IL-23: one cytokine in control of autoimmunity (Q38040747)

27 August 2017

IL-23: one cytokine in control of autoimmunity (English)

1 reference

27 August 2017

2

Florian Mair

1 reference

27 August 2017

3

Burkhard Becher

1 reference

27 August 2017

Andrew L Croxford

1

1 reference

PubMed ID

22949325

27 August 2017

language of work or name

English

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publication date

1 September 2012

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European Journal of Immunology

27 August 2017

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27 August 2017

42

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27 August 2017

9

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27 August 2017

2263-2273

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APC-derived cytokines and T cell polarization in autoimmune inflammation

27 August 2017

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201242598

Plasticity of CD4+ T cell lineage differentiation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201242598

Decoding the patterns of self and nonself by the innate immune system

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201242598

A human homologue of the Drosophila Toll protein signals activation of adaptive immunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201242598

Antiviral immune responses: triggers of or triggered by autoimmunity?

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201242598

The danger model: a renewed sense of self

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201242598

Molecular identification of a danger signal that alerts the immune system to dying cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201242598

Alarmins: chemotactic activators of immune responses

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201242598

Purification to homogeneity and partial characterization of cytotoxic lymphocyte maturation factor from human B-lymphoblastoid cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201242598

Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201242598

The interleukin-12/interleukin-12-receptor system: role in normal and pathologic immune responses

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201242598

The role of macrophage- and dendritic cell-derived IL12 in Th1 phenotype development

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201242598

Development of TH1 CD4+ T cells through IL-12 produced by Listeria-induced macrophages

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201242598

Regulation of the interleukin (IL)-12R beta 2 subunit expression in developing T helper 1 (Th1) and Th2 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201242598

The costimulatory effect of IL-18 on the induction of antigen-specific IFN-gamma production by resting T cells is IL-12 dependent and is mediated by up-regulation of the IL-12 receptor beta2 subunit.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201242598

Role of costimulation in the induction of the IL-12/IL-12 receptor pathway and the development of autoimmunity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201242598

Prevention of experimental autoimmune encephalomyelitis by antibodies against interleukin 12.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201242598

Experimental autoimmune encephalitis and inflammation in the absence of interleukin-12

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201242598

Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201242598

IL-23 drives a pathogenic T cell population that induces autoimmune inflammation

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201242598

Transcriptional regulation of Th17 cell differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201242598

A receptor for the heterodimeric cytokine IL-23 is composed of IL-12Rbeta1 and a novel cytokine receptor subunit, IL-23R

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201242598

Role of IL-12 Receptor β1 in Regulation of T Cell Response by APC in Experimental Autoimmune Encephalomyelitis

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201242598

Cutting edge: IL-23 receptor gfp reporter mice reveal distinct populations of IL-17-producing cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201242598

Essential autocrine regulation by IL-21 in the generation of inflammatory T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201242598

IL-6 programs T(H)-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201242598

IRF4 is essential for IL-21-mediated induction, amplification, and stabilization of the Th17 phenotype

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201242598

IL-21 is produced by Th17 cells and drives IL-17 production in a STAT3-dependent manner

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201242598

IL-21 and IL-21R are not required for development of Th17 cells and autoimmunity in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201242598

Signals mediated by transforming growth factor-beta initiate autoimmune encephalomyelitis, but chronic inflammation is needed to sustain disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201242598

T helper 17 cell heterogeneity and pathogenicity in autoimmune disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201242598

Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201242598

Structural basis for the dual recognition of IL-12 and IL-23 by ustekinumab

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201242598

Efficacy and safety of ustekinumab, a human interleukin-12/23 monoclonal antibody, in patients with psoriasis: 76-week results from a randomised, double-blind, placebo-controlled trial (PHOENIX 1)

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201242598

Efficacy and safety of ustekinumab, a human interleukin-12/23 monoclonal antibody, in patients with psoriasis: 52-week results from a randomised, double-blind, placebo-controlled trial (PHOENIX 2)

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201242598

Comparison of ustekinumab and etanercept for moderate-to-severe psoriasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201242598

Repeated subcutaneous injections of IL12/23 p40 neutralising antibody, ustekinumab, in patients with relapsing-remitting multiple sclerosis: a phase II, double-blind, placebo-controlled, randomised, dose-ranging study

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201242598

IL-23 produced by CNS-resident cells controls T cell encephalitogenicity during the effector phase of experimental autoimmune encephalomyelitis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201242598

Contribution of interleukin 17 to synovium matrix destruction in rheumatoid arthritis

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201242598

A genome-wide association study identifies IL23R as an inflammatory bowel disease gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201242598

Increased expression of interleukin 17 in inflammatory bowel disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201242598

Human TH17 lymphocytes promote blood-brain barrier disruption and central nervous system inflammation

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201242598

Gene-microarray analysis of multiple sclerosis lesions yields new targets validated in autoimmune encephalomyelitis

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201242598

IL-23 is essential for T cell-mediated colitis and promotes inflammation via IL-17 and IL-6

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201242598

Neutralization of interleukin-17 aggravates dextran sulfate sodium-induced colitis in mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201242598

Effects of AIN457, a Fully Human Antibody to Interleukin-17A, on Psoriasis, Rheumatoid Arthritis, and Uveitis

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201242598

Treatment of multiple sclerosis with gamma interferon: exacerbations associated with activation of the immune system

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201242598

Interleukin-17 family members and inflammation

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201242598

Differential roles of interleukin-17A and -17F in host defense against mucoepithelial bacterial infection and allergic responses.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201242598

RORgamma-expressing Th17 cells induce murine chronic intestinal inflammation via redundant effects of IL-17A and IL-17F.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201242598

A protective function for interleukin 17A in T cell-mediated intestinal inflammation

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201242598

Interleukin-23 promotes a distinct CD4 T cell activation state characterized by the production of interleukin-17

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201242598

Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201242598

TGFbeta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201242598

Protective effect of transforming growth factor beta 1 on experimental autoimmune diseases in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201242598

Generation of pathogenic T(H)17 cells in the absence of TGF-β signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201242598

TGF-beta and IL-6 drive the production of IL-17 and IL-10 by T cells and restrain T(H)-17 cell-mediated pathology

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201242598

IL-21 initiates an alternative pathway to induce proinflammatory T(H)17 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201242598

Transforming growth factor-beta induces development of the T(H)17 lineage

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201242598

Th17 lymphocytes traffic to the central nervous system independently of α4 integrin expression during EAE

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201242598

Cutting edge: Th1 cells facilitate the entry of Th17 cells to the central nervous system during experimental autoimmune encephalomyelitis

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201242598

RORγt drives production of the cytokine GM-CSF in helper T cells, which is essential for the effector phase of autoimmune neuroinflammation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201242598

Fate mapping of IL-17-producing T cells in inflammatory responses

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201242598

Interleukin-23 drives intestinal inflammation through direct activity on T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201242598

Genetic proof for the transient nature of the Th17 phenotype.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201242598

IL-23 receptor regulates unconventional IL-17-producing T cells that control bacterial infections

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201242598

IL-22 is required for imiquimod-induced psoriasiform skin inflammation in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201242598

Tumor-infiltrating IL-17-producing gammadelta T cells support the progression of tumor by promoting angiogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201242598

Interleukin-1 and IL-23 induce innate IL-17 production from gammadelta T cells, amplifying Th17 responses and autoimmunity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201242598

Innate IL-17-producing cells: the sentinels of the immune system

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201242598

γδ T cells enhance autoimmunity by restraining regulatory T cell responses via an interleukin-23-dependent mechanism.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201242598

Interleukin-23 is critical for full-blown expression of a non-autoimmune destructive arthritis and regulates interleukin-17A and RORgammat in gammadelta T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201242598

Pivotal role of dermal IL-17-producing γδ T cells in skin inflammation

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201242598

Rorγt+ innate lymphocytes and γδ T cells initiate psoriasiform plaque formation in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201242598

The IL-23/Th17 axis in the immunopathogenesis of psoriasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201242598

Th17 cytokines stimulate CCL20 expression in keratinocytes in vitro and in vivo: implications for psoriasis pathogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201242598

Imiquimod-induced psoriasis-like skin inflammation in mice is mediated via the IL-23/IL-17 axis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201242598

Interleukin-23 drives innate and T cell-mediated intestinal inflammation

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201242598

Differential activity of IL-12 and IL-23 in mucosal and systemic innate immune pathology.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201242598

Innate lymphoid cells drive interleukin-23-dependent innate intestinal pathology.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201242598

Th17 cells: effector T cells with inflammatory properties

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201242598

Hallmarks of Cancer: The Next Generation

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201242598

Antitumor and antimetastatic activity of IL-23

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201242598

IL-23 promotes tumour incidence and growth

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201242598

T helper 17 cells promote cytotoxic T cell activation in tumor immunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201242598

Tumor-specific Th17-polarized cells eradicate large established melanoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201242598

Ablation of IL-17A abrogates progression of spontaneous intestinal tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201242598

IL-17 can promote tumor growth through an IL-6-Stat3 signaling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201242598

Combination immunotherapy of B16 melanoma using anti-cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) and granulocyte/macrophage colony-stimulating factor (GM-CSF)-producing vaccines induces rejection of subcutaneous and metastatic tumors accomp

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201242598

Identification and purification of natural killer cell stimulatory factor (NKSF), a cytokine with multiple biologic effects on human lymphocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201242598

A functional interleukin 12 receptor complex is composed of two beta-type cytokine receptor subunits

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201242598

Treatment of rheumatoid arthritis with a recombinant human tumor necrosis factor receptor (p75)-Fc fusion protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201242598

7 January 2021

T-bet is a STAT1-induced regulator of IL-12R expression in naïve CD4+ T cells

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201242598

7 January 2021

Interleukin 18-independent engagement of interleukin 18 receptor-alpha is required for autoimmune inflammation

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201242598

7 January 2021

Induction of experimental autoimmune encephalomyelitis in IL-12 receptor-beta 2-deficient mice: IL-12 responsiveness is not required in the pathogenesis of inflammatory demyelination in the central nervous system

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201242598

7 January 2021

IL-23-driven encephalo-tropism and Th17 polarization during CNS-inflammation in vivo

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201242598

7 January 2021

Suppression of experimental allergic encephalomyelitis by intraventricular administration of interferon-gamma in Lewis rats

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201242598

7 January 2021

T-bet regulates the fate of Th1 and Th17 lymphocytes in autoimmunity

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201242598

7 January 2021

IL-17 plays an important role in the development of experimental autoimmune encephalomyelitis

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201242598

7 January 2021

IL-22 is expressed by Th17 cells in an IL-23-dependent fashion, but not required for the development of autoimmune encephalomyelitis

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201242598

7 January 2021

Therapeutic efficacy of IL-17 neutralization in murine experimental autoimmune encephalomyelitis

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201242598

7 January 2021

IL-23 is required for protection against systemic infection with Listeria monocytogenes

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201242598

7 January 2021

Psoriasis Vulgaris Lesions Contain Discrete Populations of Th1 and Th17 T Cells

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201242598

7 January 2021

Identifiers

DOI

10.1002/EJI.201242598

1 reference

27 August 2017

1 reference

PubMed ID

22949325