Therapeutic promise and challenges of targeting DLL4/NOTCH1. (Q38367121)

2 September 2017

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title

Therapeutic promise and challenges of targeting DLL4/NOTCH1. (English)

1 reference

2 September 2017

Minhong Yan

1

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2 September 2017

8 August 2011

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2 September 2017

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2 September 2017

3

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2 September 2017

17

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https://scigraph.springernature.com/pub.10.1186/2045-824x-3-17

2 September 2017

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cites work

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6 September 2017

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6 September 2017

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Loss of intestinal crypt progenitor cells owing to inactivation of both Notch1 and Notch2 is accompanied by derepression of CDK inhibitors p27Kip1 and p57Kip2.

6 September 2017

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Delta-like 4/Notch signaling and its therapeutic implications

6 September 2017

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Structural basis for autoinhibition of Notch

6 September 2017

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Notch signaling, gamma-secretase inhibitors, and cancer therapy

6 September 2017

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Inhibition of Dll4-mediated signaling induces proliferation of immature vessels and results in poor tissue perfusion

6 September 2017

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Notch signalling limits angiogenic cell behaviour in developing zebrafish arteries

6 September 2017

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Chemotherapy regimen predicts steatohepatitis and an increase in 90-day mortality after surgery for hepatic colorectal metastases

6 September 2017

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Notch/gamma-secretase inhibition turns proliferative cells in intestinal crypts and adenomas into goblet cells

6 September 2017

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Essential role of endothelial Notch1 in angiogenesis

6 September 2017

1 reference

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Haploinsufficiency of delta-like 4 ligand results in embryonic lethality due to major defects in arterial and vascular development.

6 September 2017

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6 September 2017

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Dosage-sensitive requirement for mouse Dll4 in artery development

6 September 2017

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6 September 2017

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Notch signaling is essential for vascular morphogenesis in mice

6 September 2017

1 reference

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Dll4, a novel Notch ligand expressed in arterial endothelium

6 September 2017

1 reference

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DLL4 blockade inhibits tumor growth and reduces tumor-initiating cell frequency

6 September 2017

1 reference

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Inhibition of Dll4 signalling inhibits tumour growth by deregulating angiogenesis

14 September 2017

1 reference

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Blockade of Dll4 inhibits tumour growth by promoting non-productive angiogenesis

14 September 2017

1 reference

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Isolation and characterization of the notch ligand delta4.

14 September 2017

1 reference

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Delta-like 4 is indispensable in thymic environment specific for T cell development

27 September 2017

1 reference

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Anti-DLL4 inhibits growth and reduces tumor-initiating cell frequency in colorectal tumors with oncogenic KRAS mutations

23 June 2018

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Endothelial cells dynamically compete for the tip cell position during angiogenic sprouting

31 August 2018

1 reference

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Delta-like 4 Notch ligand regulates tumor angiogenesis, improves tumor vascular function, and promotes tumor growth in vivo.

31 August 2018

1 reference

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Bevacizumab improves pathologic response and protects against hepatic injury in patients treated with oxaliplatin-based chemotherapy for colorectal liver metastases

31 August 2018

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31 August 2018

1 reference

https://pubmed.ncbi.nlm.nih.gov/21824400

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Chronic DLL4 blockade induces vascular neoplasms

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21824400

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1186/2045-824X-3-17

1 reference

PMCID

3170613

Dimensions Publication ID

2 September 2017

0 references

1 reference

2 September 2017

1 reference

PMCID

3170613