Fibroblastic niches prime T cell alloimmunity through Delta-like Notch ligands (Q37730667)

22 August 2017

Fibroblastic niches prime T cell alloimmunity through Delta-like Notch ligands (English)

1 reference

22 August 2017

2

1 reference

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1 June 2020

Alex Y. Huang

19

1 reference

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1 June 2020

Freddy Radtke

24

1 reference

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1 June 2020

Sanjiv A Luther

25

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1 June 2020

Ivan Maillard

26

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1 June 2020

18

Bruce R Blazar

1 reference

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1 June 2020

author name string

Jooho Chung

1

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1 June 2020

Eric Perkey

3

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1 June 2020

Vedran Radojcic

4

1 reference

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1 June 2020

Ute Koch

5

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1 June 2020

Leonardo Scarpellino

6

1 reference

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1 June 2020

Alexander Tong

7

1 reference

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1 June 2020

Frederick Allen

8

1 reference

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1 June 2020

Sherri Wood

9

1 reference

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1 June 2020

Jiane Feng

10

1 reference

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1 June 2020

Ann Friedman

11

1 reference

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1 June 2020

David Granadier

12

1 reference

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1 June 2020

Ivy T Tran

13

1 reference

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1 June 2020

Qian Chai

14

1 reference

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1 June 2020

Lucas Onder

15

1 reference

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1 June 2020

Minhong Yan

16

1 reference

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1 June 2020

Pavan Reddy

17

1 reference

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1 June 2020

Todd V Brennan

20

1 reference

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1 June 2020

D Keith Bishop

21

1 reference

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1 June 2020

Christian W Siebel

23

1 reference

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1 June 2020

Burkhard Ludewig

22

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1 June 2020

language of work or name

English

0 references

publication date

20 March 2017

1 reference

Journal of Clinical Investigation

22 August 2017

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28319044%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

volume

127

1 reference

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1 June 2020

issue

4

1 reference

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1 June 2020

page(s)

1574-1588

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describes a project that uses

1 June 2020

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC5373885/fullTextXML

inferred from PubMed Central ID database lookup

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Transient blockade of delta-like Notch ligands prevents allograft rejection mediated by cellular and humoral mechanisms in a mouse model of heart transplantation.

23 August 2017

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Notch signaling regulates antigen sensitivity of naive CD4+ T cells by tuning co-stimulation

23 August 2017

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Long-range enhancer activity determines Myc sensitivity to Notch inhibitors in T cell leukemia

23 August 2017

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A central role for Notch in effector CD8(+) T cell differentiation

23 August 2017

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Specific fibroblastic niches in secondary lymphoid organs orchestrate distinct Notch-regulated immune responses

23 August 2017

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A NOTCH1-driven MYC enhancer promotes T cell development, transformation and acute lymphoblastic leukemia

23 August 2017

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B cell homeostasis and follicle confines are governed by fibroblastic reticular cells

23 August 2017

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Intravital imaging of donor allogeneic effector and regulatory T cells with host dendritic cells during GVHD.

23 August 2017

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Therapeutic targeting of NOTCH signaling ameliorates immune-mediated bone marrow failure of aplastic anemia

23 August 2017

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T cell-specific notch inhibition blocks graft-versus-host disease by inducing a hyporesponsive program in alloreactive CD4+ and CD8+ T cells

23 August 2017

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Blockade of individual Notch ligands and receptors controls graft-versus-host disease

23 August 2017

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Delta-like ligand 4 identifies a previously uncharacterized population of inflammatory dendritic cells that plays important roles in eliciting allogeneic T cell responses in mice

23 August 2017

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Stromal and hematopoietic cells in secondary lymphoid organs: partners in immunity.

23 August 2017

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The Notch signalling system: recent insights into the complexity of a conserved pathway

23 August 2017

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HES1 opposes a PTEN-dependent check on survival, differentiation, and proliferation of TCRβ-selected mouse thymocytes.

23 August 2017

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Advances in graft-versus-host disease biology and therapy

23 August 2017

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Transcriptional profiling of stroma from inflamed and resting lymph nodes defines immunological hallmarks

23 August 2017

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Profound depletion of host conventional dendritic cells, plasmacytoid dendritic cells, and B cells does not prevent graft-versus-host disease induction

23 August 2017

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Fibroblastic reticular cells from lymph nodes attenuate T cell expansion by producing nitric oxide

23 August 2017

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Regulation of T cell priming by lymphoid stroma.

23 August 2017

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Induction of acute GVHD by sex-mismatched H-Y antigens in the absence of functional radiosensitive host hematopoietic-derived antigen-presenting cells

23 August 2017

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Coordinated regulation of lymph node vascular-stromal growth first by CD11c+ cells and then by T and B cells.

23 August 2017

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Notch2 receptor signaling controls functional differentiation of dendritic cells in the spleen and intestine.

23 August 2017

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Blockade of Notch ligand δ1 promotes allograft survival by inhibiting alloreactive Th1 cells and cytotoxic T cell generation

23 August 2017

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Regulated release of nitric oxide by nonhematopoietic stroma controls expansion of the activated T cell pool in lymph nodes

23 August 2017

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Notch signaling is a critical regulator of allogeneic CD4+ T-cell responses mediating graft-versus-host disease.

23 August 2017

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Therapeutic antibody targeting of individual Notch receptors

23 August 2017

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The canonical Notch signaling pathway: unfolding the activation mechanism

23 August 2017

1 reference

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Lunatic and manic fringe cooperatively enhance marginal zone B cell precursor competition for delta-like 1 in splenic endothelial niches

23 August 2017

1 reference

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Delta-like 4 is the essential, nonredundant ligand for Notch1 during thymic T cell lineage commitment.

23 August 2017

1 reference

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Notch ligand Delta-like 4 regulates disease pathogenesis during respiratory viral infections by modulating Th2 cytokines

23 August 2017

1 reference

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Mutational loss of PTEN induces resistance to NOTCH1 inhibition in T-cell leukemia

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5373885

Graft-versus-host disease

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5373885

Dll4 signalling through Notch1 regulates formation of tip cells during angiogenesis

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5373885

Stromal cell networks regulate lymphocyte entry, migration, and territoriality in lymph nodes

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5373885

Lymph node fibroblastic reticular cells construct the stromal reticulum via contact with lymphocytes

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5373885

A novel reticular stromal structure in lymph node cortex: an immuno-platform for interactions among dendritic cells, T cells and B cells.

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5373885

Delta-like 1 is necessary for the generation of marginal zone B cells but not T cells in vivo

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5373885

The reticulum of lymph nodes in mice studied with the electron microscope

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5373885

Notch2 is preferentially expressed in mature B cells and indispensable for marginal zone B lineage development

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5373885

Spatial and molecular organization of lymph node T cell cortex: a labyrinthine cavity bounded by an epithelium-like monolayer of fibroblastic reticular cells anchored to basement membrane-like extracellular matrix

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5373885

Dll4, a novel Notch ligand expressed in arterial endothelium

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5373885

Inducible gene targeting in mice

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5373885

Maturation of lymph node fibroblastic reticular cells from myofibroblastic precursors is critical for antiviral immunity

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5373885

Therapeutic promise and challenges of targeting DLL4/NOTCH1.

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5373885

The conduit system transports soluble antigens from the afferent lymph to resident dendritic cells in the T cell area of the lymph node

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5373885

The Notch1-Dll4 signaling pathway regulates mouse postnatal lymphatic development

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5373885

Synergistic, context-dependent, and hierarchical functions of epithelial components in thymic microenvironments

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5373885

Fibroblastic reticular cells regulate intestinal inflammation via IL-15-mediated control of group 1 ILCs.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5373885

Inhibition of Dll4 signalling inhibits tumour growth by deregulating angiogenesis

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5373885

The Notch signaling pathway controls short-lived effector CD8+ T cell differentiation but is dispensable for memory generation

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5373885

The Notch Ligand DLL4 Defines a Capability of Human Dendritic Cells in Regulating Th1 and Th17 Differentiation.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5373885

Notch controls the survival of memory CD4+ T cells by regulating glucose uptake

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5373885

Delta-like 4 is indispensable in thymic environment specific for T cell development

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5373885

Restoration of lymphoid organ integrity through the interaction of lymphoid tissue-inducer cells with stroma of the T cell zone.

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5373885

Recipient nonhematopoietic antigen-presenting cells are sufficient to induce lethal acute graft-versus-host disease

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5373885

Notch restricts lymphatic vessel sprouting induced by vascular endothelial growth factor.

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5373885

Cutting edge: thymic crosstalk regulates delta-like 4 expression on cortical epithelial cells.

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5373885

A new T-cell receptor transgenic model of the CD4+ direct pathway: level of priming determines acute versus chronic rejection.

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5373885

Fibroblastic reticular cells in lymph nodes regulate the homeostasis of naive T cells.

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5373885

Generation of new Notch2 mutant alleles.

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5373885

Host dendritic cells alone are sufficient to initiate acute graft-versus-host disease

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5373885

Instruction of distinct CD4 T helper cell fates by different notch ligands on antigen-presenting cells.

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5373885

Notch signaling augments T cell responsiveness by enhancing CD25 expression.

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5373885

Plasmacytoid dendritic cells prime alloreactive T cells to mediate graft-versus-host disease as antigen-presenting cells

1 September 2018

1 reference

12 December 2020

Chronic DLL4 blockade induces vascular neoplasms

1 reference

12 December 2020

Expression of Notch ligands, Jagged1, 2 and Delta1 in antigen presenting cells in mice

1 reference

12 December 2020

Graft-versus-host disease

1 reference

12 December 2020

Prevention of graft versus host disease by inactivation of host antigen-presenting cells

1 reference

12 December 2020

An experimental model of idiopathic pneumonia syndrome after bone marrow transplantation: I. The roles of minor H antigens and endotoxin

1 reference

12 December 2020

Identifiers

DOI

10.1172/JCI89535

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28319044%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28319044%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

1 reference