Wnt signalling and its impact on development and cancer (Q29619273)

Europe PubMed Central

title

Wnt signalling and its impact on development and cancer (English)

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30 April 2017

author name string

Klaus A

series ordinal

1

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30 April 2017

Birchmeier W

series ordinal

2

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=18432252

30 April 2017

language of work or name

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30 April 2017

publication date

May 2008

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30 April 2017

published in

Nature Reviews Cancer

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30 April 2017

volume

8

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30 April 2017

page(s)

387-98

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30 April 2017

issue

5

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Many tumors induced by the mouse mammary tumor virus contain a provirus integrated in the same region of the host genome

30 April 2017

cites work

1 reference

Targeted disruption of the murine int-1 proto-oncogene resulting in severe abnormalities in midbrain and cerebellar development

31 March 2020

1 reference

Swaying is a mutant allele of the proto-oncogene Wnt-1

31 March 2020

1 reference

The Drosophila homolog of the mouse mammary oncogene int-1 is identical to the segment polarity gene wingless

31 March 2020

1 reference

Phenocopies induced with antisense RNA identify the wingless gene.

31 March 2020

1 reference

Mutations affecting segment number and polarity in Drosophila

31 March 2020

1 reference

Mutations affecting the pattern of the larval cuticle inDrosophila melanogaster : I. Zygotic loci on the second chromosome

31 March 2020

1 reference

A new nomenclature for int-1 and related genes: the Wnt gene family

31 March 2020

1 reference

SOME POSSIBLE EFFECTS OF NURSING ON THE MAMMARY GLAND TUMOR INCIDENCE IN MICE.

31 March 2020

1 reference

Combinatorial signalling by Xwnt-11 and Xnr3 in the organizer epithelium

31 March 2020

1 reference

A molecular mechanism for the effect of lithium on development

31 March 2020

1 reference

Multiple functions of segment polarity genes in Drosophila

31 March 2020

1 reference

Autonomous requirements for the segment polarity gene armadillo during Drosophila embryogenesis.

31 March 2020

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Spatial expression of the Drosophila segment polarity gene armadillo is posttranscriptionally regulated by wingless

31 March 2020

1 reference

The Drosophila segment polarity gene dishevelled encodes a novel protein required for response to the wingless signal

31 March 2020

1 reference

dishevelled and armadillo act in the wingless signalling pathway in Drosophila

31 March 2020

1 reference

wingless signaling acts through zeste-white 3, the Drosophila homolog of glycogen synthase kinase-3, to regulate engrailed and establish cell fate

31 March 2020

1 reference

Components of wingless signalling in Drosophila.

31 March 2020

1 reference

Phosphorylation of the Drosophila adherens junction protein Armadillo: roles for wingless signal and zeste-white 3 kinase.

31 March 2020

1 reference

Ectopic expression of the proto-oncogene int-1 in Xenopus embryos leads to duplication of the embryonic axis.

31 March 2020

1 reference

Role of glycogen synthase kinase 3 beta as a negative regulator of dorsoventral axis formation in Xenopus embryos.

31 March 2020

1 reference

beta-Catenin has Wnt-like activity and mimics the Nieuwkoop signaling center in Xenopus dorsal-ventral patterning

31 March 2020

1 reference

Glycogen synthase kinase-3 and dorsoventral patterning in Xenopus embryos.

31 March 2020

1 reference

Functional interaction of beta-catenin with the transcription factor LEF-1

31 March 2020

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Nuclear localization of beta-catenin by interaction with transcription factor LEF-1

31 March 2020

1 reference

XTcf-3 transcription factor mediates beta-catenin-induced axis formation in Xenopus embryos

31 March 2020

1 reference

LEF-1, a gene encoding a lymphoid-specific protein with an HMG domain, regulates T-cell receptor alpha enhancer function [corrected]

31 March 2020

1 reference

Identification and cloning of TCF-1, a T lymphocyte-specific transcription factor containing a sequence-specific HMG box

31 March 2020

1 reference

A thymus-specific member of the HMG protein family regulates the human T cell receptor C alpha enhancer

31 March 2020

1 reference

The mouse Fused locus encodes Axin, an inhibitor of the Wnt signaling pathway that regulates embryonic axis formation

31 March 2020

1 reference

Functional interaction of an axin homolog, conductin, with beta-catenin, APC, and GSK3beta

31 March 2020

1 reference

Axis determination in Xenopus involves biochemical interactions of axin, glycogen synthase kinase 3 and beta-catenin.

31 March 2020

1 reference

Requirement for beta-catenin in anterior-posterior axis formation in mice

31 March 2020

1 reference

The effects of a lethal mutation responsible for duplications and twinning in mouse embryos

31 March 2020

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A new member of the frizzled family from Drosophila functions as a Wingless receptor

31 March 2020

1 reference

A large family of putative transmembrane receptors homologous to the product of the Drosophila tissue polarity gene frizzled

31 March 2020

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A member of the Frizzled protein family mediating axis induction by Wnt-5A

31 March 2020

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An LDL-receptor-related protein mediates Wnt signalling in mice

31 March 2020

1 reference

31 March 2020

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arrow encodes an LDL-receptor-related protein essential for Wingless signalling

31 March 2020

1 reference

Wnt/wingless signaling requires BCL9/legless-mediated recruitment of pygopus to the nuclear beta-catenin-TCF complex

31 March 2020

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A new nuclear component of the Wnt signalling pathway

31 March 2020

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Essential role of BCL9-2 in the switch between beta-catenin's adhesive and transcriptional functions

31 March 2020

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Wnt gradient formation requires retromer function in Wnt-producing cells

31 March 2020

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Wnt signaling establishes anteroposterior neuronal polarity and requires retromer in C. elegans.

31 March 2020

1 reference

The segment polarity gene porcupine encodes a putative multitransmembrane protein involved in Wingless processing

31 March 2020

1 reference

Drosophila segment polarity gene product porcupine stimulates the posttranslational N-glycosylation of wingless in the endoplasmic reticulum

31 March 2020

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Glycosaminoglycans can modulate extracellular localization of the wingless protein and promote signal transduction

31 March 2020

1 reference

Wnt proteins are lipid-modified and can act as stem cell growth factors

31 March 2020

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Interaction of Wnt-1 proteins with the binding protein BiP

31 March 2020

1 reference

Boca, an endoplasmic reticulum protein required for wingless signaling and trafficking of LDL receptor family members in Drosophila.

31 March 2020

1 reference

Mesd encodes an LRP5/6 chaperone essential for specification of mouse embryonic polarity

31 March 2020

1 reference

Wntless, a conserved membrane protein dedicated to the secretion of Wnt proteins from signaling cells

31 March 2020

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Secretion of Wnt ligands requires Evi, a conserved transmembrane protein

31 March 2020

1 reference

Sprinter: a novel transmembrane protein required for Wg secretion and signaling

31 March 2020

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Wnts as ligands: processing, secretion and reception

31 March 2020

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Helping Wingless take flight: how WNT proteins are secreted

31 March 2020

1 reference

Retromer retrieves wntless

31 March 2020

1 reference

Monounsaturated fatty acid modification of Wnt protein: its role in Wnt secretion

31 March 2020

1 reference

Purification and molecular cloning of a secreted, Frizzled-related antagonist of Wnt action

31 March 2020

1 reference

Frzb-1 is a secreted antagonist of Wnt signaling expressed in the Spemann organizer

31 March 2020

1 reference

A family of secreted proteins contains homology to the cysteine-rich ligand-binding domain of frizzled receptors

31 March 2020

1 reference

Frzb, a secreted protein expressed in the Spemann organizer, binds and inhibits Wnt-8.

31 March 2020

1 reference

Dickkopf-1 is a member of a new family of secreted proteins and functions in head induction

31 March 2020

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A new secreted protein that binds to Wnt proteins and inhibits their activities

31 March 2020

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Dickkopf1 is required for embryonic head induction and limb morphogenesis in the mouse

31 March 2020

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Kremen proteins are Dickkopf receptors that regulate Wnt/beta-catenin signalling

31 March 2020

1 reference

R-Spondin2 is a secreted activator of Wnt/beta-catenin signaling and is required for Xenopus myogenesis

31 March 2020

1 reference

Vascular development in the retina and inner ear: control by Norrin and Frizzled-4, a high-affinity ligand-receptor pair

31 March 2020

1 reference

Regulation of intracellular beta-catenin levels by the adenomatous polyposis coli (APC) tumor-suppressor protein

31 March 2020

1 reference

Biological activity of soluble wingless protein in cultured Drosophila imaginal disc cells

31 March 2020

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Casein kinase I transduces Wnt signals.

31 March 2020

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Casein kinase iepsilon in the wnt pathway: regulation of beta-catenin function

31 March 2020

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Axin-mediated CKI phosphorylation of beta-catenin at Ser 45: a molecular switch for the Wnt pathway

31 March 2020

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Control of beta-catenin phosphorylation/degradation by a dual-kinase mechanism

31 March 2020

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Casein kinase I phosphorylates the Armadillo protein and induces its degradation in Drosophila

31 March 2020

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beta-catenin is a target for the ubiquitin-proteasome pathway

31 March 2020

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Regulation of beta-catenin levels and localization by overexpression of plakoglobin and inhibition of the ubiquitin-proteasome system

31 March 2020

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Regulation of the Hedgehog and Wingless signalling pathways by the F-box/WD40-repeat protein Slimb.

31 March 2020

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beta-TrCP is a negative regulator of Wnt/beta-catenin signaling pathway and dorsal axis formation in Xenopus embryos.

31 March 2020

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Drosophila Tcf and Groucho interact to repress Wingless signalling activity.

31 March 2020

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Transcriptional repression by AML1 and LEF-1 is mediated by the TLE/Groucho corepressors

31 March 2020

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The Xenopus Wnt effector XTcf-3 interacts with Groucho-related transcriptional repressors

31 March 2020

1 reference

Casein kinase 1 gamma couples Wnt receptor activation to cytoplasmic signal transduction

31 March 2020

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A dual-kinase mechanism for Wnt co-receptor phosphorylation and activation

31 March 2020

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Wnt induces LRP6 signalosomes and promotes dishevelled-dependent LRP6 phosphorylation

31 March 2020

1 reference

The DIX domain of Dishevelled confers Wnt signaling by dynamic polymerization

31 March 2020

1 reference

Caveolin is necessary for Wnt-3a-dependent internalization of LRP6 and accumulation of beta-catenin

31 March 2020

1 reference

The p300/CBP acetyltransferases function as transcriptional coactivators of beta-catenin in vertebrates

31 March 2020

1 reference

Parafibromin/Hyrax activates Wnt/Wg target gene transcription by direct association with beta-catenin/Armadillo

31 March 2020

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Acetylation of beta-catenin by CREB-binding protein (CBP).

31 March 2020

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Wingless-independent association of Pygopus with dTCF target genes.

31 March 2020

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Beta-catenin directly displaces Groucho/TLE repressors from Tcf/Lef in Wnt-mediated transcription activation.

31 March 2020

1 reference

Identification of c-MYC as a target of the APC pathway

31 March 2020

1 reference

LEF-1, a nuclear factor coordinating signaling inputs from wingless and decapentaplegic.

31 March 2020

1 reference

Frizzled/PCP signalling: a conserved mechanism regulating cell polarity and directed motility

31 March 2020

1 reference

A second canon. Functions and mechanisms of beta-catenin-independent Wnt signaling

31 March 2020

1 reference

Wnt5a signaling directly affects cell motility and invasion of metastatic melanoma

31 March 2020

1 reference

Wnt11 signaling promotes proliferation, transformation, and migration of IEC6 intestinal epithelial cells

31 March 2020

1 reference

Association of the APC gene product with beta-catenin

31 March 2020

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Association of the APC tumor suppressor protein with catenins

31 March 2020

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E-cadherin and APC compete for the interaction with beta-catenin and the cytoskeleton

31 March 2020

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Lessons from hereditary colorectal cancer

31 March 2020

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Localization of the gene for familial adenomatous polyposis on chromosome 5.

31 March 2020

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The gene for familial polyposis coli maps to the long arm of chromosome 5.

31 March 2020

1 reference

Identification and characterization of the familial adenomatous polyposis coli gene

31 March 2020

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Downregulation of beta-catenin by human Axin and its association with the APC tumor suppressor, beta-catenin and GSK3 beta

31 March 2020

1 reference

Apc1638T: a mouse model delineating critical domains of the adenomatous polyposis coli protein involved in tumorigenesis and development

31 March 2020

1 reference

Mutations in AXIN2 cause colorectal cancer with defective mismatch repair by activating beta-catenin/TCF signalling

31 March 2020

1 reference

AXIN1 mutations in hepatocellular carcinomas, and growth suppression in cancer cells by virus-mediated transfer of AXIN1

31 March 2020

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A dominant mutation that predisposes to multiple intestinal neoplasia in the mouse

31 March 2020

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Multiple intestinal neoplasia caused by a mutation in the murine homolog of the APC gene

31 March 2020

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Constitutive transcriptional activation by a beta-catenin-Tcf complex in APC-/- colon carcinoma

31 March 2020

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Activation of beta-catenin-Tcf signaling in colon cancer by mutations in beta-catenin or APC

31 March 2020

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Stabilization of beta-catenin by genetic defects in melanoma cell lines

31 March 2020

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The many ways of Wnt in cancer

31 March 2020

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Intestinal polyposis in mice with a dominant stable mutation of the beta-catenin gene

31 March 2020

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The cyclin D1 gene is a target of the beta-catenin/LEF-1 pathway

31 March 2020

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Beta-catenin regulates expression of cyclin D1 in colon carcinoma cells

31 March 2020

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Wilms tumor suppressor WTX negatively regulates WNT/beta-catenin signaling

31 March 2020

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An X chromosome gene, WTX, is commonly inactivated in Wilms tumor

31 March 2020

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beta-Catenin stabilization dysregulates mesenchymal cell proliferation, motility, and invasiveness and causes aggressive fibromatosis and hyperplastic cutaneous wounds

31 March 2020

1 reference

WNT and beta-catenin signalling: diseases and therapies

31 March 2020

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WNT2B2 mRNA, up-regulated in primary gastric cancer, is a positive regulator of the WNT- beta-catenin-TCF signaling pathway

31 March 2020

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The Wnt antagonist sFRP1 in colorectal tumorigenesis

31 March 2020

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Epigenetic inactivation of SFRP genes allows constitutive WNT signaling in colorectal cancer

31 March 2020

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Frequent epigenetic inactivation of DICKKOPF family genes in human gastrointestinal tumors.

31 March 2020

1 reference

An LRP5 receptor with internal deletion in hyperparathyroid tumors with implications for deregulated WNT/beta-catenin signaling

31 March 2020

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Prevalence of ras gene mutations in human colorectal cancers

31 March 2020

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Detection of high incidence of K-ras oncogenes during human colon tumorigenesis

31 March 2020

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Chromosome 17 deletions and p53 gene mutations in colorectal carcinomas

31 March 2020

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A genetic model for colorectal tumorigenesis

31 March 2020

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APC, signal transduction and genetic instability in colorectal cancer

31 March 2020

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SMAD4-deficient intestinal tumors recruit CCR1+ myeloid cells that promote invasion

31 March 2020

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Indian Hedgehog is an antagonist of Wnt signaling in colonic epithelial cell differentiation

31 March 2020

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Vitamin D(3) promotes the differentiation of colon carcinoma cells by the induction of E-cadherin and the inhibition of beta-catenin signaling.

31 March 2020

1 reference

Sulindac targets nuclear beta-catenin accumulation and Wnt signalling in adenomas of patients with familial adenomatous polyposis and in human colorectal cancer cell lines

31 March 2020

1 reference

Wnt/beta-catenin-pathway as a molecular target for future anti-cancer therapeutics

31 March 2020

1 reference

Mining the Wnt pathway for cancer therapeutics

31 March 2020

1 reference

Arthritis drug approved for polyp prevention blazes trail for other prevention trials

31 March 2020

1 reference

Small-molecule antagonists of the oncogenic Tcf/beta-catenin protein complex

31 March 2020

1 reference

An anti-Wnt-2 monoclonal antibody induces apoptosis in malignant melanoma cells and inhibits tumor growth.

31 March 2020

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Therapeutic potential of antibodies against FZD 10, a cell-surface protein, for synovial sarcomas

31 March 2020

1 reference

The soluble wnt receptor Frizzled8CRD-hFc inhibits the growth of teratocarcinomas in vivo

31 March 2020

1 reference

Replicating parvoviruses that target colon cancer cells

31 March 2020

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Crystal structure of a beta-catenin/Tcf complex

31 March 2020

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The structure of the beta-catenin/E-cadherin complex and the molecular basis of diverse ligand recognition by beta-catenin

31 March 2020

1 reference

Crystal structure of a beta-catenin/axin complex suggests a mechanism for the beta-catenin destruction complex

31 March 2020

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A small-molecule agonist of the Wnt signaling pathway

31 March 2020

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Identification of a specific inhibitor of the dishevelled PDZ domain

31 March 2020

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Crystal structure of a beta-catenin/BCL9/Tcf4 complex

31 March 2020

1 reference

Dissecting nuclear Wingless signalling: recruitment of the transcriptional co-activator Pygopus by a chain of adaptor proteins

31 March 2020

1 reference

Specific inhibition of CBP/beta-catenin interaction rescues defects in neuronal differentiation caused by a presenilin-1 mutation

31 March 2020

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Depletion of epithelial stem-cell compartments in the small intestine of mice lacking Tcf-4

31 March 2020

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De novo crypt formation and juvenile polyposis on BMP inhibition in mouse intestine.

31 March 2020

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BMP signaling inhibits intestinal stem cell self-renewal through suppression of Wnt-beta-catenin signaling

31 March 2020

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Notch/gamma-secretase inhibition turns proliferative cells in intestinal crypts and adenomas into goblet cells

31 March 2020

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beta-Catenin controls hair follicle morphogenesis and stem cell differentiation in the skin

31 March 2020

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De Novo hair follicle morphogenesis and hair tumors in mice expressing a truncated beta-catenin in skin

31 March 2020

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A common human skin tumour is caused by activating mutations in beta-catenin

31 March 2020

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A role for Wnt signalling in self-renewal of haematopoietic stem cells

31 March 2020

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Activation of the canonical Wnt pathway leads to loss of hematopoietic stem cell repopulation and multilineage differentiation block.

31 March 2020

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Hematopoietic stem cell and multilineage defects generated by constitutive β-catenin activation

31 March 2020

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Integration of Notch and Wnt signaling in hematopoietic stem cell maintenance

31 March 2020

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Instructive role of Wnt/beta-catenin in sensory fate specification in neural crest stem cells

31 March 2020

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Bmp and Wnt/beta-catenin signals control expression of the transcription factor Olig3 and the specification of spinal cord neurons.

31 March 2020

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Distinct roles of Wnt/beta-catenin and Bmp signaling during early cardiogenesis

31 March 2020

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The renewal and differentiation of Isl1+ cardiovascular progenitors are controlled by a Wnt/beta-catenin pathway

31 March 2020

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Wnt/beta-catenin signaling and cardiogenesis: timing does matter

31 March 2020

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Wnt/beta-catenin signaling regulates vertebrate limb regeneration

31 March 2020

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Distinct Wnt signaling pathways have opposing roles in appendage regeneration

31 March 2020

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Increased Wnt signaling during aging alters muscle stem cell fate and increases fibrosis

31 March 2020

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Augmented Wnt signaling in a mammalian model of accelerated aging

31 March 2020

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Beta-catenin defines head versus tail identity during planarian regeneration and homeostasis

31 March 2020

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Smed-betacatenin-1 is required for anteroposterior blastema polarity in planarian regeneration

31 March 2020

1 reference

Location, location, location: the cancer stem cell niche

31 March 2020

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Generation of a functional mammary gland from a single stem cell

31 March 2020

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Cutaneous cancer stem cell maintenance is dependent on beta-catenin signalling

31 March 2020

1 reference

The biology of cancer stem cells

31 March 2020

1 reference

Cancer stem cells: lessons from leukemia.

31 March 2020

1 reference

The metastasis-associated gene S100A4 is a novel target of beta-catenin/T-cell factor signaling in colon cancer

31 March 2020

1 reference

Comprehensive identification of Drosophila dorsal-ventral patterning genes using a whole-genome tiling array.

31 March 2020

1 reference

Functional genomic analysis of the Wnt-wingless signaling pathway

31 March 2020

1 reference

A signaling network for patterning of neuronal connectivity in the Drosophila brain

31 March 2020

1 reference

A human protein-protein interaction network: a resource for annotating the proteome

31 March 2020

1 reference

Wnt signaling: is the party in the nucleus?

31 March 2020

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Deregulated GSK3beta activity in colorectal cancer: its association with tumor cell survival and proliferation.

31 March 2020

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Antisense suppression of pygopus2 results in growth arrest of epithelial ovarian cancer

31 March 2020

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Wnt inhibitory factor-1 gene transfer inhibits melanoma cell growth

31 March 2020

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Inhibition of protein-protein interactions: The discovery of druglike β-catenin inhibitors by combining virtual and biophysical screening

31 March 2020

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Tyrosine kinase inhibitor STI-571/Gleevec down-regulates the β-catenin signaling activity

31 March 2020

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The Wnt/beta-catenin signaling pathway as a target in drug discovery

31 March 2020

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Renal abnormalities and their developmental origin

31 March 2020

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APC dosage effects in tumorigenesis and stem cell differentiation

31 March 2020

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The subcellular destinations of APC proteins

31 March 2020

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ADAM10 mediates E-cadherin shedding and regulates epithelial cell-cell adhesion, migration, and beta-catenin translocation.

31 March 2020

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Mutations of chromosome 5q21 genes in FAP and colorectal cancer patients

31 March 2020

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A homolog of the armadillo protein in Drosophila (plakoglobin) associated with E-cadherin

31 March 2020

1 reference

Beta-catenin translocation into nuclei demarcates the dorsalizing centers in frog and fish embryos

31 March 2020

1 reference

The axis-inducing activity, stability, and subcellular distribution of beta-catenin is regulated in Xenopus embryos by glycogen synthase kinase 3

31 March 2020

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Three-dimensional structure of the armadillo repeat region of beta-catenin

31 March 2020

1 reference

Identification of a domain of Axin that binds to the serine/threonine protein phosphatase 2A and a self-binding domain

31 March 2020

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Regulation of beta-catenin signaling by the B56 subunit of protein phosphatase 2A

31 March 2020

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Dally cooperates with Drosophila Frizzled 2 to transduce Wingless signalling.

31 March 2020

1 reference

The cell-surface proteoglycan Dally regulates Wingless signalling in Drosophila

31 March 2020

1 reference

Low-density lipoprotein receptor-related protein-5 binds to Axin and regulates the canonical Wnt signaling pathway

31 March 2020

1 reference

Alterations of frizzled (FzE3) and secreted frizzled related protein (hsFRP) expression in gastric cancer.

31 March 2020

1 reference

WNT pathway and mammary carcinogenesis: loss of expression of candidate tumor suppressor gene SFRP1 in most invasive carcinomas except of the medullary type

31 March 2020

1 reference

Activation of the Wnt pathway in non small cell lung cancer: evidence of dishevelled overexpression

31 March 2020

1 reference

WIF1, a component of the Wnt pathway, is down‐regulated in prostate, breast, lung, and bladder cancer

31 March 2020

1 reference

Wnt-mediated axon guidance via the Drosophila Derailed receptor

31 March 2020

1 reference

Maternal wnt11 activates the canonical wnt signaling pathway required for axis formation in Xenopus embryos

31 March 2020

1 reference

Sclerostin binds to LRP5/6 and antagonizes canonical Wnt signaling

31 March 2020

1 reference

SOST is a ligand for LRP5/LRP6 and a Wnt signaling inhibitor

31 March 2020

1 reference

Human sebaceous tumors harbor inactivating mutations in LEF1.

31 March 2020

1 reference

MicroRNA control of Nodal signalling

31 March 2020

1 reference

Identification of stem cells in small intestine and colon by marker gene Lgr5

31 March 2020

1 reference

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31 March 2020

Identifiers

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519235

1028228628

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Fatcat ID

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Consolidated OpenCitations Corpus – April 2017

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30 April 2017

Consolidated OpenCitations Corpus – April 2017