Cytotoxic activity of the novel Akt inhibitor, MK-2206, in T-cell acute lymphoblastic leukemia. (Q39344848)

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2 February 2020

title

Cytotoxic activity of the novel Akt inhibitor, MK-2206, in T-cell acute lymphoblastic leukemia (English)

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Luca Maria Neri

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Francesca Chiarini

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Camilla Evangelisti

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Alice Cani

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Andrea Pession

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James A. McCubrey

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Silvano Capitani

14

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author name string

G Tabellini

3

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F Ricci

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D Bressanin

5

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P L Tazzari

9

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F Melchionda

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P Pagliaro

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A M Martelli

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publication date

22 May 2012

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2 February 2020

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volume

26

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issue

11

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page(s)

2336-2342

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https://scigraph.springernature.com/pub.10.1038/leu.2012.136

2 February 2020

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cites work

Redundancy and specificity of the metalloprotease system mediating oncogenic NOTCH1 activation in T-ALL.

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.136

Acute lymphoblastic leukaemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.136

21 January 2018

It's T-ALL about Notch

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.136

Targeting the translational apparatus to improve leukemia therapy: roles of the PI3K/PTEN/Akt/mTOR pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.136

Cisplatin induces PKB/Akt activation and p38(MAPK) phosphorylation of the EGF receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.136

The miRNA-17∼92 cluster mediates chemoresistance and enhances tumor growth in mantle cell lymphoma via PI3K/AKT pathway activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.136

Developments in selective small molecule ATP-targeting the serine/threonine kinase Akt/PKB.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.136

The PI3K/PKB signaling module as key regulator of hematopoiesis: implications for therapeutic strategies in leukemia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.136

PTEN posttranslational inactivation and hyperactivation of the PI3K/Akt pathway sustain primary T cell leukemia viability

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.136

Targeted therapy in T-cell malignancies: dysregulation of the cellular signaling pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.136

Constitutively active AKT depletes hematopoietic stem cells and induces leukemia in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.136

T-lymphoblastic lymphoma cells express high levels of BCL2, S1P1, and ICAM1, leading to a blockade of tumor cell intravasation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.136

Drug discovery approaches targeting the PI3K/Akt pathway in cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.136

MK-2206, an allosteric Akt inhibitor, enhances antitumor efficacy by standard chemotherapeutic agents or molecular targeted drugs in vitro and in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.136

MK-2206, a novel allosteric inhibitor of Akt, synergizes with gefitinib against malignant glioma via modulating both autophagy and apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.136

Next-generation Akt inhibitors provide greater specificity: effects on glucose metabolism in adipocytes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.136

The dual mTORC1 and mTORC2 inhibitor AZD8055 has anti-tumor activity in acute myeloid leukemia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.136

Targeted inhibition of mTORC1 and mTORC2 by active-site mTOR inhibitors has cytotoxic effects in T-cell acute lymphoblastic leukemia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.136

Proapoptotic activity and chemosensitizing effect of the novel Akt inhibitor perifosine in acute myelogenous leukemia cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.136

Erucylphosphohomocholine, the first intravenously applicable alkylphosphocholine, is cytotoxic to acute myelogenous leukemia cells through JNK- and PP2A-dependent mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.136

The novel Akt inhibitor, perifosine, induces caspase-dependent apoptosis and downregulates P-glycoprotein expression in multidrug-resistant human T-acute leukemia cells by a JNK-dependent mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.136

AMP-dependent kinase/mammalian target of rapamycin complex 1 signaling in T-cell acute lymphoblastic leukemia: therapeutic implications.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.136

mTOR signaling in disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.136

The crosstalk between autophagy and apoptosis: where does this lead?

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.136

The impact of PTEN regulation by CK2 on PI3K-dependent signaling and leukemia cell survival

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.136

Intracellular reactive oxygen species are essential for PI3K/Akt/mTOR-dependent IL-7-mediated viability of T-cell acute lymphoblastic leukemia cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.136

Dual inhibition of class IA phosphatidylinositol 3-kinase and mammalian target of rapamycin as a new therapeutic option for T-cell acute lymphoblastic leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.136

mTOR signaling in growth control and disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.136

mTOR regulation of autophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.136

Negative regulation of autophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.136

Autophagy in aging, disease and death: the true identity of a cell death impostor

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.136

Novel inhibitors of AKT: assessment of a different approach targeting the pleckstrin homology domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.136

Targeting the leukemic stem cell: the Holy Grail of leukemia therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.136

Synergistic induction of apoptosis in human leukemia T cells by the Akt inhibitor perifosine and etoposide through activation of intrinsic and Fas-mediated extrinsic cell death pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.136

TAL1/SCL is downregulated upon histone deacetylase inhibition in T-cell acute lymphoblastic leukemia cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.136

Occurrence of identical NOTCH1 mutation in non-twinned sisters with T-cell acute lymphoblastic leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.136

Notch3-mediated regulation of MKP-1 levels promotes survival of T acute lymphoblastic leukemia cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.136

7 January 2021

Microarray detection of multiple recurring submicroscopic chromosomal aberrations in pediatric T-cell acute lymphoblastic leukemia

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.136

7 January 2021

Long-term follow-up results of hyperfractionated cyclophosphamide, vincristine, doxorubicin, and dexamethasone (Hyper-CVAD), a dose-intensive regimen, in adult acute lymphocytic leukemia

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.136

7 January 2021

Characterization of a progenitor cell population in childhood T-cell acute lymphoblastic leukemia

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.136

7 January 2021