Functional and therapeutic analysis of hepatitis C virus NS3.4A protease control of antiviral immune defense (Q40173025)

18 September 2017

Functional and therapeutic analysis of hepatitis C virus NS3.4A protease control of antiviral immune defense (English)

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18 September 2017

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3

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18 September 2017

David M Owen

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author name string

Cynthia L Johnson

series ordinal

1

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PubMed ID

17289677

18 September 2017

language of work or name

English

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publication date

8 February 2007

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Journal of Biological Chemistry

18 September 2017

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18 September 2017

282

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18 September 2017

10792-10803

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18 September 2017

14

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Recovery, persistence, and sequelae in hepatitis C virus infection: a perspective on long-term outcome

18 September 2017

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610361200

Evasion of intracellular host defence by hepatitis C virus

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M610361200

Principles of intracellular viral recognition.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610361200

Shared and unique functions of the DExD/H-box helicases RIG-I, MDA5, and LGP2 in antiviral innate immunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610361200

The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M610361200

Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M610361200

Regulation of innate antiviral defenses through a shared repressor domain in RIG-I and LGP2

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610361200

Regulating intracellular antiviral defense and permissiveness to hepatitis C virus RNA replication through a cellular RNA helicase, RIG-I

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M610361200

Viral evolution and interferon resistance of hepatitis C virus RNA replication in a cell culture model

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M610361200

CARD games between virus and host get a new player

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M610361200

IPS-1, an adaptor triggering RIG-I- and Mda5-mediated type I interferon induction

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M610361200

Identification and characterization of MAVS, a mitochondrial antiviral signaling protein that activates NF-kappaB and IRF 3

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M610361200

VISA is an adapter protein required for virus-triggered IFN-beta signaling

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M610361200

Cardif is an adaptor protein in the RIG-I antiviral pathway and is targeted by hepatitis C virus

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M610361200

IKKepsilon and TBK1 are essential components of the IRF3 signaling pathway

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M610361200

Control of IRF-3 activation by phosphorylation

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M610361200

Transcriptional profiling of interferon regulatory factor 3 target genes: direct involvement in the regulation of interferon-stimulated genes

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M610361200

21 January 2018

Signaling to NF-kappaB

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https://api.crossref.org/works/10.1074%2FJBC.M610361200

Regulation of PKR and IRF-1 during hepatitis C virus RNA replication

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M610361200

Alpha interferon induces distinct translational control programs to suppress hepatitis C virus RNA replication

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M610361200

Regulation of Interferon Regulatory Factor-3 by the Hepatitis C Virus Serine Protease

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M610361200

21 January 2018

Viruses and interferons

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https://api.crossref.org/works/10.1074%2FJBC.M610361200

Control of antiviral defenses through hepatitis C virus disruption of retinoic acid-inducible gene-I signaling

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M610361200

Hepatitis C virus protease NS3/4A cleaves mitochondrial antiviral signaling protein off the mitochondria to evade innate immunity

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M610361200

Viral and therapeutic control of IFN-beta promoter stimulator 1 during hepatitis C virus infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610361200

The NS3/4A proteinase of the hepatitis C virus: unravelling structure and function of an unusual enzyme and a prime target for antiviral therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610361200

Recent advances in the molecular biology of hepatitis C virus

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M610361200

Subcellular localization, stability, and trans-cleavage competence of the hepatitis C virus NS3-NS4A complex expressed in tetracycline-regulated cell lines

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M610361200

Hepatitis C virus NS3 RNA helicase activity is modulated by the two domains of NS3 and NS4A.

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M610361200

The RNA-unwinding activity of hepatitis C virus non-structural protein 3 (NS3) is positively modulated by its protease domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610361200

Stimulation of hepatitis C virus (HCV) nonstructural protein 3 (NS3) helicase activity by the NS3 protease domain and by HCV RNA-dependent RNA polymerase

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M610361200

An RNA ligand inhibits hepatitis C virus NS3 protease and helicase activities

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M610361200

Inhibition of HCV NS3 protease by RNA aptamers in cells

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M610361200

Molecular views of viral polyprotein processing revealed by the crystal structure of the hepatitis C virus bifunctional protease-helicase

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M610361200

Protein kinase C recognizes the protein kinase A-binding motif of nonstructural protein 3 of hepatitis C virus

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610361200

Strategies for hepatitis C therapeutic intervention: now and next

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610361200

Mechanism of action of interferon and ribavirin in treatment of hepatitis C

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610361200

Construction, expression, and characterization of a novel fully activated recombinant single-chain hepatitis C virus protease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610361200

Identification of FBL2 as a geranylgeranylated cellular protein required for hepatitis C virus RNA replication

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610361200

Activation of the interferon-beta promoter during hepatitis C virus RNA replication.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610361200

Continuous human cell lines inducibly expressing hepatitis C virus structural and nonstructural proteins

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M610361200

Non-peptidic small-molecule inhibitors of the single-chain hepatitis C virus NS3 protease/NS4A cofactor complex discovered by structure-based NMR screening

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M610361200

Production of infectious hepatitis C virus in tissue culture from a cloned viral genome

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M610361200

The crystal structure of hepatitis C virus NS3 proteinase reveals a trypsin-like fold and a structural zinc binding site

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M610361200

Non-structural protein 4A of Hepatitis C virus accumulates on mitochondria and renders the cells prone to undergoing mitochondria-mediated apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610361200

Crystal structure of the hepatitis C virus NS3 protease domain complexed with a synthetic NS4A cofactor peptide

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610361200

The conformation of hepatitis C virus NS3 proteinase with and without NS4A: a structural basis for the activation of the enzyme by its cofactor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610361200

Immune evasion by hepatitis C virus NS3/4A protease-mediated cleavage of the Toll-like receptor 3 adaptor protein TRIF

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610361200

Molecular determinants of TRIF proteolysis mediated by the hepatitis C virus NS3/4A protease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610361200

NF-kappaB signaling pathways in mammalian and insect innate immunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610361200

Dissociation of a MAVS/IPS-1/VISA/Cardif-IKKepsilon molecular complex from the mitochondrial outer membrane by hepatitis C virus NS3-4A proteolytic cleavage

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610361200

Regulation of antiviral responses by a direct and specific interaction between TRAF3 and Cardif

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610361200

Hepatitis C and liver transplantation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610361200

21 January 2018

Identifiers

DOI

10.1074/JBC.M610361200

1 reference

18 September 2017

1 reference

PubMed ID

17289677