Mutual stimulation of beta-amyloid fibrillogenesis by clioquinol and divalent metals (Q39949423)

15 September 2017

Mutual stimulation of beta-amyloid fibrillogenesis by clioquinol and divalent metals (English)

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15 September 2017

3

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15 September 2017

Silvia Bolognin

1

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15 September 2017

Paolo Zatta

2

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15 September 2017

Giuseppe Tognon

4

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15 September 2017

Pier Paolo Parnigotto

5

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15 September 2017

Fernanda Ricchelli

6

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15 September 2017

19 August 2008

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15 September 2017

NeuroMolecular Medicine

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15 September 2017

10

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15 September 2017

322-332

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15 September 2017

4

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https://scigraph.springernature.com/pub.10.1007/s12017-008-8046-x

15 September 2017

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The oxidative neurotoxicity of clioquinol

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The critical role of methionine 35 in Alzheimer's amyloid beta-peptide (1-42)-induced oxidative stress and neurotoxicity

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Thioflavine T interaction with synthetic Alzheimer's disease beta-amyloid peptides: detection of amyloid aggregation in solution

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Metals and amyloid-beta in Alzheimer's disease

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Metal binding modes of Alzheimer's amyloid beta-peptide in insoluble aggregates and soluble complexes.

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Aggregation/fibrillogenesis of recombinant human prion protein and Gerstmann-Sträussler-Scheinker disease peptides in the presence of metal ions

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Metal chelation as a potential therapy for Alzheimer's disease.

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12 December 2020

The intracellular component of cellular 3-(4,5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide (MTT) reduction is specifically inhibited by beta-amyloid peptides.

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12 December 2020

Clioquinol and pyrrolidine dithiocarbamate complex with copper to form proteasome inhibitors and apoptosis inducers in human breast cancer cells

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12 December 2020

Correlative Memory Deficits, Abeta Elevation, and Amyloid Plaques in Transgenic Mice

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12 December 2020

Metal ion-dependent effects of clioquinol on the fibril growth of an amyloid {beta} peptide

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12 December 2020

Aluminum-triggered structural modifications and aggregation of beta-amyloids

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12 December 2020

Copper, beta-amyloid, and Alzheimer's disease: tapping a sensitive connection

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12 December 2020

Clioquinol, a drug for Alzheimer's disease specifically interfering with brain metal metabolism: structural characterization of its zinc(II) and copper(II) complexes

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12 December 2020

Aluminium, iron, zinc and copper influence the in vitro formation of amyloid fibrils of Abeta42 in a manner which may have consequences for metal chelation therapy in Alzheimer's disease.

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Alzheimer's disease: the amyloid cascade hypothesis

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Clioquinol inhibits peroxide-mediated toxicity through up-regulation of phosphoinositol-3-kinase and inhibition of p53 activity

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Clioquinol's return: cautions from Japan

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Clioquinol mediates copper uptake and counteracts copper efflux activities of the amyloid precursor protein of Alzheimer's disease

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Mechanisms of neuronal degeneration in Alzheimer's disease

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12 December 2020

Degradation of the Alzheimer disease amyloid beta-peptide by metal-dependent up-regulation of metalloprotease activity

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Metal protein attenuating compounds for the treatment of Alzheimer's disease

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Copper, Zinc, and the Metallobiology of Alzheimer Disease

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Molecular basis of Alzheimer's disease

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The role of cell-derived oligomers of Abeta in Alzheimer's disease and avenues for therapeutic intervention.

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Copper(II) inhibits in vitro conversion of prion protein into amyloid fibrils.

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Potential pathogenic role of beta-amyloid(1-42)-aluminum complex in Alzheimer's disease

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12 December 2020

Amyloid-beta causes apoptosis of neuronal cells via caspase cascade, which can be prevented by amyloid-beta-derived short peptides

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12 December 2020

Copper, iron and zinc in Alzheimer's disease senile plaques.

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12 December 2020

Oligomeric and fibrillar species of amyloid-beta peptides differentially affect neuronal viability.

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12 December 2020

Hypothesis: is Alzheimer's disease a metal-induced immune disorder?

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12 December 2020

The plasma membrane: a target and hurdle for the development of anti-Abeta drugs?

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12 December 2020

Redox metals in Alzheimer's disease

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12 December 2020

In vitro and in vivo oxidative stress associated with Alzheimer's amyloid beta-peptide (1-42)

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Different conformations of amyloid beta induce neurotoxicity by distinct mechanisms in human cortical neurons.

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Treatment with a copper-zinc chelator markedly and rapidly inhibits beta-amyloid accumulation in Alzheimer's disease transgenic mice.

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Dramatic aggregation of Alzheimer abeta by Cu(II) is induced by conditions representing physiological acidosis.

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Is oxidative damage the fundamental pathogenic mechanism of Alzheimer's and other neurodegenerative diseases?

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Metal-protein attenuation with iodochlorhydroxyquin (clioquinol) targeting Abeta amyloid deposition and toxicity in Alzheimer disease: a pilot phase 2 clinical trial

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Clioquinol and docosahexaenoic acid act synergistically to kill tumor cells.

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Stoichiometry and conditional stability constants of Cu(II) or Zn(II) clioquinol complexes; implications for Alzheimer's and Huntington's disease therapy

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12 December 2020

Amyloid accumulation and pathogensis of Alzheimer's disease: significance of monomeric, oligomeric and fibrillar Abeta.

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12 December 2020

Changes in uptake of vitamin B(12) and trace metals in brains of mice treated with clioquinol

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12 December 2020

Copper and clioquinol treatment in young APP transgenic and wild-type mice: effects on life expectancy, body weight, and metal-ion levels.

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12 December 2020

The galvanization of beta-amyloid in Alzheimer's disease

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12 December 2020

Characterization of Copper Interactions with Alzheimer Amyloid β Peptides

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12 December 2020

Rapid induction of Alzheimer A beta amyloid formation by zinc.

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12 December 2020

Clioquinol for the treatment of Alzheimer's Disease

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12 December 2020

Rodent Abeta(1-42) exhibits oxidative stress properties similar to those of human Abeta(1-42): Implications for proposed mechanisms of toxicity.

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12 December 2020

Development of a novel diffusion-based method to estimate the size of the aggregated Abeta species responsible for neurotoxicity.

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12 December 2020

Clioquinol down-regulates mutant huntingtin expression in vitro and mitigates pathology in a Huntington's disease mouse model

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12 December 2020

Genetic or pharmacological iron chelation prevents MPTP-induced neurotoxicity in vivo: a novel therapy for Parkinson's disease

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12 December 2020

A specific amyloid-beta protein assembly in the brain impairs memory

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12 December 2020

Aluminum and other metals in Alzheimer's disease: a review of potential therapy with chelating agents.

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12 December 2020

Aqueous dissolution of Alzheimer's disease Abeta amyloid deposits by biometal depletion.

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12 December 2020

Characterization of the interactions of Alzheimer beta-amyloid peptides with phospholipid membranes.

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Oral administration of metal chelator ameliorates motor dysfunction after a small hemorrhage near the internal capsule in rat.

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The crucial role of metal ions in neurodegeneration: the basis for a promising therapeutic strategy

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12 December 2020

10.1007/S12017-008-8046-X

Identifiers

DOI

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15 September 2017

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