An inhibitor of the protein kinases TBK1 and IKK-ɛ improves obesity-related metabolic dysfunctions in mice (Q34327061)

1 August 2017

An inhibitor of the protein kinases TBK1 and IKK-ɛ improves obesity-related metabolic dysfunctions in mice (English)

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1 August 2017

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14

Ronald M Evans

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Shannon M Reilly

Shannon M Reilly

1

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Pingping Li

Pingping Li

16

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Alan R. Saltiel

Alan R Saltiel

18

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Jerrold M. Olefsky

17

Jerrold M Olefsky

1 reference

1 August 2017

Shian-Huey Chiang

2

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1 August 2017

Stuart J Decker

3

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1 August 2017

Louise Chang

4

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1 August 2017

Maeran Uhm

5

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1 August 2017

Martha J Larsen

6

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1 August 2017

John R Rubin

7

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1 August 2017

Jonathan Mowers

8

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1 August 2017

Nicole M White

9

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1 August 2017

Irit Hochberg

10

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1 August 2017

Michael Downes

11

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1 August 2017

Ruth T Yu

12

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1 August 2017

Christopher Liddle

13

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1 August 2017

Dayoung Oh

15

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1 August 2017

language of work or name

English

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publication date

10 February 2013

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1 August 2017

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19

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313-321

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1 August 2017

3

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describes a project that uses

1 August 2017

ImageQuant

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3594079/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

exact match

https://scigraph.springernature.com/pub.10.1038/nm.3082

0 references

cites work

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The TRAF-associated protein TANK facilitates cross-talk within the IkappaB kinase family during Toll-like receptor signaling

6 July 2018

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Association between disease-modifying antirheumatic drugs and diabetes risk in patients with rheumatoid arthritis and psoriasis

6 July 2018

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Inflammatory links between obesity and metabolic disease

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B cells promote insulin resistance through modulation of T cells and production of pathogenic IgG antibodies

6 July 2018

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Selective inactivation of c-Jun NH2-terminal kinase in adipose tissue protects against diet-induced obesity and improves insulin sensitivity in both liver and skeletal muscle in mice

6 July 2018

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The NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistance

6 July 2018

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Novel cross-talk within the IKK family controls innate immunity

6 July 2018

1 reference

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Alternative macrophage activation and metabolism

6 July 2018

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GPR120 is an omega-3 fatty acid receptor mediating potent anti-inflammatory and insulin-sensitizing effects

6 July 2018

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Functional heterogeneity of CD11c-positive adipose tissue macrophages in diet-induced obese mice

6 July 2018

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Endoplasmic reticulum stress and the inflammatory basis of metabolic disease

6 July 2018

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The effects of salsalate on glycemic control in patients with type 2 diabetes: a randomized trial

6 July 2018

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Sphingolipids and insulin resistance: the five Ws.

6 July 2018

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Macrophages, inflammation, and insulin resistance

6 July 2018

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Double-stranded RNA-dependent protein kinase links pathogen sensing with stress and metabolic homeostasis

6 July 2018

1 reference

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Hematopoietic cell-specific deletion of toll-like receptor 4 ameliorates hepatic and adipose tissue insulin resistance in high-fat-fed mice

6 July 2018

1 reference

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The protein kinase IKKepsilon regulates energy balance in obese mice

6 July 2018

1 reference

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The NF-kappaB-independent functions of IKK subunits in immunity and cancer

6 July 2018

1 reference

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CD8+ effector T cells contribute to macrophage recruitment and adipose tissue inflammation in obesity

6 July 2018

1 reference

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Normalization of obesity-associated insulin resistance through immunotherapy

6 July 2018

1 reference

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Lean, but not obese, fat is enriched for a unique population of regulatory T cells that affect metabolic parameters

6 July 2018

1 reference

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Genetic deficiency and pharmacological stabilization of mast cells reduce diet-induced obesity and diabetes in mice

6 July 2018

1 reference

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Insulin sensitivity: modulation by nutrients and inflammation

6 July 2018

1 reference

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The emerging genetic architecture of type 2 diabetes

6 July 2018

1 reference

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Are the IKKs and IKK-related kinases TBK1 and IKK-epsilon similarly activated?

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3594079

Hepatic NF-kappa B essential modulator deficiency prevents obesity-induced insulin resistance but synergizes with high-fat feeding in tumorigenesis

6 July 2018

1 reference

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Signaling to NF-kappaB by Toll-like receptors

6 July 2018

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Amlexanox for the treatment of recurrent aphthous ulcers

6 July 2018

1 reference

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Coordinated regulation of nutrient and inflammatory responses by STAMP2 is essential for metabolic homeostasis

6 July 2018

1 reference

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Bone marrow-specific Cap gene deletion protects against high-fat diet-induced insulin resistance

6 July 2018

1 reference

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Inhibition of ceramide synthesis ameliorates glucocorticoid-, saturated-fat-, and obesity-induced insulin resistance

6 July 2018

1 reference

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Obesity induces a phenotypic switch in adipose tissue macrophage polarization

6 July 2018

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TLR4 links innate immunity and fatty acid-induced insulin resistance

6 July 2018

1 reference

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Macrophages block insulin action in adipocytes by altering expression of signaling and glucose transport proteins.

6 July 2018

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Critical nodes in signalling pathways: insights into insulin action

6 July 2018

1 reference

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From mice to men: insights into the insulin resistance syndromes

6 July 2018

1 reference

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The insulin resistance syndrome: definition and dietary approaches to treatment

6 July 2018

1 reference

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Type 2 diabetes: principles of pathogenesis and therapy

6 July 2018

1 reference

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IKK-beta links inflammation to obesity-induced insulin resistance

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3594079

Ser/Thr phosphorylation of IRS proteins: a molecular basis for insulin resistance

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3594079

Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3594079

Modern science versus the stigma of obesity

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3594079

Chronic sympathetic activation: consequence and cause of age-associated obesity?

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3594079

The IKK NF-kappa B system: a treasure trove for drug development

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3594079

Obesity is associated with macrophage accumulation in adipose tissue

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3594079

IKKi/IKKϵ Plays a Key Role in Integrating Signals Induced by Pro-inflammatory Stimuli

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3594079

Mechanism by which high-dose aspirin improves glucose metabolism in type 2 diabetes

6 July 2018

1 reference

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C-reactive protein, interleukin 6, and risk of developing type 2 diabetes mellitus

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3594079

PPAR gamma and the treatment of insulin resistance

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3594079

Leptin and the regulation of body weight in mammals

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3594079

Mechanism of action of an antiallergic agent, amlexanox (AA-673), in inhibiting histamine release from mast cells. Acceleration of cAMP generation and inhibition of phosphodiesterase

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3594079

Human adipose tissue macrophages: m1 and m2 cell surface markers in subcutaneous and omental depots and after weight loss

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3594079

Postprandial variations of plasma inflammatory markers in abdominally obese men.

27 October 2018

1 reference

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Why Syndrome X? From Harold Himsworth to the insulin resistance syndrome

27 October 2018

1 reference

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Elevated levels of acute-phase proteins and plasminogen activator inhibitor-1 predict the development of type 2 diabetes: the insulin resistance atherosclerosis study

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3594079

Insulin Resistance in the Defense against Obesity

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3594079

5-(1H-Benzimidazol-1-yl)-3-alkoxy-2-thiophenecarbonitriles as potent, selective, inhibitors of IKK-epsilon kinase

27 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23396211

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/NM.3082

1 reference

1 August 2017

1 reference

1 August 2017

1 reference