Untangling knots between autophagic targets and candidate drugs, in cancer therapy (Q38343562)

2 September 2017

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title

Untangling knots between autophagic targets and candidate drugs, in cancer therapy (English)

1 reference

2 September 2017

0 references

Tao Xie

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6496907&resulttype=core&format=json

14 May 2020

Si-Jia Li

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6496907&resulttype=core&format=json

14 May 2020

Ming-Rui Guo

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6496907&resulttype=core&format=json

14 May 2020

Yue Wu

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6496907&resulttype=core&format=json

14 May 2020

Hang-Yu Wang

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6496907&resulttype=core&format=json

14 May 2020

Ke Zhang

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6496907&resulttype=core&format=json

14 May 2020

Xue Zhang

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6496907&resulttype=core&format=json

14 May 2020

Liang Ouyang

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6496907&resulttype=core&format=json

14 May 2020

Jie Liu

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6496907&resulttype=core&format=json

14 May 2020

language of work or name

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4 February 2015

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2 September 2017

21

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inferred from page(s)

published in

Cell Proliferation

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6496907&resulttype=core&format=json

14 May 2020

volume

48

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6496907&resulttype=core&format=json

14 May 2020

page(s)

119-139

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6496907&resulttype=core&format=json

14 May 2020

issue

2

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6496907&resulttype=core&format=json

Oncogenic and tumor suppressive roles of microRNAs in apoptosis and autophagy

14 May 2020

cites work

1 reference

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Beclin-1: autophagic regulator and therapeutic target in cancer

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Core signaling pathways of survival/death in autophagy-related cancer networks

21 January 2018

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ULK-Atg13-FIP200 complexes mediate mTOR signaling to the autophagy machinery

21 January 2018

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mTOR regulation of autophagy

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The Beclin 1 network regulates autophagy and apoptosis

21 January 2018

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The Beclin 1-VPS34 complex--at the crossroads of autophagy and beyond

21 January 2018

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Mouse Apg16L, a novel WD-repeat protein, targets to the autophagic isolation membrane with the Apg12-Apg5 conjugate

21 January 2018

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Role of the Apg12 conjugation system in mammalian autophagy

21 January 2018

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A ubiquitin-like system mediates protein lipidation

21 January 2018

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The Atg8 and Atg12 ubiquitin-like conjugation systems in macroautophagy. 'Protein modifications: beyond the usual suspects' review series

21 January 2018

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The reversible modification regulates the membrane-binding state of Apg8/Aut7 essential for autophagy and the cytoplasm to vacuole targeting pathway

21 January 2018

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The role of ESCRT proteins in fusion events involving lysosomes, endosomes and autophagosomes

21 January 2018

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Maturation of autophagic vacuoles in Mammalian cells

21 January 2018

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Targeting autophagic pathways for cancer drug discovery

21 January 2018

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TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling

21 January 2018

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Amino acid regulation of TOR complex 1.

21 January 2018

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Autophagic pathways as new targets for cancer drug development

21 January 2018

1 reference

Distinct regulation of autophagic activity by Atg14L and Rubicon associated with Beclin 1-phosphatidylinositol-3-kinase complex

21 January 2018

1 reference

Beclin 1 forms two distinct phosphatidylinositol 3-kinase complexes with mammalian Atg14 and UVRAG

21 January 2018

1 reference

Autophagic and tumour suppressor activity of a novel Beclin1-binding protein UVRAG

21 January 2018

1 reference

Bif-1 interacts with Beclin 1 through UVRAG and regulates autophagy and tumorigenesis

21 January 2018

1 reference

Endogenous HMGB1 regulates autophagy

21 January 2018

1 reference

Interaction of Beclin 1 with survivin regulates sensitivity of human glioma cells to TRAIL-induced apoptosis

21 January 2018

1 reference

Bcl-2 and Bcl-xL play important roles in the crosstalk between autophagy and apoptosis

21 January 2018

1 reference

Autophagy regulation by p53.

21 January 2018

1 reference

p53: The Janus of autophagy?

21 January 2018

1 reference

p53 signaling and autophagy in cancer: a revolutionary strategy could be developed for cancer treatment

21 January 2018

1 reference

Regulation of autophagy by cytoplasmic p53

21 January 2018

1 reference

The NAD biosynthesis inhibitor APO866 has potent antitumor activity against hematologic malignancies

21 January 2018

1 reference

Resveratrol promotes autophagic cell death in chronic myelogenous leukemia cells via JNK-mediated p62/SQSTM1 expression and AMPK activation

21 January 2018

1 reference

Autophagy is a critical mechanism for the induction of the antileukemic effects of arsenic trioxide

21 January 2018

1 reference

Antitumor effect of arsenic trioxide in human K562 and K562/ADM cells by autophagy

21 January 2018

1 reference

Platonin induces autophagy-associated cell death in human leukemia cells

21 January 2018

1 reference

Targeting the PI3K/Akt/mTOR signaling pathway in B-precursor acute lymphoblastic leukemia and its therapeutic potential.

21 January 2018

1 reference

RAD001 (Everolimus) induces autophagy in acute lymphoblastic leukemia

21 January 2018

1 reference

Activity of the novel dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor NVP-BEZ235 against T-cell acute lymphoblastic leukemia.

21 January 2018

1 reference

Cytotoxic activity of the novel Akt inhibitor, MK-2206, in T-cell acute lymphoblastic leukemia.

21 January 2018

1 reference

Preclinical testing of the Akt inhibitor triciribine in T-cell acute lymphoblastic leukemia.

21 January 2018

1 reference

Cell death induced by dexamethasone in lymphoid leukemia is mediated through initiation of autophagy

21 January 2018

1 reference

Induction of autophagy-dependent necroptosis is required for childhood acute lymphoblastic leukemia cells to overcome glucocorticoid resistance

21 January 2018

1 reference

Targeting autophagy potentiates tyrosine kinase inhibitor-induced cell death in Philadelphia chromosome-positive cells, including primary CML stem cells

21 January 2018

1 reference

Vitamin D3 induces autophagy of human myeloid leukemia cells

21 January 2018

1 reference

Vitamin K2 induces autophagy and apoptosis simultaneously in leukemia cells

21 January 2018

1 reference

Adding chloroquine to conventional treatment for glioblastoma multiforme: a randomized, double-blind, placebo-controlled trial

21 January 2018

1 reference

Thymoquinone inhibits autophagy and induces cathepsin-mediated, caspase-independent cell death in glioblastoma cells

21 January 2018

1 reference

Cucurbitacin I induces protective autophagy in glioblastoma in vitro and in vivo

21 January 2018

1 reference

Apoptosis induction in human glioblastoma multiforme T98G cells upon temozolomide and quercetin treatment

21 January 2018

1 reference

Piperlongumine promotes autophagy via inhibition of Akt/mTOR signalling and mediates cancer cell death

21 January 2018

1 reference

Evodiamine, a plant alkaloid, induces calcium/JNK-mediated autophagy and calcium/mitochondria-mediated apoptosis in human glioblastoma cells

21 January 2018

1 reference

Akt and autophagy cooperate to promote survival of drug-resistant glioma

21 January 2018

1 reference

Alkylphospholipids deregulate cholesterol metabolism and induce cell-cycle arrest and autophagy in U-87 MG glioblastoma cells

21 January 2018

1 reference

The short chain cell-permeable ceramide (C6) restores cell apoptosis and perifosine sensitivity in cultured glioblastoma cells.

21 January 2018

1 reference

Autophagy inhibition induces enhanced proapoptotic effects of ZD6474 in glioblastoma

21 January 2018

1 reference

Quercetin induces mitochondrial mediated apoptosis and protective autophagy in human glioblastoma U373MG cells

21 January 2018

1 reference

Inhibition of autophagy enhances apoptosis induced by proteasome inhibitor bortezomib in human glioblastoma U87 and U251 cells

21 January 2018

1 reference

Autophagy inhibition cooperates with erlotinib to induce glioblastoma cell death

21 January 2018

1 reference

Anti-neoplastic activity of low-dose endothelial-monocyte activating polypeptide-II results from defective autophagy and G2/M arrest mediated by PI3K/Akt/FoxO1 axis in human glioblastoma stem cells

21 January 2018

1 reference

Resveratrol abrogates the temozolomide-induced G2 arrest leading to mitotic catastrophe and reinforces the temozolomide-induced senescence in glioma cells

21 January 2018

1 reference

The tricyclic antidepressant imipramine induces autophagic cell death in U-87MG glioma cells

21 January 2018

1 reference

Cordyceps militaris and mycelial fermentation induced apoptosis and autophagy of human glioblastoma cells

21 January 2018

1 reference

Purine nucleoside analog--sulfinosine modulates diverse mechanisms of cancer progression in multi-drug resistant cancer cell lines

21 January 2018

1 reference

Concanavalin-A-induced autophagy biomarkers requires membrane type-1 matrix metalloproteinase intracellular signaling in glioblastoma cells

21 January 2018

1 reference

EDL-291, a novel isoquinoline, presents antiglioblastoma effects in vitro and in vivo

21 January 2018

1 reference

Bromopyruvate mediates autophagy and cardiolipin degradation to monolyso-cardiolipin in GL15 glioblastoma cells.

21 January 2018

1 reference

Curcumin promotes differentiation of glioma-initiating cells by inducing autophagy.

21 January 2018

1 reference

Cardiac glycosides induce autophagy in human non-small cell lung cancer cells through regulation of dual signaling pathways

21 January 2018

1 reference

Cardiac glycoside ouabain induces autophagic cell death in non-small cell lung cancer cells via a JNK-dependent decrease of Bcl-2.

21 January 2018

1 reference

The β-carboline alkaloid harmol induces cell death via autophagy but not apoptosis in human non-small cell lung cancer A549 cells

21 January 2018

1 reference

PM02734 (elisidepsin) induces caspase-independent cell death associated with features of autophagy, inhibition of the Akt/mTOR signaling pathway, and activation of death-associated protein kinase

21 January 2018

1 reference

Activation of ERK-p53 and ERK-mediated phosphorylation of Bcl-2 are involved in autophagic cell death induced by the c-Met inhibitor SU11274 in human lung cancer A549 cells

21 January 2018

1 reference

TW01001, a novel piperazinedione compound, induces mitotic arrest and autophagy in non-small cell lung cancer A549 cells.

21 January 2018

1 reference

Erlotinib-induced autophagy in epidermal growth factor receptor mutated non-small cell lung cancer.

21 January 2018

1 reference

The autophagy inhibitor chloroquine overcomes the innate resistance of wild-type EGFR non-small-cell lung cancer cells to erlotinib

21 January 2018

1 reference

Combination erlotinib-cisplatin and Atg3-mediated autophagy in erlotinib resistant lung cancer

21 January 2018

1 reference

Salinomycin induces cell death with autophagy through activation of endoplasmic reticulum stress in human cancer cells.

21 January 2018

1 reference

Induction of apoptosis and autophagy by sodium selenite in A549 human lung carcinoma cells through generation of reactive oxygen species

21 January 2018

1 reference

Augmentation of NVP-BEZ235's anticancer activity against human lung cancer cells by blockage of autophagy

21 January 2018

1 reference

Autophagy inhibition enhances pan-Bcl-2 inhibitor AT-101-induced apoptosis in non-small cell lung cancer

21 January 2018

1 reference

Autophagy inhibition promotes 5-fluorouraci-induced apoptosis by stimulating ROS formation in human non-small cell lung cancer A549 cells

21 January 2018

1 reference

Plumbagin induces apoptotic and autophagic cell death through inhibition of the PI3K/Akt/mTOR pathway in human non-small cell lung cancer cells

21 January 2018

1 reference

Calyxin Y induces hydrogen peroxide-dependent autophagy and apoptosis via JNK activation in human non-small cell lung cancer NCI-H460 cells

21 January 2018

1 reference

Nilotinib induces autophagy in hepatocellular carcinoma through AMPK activation

21 January 2018

1 reference

Andrographolide induces autophagic cell death in human liver cancer cells through cyclophilin D-mediated mitochondrial permeability transition pore.

21 January 2018

1 reference

Beclin 1-mediated autophagy in hepatocellular carcinoma cells: implication in anticancer efficiency of oroxylin A via inhibition of mTOR signaling.

21 January 2018

1 reference

Induction of autophagy in hepatocellular carcinoma cells by SB203580 requires activation of AMPK and DAPK but not p38 MAPK.

21 January 2018

1 reference

Galangin induces autophagy through upregulation of p53 in HepG2 cells.

21 January 2018

1 reference

Fangchinoline induces autophagic cell death via p53/sestrin2/AMPK signalling in human hepatocellular carcinoma cells

21 January 2018

1 reference

Cisplatin-induced downregulation of miR-199a-5p increases drug resistance by activating autophagy in HCC cell

21 January 2018

1 reference

Synergistic combination therapy with nanoliposomal C6-ceramide and vinblastine is associated with autophagy dysfunction in hepatocarcinoma and colorectal cancer models

21 January 2018

1 reference

Inhibition of autophagy enhances anticancer effects of bevacizumab in hepatocarcinoma

21 January 2018

1 reference

Proteasome inhibitor interacts synergistically with autophagy inhibitor to suppress proliferation and induce apoptosis in hepatocellular carcinoma

21 January 2018

1 reference

Neferine isolated from Nelumbo nucifera enhances anti-cancer activities in Hep3B cells: molecular mechanisms of cell cycle arrest, ER stress induced apoptosis and anti-angiogenic response

21 January 2018

1 reference

Sorafenib-mediated targeting of the AAA⁺ ATPase p97/VCP leads to disruption of the secretory pathway, endoplasmic reticulum stress, and hepatocellular cancer cell death

21 January 2018

1 reference

Fluoro-Sorafenib (Regorafenib) effects on hepatoma cells: growth inhibition, quiescence, and recovery

21 January 2018

1 reference

4-O-carboxymethyl ascochlorin causes ER stress and induced autophagy in human hepatocellular carcinoma cells

21 January 2018

1 reference

Combination therapy for hepatocellular carcinoma: additive preclinical efficacy of the HDAC inhibitor panobinostat with sorafenib

21 January 2018

1 reference

Prognostic significance of autophagy-related protein expression in resected pancreatic ductal adenocarcinoma.

21 January 2018

1 reference

Autophagy induced by p53-reactivating molecules protects pancreatic cancer cells from apoptosis.

21 January 2018

1 reference

Rottlerin induces autophagy which leads to apoptotic cell death through inhibition of PI3K/Akt/mTOR pathway in human pancreatic cancer stem cells

21 January 2018

1 reference

EPA, an omega-3 fatty acid, induces apoptosis in human pancreatic cancer cells: role of ROS accumulation, caspase-8 activation, and autophagy induction

21 January 2018

1 reference

The marine natural product manzamine A targets vacuolar ATPases and inhibits autophagy in pancreatic cancer cells

21 January 2018

1 reference

Mechanistic evaluation of a novel small molecule targeting mitochondria in pancreatic cancer cells

21 January 2018

1 reference

Selective induction of apoptosis and autophagy through treatment with dandelion root extract in human pancreatic cancer cells

21 January 2018

1 reference

Calix[6]arene bypasses human pancreatic cancer aggressiveness: downregulation of receptor tyrosine kinases and induction of cell death by reticulum stress and autophagy

21 January 2018

1 reference

Cannabinoids inhibit energetic metabolism and induce AMPK-dependent autophagy in pancreatic cancer cells.

21 January 2018

1 reference

Antroquinonol, a natural ubiquinone derivative, induces a cross talk between apoptosis, autophagy and senescence in human pancreatic carcinoma cells.

21 January 2018

1 reference

Rottlerin-induced autophagy leads to the apoptosis in breast cancer stem cells: molecular mechanisms.

21 January 2018

1 reference

Suberoylanilide hydroxamic acid, an inhibitor of histone deacetylase, enhances radiosensitivity and suppresses lung metastasis in breast cancer in vitro and in vivo.

21 January 2018

1 reference

A novel protoapigenone analog RY10-4 induces breast cancer MCF-7 cell death through autophagy via the Akt/mTOR pathway

21 January 2018

1 reference

Autophagy stimulates apoptosis in HER2-overexpressing breast cancers treated by lapatinib

21 January 2018

1 reference

Saxifragifolin D induces the interplay between apoptosis and autophagy in breast cancer cells through ROS-dependent endoplasmic reticulum stress

21 January 2018

1 reference

Omega-3 PUFA ethanolamides DHEA and EPEA induce autophagy through PPARγ activation in MCF-7 breast cancer cells

21 January 2018

1 reference

Induction of autophagy is an early response to gefitinib and a potential therapeutic target in breast cancer

21 January 2018

1 reference

Interplay between autophagy and apoptosis mediated by copper oxide nanoparticles in human breast cancer cells MCF7.

21 January 2018

1 reference

Salinomycin induces activation of autophagy, mitophagy and affects mitochondrial polarity: differences between primary and cancer cells

21 January 2018

1 reference

Inhibition of the autophagic flux by salinomycin in breast cancer stem-like/progenitor cells interferes with their maintenance

21 January 2018

1 reference

Rapamycin induces apoptosis when autophagy is inhibited in T-47D mammary cells and both processes are regulated by Phlda1.

21 January 2018

1 reference

Methyl 3-hydroxyimino-11-oxoolean-12-en-28-oate (HIMOXOL), a synthetic oleanolic acid derivative, induces both apoptosis and autophagy in MDA-MB-231 breast cancer cells.

21 January 2018

1 reference

γ-Tocotrienol-induced autophagy in malignant mammary cancer cells

21 January 2018

1 reference

Parthenolide generates reactive oxygen species and autophagy in MDA-MB231 cells. A soluble parthenolide analogue inhibits tumour growth and metastasis in a xenograft model of breast cancer

21 January 2018

1 reference

Sulforaphane inhibits growth of phenotypically different breast cancer cells

21 January 2018

1 reference

GX15-070 (obatoclax) induces apoptosis and inhibits cathepsin D- and L-mediated autophagosomal lysis in antiestrogen-resistant breast cancer cells

21 January 2018

1 reference

Cytotoxic constituents from Celastrus paniculatus induce apoptosis and autophagy in breast cancer cells.

21 January 2018

1 reference

Synthesis of clionamine B, an autophagy stimulating aminosteroid isolated from the sponge Cliona celata.

21 January 2018

1 reference

Intracellular glutathione regulates sesquiterpene lactone-induced conversion of autophagy to apoptosis in human leukemia HL60 cells.

21 January 2018

1 reference

12 December 2020

Ambra1 regulates autophagy and development of the nervous system

1 reference

12 December 2020

In vitro changes in mitochondrial potential, aggresome formation and caspase activity by a novel 17-β-estradiol analogue in breast adenocarcinoma cells.

1 reference

12 December 2020

The mTOR inhibitor RAD001 augments radiation-induced growth inhibition in a hepatocellular carcinoma cell line by increasing autophagy.

1 reference

12 December 2020

Resveratrol induces apoptosis and autophagy in T-cell acute lymphoblastic leukemia cells by inhibiting Akt/mTOR and activating p38-MAPK.

1 reference

12 December 2020

A subcellular analysis of genetic modulation of PINK1 on mitochondrial alterations, autophagy and cell death

1 reference

12 December 2020

Rapamycin provides a therapeutic option through inhibition of mTOR signaling in chronic myelogenous leukemia

1 reference

12 December 2020

Role of autophagy in apoptotic regulation by Akt in pancreatic cancer

1 reference

12 December 2020

β-Elemene induces apoptosis as well as protective autophagy in human non-small-cell lung cancer A549 cells

1 reference

12 December 2020

Dual PI3K/mTOR inhibitor NVP-BEZ235-induced apoptosis of hepatocellular carcinoma cell lines is enhanced by inhibitors of autophagy

1 reference

12 December 2020

Oleifolioside B-mediated autophagy promotes apoptosis in A549 human non-small cell lung cancer cells

1 reference

12 December 2020

The mTOR inhibitor RAD001 potentiates autophagic cell death induced by temozolomide in a glioblastoma cell line

1 reference

12 December 2020

Bufalin increases sensitivity to AKT/mTOR-induced autophagic cell death in SK-HEP-1 human hepatocellular carcinoma cells

1 reference

12 December 2020

Ophiopogonin B-induced autophagy in non-small cell lung cancer cells via inhibition of the PI3K/Akt signaling pathway

1 reference

12 December 2020

Role of autophagy in apoptosis induction by methylene chloride extracts of Mori cortex in NCI-H460 human lung carcinoma cells

1 reference

12 December 2020

Prospective impact of 5-FU in the induction of endoplasmic reticulum stress, modulation of GRP78 expression and autophagy in Sk-Hep1 cells

1 reference

12 December 2020

Papuamine causes autophagy following the reduction of cell survival through mitochondrial damage and JNK activation in MCF-7 human breast cancer cells.

1 reference

12 December 2020

Autophagy induced by baicalin involves downregulation of CD147 in SMMC-7721 cells in vitro

1 reference

12 December 2020

Indirubin-3'-monoxime promotes autophagic and apoptotic death in JM1 human acute lymphoblastic leukemia cells and K562 human chronic myelogenous leukemia cells

1 reference

12 December 2020

Identifiers

DOI

10.1111/CPR.12167

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6496907&resulttype=core&format=json

14 May 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6496907&resulttype=core&format=json

14 May 2020

1 reference