blunt double-stranded RNA as contained in panhandle of negative-strand virus

31 March 2020

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Yellow fever vaccine YF-17D activates multiple dendritic cell subsets via TLR2, 7, 8, and 9 to stimulate polyvalent immunity

31 March 2020

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Vaccine adjuvants: putting innate immunity to work

31 March 2020

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Synthetic Toll-like receptor 4 (TLR4) and TLR7 ligands as influenza virus vaccine adjuvants induce rapid, sustained, and broadly protective responses

31 March 2020

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TLR9 and STING agonists synergistically induce innate and adaptive type-II IFN.

31 March 2020

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Immunologically active autoantigens: the role of toll-like receptors in the development of chronic inflammatory disease.

31 March 2020

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Nucleic acids of mammalian origin can act as endogenous ligands for Toll-like receptors and may promote systemic lupus erythematosus

31 March 2020

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Mechanism of endosomal TLR inhibition by antimalarial drugs and imidazoquinolines

31 March 2020

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Increased ribonuclease expression reduces inflammation and prolongs survival in TLR7 transgenic mice.

31 March 2020

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Presence of cutaneous interferon-alpha producing cells in patients with systemic lupus erythematosus

31 March 2020

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Plasmacytoid dendritic cells (natural interferon- alpha/beta-producing cells) accumulate in cutaneous lupus erythematosus lesions

31 March 2020

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TLR7 ligands induce higher IFN-alpha production in females.

31 March 2020

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X-Chromosome complement and estrogen receptor signaling independently contribute to the enhanced TLR7-mediated IFN-α production of plasmacytoid dendritic cells from women.

31 March 2020

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Netting neutrophils are major inducers of type I IFN production in pediatric systemic lupus erythematosus

31 March 2020

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Neutrophils activate plasmacytoid dendritic cells by releasing self-DNA-peptide complexes in systemic lupus erythematosus

31 March 2020

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Chromatin-IgG complexes activate B cells by dual engagement of IgM and Toll-like receptors

31 March 2020

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RNA-associated autoantigens activate B cells by combined B cell antigen receptor/Toll-like receptor 7 engagement.

31 March 2020

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Plasma DNA aberrations in systemic lupus erythematosus revealed by genomic and methylomic sequencing

31 March 2020

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Immune stimulation mediated by autoantigen binding sites within small nuclear RNAs involves Toll-like receptors 7 and 8.

31 March 2020

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Using Poly I:C as an adjuvant does not induce or exacerbate models of systemic lupus erythematosus

31 March 2020

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Control of toll-like receptor 7 expression is essential to restrict autoimmunity and dendritic cell proliferation

31 March 2020

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Toll-like receptor 7 and TLR9 dictate autoantibody specificity and have opposing inflammatory and regulatory roles in a murine model of lupus.

31 March 2020

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Requirement of Toll-like receptor 7 for pristane-induced production of autoantibodies and development of murine lupus nephritis

31 March 2020

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The functional effects of physical interactions among Toll-like receptors 7, 8, and 9.

31 March 2020

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Unc93B1 restricts systemic lethal inflammation by orchestrating Toll-like receptor 7 and 9 trafficking

31 March 2020

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TLR9 regulates TLR7- and MyD88-dependent autoantibody production and disease in a murine model of lupus

31 March 2020

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TLR8 on dendritic cells and TLR9 on B cells restrain TLR7-mediated spontaneous autoimmunity in C57BL/6 mice

31 March 2020

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Inflammatory arthritis can be reined in by CpG-induced DC-NK cell cross talk.

31 March 2020

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IDO mediates TLR9-driven protection from experimental autoimmune diabetes.

31 March 2020

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Systemic application of CpG-rich DNA suppresses adaptive T cell immunity via induction of IDO.

31 March 2020

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Human plasmacytoid dendritic cells activated by CpG oligodeoxynucleotides induce the generation of CD4+CD25+ regulatory T cells

31 March 2020

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A tolerogenic role for Toll-like receptor 9 is revealed by B-cell interaction with DNA complexes expressed on apoptotic cells

31 March 2020

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Inhibition of Toll-like receptor-7 (TLR-7) or TLR-7 plus TLR-9 attenuates glomerulonephritis and lung injury in experimental lupus

31 March 2020

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Treatment of lupus-prone mice with a dual inhibitor of TLR7 and TLR9 leads to reduction of autoantibody production and amelioration of disease symptoms

31 March 2020

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A novel antagonist of Toll-like receptors 7, 8 and 9 suppresses lupus disease-associated parameters in NZBW/F1 mice

31 March 2020

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TLR recognition of self nucleic acids hampers glucocorticoid activity in lupus

31 March 2020

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In psoriasis lesional skin the type I interferon signaling pathway is activated, whereas interferon-alpha sensitivity is unaltered

31 March 2020

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Self-RNA-antimicrobial peptide complexes activate human dendritic cells through TLR7 and TLR8.

31 March 2020

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Modifications incorporated in CpG motifs of oligodeoxynucleotides lead to antagonist activity of toll-like receptors 7 and 9

31 March 2020

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Secukinumab in plaque psoriasis--results of two phase 3 trials.

31 March 2020

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Suppression of molecular inflammatory pathways by Toll-like receptor 7, 8, and 9 antagonists in a model of IL-23-induced skin inflammation

31 March 2020

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Interleukins 1beta and 6 but not transforming growth factor-beta are essential for the differentiation of interleukin 17-producing human T helper cells

31 March 2020

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Oncogenically active MYD88 mutations in human lymphoma

31 March 2020

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Consequences of the recurrent MYD88(L265P) somatic mutation for B cell tolerance

31 March 2020

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Type I interferonopathies: mendelian type I interferon up-regulation

31 March 2020

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Mutations in the gene encoding the 3'-5' DNA exonuclease TREX1 are associated with systemic lupus erythematosus.

31 March 2020

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Gain-of-function mutations in IFIH1 cause a spectrum of human disease phenotypes associated with upregulated type I interferon signaling

31 March 2020

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Autoimmune disorders associated with gain of function of the intracellular sensor MDA5.

31 March 2020

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Ifih1 gene dose effect reveals MDA5-mediated chronic type I IFN gene signature, viral resistance, and accelerated autoimmunity

31 March 2020

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Activated STING in a vascular and pulmonary syndrome

31 March 2020

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Suppression of systemic autoimmunity by the innate immune adaptor STING.

31 March 2020

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Cutting edge: DNA sensing via the STING adaptor in myeloid dendritic cells induces potent tolerogenic responses

31 March 2020

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Cyclic GMP-AMP Containing Mixed Phosphodiester Linkages Is An Endogenous High-Affinity Ligand for STING

31 March 2020

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Structural mechanism of cytosolic DNA sensing by cGAS

31 March 2020

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The innate immune DNA sensor cGAS produces a noncanonical cyclic dinucleotide that activates human STING

31 March 2020

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Structure of Human cGAS Reveals a Conserved Family of Second-Messenger Enzymes in Innate Immunity

31 March 2020

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Novel small molecule inhibitors of TLR7 and TLR9: mechanism of action and efficacy in vivo

31 March 2020

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Cutting edge: AIM2 and endosomal TLRs differentially regulate arthritis and autoantibody production in DNase II-deficient mice

31 March 2020

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Oxidative damage of DNA confers resistance to cytosolic nuclease TREX1 degradation and potentiates STING-dependent immune sensing

31 March 2020

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Nucleic acid-sensing Toll-like receptors are essential for the control of endogenous retrovirus viremia and ERV-induced tumors

31 March 2020

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Infectious disease. Life-threatening influenza and impaired interferon amplification in human IRF7 deficiency

31 March 2020

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A narrow repertoire of transcriptional modules responsive to pyogenic bacteria is impaired in patients carrying loss-of-function mutations in MYD88 or IRAK4

31 March 2020

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Apoptotic caspases suppress mtDNA-induced STING-mediated type I IFN production

31 March 2020

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RETRACTED: MAVS, cGAS, and endogenous retroviruses in T-independent B cell responses

31 March 2020

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Canakinumab (ACZ885, a fully human IgG1 anti-IL-1β mAb) induces sustained remission in pediatric patients with cryopyrin-associated periodic syndrome (CAPS)

31 March 2020

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Two randomized trials of canakinumab in systemic juvenile idiopathic arthritis

31 March 2020

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Mitochondrial DNA stress primes the antiviral innate immune response

31 March 2020

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Down-regulation of interferon signature in systemic lupus erythematosus patients by active immunization with interferon α-kinoid

31 March 2020

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Lupuzor/P140 peptide in patients with systemic lupus erythematosus: a randomised, double-blind, placebo-controlled phase IIb clinical trial

31 March 2020

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An inhibitor of the protein kinases TBK1 and IKK-ɛ improves obesity-related metabolic dysfunctions in mice

31 March 2020

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Recent advances in the discovery of small molecule inhibitors of interleukin-1 receptor-associated kinase 4 (IRAK4) as a therapeutic target for inflammation and oncology disorders

31 March 2020

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Polymorphisms within Toll-like receptors are associated with systemic lupus erythematosus in a cohort of Danish females

31 March 2020

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Polymorphisms in the TLR3 gene are associated with risk for type 1 diabetes mellitus

31 March 2020

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Association of TLR7 copy number variation with susceptibility to childhood-onset systemic lupus erythematosus in Mexican population.

31 March 2020

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TLR7 single-nucleotide polymorphisms in the 3' untranslated region and intron 2 independently contribute to systemic lupus erythematosus in Japanese women: a case-control association study.

31 March 2020

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Contribution of toll-like receptor 9 gene single-nucleotide polymorphism to systemic lupus erythematosus

31 March 2020

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Association of IFIH1 rs1990760 polymorphism with susceptibility to autoimmune diseases: a meta-analysis

31 March 2020

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Anti-MDA5 autoantibodies in juvenile dermatomyositis identify a distinct clinical phenotype: a prospective cohort study

31 March 2020

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Rare variants of IFIH1, a gene implicated in antiviral responses, protect against type 1 diabetes

31 March 2020

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Identification of loss of function mutations in human genes encoding RIG-I and MDA5: implications for resistance to type I diabetes

31 March 2020

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Neurologic Phenotypes Associated with Mutations in TREX1, RNASEH2A, RNASEH2B, RNASEH2C, SAMHD1, ADAR1, and IFIH1: Aicardi-Goutières Syndrome and Beyond

31 March 2020

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Autosomal dominant inheritance of a heterozygous mutation in SAMHD1 causing familial chilblain lupus

31 March 2020

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C-terminal truncations in human 3'-5' DNA exonuclease TREX1 cause autosomal dominant retinal vasculopathy with cerebral leukodystrophy

31 March 2020

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A specific IFIH1 gain-of-function mutation causes Singleton-Merten syndrome

31 March 2020

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Mutations in DDX58, which encodes RIG-I, cause atypical Singleton-Merten syndrome.

31 March 2020

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Human intracellular ISG15 prevents interferon-α/β over-amplification and auto-inflammation

31 March 2020

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The SKIV2L RNA exosome limits activation of the RIG-I-like receptors

31 March 2020

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Mutations in CECR1 associated with a neutrophil signature in peripheral blood

31 March 2020

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Tartrate-resistant acid phosphatase deficiency causes a bone dysplasia with autoimmunity and a type I interferon expression signature

31 March 2020

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A Conserved Histidine in the RNA Sensor RIG-I Controls Immune Tolerance to N1-2'O-Methylated Self RNA.

31 March 2020

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The RNA-editing enzyme ADAR1 controls innate immune responses to RNA.

31 March 2020

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RNA editing by ADAR1 prevents MDA5 sensing of endogenous dsRNA as nonself

31 March 2020

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Characterization of human disease phenotypes associated with mutations in TREX1, RNASEH2A, RNASEH2B, RNASEH2C, SAMHD1, ADAR, and IFIH1.

31 March 2020

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/26292638

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Poly(I:C) as cancer vaccine adjuvant: knocking on the door of medical breakthroughs.

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/26292638

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

TLR8 deficiency leads to autoimmunity in mice

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/26292638

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/NRI3875

1 reference

4 September 2017

1 reference

PubMed ID

26292638