The DNA damage-induced cell death response: a roadmap to kill cancer cells (Q38704734)

5 September 2017

The DNA damage-induced cell death response: a roadmap to kill cancer cells (English)

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5 September 2017

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Sonja Matt

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PubMed ID

26791483

5 September 2017

Thomas G Hofmann

series ordinal

2

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5 September 2017

20 January 2016

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Cellular and Molecular Life Sciences

5 September 2017

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5 September 2017

73

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5 September 2017

2829-2850

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5 September 2017

15

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https://scigraph.springernature.com/pub.10.1007/s00018-016-2130-4

5 September 2017

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cites work

Regulation of p73 activity by post-translational modifications

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12 December 2020

Mixed lineage kinase domain-like protein MLKL causes necrotic membrane disruption upon phosphorylation by RIP3.

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12 December 2020

Control of HIPK2 stability by ubiquitin ligase Siah-1 and checkpoint kinases ATM and ATR.

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12 December 2020

Push back to respond better: regulatory inhibition of the DNA double-strand break response

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12 December 2020

Molecular linkage between the kinase ATM and NF-kappaB signaling in response to genotoxic stimuli

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12 December 2020

Extensive post-transcriptional regulation of microRNAs and its implications for cancer

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12 December 2020

miR-15 and miR-16 induce apoptosis by targeting BCL2

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12 December 2020

Involvement of ATM in homologous recombination after end resection and RAD51 nucleofilament formation

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12 December 2020

The tumor-modulatory effects of Caspase-2 and Pidd1 do not require the scaffold protein Raidd

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12 December 2020

Noncanonical NF-kappaB activation requires coordinated assembly of a regulatory complex of the adaptors cIAP1, cIAP2, TRAF2 and TRAF3 and the kinase NIK.

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12 December 2020

Defects in regulation of apoptosis in caspase-2-deficient mice

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12 December 2020

PIASy mediates NEMO sumoylation and NF-kappaB activation in response to genotoxic stress.

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12 December 2020

Autoregulatory control of the p53 response by caspase-mediated processing of HIPK2.

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12 December 2020

ATM signaling facilitates repair of DNA double-strand breaks associated with heterochromatin

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12 December 2020

Homeodomain interacting protein kinase 2 promotes apoptosis by downregulating the transcriptional corepressor CtBP.

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12 December 2020

The prolyl-isomerase Pin1 activates the mitochondrial death program of p53

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12 December 2020

DNA damage-induced cell death: from specific DNA lesions to the DNA damage response and apoptosis

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12 December 2020

Sp100 is important for the stimulatory effect of homeodomain-interacting protein kinase-2 on p53-dependent gene expression

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12 December 2020

Regulated necrosis: the expanding network of non-apoptotic cell death pathways.

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12 December 2020

Interaction between ATM protein and c-Abl in response to DNA damage

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12 December 2020

ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage

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12 December 2020

Control of apoptosis by the BCL-2 protein family: implications for physiology and therapy.

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12 December 2020

MicroRNAs: key players in the immune system, differentiation, tumorigenesis and cell death

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12 December 2020

p63/p73 in the control of cell cycle and cell death.

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12 December 2020

Modulation of microRNA processing by p53

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12 December 2020

Ataxia telangiectasia mutant protein activates c-Abl tyrosine kinase in response to ionizing radiation

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12 December 2020

JNK phosphorylation of 14-3-3 proteins regulates nuclear targeting of c-Abl in the apoptotic response to DNA damage

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12 December 2020

IAP antagonists induce autoubiquitination of c-IAPs, NF-kappaB activation, and TNFalpha-dependent apoptosis

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12 December 2020

HIPK2 catalytic activity and subcellular localization are regulated by activation-loop Y354 autophosphorylation.

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12 December 2020

Stabilization of HIPK2 by escape from proteasomal degradation mediated by the E3 ubiquitin ligase Siah1.

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12 December 2020

Atm and c-Abl cooperate in the response to genotoxic stress during nervous system development.

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12 December 2020

The pseudokinase MLKL mediates necroptosis via a molecular switch mechanism

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12 December 2020

The role of PML in tumor suppression

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12 December 2020

Divergent evolution of human p53 binding sites: cell cycle versus apoptosis

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12 December 2020

Beyond repair foci: subnuclear domains and the cellular response to DNA damage

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12 December 2020

Regulation of p53 functions: let's meet at the nuclear bodies.

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12 December 2020

Stem cell aging: mechanisms, regulators and therapeutic opportunities

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12 December 2020

Identification of XAF1 as an antagonist of XIAP anti-Caspase activity

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12 December 2020

Apoptosis and autophagy: Regulation of apoptosis by DNA damage signalling - roles of p53, p73 and HIPK2.

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12 December 2020

E1A activates transcription of p73 and Noxa to induce apoptosis

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12 December 2020

p53 has a direct apoptogenic role at the mitochondria

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12 December 2020

Ubiquitination and degradation of homeodomain-interacting protein kinase 2 by WD40 repeat/SOCS box protein WSB-1

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12 December 2020

Essential function for the kinase TAK1 in innate and adaptive immune responses.

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12 December 2020

The hMre11/hRad50 protein complex and Nijmegen breakage syndrome: linkage of double-strand break repair to the cellular DNA damage response

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12 December 2020

p53 opens the mitochondrial permeability transition pore to trigger necrosis

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12 December 2020

Caspase-2 acts upstream of mitochondria to promote cytochrome c release during etoposide-induced apoptosis

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12 December 2020

cIAP1, cIAP2, and XIAP act cooperatively via nonredundant pathways to regulate genotoxic stress-induced nuclear factor-kappaB activation

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12 December 2020

Identification of the molecular basis of doxorubicin-induced cardiotoxicity

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12 December 2020

PIDD death-domain phosphorylation by ATM controls prodeath versus prosurvival PIDDosome signaling

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12 December 2020

Death receptor signal transducers: nodes of coordination in immune signaling networks

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12 December 2020

Necroptosis and its role in inflammation

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12 December 2020

Extrinsic versus intrinsic apoptosis pathways in anticancer chemotherapy

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12 December 2020

Loss of cyclophilin D reveals a critical role for mitochondrial permeability transition in cell death

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12 December 2020

Cutaneous HPV23 E6 prevents p53 phosphorylation through interaction with HIPK2.

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12 December 2020

HIPK2 kinase activity depends on cis-autophosphorylation of its activation loop

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12 December 2020

ATM- and cell cycle-dependent regulation of ATR in response to DNA double-strand breaks

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12 December 2020

HIPK2 regulates transforming growth factor-beta-induced c-Jun NH(2)-terminal kinase activation and apoptosis in human hepatoma cells

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12 December 2020

Death of p53-defective cells triggered by forced mitotic entry in the presence of DNA damage is not uniquely dependent on Caspase-2 or the PIDDosome

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12 December 2020

Induction of amphiregulin by p53 promotes apoptosis via control of microRNA biogenesis in response to DNA damage

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12 December 2020

Transactivation of miR-34a by p53 broadly influences gene expression and promotes apoptosis

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12 December 2020

ShaPINg Cell Fate Upon DNA Damage: Role of Pin1 Isomerase in DNA Damage-Induced Cell Death and Repair

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12 December 2020

Post-translational modification of p53 in tumorigenesis

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12 December 2020

Functional evolution of the p53 regulatory network through its target response elements

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12 December 2020

p73, the "assistant" guardian of the genome?

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12 December 2020

Axin stimulates p53 functions by activation of HIPK2 kinase through multimeric complex formation

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12 December 2020

Homeodomain-interacting protein kinase-2 phosphorylates p53 at Ser 46 and mediates apoptosis.

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12 December 2020

DYRK2 is targeted to the nucleus and controls p53 via Ser46 phosphorylation in the apoptotic response to DNA damage

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12 December 2020

The Tyrosine Kinase c-Abl Promotes Homeodomain-interacting Protein Kinase 2 (HIPK2) Accumulation and Activation in Response to DNA Damage

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12 December 2020

Blinded by the Light: The Growing Complexity of p53

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12 December 2020

Cellular senescence: from growth arrest to immunogenic conversion

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12 December 2020

Regulation of apoptosis by PML and the PML-NBs.

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12 December 2020

Absence of RIPK3 predicts necroptosis resistance in malignant melanoma

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12 December 2020

Fas triggers an alternative, caspase-8-independent cell death pathway using the kinase RIP as effector molecule

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12 December 2020

De-ubiquitination and ubiquitin ligase domains of A20 downregulate NF-kappaB signalling

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12 December 2020

Receptor interacting protein kinase-3 determines cellular necrotic response to TNF-alpha

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12 December 2020

CYLD deubiquitinates RIP1 in the TNFα-induced necrosome to facilitate kinase activation and programmed necrosis

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12 December 2020

Daxx cooperates with the Axin/HIPK2/p53 complex to induce cell death.

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12 December 2020

The DNA-damage response in human biology and disease

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12 December 2020

microRNAs join the p53 network--another piece in the tumour-suppression puzzle

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12 December 2020

Rotational positioning of nucleosomes facilitates selective binding of p53 to response elements associated with cell cycle arrest

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12 December 2020

ATM and ataxia telangiectasia

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12 December 2020

The ATM protein kinase: regulating the cellular response to genotoxic stress, and more

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12 December 2020

Chromatin relaxation in response to DNA double-strand breaks is modulated by a novel ATM- and KAP-1 dependent pathway

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12 December 2020

Posttranslational modifications regulate HIPK2, a driver of proliferative diseases

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12 December 2020

Updates on HIPK2: a resourceful oncosuppressor for clearing cancer

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12 December 2020

Autophosphorylation and Pin1 binding coordinate DNA damage-induced HIPK2 activation and cell death

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12 December 2020

Ser46 phosphorylation and prolyl-isomerase Pin1-mediated isomerization of p53 are key events in p53-dependent apoptosis induced by mutant huntingtin.

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12 December 2020

The BCL-2 protein family: opposing activities that mediate cell death

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12 December 2020

The PIDDosome, DNA-damage-induced apoptosis and beyond

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12 December 2020

Transcriptional activation of miR-34a contributes to p53-mediated apoptosis

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12 December 2020

Src kinase modulates the apoptotic p53 pathway by altering HIPK2 localization.

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12 December 2020

Body language: the function of PML nuclear bodies in apoptosis regulation

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12 December 2020

Requirement for caspase-2 in stress-induced apoptosis before mitochondrial permeabilization

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12 December 2020

The tyrosine kinase c-Abl regulates p73 in apoptotic response to cisplatin-induced DNA damage

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12 December 2020

ATM regulates ATR chromatin loading in response to DNA double-strand breaks

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12 December 2020

Decision making by p53: life, death and cancer

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12 December 2020

DNA Damage, Aging, and Cancer

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12 December 2020

Pin1-Induced Proline Isomerization in Cytosolic p53 Mediates BAX Activation and Apoptosis

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12 December 2020

Activation of AMP-activated protein kinase induces p53-dependent apoptotic cell death in response to energetic stress.

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12 December 2020

Zyxin is a critical regulator of the apoptotic HIPK2-p53 signaling axis

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12 December 2020

The kinase TAK1 can activate the NIK-I kappaB as well as the MAP kinase cascade in the IL-1 signalling pathway

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12 December 2020

DNA damage-dependent acetylation of p73 dictates the selective activation of apoptotic target genes.

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12 December 2020

p53 ubiquitination: Mdm2 and beyond

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12 December 2020

A tumor suppressor function for caspase-2

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12 December 2020

Requirement of ATM for rapid p53 phosphorylation at Ser46 without Ser/Thr-Gln sequences

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12 December 2020

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12 December 2020

How cells switch HIPK2 on and off

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12 December 2020

Interaction of c-Abl and p73alpha and their collaboration to induce apoptosis

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12 December 2020

Sequential modification of NEMO/IKKgamma by SUMO-1 and ubiquitin mediates NF-kappaB activation by genotoxic stress

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12 December 2020

Role of nuclear bodies in apoptosis signalling

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12 December 2020

Regulation of p53 activity by its interaction with homeodomain-interacting protein kinase-2

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12 December 2020

HIPK2: A tumour suppressor that controls DNA damage-induced cell fate and cytokinesis

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12 December 2020

XAF1 directs apoptotic switch of p53 signaling through activation of HIPK2 and ZNF313

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12 December 2020

Axin determines cell fate by controlling the p53 activation threshold after DNA damage

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12 December 2020

Live to die another way: modes of programmed cell death and the signals emanating from dying cells

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12 December 2020

The ATM kinase induces microRNA biogenesis in the DNA damage response.

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12 December 2020

Caspase-2 deficiency promotes aberrant DNA-damage response and genetic instability

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12 December 2020

Mechanisms and pathways of growth failure in primordial dwarfism.

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12 December 2020

PML regulates p53 acetylation and premature senescence induced by oncogenic Ras

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12 December 2020

A telomere-dependent DNA damage checkpoint induced by prolonged mitotic arrest

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12 December 2020

Role of Pin1 in the regulation of p53 stability and p21 transactivation, and cell cycle checkpoints in response to DNA damage

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12 December 2020

MicroRNA expression profiles classify human cancers

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12 December 2020

DAI/ZBP1/DLM-1 complexes with RIP3 to mediate virus-induced programmed necrosis that is targeted by murine cytomegalovirus vIRA.

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12 December 2020

Mutant p53: one name, many proteins

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12 December 2020

Regulation of DNA damage responses by ubiquitin and SUMO.

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12 December 2020

A cytoplasmic ATM-TRAF6-cIAP1 module links nuclear DNA damage signaling to ubiquitin-mediated NF-κB activation.

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12 December 2020

Comparative binding of p53 to its promoter and DNA recognition elements.

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12 December 2020

DNA-PK: a dynamic enzyme in a versatile DSB repair pathway

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12 December 2020

HIPK2 restricts SIRT1 activity upon severe DNA damage by a phosphorylation-controlled mechanism

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12 December 2020

An oncogene-induced DNA damage model for cancer development

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12 December 2020

NEMO and RIP1 control cell fate in response to extensive DNA damage via TNF-α feedforward signaling

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12 December 2020

Cellular processing of platinum anticancer drugs

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12 December 2020

Targeting the DNA Damage Response in Cancer

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12 December 2020

p53DINP1, a p53-inducible gene, regulates p53-dependent apoptosis

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12 December 2020

Toll-like receptors activate programmed necrosis in macrophages through a receptor-interacting kinase-3-mediated pathway

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12 December 2020

A cytosolic ATM/NEMO/RIP1 complex recruits TAK1 to mediate the NF-kappaB and p38 mitogen-activated protein kinase (MAPK)/MAPK-activated protein 2 responses to DNA damage

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12 December 2020

The ubiquitin-protein ligase Itch regulates p73 stability

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12 December 2020

The DNA Damage Response: Making It Safe to Play with Knives

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12 December 2020

Protein kinase C delta regulates Ser46 phosphorylation of p53 tumor suppressor in the apoptotic response to DNA damage

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12 December 2020

Homeodomain-interacting protein kinase 2 is the ionizing radiation-activated p53 serine 46 kinase and is regulated by ATM.

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12 December 2020

A redox-regulated SUMO/acetylation switch of HIPK2 controls the survival threshold to oxidative stress.

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12 December 2020

Caspase 2 in apoptosis, the DNA damage response and tumour suppression: enigma no more?

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12 December 2020

DNA damage sensing by the ATM and ATR kinases.

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12 December 2020

The Yes-associated protein 1 stabilizes p73 by preventing Itch-mediated ubiquitination of p73.

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12 December 2020

p53 mutations in human cancers

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12 December 2020

Dual signaling of the Fas receptor: initiation of both apoptotic and necrotic cell death pathways

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12 December 2020

The prolyl isomerase Pin1 is a regulator of p53 in genotoxic response.

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12 December 2020

ATM- and NEMO-dependent ELKS ubiquitination coordinates TAK1-mediated IKK activation in response to genotoxic stress

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12 December 2020

TP53INP1s and homeodomain-interacting protein kinase-2 (HIPK2) are partners in regulating p53 activity.

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12 December 2020

The prolyl isomerase Pin1 reveals a mechanism to control p53 functions after genotoxic insults

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12 December 2020

The PIDDosome, a protein complex implicated in activation of caspase-2 in response to genotoxic stress

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12 December 2020

Mitochondrial outer membrane permeabilization during apoptosis: the innocent bystander scenario

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12 December 2020

Yap1 phosphorylation by c-Abl is a critical step in selective activation of proapoptotic genes in response to DNA damage

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12 December 2020

The impact of p53 and p73 on aneuploidy and cancer

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12 December 2020

Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis

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12 December 2020

Defect in serine 46 phosphorylation of p53 contributes to acquisition of p53 resistance in oral squamous cell carcinoma cells.

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12 December 2020

A nuclear poly(ADP-ribose)-dependent signalosome confers DNA damage-induced IkappaB kinase activation

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12 December 2020

ATM is required for IkappaB kinase (IKKk) activation in response to DNA double strand breaks

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12 December 2020

Regulation of homeodomain-interacting protein kinase 2 (HIPK2) effector function through dynamic small ubiquitin-related modifier-1 (SUMO-1) modification

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12 December 2020

Characterization of RIPK3-mediated phosphorylation of the activation loop of MLKL during necroptosis

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12 December 2020

Mitochondria and cell death: outer membrane permeabilization and beyond

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12 December 2020

p63 and p73, the ancestors of p53.

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12 December 2020

p53AIP1, a potential mediator of p53-dependent apoptosis, and its regulation by Ser-46-phosphorylated p53

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12 December 2020

Methylation-dependent loss of RIP3 expression in cancer represses programmed necrosis in response to chemotherapeutics

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12 December 2020

The codon 47 polymorphism in p53 is functionally significant.

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12 December 2020

Expression and genetic analysis of XIAP-associated factor 1 (XAF1) in cancer cell lines

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12 December 2020

Live or let die: the cell's response to p53

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12 December 2020

The ATM protein is required for sustained activation of NF-kappaB following DNA damage.

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12 December 2020

Drugging the p53 pathway: understanding the route to clinical efficacy

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12 December 2020

FOXO3 signalling links ATM to the p53 apoptotic pathway following DNA damage

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12 December 2020

Ubiquitin-dependent degradation of p73 is inhibited by PML.

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12 December 2020

Molecular mechanisms of necroptosis: an ordered cellular explosion

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12 December 2020

PML is required for homeodomain-interacting protein kinase 2 (HIPK2)-mediated p53 phosphorylation and cell cycle arrest but is dispensable for the formation of HIPK domains.

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12 December 2020

Homeodomain-interacting protein kinase-2 activity and p53 phosphorylation are critical events for cisplatin-mediated apoptosis

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12 December 2020

A method for detecting abasic sites in living cells: age-dependent changes in base excision repair

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12 December 2020

XIAP-associated factor 1 (XAF1), a novel target of p53, enhances p53-mediated apoptosis via post-translational modification

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12 December 2020

PIDD mediates NF-kappaB activation in response to DNA damage

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12 December 2020

How cancer cells hijack DNA double-strand break repair pathways to gain genomic instability

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12 December 2020

The diverse role of RIP kinases in necroptosis and inflammation

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12 December 2020

The apoptosome: signalling platform of cell death

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12 December 2020

10.1007/S00018-016-2130-4

Identifiers

DOI

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5 September 2017

1 reference

PubMed ID

26791483