Targeted expression of HGF/SF in mouse mammary epithelium leads to metastatic adenosquamous carcinomas through the activation of multiple signal transduction pathways. (Q44662285)

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scientific article published in November 2003

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English	Targeted expression of HGF/SF in mouse mammary epithelium leads to metastatic adenosquamous carcinomas through the activation of multiple signal transduction pathways.	scientific article published in November 2003

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scholarly article

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21 December 2019

Targeted expression of HGF/SF in mouse mammary epithelium leads to metastatic adenosquamous carcinomas through the activation of multiple signal transduction pathways (English)

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21 December 2019

Lothar Hennighausen

3

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21 December 2019

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Marta I Gallego

1

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21 December 2019

Brian Bierie

2

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21 December 2019

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1 November 2003

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21 December 2019

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21 December 2019

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21 December 2019

8498-8508

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21 December 2019

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21 December 2019

https://scigraph.springernature.com/pub.10.1038/sj.onc.1207063

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The role of hepatocyte growth factor (scatter factor) in epithelial-mesenchymal transition and breast cancer

1 reference

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Scatter factor/hepatocyte growth factor and its receptor, the c-met tyrosine kinase, can mediate a signal exchange between mesenchyme and epithelia during mouse development

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Sequential requirement of hepatocyte growth factor and neuregulin in the morphogenesis and differentiation of the mammary gland

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In vivo effects of hepatocyte growth factor/scatter factor on mouse mammary gland development.

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Neutralization of hepatocyte growth factor leads to retarded cutaneous wound healing associated with decreased neovascularization and granulation tissue formation

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HGF/SF-met signaling in the control of branching morphogenesis and invasion

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Met expression is associated with poor outcome in patients with axillary lymph node negative breast carcinoma

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Somatic mutations of the MET oncogene are selected during metastatic spread of human HNSC carcinomas

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Met receptor tyrosine kinase: enhanced signaling through adapter proteins

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Inactivation of Apc perturbs mammary development, but only directly results in acanthoma in the context of Tcf-1 deficiency.

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Expression of c-met is a strong independent prognostic factor in breast carcinoma

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Expression of scatter factor and c-met receptor in benign and malignant breast tissue

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HER2/PI-3K/Akt activation leads to a multidrug resistance in human breast adenocarcinoma cells.

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A novel non-mouse mammary tumor virus activation of the Int-3 gene in a spontaneous mouse mammary tumor.

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beta-catenin is a downstream effector of Wnt-mediated tumorigenesis in the mammary gland

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c-met tyrosine kinase receptor expression is associated with abnormal beta-catenin expression and favourable prognostic factors in invasive breast carcinoma

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Hypoxia promotes invasive growth by transcriptional activation of the met protooncogene

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7 January 2021

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Tissue microarray-based studies of patients with lymph node negative breast carcinoma show that met expression is associated with worse outcome but is not correlated with epidermal growth factor family receptors

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7 January 2021

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Osteopontin-induced, integrin-dependent migration of human mammary epithelial cells involves activation of the hepatocyte growth factor receptor (Met)

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7 January 2021

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inferred from DOI database lookup

Identifiers

10.1038/SJ.ONC.1207063

1 reference

Europe PubMed Central

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21 December 2019

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14627990%20AND%20SRC:MED&resulttype=core&format=json

21 December 2019

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