p73, the "assistant" guardian of the genome? (Q34307362)

1 August 2017

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title

p73, the "assistant" guardian of the genome? (English)

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1 August 2017

Gerry Melino

1

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PubMed ID

15033688

1 August 2017

language of work or name

English

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publication date

1 December 2003

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Annals of the New York Academy of Sciences

1 August 2017

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1 August 2017

1010

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1 August 2017

9-15

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Genome maintenance mechanisms for preventing cancer

1 August 2017

1 reference

https://api.crossref.org/works/10.1196%2FANNALS.1299.002

Quality control by DNA repair

21 January 2018

1 reference

https://api.crossref.org/works/10.1196%2FANNALS.1299.002

21 January 2018

Human DNA repair genes

1 reference

https://api.crossref.org/works/10.1196%2FANNALS.1299.002

DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation

21 January 2018

1 reference

https://api.crossref.org/works/10.1196%2FANNALS.1299.002

Enhanced phosphorylation of p53 by ATM in response to DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1196%2FANNALS.1299.002

Activation of the ATM kinase by ionizing radiation and phosphorylation of p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1196%2FANNALS.1299.002

Cell cycle control and cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1196%2FANNALS.1299.002

Cell cycle checkpoints: preventing an identity crisis

21 January 2018

1 reference

https://api.crossref.org/works/10.1196%2FANNALS.1299.002

21 January 2018

Surfing the p53 network

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https://api.crossref.org/works/10.1196%2FANNALS.1299.002

Live or let die: the cell's response to p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1196%2FANNALS.1299.002

Transcriptional repression mediated by the p53 tumour suppressor

21 January 2018

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https://api.crossref.org/works/10.1196%2FANNALS.1299.002

Regulation of p53 responses by post-translational modifications

21 January 2018

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https://api.crossref.org/works/10.1196%2FANNALS.1299.002

Mouse models with modified p53 sequences to study cancer and ageing.

21 January 2018

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https://api.crossref.org/works/10.1196%2FANNALS.1299.002

Decision making by p53: life, death and cancer

21 January 2018

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https://api.crossref.org/works/10.1196%2FANNALS.1299.002

Renewing the debate over the p53 apoptotic response

21 January 2018

1 reference

https://api.crossref.org/works/10.1196%2FANNALS.1299.002

Deubiquitination of p53 by HAUSP is an important pathway for p53 stabilization

21 January 2018

1 reference

https://api.crossref.org/works/10.1196%2FANNALS.1299.002

MDM2-HDAC1-mediated deacetylation of p53 is required for its degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1196%2FANNALS.1299.002

Nitric oxide-mediated inhibition of Hdm2-p53 binding

21 January 2018

1 reference

https://api.crossref.org/works/10.1196%2FANNALS.1299.002

Nitric oxide-induced cellular stress and p53 activation in chronic inflammation

21 January 2018

1 reference

https://api.crossref.org/works/10.1196%2FANNALS.1299.002

p53 Activation by nitric oxide involves down-regulation of Mdm2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1196%2FANNALS.1299.002

Nitric oxide promotes p53 nuclear retention and sensitizes neuroblastoma cells to apoptosis by ionizing radiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1196%2FANNALS.1299.002

Parc: a cytoplasmic anchor for p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1196%2FANNALS.1299.002

The prolyl isomerase Pin1 reveals a mechanism to control p53 functions after genotoxic insults

21 January 2018

1 reference

https://api.crossref.org/works/10.1196%2FANNALS.1299.002

The prolyl isomerase Pin1 is a regulator of p53 in genotoxic response.

21 January 2018

1 reference

https://api.crossref.org/works/10.1196%2FANNALS.1299.002

ASPP proteins specifically stimulate the apoptotic function of p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1196%2FANNALS.1299.002

The Brn-3a transcription factor inhibits the pro-apoptotic effect of p53 and enhances cell cycle arrest by differentially regulating the activity of the p53 target genes encoding Bax and p21(CIP1/Waf1).

21 January 2018

1 reference

https://api.crossref.org/works/10.1196%2FANNALS.1299.002

Human delta Np73 regulates a dominant negative feedback loop for TAp73 and p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1196%2FANNALS.1299.002

Monoallelically expressed gene related to p53 at 1p36, a region frequently deleted in neuroblastoma and other human cancers

21 January 2018

1 reference

https://api.crossref.org/works/10.1196%2FANNALS.1299.002

p63, a p53 homolog at 3q27-29, encodes multiple products with transactivating, death-inducing, and dominant-negative activities

21 January 2018

1 reference

https://api.crossref.org/works/10.1196%2FANNALS.1299.002

p73-deficient mice have neurological, pheromonal and inflammatory defects but lack spontaneous tumours

21 January 2018

1 reference

https://api.crossref.org/works/10.1196%2FANNALS.1299.002

Induction of neuronal differentiation by p73 in a neuroblastoma cell line

21 January 2018

1 reference

https://api.crossref.org/works/10.1196%2FANNALS.1299.002

On the shoulders of giants: p63, p73 and the rise of p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1196%2FANNALS.1299.002

p73: Friend or foe in tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1196%2FANNALS.1299.002

Two new p73 splice variants, gamma and delta, with different transcriptional activity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1196%2FANNALS.1299.002

Transactivation-deficient p73alpha (p73Deltaexon2) inhibits apoptosis and competes with p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1196%2FANNALS.1299.002

Role for the p53 homologue p73 in E2F-1-induced apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1196%2FANNALS.1299.002

Akt phosphorylates the Yes-associated protein, YAP, to induce interaction with 14-3-3 and attenuation of p73-mediated apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1196%2FANNALS.1299.002

A common polymorphism acts as an intragenic modifier of mutant p53 behaviour

21 January 2018

1 reference

https://api.crossref.org/works/10.1196%2FANNALS.1299.002

An anti-apoptotic role for the p53 family member, p73, during developmental neuron death

21 January 2018

1 reference

https://api.crossref.org/works/10.1196%2FANNALS.1299.002

DeltaNp73, a dominant-negative inhibitor of wild-type p53 and TAp73, is up-regulated in human tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1196%2FANNALS.1299.002

The tyrosine kinase c-Abl regulates p73 in apoptotic response to cisplatin-induced DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1196%2FANNALS.1299.002

Interaction of c-Abl and p73alpha and their collaboration to induce apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1196%2FANNALS.1299.002

p73 is regulated by tyrosine kinase c-Abl in the apoptotic response to DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1196%2FANNALS.1299.002

Regulation of p73 by c-Abl through the p38 MAP kinase pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.1196%2FANNALS.1299.002

Functional regulation of p73 and p63: development and cancer

21 January 2018

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https://api.crossref.org/works/10.1196%2FANNALS.1299.002

Additional complexity in p73: induction by mitogens in lymphoid cells and identification of two new splicing variants ε and ζ

21 January 2018

1 reference

https://api.crossref.org/works/10.1196%2FANNALS.1299.002

p63 and p73 are required for p53-dependent apoptosis in response to DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1196%2FANNALS.1299.002

21 January 2018

DNA repair: Damage alert

1 reference

https://api.crossref.org/works/10.1196%2FANNALS.1299.002

Parc-ing p53 in the cytoplasm

21 January 2018

1 reference

https://api.crossref.org/works/10.1196%2FANNALS.1299.002

Expression of DeltaNp73 is a molecular marker for adverse outcome in neuroblastoma patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1196%2FANNALS.1299.002

21 January 2018

Identifiers

DOI

10.1196/ANNALS.1299.002

1 reference

1 August 2017

1 reference

PubMed ID

15033688