Interactions of Zn(II) and Cu(II) ions with Alzheimer's amyloid-beta peptide. Metal ion binding, contribution to fibrillization and toxicity (Q37848098)

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scientific article published on 25 February 2011

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English	Interactions of Zn(II) and Cu(II) ions with Alzheimer's amyloid-beta peptide. Metal ion binding, contribution to fibrillization and toxicity	scientific article published on 25 February 2011

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scholarly article

1 reference

Europe PubMed Central

24 August 2017

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Europe PubMed Central

Interactions of Zn(II) and Cu(II) ions with Alzheimer's amyloid-beta peptide. Metal ion binding, contribution to fibrillization and toxicity (English)

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Europe PubMed Central

24 August 2017

Alzheimer's disease

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metal poisoning

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object named as

Vello Tõugu

1

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author name string

Ann Tiiman

2

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Europe PubMed Central

24 August 2017

Peep Palumaa

3

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Europe PubMed Central

24 August 2017

publication date

25 February 2011

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Europe PubMed Central

24 August 2017

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Europe PubMed Central

24 August 2017

3

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Europe PubMed Central

24 August 2017

3

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Europe PubMed Central

24 August 2017

250-261

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Europe PubMed Central

24 August 2017

Alzheimer's disease: the amyloid cascade hypothesis

1 reference

https://api.crossref.org/works/10.1039%2FC0MT00073F

21 January 2018

Cellular processing of beta-amyloid precursor protein and the genesis of amyloid beta-peptide

1 reference

https://api.crossref.org/works/10.1039%2FC0MT00073F

21 January 2018

A beta oligomers - a decade of discovery

1 reference

https://api.crossref.org/works/10.1039%2FC0MT00073F

21 January 2018

Copper homeostasis and neurodegenerative disorders (Alzheimer's, prion, and Parkinson's diseases and amyotrophic lateral sclerosis).

1 reference

https://api.crossref.org/works/10.1039%2FC0MT00073F

21 January 2018

Alzheimer's disease, metal ions and metal homeostatic therapy

1 reference

https://api.crossref.org/works/10.1039%2FC0MT00073F

21 January 2018

Copper in the brain and Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1039%2FC0MT00073F

21 January 2018

Copper and Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1039%2FC0MT00073F

21 January 2018

Metals in Alzheimer's and Parkinson's diseases

1 reference

https://api.crossref.org/works/10.1039%2FC0MT00073F

21 January 2018

Zinc in the physiology and pathology of the CNS.

1 reference

https://api.crossref.org/works/10.1039%2FC0MT00073F

21 January 2018

NMDA receptor activation mediates copper homeostasis in hippocampal neurons

1 reference

https://api.crossref.org/works/10.1039%2FC0MT00073F

21 January 2018

Methods for studying synaptosomal copper release

1 reference

https://api.crossref.org/works/10.1039%2FC0MT00073F

21 January 2018

Therapeutics for Alzheimer's disease based on the metal hypothesis

1 reference

https://api.crossref.org/works/10.1039%2FC0MT00073F

21 January 2018

The modulation of metal bio-availability as a therapeutic strategy for the treatment of Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1039%2FC0MT00073F

21 January 2018

Copper, iron and zinc in Alzheimer's disease senile plaques.

1 reference

https://api.crossref.org/works/10.1039%2FC0MT00073F

21 January 2018

Synchrotron-based infrared and X-ray imaging shows focalized accumulation of Cu and Zn co-localized with beta-amyloid deposits in Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1039%2FC0MT00073F

21 January 2018

A novel approach to the identification and quantitative elemental analysis of amyloid deposits--insights into the pathology of Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1039%2FC0MT00073F

21 January 2018

Imaging and spatial distribution of beta-amyloid peptide and metal ions in Alzheimer's plaques by laser ablation-inductively coupled plasma-mass spectrometry

1 reference

https://api.crossref.org/works/10.1039%2FC0MT00073F

21 January 2018

Alzheimer's disease amyloid-beta binds copper and zinc to generate an allosterically ordered membrane-penetrating structure containing superoxide dismutase-like subunits

1 reference

https://api.crossref.org/works/10.1039%2FC0MT00073F

21 January 2018

Binding of Zn(II), Cu(II), and Fe(II) ions to Alzheimer's A beta peptide studied by fluorescence

1 reference

https://api.crossref.org/works/10.1039%2FC0MT00073F

21 January 2018

Dramatic aggregation of Alzheimer abeta by Cu(II) is induced by conditions representing physiological acidosis.

1 reference

https://api.crossref.org/works/10.1039%2FC0MT00073F

21 January 2018

Metal binding and oxidation of amyloid-beta within isolated senile plaque cores: Raman microscopic evidence

1 reference

https://api.crossref.org/works/10.1039%2FC0MT00073F

21 January 2018

Aluminum-triggered structural modifications and aggregation of beta-amyloids

1 reference

https://api.crossref.org/works/10.1039%2FC0MT00073F

21 January 2018

Trace metal contamination initiates the apparent auto-aggregation, amyloidosis, and oligomerization of Alzheimer's Abeta peptides.

1 reference

https://api.crossref.org/works/10.1039%2FC0MT00073F

21 January 2018

Mutual stimulation of beta-amyloid fibrillogenesis by clioquinol and divalent metals

1 reference

https://api.crossref.org/works/10.1039%2FC0MT00073F

21 January 2018

Effects of cyclen and cyclam on zinc(II)- and copper(II)-induced amyloid beta-peptide aggregation and neurotoxicity.

1 reference

https://api.crossref.org/works/10.1039%2FC0MT00073F

21 January 2018

Design, selection, and characterization of thioflavin-based intercalation compounds with metal chelating properties for application in Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1039%2FC0MT00073F

21 January 2018

Mechanism of zinc(II)-promoted amyloid formation: zinc(II) binding facilitates the transition from the partially alpha-helical conformer to aggregates of amyloid beta protein(1-28).

1 reference

https://api.crossref.org/works/10.1039%2FC0MT00073F

21 January 2018

Concentration dependent Cu2+ induced aggregation and dityrosine formation of the Alzheimer's disease amyloid-beta peptide.

1 reference

https://api.crossref.org/works/10.1039%2FC0MT00073F

21 January 2018

Substoichiometric levels of Cu2+ ions accelerate the kinetics of fiber formation and promote cell toxicity of amyloid-{beta} from Alzheimer disease

1 reference

https://api.crossref.org/works/10.1039%2FC0MT00073F

21 January 2018

Contribution by synaptic zinc to the gender-disparate plaque formation in human Swedish mutant APP transgenic mice

1 reference

https://api.crossref.org/works/10.1039%2FC0MT00073F

21 January 2018

Trace amounts of copper in water induce beta-amyloid plaques and learning deficits in a rabbit model of Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1039%2FC0MT00073F

21 January 2018

Control of Alzheimer's amyloid beta toxicity by the high molecular weight immunophilin FKBP52 and copper homeostasis in Drosophila

1 reference

https://api.crossref.org/works/10.1039%2FC0MT00073F

21 January 2018

Cu(II) potentiation of alzheimer abeta neurotoxicity. Correlation with cell-free hydrogen peroxide production and metal reduction.

1 reference

https://api.crossref.org/works/10.1039%2FC0MT00073F

21 January 2018

The redox chemistry of the Alzheimer's disease amyloid beta peptide.

1 reference

https://api.crossref.org/works/10.1039%2FC0MT00073F

21 January 2018

The Cu(II)/Abeta/human serum albumin model of control mechanism for copper-related amyloid neurotoxicity.

1 reference

https://api.crossref.org/works/10.1039%2FC0MT00073F

21 January 2018

Copper transfer from Cu-Abeta to human serum albumin inhibits aggregation, radical production and reduces Abeta toxicity.

1 reference

https://api.crossref.org/works/10.1039%2FC0MT00073F

21 January 2018

Redox silencing of copper in metal-linked neurodegenerative disorders: reaction of Zn7metallothionein-3 with Cu2+ ions.

1 reference

https://api.crossref.org/works/10.1039%2FC0MT00073F

21 January 2018

Aqueous dissolution of Alzheimer's disease Abeta amyloid deposits by biometal depletion.

1 reference

https://api.crossref.org/works/10.1039%2FC0MT00073F

21 January 2018

Bioinorganic chemistry of copper and zinc ions coordinated to amyloid-beta peptide

1 reference

https://api.crossref.org/works/10.1039%2FC0MT00073F

21 January 2018

Copper binding to the amyloid-beta (Abeta) peptide associated with Alzheimer's disease: folding, coordination geometry, pH dependence, stoichiometry, and affinity of Abeta-(1-28): insights from a range of complementary spectroscopic techniques

1 reference

https://api.crossref.org/works/10.1039%2FC0MT00073F

21 January 2018

Structural and thermodynamical properties of CuII amyloid-beta16/28 complexes associated with Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1039%2FC0MT00073F

21 January 2018

Identifying the minimal copper- and zinc-binding site sequence in amyloid-beta peptides

1 reference

https://api.crossref.org/works/10.1039%2FC0MT00073F

21 January 2018

Copper(I) and copper(II) binding to β-amyloid 16 (Aβ16) studied by electrospray ionization mass spectrometry

1 reference

https://api.crossref.org/works/10.1039%2FC0MT00073F

21 January 2018

Deprotonation of the Asp1-Ala2 peptide bond induces modification of the dynamic copper(II) environment in the amyloid-beta peptide near physiological pH.

1 reference

https://api.crossref.org/works/10.1039%2FC0MT00073F

21 January 2018

Alanine-2 carbonyl is an oxygen ligand in Cu2+ coordination of Alzheimer's disease amyloid-beta peptide--relevance to N-terminally truncated forms.

1 reference

https://api.crossref.org/works/10.1039%2FC0MT00073F

21 January 2018

Direct evidence that all three histidine residues coordinate to Cu(II) in amyloid-beta1-16.

1 reference

https://api.crossref.org/works/10.1039%2FC0MT00073F

21 January 2018

Coordination of copper(II) ions by the 11-20 and 11-28 fragments of human and mouse beta-amyloid peptide

1 reference

https://api.crossref.org/works/10.1039%2FC0MT00073F

21 January 2018

Copper(II) binding to amyloid-beta fibrils of Alzheimer's disease reveals a picomolar affinity: stoichiometry and coordination geometry are independent of Abeta oligomeric form

1 reference

https://api.crossref.org/works/10.1039%2FC0MT00073F

21 January 2018

Pleomorphic copper coordination by Alzheimer's disease amyloid-beta peptide

1 reference

https://api.crossref.org/works/10.1039%2FC0MT00073F

21 January 2018

The second Cu(II)-binding site in a proton-rich environment interferes with the aggregation of amyloid-beta(1-40) into amyloid fibrils

1 reference

https://api.crossref.org/works/10.1039%2FC0MT00073F

21 January 2018

Metal binding modes of Alzheimer's amyloid beta-peptide in insoluble aggregates and soluble complexes.

1 reference

https://api.crossref.org/works/10.1039%2FC0MT00073F

21 January 2018

The aggregated state of amyloid-beta peptide in vitro depends on Cu2+ ion concentration.

1 reference

https://api.crossref.org/works/10.1039%2FC0MT00073F

21 January 2018

Copper-mediated amyloid-beta toxicity is associated with an intermolecular histidine bridge.

1 reference

https://api.crossref.org/works/10.1039%2FC0MT00073F

21 January 2018

Cu(II) binding to monomeric, oligomeric, and fibrillar forms of the Alzheimer's disease amyloid-beta peptide.

1 reference

https://api.crossref.org/works/10.1039%2FC0MT00073F

21 January 2018

Binding of zinc(II) and copper(II) to the full-length Alzheimer's amyloid-beta peptide

1 reference

https://api.crossref.org/works/10.1039%2FC0MT00073F

21 January 2018

The Cu(II) complex of Abeta40 peptide in ammonium acetate solutions. Evidence for ternary species formation

1 reference

https://api.crossref.org/works/10.1039%2FC0MT00073F

21 January 2018

A direct determination of the dissociation constant for the Cu(II) complex of amyloid beta 1-40 peptide

1 reference

https://api.crossref.org/works/10.1039%2FC0MT00073F

21 January 2018

Quantification of the binding constant of copper(II) to the amyloid-beta peptide

1 reference

https://api.crossref.org/works/10.1039%2FC0MT00073F

21 January 2018

The challenges of determining metal-protein affinities

1 reference

https://api.crossref.org/works/10.1039%2FC0MT00073F

21 January 2018

N-Terminal deletions modify the Cu2+ binding site in amyloid-beta

1 reference

https://api.crossref.org/works/10.1039%2FC0MT00073F

21 January 2018

Determining thermodynamic parameters from isothermal calorimetric isotherms of the binding of macromolecules to metal cations originally chelated by a weak ligand

1 reference

https://api.crossref.org/works/10.1039%2FC0MT00073F

21 January 2018

Zinc binding to amyloid-beta: isothermal titration calorimetry and Zn competition experiments with Zn sensors.

1 reference

https://api.crossref.org/works/10.1039%2FC0MT00073F

21 January 2018

Characterization of the ZnII binding to the peptide amyloid-beta1-16 linked to Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1039%2FC0MT00073F

21 January 2018

Importance of dynamical processes in the coordination chemistry and redox conversion of copper amyloid-beta complexes.

1 reference

https://api.crossref.org/works/10.1039%2FC0MT00073F

21 January 2018

Cu(II) complexation by "non-coordinating" N-2-hydroxyethylpiperazine-N'-2-ethanesulfonic acid (HEPES buffer).

1 reference

https://api.crossref.org/works/10.1039%2FC0MT00073F

21 January 2018

Affinity gradients drive copper to cellular destinations

1 reference

https://api.crossref.org/works/10.1039%2FC0MT00073F

21 January 2018

Zn(II)- and Cu(II)-induced non-fibrillar aggregates of amyloid-beta (1-42) peptide are transformed to amyloid fibrils, both spontaneously and under the influence of metal chelators.

1 reference

https://api.crossref.org/works/10.1039%2FC0MT00073F

21 January 2018

Zinc-induced Alzheimer's Abeta1-40 aggregation is mediated by conformational factors.

1 reference

https://api.crossref.org/works/10.1039%2FC0MT00073F

21 January 2018

Aluminum, iron, and zinc ions promote aggregation of physiological concentrations of beta-amyloid peptide.

1 reference

https://api.crossref.org/works/10.1039%2FC0MT00073F

21 January 2018

Metal swap between Zn7-metallothionein-3 and amyloid-beta-Cu protects against amyloid-beta toxicity.

1 reference

https://api.crossref.org/works/10.1039%2FC0MT00073F

21 January 2018

Metalloenzyme-like activity of Alzheimer's disease beta-amyloid. Cu-dependent catalytic conversion of dopamine, cholesterol, and biological reducing agents to neurotoxic H(2)O(2).

1 reference

https://api.crossref.org/works/10.1039%2FC0MT00073F

21 January 2018

The amyloid-beta peptide of Alzheimer's disease binds Cu(I) in a linear bis-his coordination environment: insight into a possible neuroprotective mechanism for the amyloid-beta peptide

1 reference

https://api.crossref.org/works/10.1039%2FC0MT00073F

21 January 2018

Electrochemical and conformational consequences of copper (Cu(I) and Cu(II)) binding to beta-amyloid(1-40).

1 reference

https://api.crossref.org/works/10.1039%2FC0MT00073F

21 January 2018

Abeta-mediated ROS production by Cu ions: structural insights, mechanisms and relevance to Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1039%2FC0MT00073F

21 January 2018

NMR studies of the Zn2+ interactions with rat and human beta-amyloid (1-28) peptides in water-micelle environment.

1 reference

https://api.crossref.org/works/10.1039%2FC0MT00073F

21 January 2018

Rapid induction of Alzheimer A beta amyloid formation by zinc.

1 reference

https://api.crossref.org/works/10.1039%2FC0MT00073F

21 January 2018

Zinc-amyloid beta interactions on a millisecond time-scale stabilize non-fibrillar Alzheimer-related species.

1 reference

https://api.crossref.org/works/10.1039%2FC0MT00073F

21 January 2018

Structural changes of region 1-16 of the Alzheimer disease amyloid beta-peptide upon zinc binding and in vitro aging

1 reference

https://api.crossref.org/works/10.1039%2FC0MT00073F

21 January 2018

Zinc ions promote Alzheimer Abeta aggregation via population shift of polymorphic states

1 reference

https://api.crossref.org/works/10.1039%2FC0MT00073F

21 January 2018

High-resolution NMR studies of the zinc-binding site of the Alzheimer's amyloid beta-peptide.

1 reference

https://api.crossref.org/works/10.1039%2FC0MT00073F

21 January 2018

Copper and zinc binding to amyloid-beta: coordination, dynamics, aggregation, reactivity and metal-ion transfer

1 reference

https://api.crossref.org/works/10.1039%2FC0MT00073F

21 January 2018

Amyloid β-protein aggregation produces highly reproducible kinetic data and occurs by a two-phase process

1 reference

https://api.crossref.org/works/10.1039%2FC0MT00073F

21 January 2018

New insights on how metals disrupt amyloid beta-aggregation and their effects on amyloid-beta cytotoxicity

1 reference

https://api.crossref.org/works/10.1039%2FC0MT00073F

21 January 2018

Metal ion-dependent effects of clioquinol on the fibril growth of an amyloid {beta} peptide

1 reference

https://api.crossref.org/works/10.1039%2FC0MT00073F

21 January 2018

Influence of multiple metal ions on beta-amyloid aggregation and dissociation on a solid surface.

1 reference

https://api.crossref.org/works/10.1039%2FC0MT00073F

21 January 2018

Cu(2+) Inhibits the Aggregation of Amyloid beta-Peptide(1-42) in vitro We thank JEOL for the AFM measurement. This work was supported in part by Grants-in-Aid from the Japanese Ministry of Education, Science, Sports, and Culture, and a Grant from "R

1 reference

https://api.crossref.org/works/10.1039%2FC0MT00073F

21 January 2018

Inhibitory effect of copper(II) on zinc(II)-induced aggregation of amyloid beta-peptide

1 reference

https://api.crossref.org/works/10.1039%2FC0MT00073F

21 January 2018

Copper enhances amyloid-beta peptide neurotoxicity and non beta-aggregation: a series of experiments conducted upon copper-bound and copper-free amyloid-beta peptide

1 reference

https://api.crossref.org/works/10.1039%2FC0MT00073F

21 January 2018

Beta-amyloid protein oligomers induced by metal ions and acid pH are distinct from those generated by slow spontaneous ageing at neutral pH.

1 reference

https://api.crossref.org/works/10.1039%2FC0MT00073F

21 January 2018

Effects of clioquinol on metal-triggered amyloid-beta aggregation revisited

1 reference

https://api.crossref.org/works/10.1039%2FC0MT00073F

21 January 2018

Quenched hydrogen/deuterium exchange NMR characterization of amyloid-beta peptide aggregates formed in the presence of Cu2+ or Zn2+

1 reference

https://api.crossref.org/works/10.1039%2FC0MT00073F

21 January 2018

Metal ions differentially influence the aggregation and deposition of Alzheimer's beta-amyloid on a solid template.

1 reference

https://api.crossref.org/works/10.1039%2FC0MT00073F

21 January 2018

Selective Cu2+ binding, redox silencing, and cytoprotective effects of the small heat shock proteins alphaA- and alphaB-crystallin

1 reference

https://api.crossref.org/works/10.1039%2FC0MT00073F

21 January 2018

Label-free high-throughput screening assay for inhibitors of Alzheimer's amyloid-β peptide aggregation based on MALDI MS.

1 reference

https://api.crossref.org/works/10.1039%2FC0MT00073F

21 January 2018

Solution NMR studies of the A beta(1-40) and A beta(1-42) peptides establish that the Met35 oxidation state affects the mechanism of amyloid formation

1 reference

https://api.crossref.org/works/10.1039%2FC0MT00073F

21 January 2018

Modulating amyloid self-assembly and fibril morphology with Zn(II)

1 reference

https://api.crossref.org/works/10.1039%2FC0MT00073F

21 January 2018

Quantification of the binding properties of Cu2+ to the amyloid beta peptide: coordination spheres for human and rat peptides and implication on Cu2+-induced aggregation

1 reference

https://api.crossref.org/works/10.1039%2FC0MT00073F

21 January 2018

Treatment with a copper-zinc chelator markedly and rapidly inhibits beta-amyloid accumulation in Alzheimer's disease transgenic mice.

1 reference

https://api.crossref.org/works/10.1039%2FC0MT00073F

21 January 2018

Rapid restoration of cognition in Alzheimer's transgenic mice with 8-hydroxy quinoline analogs is associated with decreased interstitial Abeta

1 reference

https://api.crossref.org/works/10.1039%2FC0MT00073F

21 January 2018

Degradation of the Alzheimer disease amyloid beta-peptide by metal-dependent up-regulation of metalloprotease activity

1 reference

https://api.crossref.org/works/10.1039%2FC0MT00073F

21 January 2018

Restored degradation of the Alzheimer's amyloid-beta peptide by targeting amyloid formation

1 reference

https://api.crossref.org/works/10.1039%2FC0MT00073F

21 January 2018

Metallothionein III is reduced in Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1039%2FC0MT00073F

21 January 2018

Diffusible, nonfibrillar ligands derived from Abeta1-42 are potent central nervous system neurotoxins

1 reference

https://api.crossref.org/works/10.1039%2FC0MT00073F

21 January 2018

In vitro characterization of conditions for amyloid-beta peptide oligomerization and fibrillogenesis

1 reference

https://api.crossref.org/works/10.1039%2FC0MT00073F

21 January 2018

A specific amyloid-beta protein assembly in the brain impairs memory

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https://api.crossref.org/works/10.1039%2FC0MT00073F

21 January 2018

Rapid appearance and local toxicity of amyloid-beta plaques in a mouse model of Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1039%2FC0MT00073F

21 January 2018

Lipids revert inert Abeta amyloid fibrils to neurotoxic protofibrils that affect learning in mice

1 reference

https://api.crossref.org/works/10.1039%2FC0MT00073F

21 January 2018

Hydrogen peroxide mediates amyloid beta protein toxicity

1 reference

https://api.crossref.org/works/10.1039%2FC0MT00073F

21 January 2018

Amyloid plaques in PSAPP mice bind less metal than plaques in human Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1039%2FC0MT00073F

21 January 2018

Characterization of Copper Interactions with Alzheimer Amyloid β Peptides

1 reference

https://api.crossref.org/works/10.1039%2FC0MT00073F

21 January 2018

Zinc Binding to Alzheimer's Aβ(1–16) Peptide Results in Stable Soluble Complex

1 reference

https://api.crossref.org/works/10.1039%2FC0MT00073F

21 January 2018

The Aβ Peptide of Alzheimer's Disease Directly Produces Hydrogen Peroxide through Metal Ion Reduction†

1 reference

https://api.crossref.org/works/10.1039%2FC0MT00073F

21 January 2018

Identifiers

10.1039/C0MT00073F

1 reference

Europe PubMed Central

24 August 2017

1 reference

Europe PubMed Central

24 August 2017

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