The IL-23-IL-17 axis in inflammatory arthritis (Q38439641)

3 September 2017

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title

The IL-23-IL-17 axis in inflammatory arthritis. (English)

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3 September 2017

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Erik Lubberts

1

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PubMed ID

25907700

3 September 2017

language of work or name

English

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publication date

28 April 2015

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Nature Reviews Rheumatology

3 September 2017

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3 September 2017

11

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3 September 2017

7

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3 September 2017

415-429

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https://scigraph.springernature.com/pub.10.1038/nrrheum.2015.53

3 September 2017

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cites work

Treatment with a neutralizing anti-murine interleukin-17 antibody after the onset of collagen-induced arthritis reduces joint inflammation, cartilage destruction, and bone erosion

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.53

The role of T-cell interleukin-17 in conducting destructive arthritis: lessons from animal models

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.53

Targeting IL-17 and TH17 cells in chronic inflammation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.53

Overexpression of IL-17 in the knee joint of collagen type II immunized mice promotes collagen arthritis and aggravates joint destruction

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.53

Requirement of IL-17 receptor signaling in radiation-resistant cells in the joint for full progression of destructive synovitis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.53

Interleukin-17 receptor deficiency results in impaired synovial expression of interleukin-1 and matrix metalloproteinases 3, 9, and 13 and prevents cartilage destruction during chronic reactivated streptococcal cell wall-induced arthritis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.53

Microbial lipopeptides induce the production of IL-17 in Th cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.53

Interleukin-17 family and IL-17 receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.53

Interleukin-17 family members and inflammation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.53

Functional specialization of interleukin-17 family members

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.53

Identification of an interleukin 17F/17A heterodimer in activated human CD4+ T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.53

Cutting edge: interleukin 17 signals through a heteromeric receptor complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.53

The human IL-17F/IL-17A heterodimeric cytokine signals through the IL-17RA/IL-17RC receptor complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.53

Structure and signalling in the IL-17 receptor family

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.53

IL-17RE is the functional receptor for IL-17C and mediates mucosal immunity to infection with intestinal pathogens

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.53

Interleukin-17C promotes Th17 cell responses and autoimmune disease via interleukin-17 receptor E.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.53

Effect of IL-17A blockade with secukinumab in autoimmune diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.53

IL-23: one cytokine in control of autoimmunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.53

TGF-beta and IL-6 drive the production of IL-17 and IL-10 by T cells and restrain T(H)-17 cell-mediated pathology

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.53

Pathogen-induced human TH17 cells produce IFN-γ or IL-10 and are regulated by IL-1β.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.53

Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.53

Cutting edge: IL-23 receptor gfp reporter mice reveal distinct populations of IL-17-producing cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.53

The interleukin 23 receptor is essential for the terminal differentiation of interleukin 17-producing effector T helper cells in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.53

Divergent pro- and antiinflammatory roles for IL-23 and IL-12 in joint autoimmune inflammation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.53

Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.53

IL-23 drives a pathogenic T cell population that induces autoimmune inflammation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.53

Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.53

A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.53

Mast cells express IL-17A in rheumatoid arthritis synovium

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.53

Heterogeneous expression pattern of interleukin 17A (IL-17A), IL-17F and their receptors in synovium of rheumatoid arthritis, psoriatic arthritis and osteoarthritis: possible explanation for nonresponse to anti-IL-17 therapy?

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.53

IL-17A expression is localised to both mononuclear and polymorphonuclear synovial cell infiltrates

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.53

Analysis of IL-17(+) cells in facet joints of patients with spondyloarthritis suggests that the innate immune pathway might be of greater relevance than the Th17-mediated adaptive immune response

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.53

Innate IL-17-producing cells: the sentinels of the immune system

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.53

Innate lymphoid cells--a proposal for uniform nomenclature

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.53

Interleukin-23 is critical for full-blown expression of a non-autoimmune destructive arthritis and regulates interleukin-17A and RORgammat in gammadelta T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.53

The encephalitogenicity of T(H)17 cells is dependent on IL-1- and IL-23-induced production of the cytokine GM-CSF.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.53

RORγt drives production of the cytokine GM-CSF in helper T cells, which is essential for the effector phase of autoimmune neuroinflammation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.53

Efficacy and safety of mavrilimumab in subjects with rheumatoid arthritis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.53

Th17 cytokines and arthritis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.53

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.53

Act1, a negative regulator in CD40- and BAFF-mediated B cell survival

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.53

The adaptor protein CIKS/ACT1 is necessary for collagen-induced arthritis, and it contributes to the production of collagen-specific antibody

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.53

Safety and efficacy of combination therapy of iguratimod with methotrexate for patients with active rheumatoid arthritis with an inadequate response to methotrexate: an open-label extension of a randomized, double-blind, placebo-controlled trial

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.53

IL-23 induces human osteoclastogenesis via IL-17 in vitro, and anti-IL-23 antibody attenuates collagen-induced arthritis in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.53

IL-23 dependent and independent stages of experimental arthritis: no clinical effect of therapeutic IL-23p19 inhibition in collagen-induced arthritis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.53

IL-23 is critical for induction of arthritis, osteoclast formation, and maintenance of bone mass.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.53

IL-23 promotes osteoclast formation by up-regulation of receptor activator of NF-kappaB (RANK) expression in myeloid precursor cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.53

IL-23 induces receptor activator of NF-kappaB ligand expression in fibroblast-like synoviocytes via STAT3 and NF-kappaB signal pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.53

Expression of interleukin-22 in rheumatoid arthritis: potential role as a proinflammatory cytokine.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.53

Proinflammatory role of the Th17 cytokine interleukin-22 in collagen-induced arthritis in C57BL/6 mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.53

IL-23 inhibits osteoclastogenesis indirectly through lymphocytes and is required for the maintenance of bone mass in mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.53

IL-23 induces receptor activator of NF-kappaB ligand expression on CD4+ T cells and promotes osteoclastogenesis in an autoimmune arthritis model

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.53

IL-17/Th17 mediated synovial inflammation is IL-22 independent

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.53

Induction of osteoclastogenesis and bone loss by human autoantibodies against citrullinated vimentin

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.53

Interleukin (IL)-22 and IL-17 are coexpressed by Th17 cells and cooperatively enhance expression of antimicrobial peptides

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.53

Interleukin-22, a T(H)17 cytokine, mediates IL-23-induced dermal inflammation and acanthosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.53

Interleukin-23 promotes Th17 differentiation by inhibiting T-bet and FoxP3 and is required for elevation of interleukin-22, but not interleukin-21, in autoimmune experimental arthritis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.53

Evolving concepts of rheumatoid arthritis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.53

IL-17/Th17 targeting: on the road to prevent chronic destructive arthritis?

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.53

IL-17 in synovial fluids from patients with rheumatoid arthritis is a potent stimulator of osteoclastogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.53

Change in the Th1/Th2 phenotype of memory T-cell clones from rheumatoid arthritis synovium.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.53

1,25-dihydroxyvitamin D3 modulates Th17 polarization and interleukin-22 expression by memory T cells from patients with early rheumatoid arthritis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.53

Th17 cells, but not Th1 cells, from patients with early rheumatoid arthritis are potent inducers of matrix metalloproteinases and proinflammatory cytokines upon synovial fibroblast interaction, including autocrine interleukin-17A production.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.53

Th1 but not Th17 cells predominate in the joints of patients with rheumatoid arthritis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.53

Interleukin-17-producing T cells are enriched in the joints of children with arthritis, but have a reciprocal relationship to regulatory T cell numbers.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.53

Elevated levels of T helper 17 cells are associated with disease activity in patients with rheumatoid arthritis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.53

Frequency of Th17 CD4+ T cells in early rheumatoid arthritis: a marker of anti-CCP seropositivity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.53

Surface phenotype and antigenic specificity of human interleukin 17-producing T helper memory cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.53

Preferential recruitment of CCR6-expressing Th17 cells to inflamed joints via CCL20 in rheumatoid arthritis and its animal model.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.53

Development of proteoglycan-induced arthritis is independent of IL-17.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.53

IL-17 producing T cells in mouse models of multiple sclerosis and rheumatoid arthritis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.53

Blocking of interleukin-17 during reactivation of experimental arthritis prevents joint inflammation and bone erosion by decreasing RANKL and interleukin-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.53

Interleukin-17 in rheumatoid arthritis: if T cells were to contribute to inflammation and destruction through synergy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.53

Evidence that cytokines play a role in rheumatoid arthritis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.53

Cell-cell interactions in synovitis. Interactions between T lymphocytes and synovial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.53

Prolonged, granulocyte-macrophage colony-stimulating factor-dependent, neutrophil survival following rheumatoid synovial fibroblast activation by IL-17 and TNFalpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.53

Molecular interactions between T cells and fibroblast-like synoviocytes: role of membrane tumor necrosis factor-alpha on cytokine-activated T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.53

Interleukin-17 promotes autoimmunity by triggering a positive-feedback loop via interleukin-6 induction.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.53

Incomplete response of inflammatory arthritis to TNFα blockade is associated with the Th17 pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.53

Synovial fibroblasts directly induce Th17 pathogenicity via the cyclooxygenase/prostaglandin E2 pathway, independent of IL-23.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.53

TNF blockade requires 1,25(OH)2D3 to control human Th17-mediated synovial inflammation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.53

Increasing levels of circulating Th17 cells and interleukin-17 in rheumatoid arthritis patients with an inadequate response to anti-TNF-α therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.53

Blockade of tumor necrosis factor in collagen-induced arthritis reveals a novel immunoregulatory pathway for Th1 and Th17 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.53

Increased IL-17 production by peripheral T helper cells after tumour necrosis factor blockade in rheumatoid arthritis is accompanied by inhibition of migration-associated chemokine receptor expression.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.53

A phase II randomized study of subcutaneous ixekizumab, an anti-interleukin-17 monoclonal antibody, in rheumatoid arthritis patients who were naive to biologic agents or had an inadequate response to tumor necrosis factor inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.53

IL-17 as a future therapeutic target for rheumatoid arthritis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.53

CTLA4-Ig (abatacept) therapy modulates T cell effector functions in autoantibody-positive rheumatoid arthritis patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.53

Increased plasma IL-17F levels in rheumatoid arthritis patients are responsive to methotrexate, anti-TNF, and T cell costimulatory modulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.53

Effects of AIN457, a Fully Human Antibody to Interleukin-17A, on Psoriasis, Rheumatoid Arthritis, and Uveitis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.53

LY2439821, a humanized anti-interleukin-17 monoclonal antibody, in the treatment of patients with rheumatoid arthritis: A phase I randomized, double-blind, placebo-controlled, proof-of-concept study

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.53

A phase Ib multiple ascending dose study evaluating safety, pharmacokinetics, and early clinical response of brodalumab, a human anti-IL-17R antibody, in methotrexate-resistant rheumatoid arthritis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.53

Efficacy and safety of secukinumab in patients with rheumatoid arthritis: a phase II, dose-finding, double-blind, randomised, placebo controlled study

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.53

One-year efficacy and safety results of secukinumab in patients with rheumatoid arthritis: phase II, dose-finding, double-blind, randomized, placebo-controlled study

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.53

Requirement of interleukin 17 receptor signaling for lung CXC chemokine and granulocyte colony-stimulating factor expression, neutrophil recruitment, and host defense

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.53

IL-17A inhibits the expansion of IL-17A-producing T cells in mice through "short-loop" inhibition via IL-17 receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.53

Brodalumab, an anti-IL17RA monoclonal antibody, in psoriatic arthritis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.53

The critical role of interleukin-23 in spondyloarthropathy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.53

Inflammatory pathways in spondyloarthritis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.53

The IL23R Arg381Gln non-synonymous polymorphism confers susceptibility to ankylosing spondylitis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.53

Genome-wide association study of ankylosing spondylitis identifies non-MHC susceptibility loci

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.53

Combinatorial control of Th17 and Th1 cell functions by genetic variations in genes associated with the interleukin-23 signaling pathway in spondyloarthritis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.53

Frequency and phenotype of peripheral blood Th17 cells in ankylosing spondylitis and rheumatoid arthritis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.53

Increased frequencies of Th22 cells as well as Th17 cells in the peripheral blood of patients with ankylosing spondylitis and rheumatoid arthritis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.53

Systemic levels of IL-23 are strongly associated with disease activity in rheumatoid arthritis but not spondyloarthritis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.53

IL-17 in spondyloarthritis: is the T-party over?

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.53

Pathogenesis of spondyloarthritis: autoimmune or autoinflammatory?

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.53

IL-17 produced by Paneth cells drives TNF-induced shock

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.53

IL-23 induces spondyloarthropathy by acting on ROR-γt+ CD3+CD4-CD8- entheseal resident T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.53

Confirmation of TNIP1 and IL23A as susceptibility loci for psoriatic arthritis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.53

Investigation of association of the IL12B and IL23R genes with psoriatic arthritis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.53

Common variants at TRAF3IP2 are associated with susceptibility to psoriatic arthritis and psoriasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.53

IL-17 receptor and its functional significance in psoriatic arthritis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.53

Synovial fluid and serum levels of IL-17, IL-23, and CCL-20 in rheumatoid arthritis and psoriatic arthritis: a Tunisian cross-sectional study

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.53

Cutting edge: A critical functional role for IL-23 in psoriasis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.53

Development, cytokine profile and function of human interleukin 17-producing helper T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.53

IL-23 stimulates epidermal hyperplasia via TNF and IL-20R2-dependent mechanisms with implications for psoriasis pathogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.53

Imiquimod-induced psoriasis-like skin inflammation in mice is mediated via the IL-23/IL-17 axis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.53

Pivotal role of dermal IL-17-producing γδ T cells in skin inflammation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.53

Th17 and Th22 cells in psoriatic arthritis and psoriasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.53

Interleukin-17+CD8+ T cells are enriched in the joints of patients with psoriatic arthritis and correlate with disease activity and joint damage progression

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.53

Psoriatic arthritis: epidemiology, clinical features, course, and outcome

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.53

The new era for the treatment of psoriasis and psoriatic arthritis: perspectives and validated strategies

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.53

The IL-23/IL-17 axis in psoriatic arthritis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.53

The IL-23-IL-17 immune axis: from mechanisms to therapeutic testing

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.53

IL-17 targeted therapies for psoriasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.53

Interleukin-17A: a unique pathway in immune-mediated diseases: psoriasis, psoriatic arthritis and rheumatoid arthritis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.53

How cytokine networks fuel inflammation: Toward a cytokine-based disease taxonomy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.53

Functional diversity of helper T lymphocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.53

A novel transcription factor, T-bet, directs Th1 lineage commitment

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.53

Molecular mechanisms regulating Th1 immune responses

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.53

T cell response in experimental autoimmune encephalomyelitis (EAE): role of self and cross-reactive antigens in shaping, tuning, and regulating the autopathogenic T cell repertoire

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.53

Chronic melatonin treatment and the hypothalamo-pituitary-adrenal axis in the rat: attenuation of the secretory response to stress and effects on hypothalamic neuropeptide content and release.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.53

Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.53

Transforming growth factor-beta induces development of the T(H)17 lineage

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.53

TGFbeta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.53

The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.53

Induction and effector functions of T(H)17 cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.53

Transcriptional and epigenetic control of T helper cell specification: molecular mechanisms underlying commitment and plasticity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.53

Reprogrammed FoxP3+ T regulatory cells become IL-17+ antigen-specific autoimmune effectors in vitro and in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.53

T helper 17 lineage differentiation is programmed by orphan nuclear receptors ROR alpha and ROR gamma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.53

Human CD25highFoxp3pos regulatory T cells differentiate into IL-17-producing cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.53

Pathogenic conversion of Foxp3+ T cells into TH17 cells in autoimmune arthritis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.53

Late developmental plasticity in the T helper 17 lineage

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.53

Th memory for interleukin-17 expression is stable in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.53

Th17 cells promote pancreatic inflammation but only induce diabetes efficiently in lymphopenic hosts after conversion into Th1 cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.53

Global mapping of H3K4me3 and H3K27me3 reveals specificity and plasticity in lineage fate determination of differentiating CD4+ T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.53

The role of IL-17-secreting mast cells in inflammatory joint disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.53

Overexpression of interleukin-23, but not interleukin-17, as an immunologic signature of subclinical intestinal inflammation in ankylosing spondylitis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.53

β-glucan triggers spondylarthritis and Crohn's disease-like ileitis in SKG mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.53

Interleukin-23 mediates the intestinal response to microbial β-1,3-glucan and the development of spondyloarthritis pathology in SKG mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.53

Anti–Interleukin-17 Monoclonal Antibody Ixekizumab in Chronic Plaque Psoriasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.53

Combined blockade of granulocyte-macrophage colony stimulating factor and interleukin 17 pathways potently suppresses chronic destructive arthritis in a tumour necrosis factor -independent mouse model

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.53

Tumor necrosis factor-interleukin-17 interplay induces S100A8, interleukin-1β, and matrix metalloproteinases, and drives irreversible cartilage destruction in murine arthritis: Rationale for combination treatment during arthritis

21 January 2018

2 references

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.53

21 January 2018

12 December 2020

Anti IL-17A therapy inhibits bone loss in TNF-α-mediated murine arthritis by modulation of the T-cell balance

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.53

Brodalumab, an Anti–Interleukin-17–Receptor Antibody for Psoriasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.53

IL-1-independent role of IL-17 in synovial inflammation and joint destruction during collagen-induced arthritis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.53

Suppression of immune induction of collagen-induced arthritis in IL-17-deficient mice

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.53

Role of Th17 cells in human autoimmune arthritis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.53

Absence of interleukin-17 receptor a signaling prevents autoimmune inflammation of the joint and leads to a Th2-like phenotype in collagen-induced arthritis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.53

An IL-17F/A heterodimer protein is produced by mouse Th17 cells and induces airway neutrophil recruitment

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.53

Interleukin-17-positive mast cells contribute to synovial inflammation in spondylarthritis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.53

A novel disease-modifying antirheumatic drug, iguratimod, ameliorates murine arthritis by blocking IL-17 signaling, distinct from methotrexate and leflunomide

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.53

Brief report: a phase IIa, randomized, double-blind, placebo-controlled trial of apilimod mesylate, an interleukin-12/interleukin-23 inhibitor, in patients with rheumatoid arthritis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.53

Interleukin-22 promotes osteoclastogenesis in rheumatoid arthritis through induction of RANKL in human synovial fibroblasts

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.53

Effects of IL-23 and IL-27 on osteoblasts and osteoclasts: inhibitory effects on osteoclast differentiation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.53

Th17 cells, not IL-17+ γδ T cells, drive arthritic bone destruction in mice and humans

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.53

Interleukin 22 serum levels are associated with radiographic progression in rheumatoid arthritis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.53

Human interleukin-17: A T cell-derived proinflammatory cytokine produced by the rheumatoid synovium

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.53

A regulatory variant in CCR6 is associated with rheumatoid arthritis susceptibility

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.53

Elevated Th22 cells correlated with Th17 cells in patients with rheumatoid arthritis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.53

Frequencies of circulating IL-17-producing CD4+CD161+ T cells and CD4+CD161+ T cells correlate with disease activity in rheumatoid arthritis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.53

Cell contact between T cells and synovial fibroblasts causes induction of adhesion molecules and cytokines.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.53

Bone marrow-derived and synovium-derived mesenchymal cells promote Th17 cell expansion and activation through caspase 1 activation: contribution to the chronicity of rheumatoid arthritis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.53

Proinflammatory Cytokines Synergistically Enhance the Production of Chemokine Ligand 20 (CCL20) from Rheumatoid Fibroblast-like Synovial Cells in vitro and Serum CCL20 Is Reduced in vivo by Biologic Disease-modifying Antirheumatic Drugs

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.53

TNF-α blockade induces IL-10 expression in human CD4+ T cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.53

Brief report: inhibition of interleukin-6 function corrects Th17/Treg cell imbalance in patients with rheumatoid arthritis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.53

Effect of interleukin-6 receptor blockade on the balance between regulatory T cells and T helper type 17 cells in rheumatoid arthritis patients

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.53

Increased numbers of circulating polyfunctional Th17 memory cells in patients with seronegative spondylarthritides

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.53

IL-23-mediated psoriasis-like epidermal hyperplasia is dependent on IL-17A

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.53

The transcription factor GATA-3 is necessary and sufficient for Th2 cytokine gene expression in CD4 T cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.53

TH1 and TH2 cells: different patterns of lymphokine secretion lead to different functional properties

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.53

Cutting edge: regulatory T cells induce CD4+CD25-Foxp3- T cells or are self-induced to become Th17 cells in the absence of exogenous TGF-beta

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.53

Predominance of CD8+ T lymphocytes in psoriatic arthritis

31 March 2020

1 reference

12 December 2020

Th1/Th17 cytokine profiles in patients with reactive arthritis/undifferentiated spondyloarthropathy

1 reference

12 December 2020

Reduction of peripheral blood T cells producing IFN-γ and IL-17 after therapy with abatacept for rheumatoid arthritis

1 reference

12 December 2020

Secukinumab induction and maintenance therapy in moderate-to-severe plaque psoriasis: a randomized, double-blind, placebo-controlled, phase II regimen-finding study

1 reference

12 December 2020

Protection from collagen-induced arthritis in granulocyte-macrophage colony-stimulating factor-deficient mice

1 reference

12 December 2020

Enhanced and persistent levels of interleukin (IL)-17⁺ CD4⁺ T cells and serum IL-17 in patients with early inflammatory arthritis.

1 reference

12 December 2020

Efficacy and safety of iguratimod for the treatment of rheumatoid arthritis

1 reference

12 December 2020

The role of IL-17 and family members in the pathogenesis of arthritis

1 reference

12 December 2020

Differences in pathophysiology between rheumatoid arthritis and ankylosing spondylitis.

1 reference

12 December 2020

Identifiers

DOI

10.1038/NRRHEUM.2015.53

1 reference

PubMed ID

25907700

Dimensions Publication ID

3 September 2017

0 references

1 reference

PubMed ID

25907700