The type I interferon response during viral infections: a "SWOT" analysis (Q37942501)

25 August 2017

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title

The type I interferon response during viral infections: a "SWOT" analysis (English)

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25 August 2017

Giel R Gaajetaan

1

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25 August 2017

Cathrien A Bruggeman

series ordinal

2

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25 August 2017

Frank R Stassen

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3

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25 August 2017

language of work or name

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3 October 2011

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25 August 2017

16

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Reviews in Medical Virology

inferred from page(s)

published in

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25 August 2017

22

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25 August 2017

122-137

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25 August 2017

2

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HIV: a discovery opening the road to novel scientific knowledge and global health improvement

25 August 2017

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Origins and evolutionary genomics of the 2009 swine-origin H1N1 influenza A epidemic

21 January 2018

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Emergence and pandemic potential of swine-origin H1N1 influenza virus

21 January 2018

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Respiratory viral infections in infants: causes, clinical symptoms, virology, and immunology

21 January 2018

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Intracellular toll-like receptors

21 January 2018

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Toll-like receptors in the induction of the innate immune response

21 January 2018

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Toll-like receptors: critical proteins linking innate and acquired immunity

21 January 2018

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The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors

21 January 2018

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Plasmacytoid dendritic cell precursors/type I interferon-producing cells sense viral infection by Toll-like receptor (TLR) 7 and TLR9.

21 January 2018

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Cooperation of Toll-like receptor signals in innate immune defence

21 January 2018

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Innate immune functions of plasmacytoid dendritic cells

21 January 2018

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Intracellular localization of Toll-like receptor 9 prevents recognition of self DNA but facilitates access to viral DNA.

21 January 2018

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Recognition of single-stranded RNA viruses by Toll-like receptor 7

21 January 2018

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Innate antiviral responses by means of TLR7-mediated recognition of single-stranded RNA

21 January 2018

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Toll-like receptor 9-mediated recognition of Herpes simplex virus-2 by plasmacytoid dendritic cells

21 January 2018

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Double-stranded RNA is produced by positive-strand RNA viruses and DNA viruses but not in detectable amounts by negative-strand RNA viruses

21 January 2018

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Pattern recognition receptors TLR4 and CD14 mediate response to respiratory syncytial virus

21 January 2018

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Dual recognition of herpes simplex viruses by TLR2 and TLR9 in dendritic cells

21 January 2018

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Toll-like receptor 2 on inflammatory monocytes induces type I interferon in response to viral but not bacterial ligands

21 January 2018

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Polymorphisms in TLR2 are associated with increased viral shedding and lesional rate in patients with genital herpes simplex virus Type 2 infection

21 January 2018

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Varicella-zoster virus activates inflammatory cytokines in human monocytes and macrophages via Toll-like receptor 2.

21 January 2018

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Recognition of viral single-stranded RNA by Toll-like receptors

21 January 2018

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Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses

21 January 2018

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Innate immune response and viral interference strategies developed by human herpesviruses

21 January 2018

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Recognition of viruses by cytoplasmic sensors

21 January 2018

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Distinct RIG-I and MDA5 Signaling by RNA Viruses in Innate Immunity

21 January 2018

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Differential recognition of double-stranded RNA by RIG-I-like receptors in antiviral immunity.

21 January 2018

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Length-dependent recognition of double-stranded ribonucleic acids by retinoic acid-inducible gene-I and melanoma differentiation-associated gene 5

21 January 2018

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DAI (DLM-1/ZBP1) is a cytosolic DNA sensor and an activator of innate immune response

21 January 2018

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Intracellular DNA recognition

21 January 2018

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Dendritic cells and C-type lectin receptors: coupling innate to adaptive immune responses

21 January 2018

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Activation of dendritic cells by toll-like receptors and C-type lectins

21 January 2018

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Signalling through C-type lectin receptors: shaping immune responses

21 January 2018

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Inflammasome recognition of influenza virus is essential for adaptive immune responses

21 January 2018

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The intracellular sensor NLRP3 mediates key innate and healing responses to influenza A virus via the regulation of caspase-1

21 January 2018

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The NLRP3 inflammasome mediates in vivo innate immunity to influenza A virus through recognition of viral RNA.

21 January 2018

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The inflammasome recognizes cytosolic microbial and host DNA and triggers an innate immune response

21 January 2018

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Innate immune sensing of modified vaccinia virus Ankara (MVA) is mediated by TLR2-TLR6, MDA-5 and the NALP3 inflammasome

21 January 2018

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Molecular mechanisms involved in inflammasome activation

21 January 2018

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The AIM2 inflammasome is essential for host defense against cytosolic bacteria and DNA viruses

21 January 2018

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Recognition of herpesviruses by the innate immune system

21 January 2018

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Innate recognition of viruses

21 January 2018

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Reconstitution of virus-mediated expression of interferon alpha genes in human fibroblast cells by ectopic interferon regulatory factor-7.

21 January 2018

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IPC: professional type 1 interferon-producing cells and plasmacytoid dendritic cell precursors

21 January 2018

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The role of type I interferon production by dendritic cells in host defense

21 January 2018

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Autophagy-dependent viral recognition by plasmacytoid dendritic cells

21 January 2018

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The ectodomain of Toll-like receptor 9 is cleaved to generate a functional receptor.

21 January 2018

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Proteolytic cleavage in an endolysosomal compartment is required for activation of Toll-like receptor 9

21 January 2018

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Toll-like receptor and RIG-I-like receptor signaling

21 January 2018

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Cell type-specific involvement of RIG-I in antiviral response

21 January 2018

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NF-kappa B RelA subunit is crucial for early IFN-beta expression and resistance to RNA virus replication

21 January 2018

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Distinct and essential roles of transcription factors IRF-3 and IRF-7 in response to viruses for IFN-alpha/beta gene induction

21 January 2018

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The interferon-alpha/beta system in antiviral responses: a multimodal machinery of gene regulation by the IRF family of transcription factors

21 January 2018

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Activation with CpG-A and CpG-B oligonucleotides reveals two distinct regulatory pathways of type I IFN synthesis in human plasmacytoid dendritic cells.

21 January 2018

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Tissue-specific positive feedback requirements for production of type I interferon following virus infection

21 January 2018

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Comparative analysis of IRF and IFN-alpha expression in human plasmacytoid and monocyte-derived dendritic cells

21 January 2018

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The nature of the principal type 1 interferon-producing cells in human blood

21 January 2018

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Plasmacytoid dendritic cells in immunity

21 January 2018

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Interferon-alpha and interleukin-12 are induced differentially by Toll-like receptor 7 ligands in human blood dendritic cell subsets

21 January 2018

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Synthetic TLR agonists reveal functional differences between human TLR7 and TLR8.

21 January 2018

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Interleukin-12 and the regulation of innate resistance and adaptive immunity

21 January 2018

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Identification of genes differentially regulated by interferon alpha, beta, or gamma using oligonucleotide arrays

21 January 2018

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Are dendritic cells afraid of commitment?

21 January 2018

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Interferon-inducible antiviral effectors

21 January 2018

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Negative regulation of protein phosphatase 2Cbeta by ISG15 conjugation

21 January 2018

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Interferon-induced human MxA GTPase blocks nuclear import of Thogoto virus nucleocapsids

21 January 2018

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The antiviral dynamin family member, MxA, tubulates lipids and localizes to the smooth endoplasmic reticulum

21 January 2018

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Antivirally active MxA protein sequesters La Crosse virus nucleocapsid protein into perinuclear complexes

21 January 2018

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2-5A induces a conformational change in the ankyrin-repeat domain of RNase L.

21 January 2018

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Inhibition of Lassa and Marburg virus production by tetherin

21 January 2018

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Antiviral activity of the interferon-induced cellular protein BST-2/tetherin

21 January 2018

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Broad-spectrum inhibition of retroviral and filoviral particle release by tetherin

21 January 2018

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Induction of APOBEC3 family proteins, a defensive maneuver underlying interferon-induced anti-HIV-1 activity

21 January 2018

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Broad antiretroviral defence by human APOBEC3G through lethal editing of nascent reverse transcripts

21 January 2018

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Recent insights into the mechanism and consequences of TRIM5α retroviral restriction

21 January 2018

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Stimulation of the primary anti-HIV antibody response by IFN-alpha in patients with acute HIV-1 infection

21 January 2018

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Type I interferons keep activated T cells alive

21 January 2018

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Interferons at age 50: past, current and future impact on biomedicine

21 January 2018

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Interferon modulation of cellular microRNAs as an antiviral mechanism

21 January 2018

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MicroRNA regulation of IFN-beta protein expression: rapid and sensitive modulation of the innate immune response

21 January 2018

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Viral evasion and subversion of pattern-recognition receptor signalling

21 January 2018

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Mechanisms of inhibition of the host interferon alpha/beta-mediated antiviral responses by viruses

21 January 2018

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Select paramyxoviral V proteins inhibit IRF3 activation by acting as alternative substrates for inhibitor of kappaB kinase epsilon (IKKe)/TBK1.

21 January 2018

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Identification of the rabies virus alpha/beta interferon antagonist: phosphoprotein P interferes with phosphorylation of interferon regulatory factor 3.

21 January 2018

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The vaccinia virus soluble alpha/beta interferon (IFN) receptor binds to the cell surface and protects cells from the antiviral effects of IFN.

21 January 2018

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Vaccinia virus B18R gene encodes a type I interferon-binding protein that blocks interferon alpha transmembrane signaling

21 January 2018

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Deubiquitinating and interferon antagonism activities of coronavirus papain-like proteases.

21 January 2018

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Influenza B virus NS1 protein inhibits conjugation of the interferon (IFN)-induced ubiquitin-like ISG15 protein

21 January 2018

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Hepatitis C virus blocks interferon effector function by inducing protein kinase R phosphorylation

21 January 2018

1 reference

Molecular mechanisms of interferon resistance mediated by viral-directed inhibition of PKR, the interferon-induced protein kinase

21 January 2018

1 reference

Evasion of innate and adaptive immune responses by influenza A virus

21 January 2018

1 reference

The multifunctional NS1 protein of influenza A viruses

21 January 2018

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Lethal H5N1 influenza viruses escape host anti-viral cytokine responses

21 January 2018

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Induction of proinflammatory cytokines in human macrophages by influenza A (H5N1) viruses: a mechanism for the unusual severity of human disease?

21 January 2018

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Fatal outcome of human influenza A (H5N1) is associated with high viral load and hypercytokinemia

21 January 2018

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Proinflammatory cytokine responses induced by influenza A (H5N1) viruses in primary human alveolar and bronchial epithelial cells

21 January 2018

1 reference

Pathology, molecular biology, and pathogenesis of avian influenza A (H5N1) infection in humans

21 January 2018

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Avian influenza A (H5N1) infection in humans

21 January 2018

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Aberrant innate immune response in lethal infection of macaques with the 1918 influenza virus

21 January 2018

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Global suppression of the host antiviral response by Ebola- and Marburgviruses: increased antagonism of the type I interferon response is associated with enhanced virulence

21 January 2018

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Monocyte-derived human macrophages and peripheral blood mononuclear cells infected with ebola virus secrete MIP-1alpha and TNF-alpha and inhibit poly-IC-induced IFN-alpha in vitro.

21 January 2018

1 reference

Decreased frequency of functional natural interferon-producing cells in peripheral blood of patients with the acquired immune deficiency syndrome

21 January 2018

1 reference

Plasmacytoid dendritic cells in HIV infection: striking a delicate balance

21 January 2018

1 reference

Exogenous HIV-1 Vpr disrupts IFN-alpha response by plasmacytoid dendritic cells (pDCs) and subsequent pDC/NK interplay

21 January 2018

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The interferon-induced protein BST-2 restricts HIV-1 release and is downregulated from the cell surface by the viral Vpu protein

21 January 2018

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HIV-1 immunopathogenesis: how good interferon turns bad.

21 January 2018

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Differential expression of IFN-alpha and TRAIL/DR5 in lymphoid tissue of progressor versus nonprogressor HIV-1-infected patients.

21 January 2018

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Combined antiviral options for the treatment of chronic hepatitis C.

21 January 2018

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Activation of anti-hepatitis C virus responses via Toll-like receptor 7.

21 January 2018

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Multiple effects of interferon on the replication of human immunodeficiency virus type 1.

21 January 2018

1 reference

Interferon-alpha in patients with asymptomatic human immunodeficiency virus (HIV) infection. A randomized, placebo-controlled trial

21 January 2018

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Low-dose IFN-alpha monotherapy in treatment-naive individuals with HIV-1 infection: evidence of potent suppression of viral replication.

21 January 2018

1 reference

High-dose interferon-alpha2a exerts potent activity against human immunodeficiency virus type 1 not associated with antitumor activity in subjects with Kaposi's sarcoma

21 January 2018

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Phase I trial of interferon alfa-n3 in early-stage human immunodeficiency virus type 1 disease: evidence for drug safety, tolerance, and antiviral activity.

21 January 2018

1 reference

A randomized controlled trial of low-dose recombinant human interferons alpha-2b nasal spray to prevent acute viral respiratory infections in military recruits

21 January 2018

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SARS: systematic review of treatment effects

21 January 2018

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Characterization of the antiviral effects of interferon-alpha against a SARS-like coronoavirus infection in vitro

21 January 2018

1 reference

Interferon alfacon-1 plus corticosteroids in severe acute respiratory syndrome: a preliminary study

21 January 2018

1 reference

Interferon and cytokine responses to SARS-coronavirus infection

21 January 2018

1 reference

Human immunopathogenesis of severe acute respiratory syndrome (SARS).

21 January 2018

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Pathogenesis of severe acute respiratory syndrome

21 January 2018

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Plasma inflammatory cytokines and chemokines in severe acute respiratory syndrome.

21 January 2018

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Lambda interferon is the predominant interferon induced by influenza A virus infection in vivo

21 January 2018

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Respiratory virus induction of alpha-, beta- and lambda-interferons in bronchial epithelial cells and peripheral blood mononuclear cells

21 January 2018

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Lambda interferon renders epithelial cells of the respiratory and gastrointestinal tracts resistant to viral infections

21 January 2018

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Influenza A virus replication is inhibited in IFN-λ2 and IFN-λ3 transfected or stimulated cells

21 January 2018

1 reference

Therapeutic potential of Toll-like receptor 9 activation

21 January 2018

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Using 3 TLR ligands as a combination adjuvant induces qualitative changes in T cell responses needed for antiviral protection in mice

21 January 2018

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Translating innate immunity into immunological memory: implications for vaccine development

21 January 2018

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Therapeutic targeting of innate immunity with Toll-like receptor agonists and antagonists

21 January 2018

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Chirality of TLR-2 ligand Pam3CysSK4 in fully synthetic peptide conjugates critically influences the induction of specific CD8+ T-cells

21 January 2018

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Role of IFN-alpha/beta signaling in the prevention of genital herpes virus type 2 infection.

21 January 2018

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Prophylaxis of acute respiratory virus infections using nucleic acid-based drugs.

21 January 2018

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Effect of pretreatment with toll-like receptor agonists in a mouse model of herpes simplex virus type 1 encephalitis

21 January 2018

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Induction of innate immunity against herpes simplex virus type 2 infection via local delivery of Toll-like receptor ligands correlates with beta interferon production.

21 January 2018

1 reference

Rational design of new CpG oligonucleotides that combine B cell activation with high IFN-alpha induction in plasmacytoid dendritic cells

21 January 2018

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Identification of a novel CpG DNA class and motif that optimally stimulate B cell and plasmacytoid dendritic cell functions

21 January 2018

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Characterization of three CpG oligodeoxynucleotide classes with distinct immunostimulatory activities.

21 January 2018

1 reference

Plasmacytoid dendritic cells produce cytokines and mature in response to the TLR7 agonists, imiquimod and resiquimod

21 January 2018

1 reference

Small anti-viral compounds activate immune cells via the TLR7 MyD88-dependent signaling pathway

21 January 2018

1 reference

Species-specific recognition of single-stranded RNA via toll-like receptor 7 and 8

21 January 2018

1 reference

Treatment of intravaginal HSV-2 infection in mice: a comparison of CpG oligodeoxynucleotides and resiquimod (R-848).

21 January 2018

1 reference

Current and potential uses of imiquimod

21 January 2018

1 reference

Isatoribine, an agonist of TLR7, reduces plasma virus concentration in chronic hepatitis C infection

21 January 2018

1 reference

Oral resiquimod in chronic HCV infection: safety and efficacy in 2 placebo-controlled, double-blind phase IIa studies

21 January 2018

1 reference

Phase 1B, randomized, double-blind, dose-escalation trial of CPG 10101 in patients with chronic hepatitis C virus

21 January 2018

1 reference

Innate immunity and chronic immune activation in HCV/HIV-1 co-infection

21 January 2018

1 reference

Toll-Like Receptor Ligands Modulate Dendritic Cells to Augment Cytomegalovirus- and HIV-1-Specific T Cell Responses

21 January 2018

1 reference

Decreased frequency and function of circulating plasmocytoid dendritic cells (pDC) in hepatitis B virus infected humans

21 January 2018

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Reduced numbers and impaired ability of myeloid and plasmacytoid dendritic cells to polarize T helper cells in chronic hepatitis C virus infection

21 January 2018

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The potential use of Toll-like receptor agonists to restore the dysfunctional immunity induced by hepatitis C virus.

21 January 2018

1 reference

Differential dysfunction in dendritic cell subsets during chronic HCV infection.

21 January 2018

1 reference

Evidence of dysregulation of dendritic cells in primary HIV infection

21 January 2018

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Loss of blood CD11c(+) myeloid and CD11c(-) plasmacytoid dendritic cells in patients with HIV-1 infection correlates with HIV-1 RNA virus load

21 January 2018

1 reference

Plasmacytoid dendritic cells limit viral replication, pulmonary inflammation, and airway hyperresponsiveness in respiratory syncytial virus infection

21 January 2018

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Targeting signal transduction as a strategy to treat inflammatory diseases.

21 January 2018

1 reference

Functional and therapeutic analysis of hepatitis C virus NS3.4A protease control of antiviral immune defense

21 January 2018

1 reference

CpG motifs in bacterial DNA and their immune effects

21 January 2018

1 reference

Plasmacytoid dendritic cells: sensing nucleic acids in viral infection and autoimmune diseases.

21 January 2018

1 reference

Type I interferon in systemic lupus erythematosus and other autoimmune diseases

21 January 2018

1 reference

Possible induction of systemic lupus erythematosus by interferon-α treatment in a patient with a malignant carcinoid tumour

21 January 2018

1 reference

TLR-dependent and TLR-independent pathways of type I interferon induction in systemic autoimmunity

21 January 2018

1 reference

Role of natural interferon-alpha producing cells (plasmacytoid dendritic cells) in autoimmunity

21 January 2018

1 reference

Use of functional genomics to understand influenza-host interactions.

21 January 2018

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TLR agonists as vaccine adjuvants: comparison of CpG ODN and Resiquimod (R-848).

21 January 2018

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A Toll-like receptor recognizes bacterial DNA

21 January 2018

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Dendritic cells from HIV-1 infected individuals are less responsive to toll-like receptor (TLR) ligands.

21 January 2018

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Cutting edge: activation of murine TLR8 by a combination of imidazoquinoline immune response modifiers and polyT oligodeoxynucleotides

21 January 2018

1 reference

The development of murine plasmacytoid dendritic cell precursors is differentially regulated by FLT3-ligand and granulocyte/macrophage colony-stimulating factor

21 January 2018

1 reference

Viral induction of low frequency interferon-alpha producing cells

21 January 2018

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New respiratory viruses of humans

21 January 2018

1 reference

TLR9-Dependent Recognition of MCMV by IPC and DC Generates Coordinated Cytokine Responses that Activate Antiviral NK Cell Function

21 January 2018

1 reference

Mechanistic Link between PKR Dimerization, Autophosphorylation, and eIF2α Substrate Recognition

21 January 2018

1 reference

Global epidemiology of HIV

21 January 2018

1 reference

Role of deficient type III interferon-λ production in asthma exacerbations

21 January 2018

1 reference

In vitro and in vivo secretion of human ISG15, an IFN-induced immunomodulatory cytokine.

21 January 2018

1 reference

12 December 2020

Clinical investigations of Toll-like receptor agonists

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12 December 2020

Side effects of therapy of hepatitis C and their management

1 reference

12 December 2020

Long-term treatment with recombinant interferon alpha-2b prolongs survival of asymptomatic HIV-infected individuals

1 reference

12 December 2020

The origin and virulence of the 1918 "Spanish" influenza virus.

1 reference

12 December 2020

Experimental rhinovirus infection as a human model of chronic obstructive pulmonary disease exacerbation

1 reference

12 December 2020

Alpha interferon-induced antiretroviral activities: restriction of viral nucleic acid synthesis and progeny virion production in human immunodeficiency virus type 1-infected monocytes

1 reference

12 December 2020

Administration of a dual toll-like receptor 7 and toll-like receptor 8 agonist protects against influenza in rats

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12 December 2020

Murine plasmacytoid pre-dendritic cells generated from Flt3 ligand-supplemented bone marrow cultures are immature APCs

1 reference

12 December 2020

Hepatic microRNA expression is associated with the response to interferon treatment of chronic hepatitis C

1 reference

12 December 2020

Specialization, kinetics, and repertoire of type 1 interferon responses by human plasmacytoid predendritic cells

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12 December 2020

ISG15 enhances the innate antiviral response by inhibition of IRF-3 degradation.

1 reference

12 December 2020

Depletion of circulating natural type 1 interferon-producing cells in HIV-infected AIDS patients

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12 December 2020

Fc gamma RIIa is expressed on natural IFN-alpha-producing cells (plasmacytoid dendritic cells) and is required for the IFN-alpha production induced by apoptotic cells combined with lupus IgG

1 reference

12 December 2020

Boosting p53 with interferon and viruses

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12 December 2020

Genomic analysis of increased host immune and cell death responses induced by 1918 influenza virus

1 reference

12 December 2020

Dendritic cell numbers in the blood of HIV-1 infected patients before and after changes in antiretroviral therapy

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12 December 2020

Cross-talk between human dendritic cell subsets influences expression of RNA sensors and inhibits picornavirus infection

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12 December 2020

Identifiers

DOI

10.1002/RMV.713

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25 August 2017

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