Graft-versus-host disease (Q36793622)

16 August 2017

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title

Graft-versus-host disease (English)

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16 August 2017

Warren D Shlomchik

1

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16 August 2017

1 May 2007

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Nature Reviews Immunology

16 August 2017

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16 August 2017

7

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16 August 2017

340-352

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16 August 2017

5

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Molecules and mechanisms of the graft-versus-leukaemia effect

16 August 2017

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Lethal graft-versus-host disease after bone marrow transplantation across minor histocompatibility barriers in mice. Prevention by removing mature T cells from marrow

31 March 2020

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Features of T cells causing H-2-restricted lethal graft-vs.-host disease across minor histocompatibility barriers

31 March 2020

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Variable capacity of L3T4+ T cells to cause lethal graft-versus-host disease across minor histocompatibility barriers in mice

31 March 2020

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Differential roles for CCR5 expression on donor T cells during graft-versus-host disease based on pretransplant conditioning

31 March 2020

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An inflammatory checkpoint regulates recruitment of graft-versus-host reactive T cells to peripheral tissues

31 March 2020

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Chronic graft versus host disease

31 March 2020

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Different types of allospecific CTL clones identified by their ability to recognize peptide loading-defective target cells

31 March 2020

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Role of endogenous peptide in human alloreactive cytotoxic T cell responses

31 March 2020

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Identification of a graft versus host disease-associated human minor histocompatibility antigen

31 March 2020

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Human H-Y: a male-specific histocompatibility antigen derived from the SMCY protein

31 March 2020

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The HLA-A*0201-restricted H-Y antigen contains a posttranslationally modified cysteine that significantly affects T cell recognition

31 March 2020

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The immunogenicity of a new human minor histocompatibility antigen results from differential antigen processing

31 March 2020

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Tetrameric HLA class I-minor histocompatibility antigen peptide complexes demonstrate minor histocompatibility antigen-specific cytotoxic T lymphocytes in patients with graft-versus-host disease

31 March 2020

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Identification of an immunodominant mouse minor histocompatibility antigen (MiHA). T cell response to a single dominant MiHA causes graft-versus-host disease

31 March 2020

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Differences that matter: major cytotoxic T cell-stimulating minor histocompatibility antigens

31 March 2020

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The H4b minor histocompatibility antigen is caused by a combination of genetically determined and posttranslational modifications

31 March 2020

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A single nucleotide polymorphism in the Emp3 gene defines the H4 minor histocompatibility antigen.

31 March 2020

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The human UTY gene encodes a novel HLA-B8-restricted H-Y antigen.

31 March 2020

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The PANE1 gene encodes a novel human minor histocompatibility antigen that is selectively expressed in B-lymphoid cells and B-CLL.

31 March 2020

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A human minor histocompatibility antigen resulting from differential expression due to a gene deletion

31 March 2020

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The DBY gene codes for an HLA-DQ5-restricted human male-specific minor histocompatibility antigen involved in graft-versus-host disease.

31 March 2020

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Identification of a mouse male-specific transplantation antigen, H-Y.

31 March 2020

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The minor histocompatibility antigen HA-1: a diallelic gene with a single amino acid polymorphism.

31 March 2020

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T cell subsets required for in vivo and in vitro responses to single and multiple minor histocompatibility antigens

31 March 2020

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Immunodominance in the immune response to "multiple" histocompatibility antigens

31 March 2020

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Real-time T-cell profiling identifies H60 as a major minor histocompatibility antigen in murine graft-versus-host disease

31 March 2020

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Immunodominance of H60 is caused by an abnormally high precursor T cell pool directed against its unique minor histocompatibility antigen peptide

31 March 2020

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Adoptive transfer of minor histocompatibility antigen-specific T lymphocytes eradicates leukemia cells without causing graft-versus-host disease

31 March 2020

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Lack of GVHD across classical, single minor histocompatibiliTy (miH) locus barriers in mice

31 March 2020

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Mismatches of minor histocompatibility antigens between HLA-identical donors and recipients and the development of graft-versus-host disease after bone marrow transplantation

31 March 2020

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Female donors contribute to a selective graft-versus-leukemia effect in male recipients of HLA-matched, related hematopoietic stem cell transplants.

31 March 2020

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In situ dissection of the graft-versus-host activities of cytotoxic T cells specific for minor histocompatibility antigens

31 March 2020

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Target antigens determine graft-versus-host disease phenotype

31 March 2020

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Properties of purified T cell subsets. II. In vivo responses to class I vs. class II H-2 differences

31 March 2020

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Antigen-induced selective recruitment of circulating lymphocytes

31 March 2020

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Effectiveness of donor natural killer cell alloreactivity in mismatched hematopoietic transplants

31 March 2020

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Acute graft-versus-host disease does not require alloantigen expression on host epithelium

31 March 2020

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Cell biology of antigen processing in vitro and in vivo

31 March 2020

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Cellular mechanisms governing cross-presentation of exogenous antigens

31 March 2020

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Prevention of graft versus host disease by inactivation of host antigen-presenting cells

31 March 2020

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Donor APCs are required for maximal GVHD but not for GVL

31 March 2020

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Distinct roles for donor- and host-derived antigen-presenting cells and costimulatory molecules in murine chronic graft-versus-host disease: requirements depend on target organ

31 March 2020

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In vivo analyses of early events in acute graft-versus-host disease reveal sequential infiltration of T-cell subsets

31 March 2020

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Transfer of allogeneic CD62L- memory T cells without graft-versus-host disease

31 March 2020

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Host dendritic cells alone are sufficient to initiate acute graft-versus-host disease.

31 March 2020

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Depletion of host Langerhans cells before transplantation of donor alloreactive T cells prevents skin graft-versus-host disease

31 March 2020

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Cytokine expanded myeloid precursors function as regulatory antigen-presenting cells and promote tolerance through IL-10-producing regulatory T cells

31 March 2020

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Regulatory dendritic cells protect mice from murine acute graft-versus-host disease and leukemia relapse

31 March 2020

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Flt3 ligand therapy for recipients of allogeneic bone marrow transplants expands host CD8 alpha(+) dendritic cells and reduces experimental acute graft-versus-host disease

31 March 2020

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Role of T cell subsets in lethal graft-versus-host disease (GVHD) directed to class I versus class II H-2 differences. I. L3T4+ cells can either augment or retard GVHD elicited by Lyt-2+ cells in class I different hosts

31 March 2020

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Low-dose donor CD8+ cells in the CD4-depleted graft prevent allogeneic marrow graft rejection and severe graft-versus-host disease for chronic myeloid leukemia patients in first chronic phase

31 March 2020

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Differential cytokine expression in acute and chronic murine graft-versus-host-disease

31 March 2020

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Enumeration of lymphokine mRNA-containing cells in vivo in a murine graft-versus-host reaction using the PCR.

31 March 2020

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Differential effects of the absence of interferon-gamma and IL-4 in acute graft-versus-host disease after allogeneic bone marrow transplantation in mice

31 March 2020

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Donor-derived interferon gamma is required for inhibition of acute graft-versus-host disease by interleukin 12.

31 March 2020

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Interleukin-18 regulates acute graft-versus-host disease by enhancing Fas-mediated donor T cell apoptosis

31 March 2020

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Interferon gamma eliminates responding CD4 T cells during mycobacterial infection by inducing apoptosis of activated CD4 T cells

31 March 2020

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Interferon gamma is required for activation-induced death of T lymphocytes

31 March 2020

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Th1 and Th2 mediate acute graft-versus-host disease, each with distinct end-organ targets

31 March 2020

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Selective T-cell subset ablation demonstrates a role for T1 and T2 cells in ongoing acute graft-versus-host disease: a model system for the reversal of disease

31 March 2020

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Importance of minor histocompatibility antigen expression by nonhematopoietic tissues in a CD4+ T cell-mediated graft-versus-host disease model

31 March 2020

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CD4+ and CD8+ T cells each can utilize a perforin-dependent pathway to mediate lethal graft-versus-host disease in major histocompatibility complex-disparate recipients

31 March 2020

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Major histocompatibility complex-mismatched allogeneic bone marrow transplantation using perforin and/or Fas ligand double-defective CD4(+) donor T cells: involvement of cytotoxic function by donor lymphocytes prior to graft-versus-host disease path

31 March 2020

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Differential use of Fas ligand and perforin cytotoxic pathways by donor T cells in graft-versus-host disease and graft-versus-leukemia effect

31 March 2020

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The role of cell-mediated cytotoxicity in acute GVHD after MHC-matched allogeneic bone marrow transplantation in mice

31 March 2020

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Donor T cells lacking Fas ligand and perforin retain the capacity to induce severe GvHD in minor histocompatibility antigen mismatched bone-marrow transplantation recipients.

31 March 2020

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Fas-deficient lpr mice are more susceptible to graft-versus-host disease

31 March 2020

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Tumor necrosis factor/cachectin is an effector of skin and gut lesions of the acute phase of graft-vs.-host disease

31 March 2020

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Role of mast cells in early epithelial target cell injury in experimental acute graft-versus-host disease

31 March 2020

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Role of tumor necrosis factor-alpha in graft-versus-host disease and graft-versus-leukemia responses

31 March 2020

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The p55 TNF-alpha receptor plays a critical role in T cell alloreactivity

31 March 2020

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T cells require TRAIL for optimal graft-versus-tumor activity

31 March 2020

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Dendritic cell-activated CD44hiCD8+ T cells are defective in mediating acute graft-versus-host disease but retain graft-versus-leukemia activity.

31 March 2020

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The generation of protective memory-like CD8+ T cells during homeostatic proliferation requires CD4+ T cells

31 March 2020

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Spontaneous proliferation, a response of naive CD4 T cells determined by the diversity of the memory cell repertoire.

31 March 2020

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L-selectin and beta7 integrin on donor CD4 T cells are required for the early migration to host mesenteric lymph nodes and acute colitis of graft-versus-host disease

31 March 2020

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A direct estimate of the human alphabeta T cell receptor diversity

31 March 2020

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Leukocyte migration and graft-versus-host disease

31 March 2020

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Graft-versus-host disease in the absence of the spleen after allogeneic bone marrow transplantation

31 March 2020

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Peyer's patch is the essential site in initiating murine acute and lethal graft-versus-host reaction

31 March 2020

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An absence of CCR5 on donor cells results in acceleration of acute graft-vs-host disease.

31 March 2020

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Peyer patches are not required for acute graft-versus-host disease after myeloablative conditioning and murine allogeneic bone marrow transplantation

31 March 2020

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Reciprocal and dynamic control of CD8 T cell homing by dendritic cells from skin- and gut-associated lymphoid tissues

31 March 2020

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Selective imprinting of gut-homing T cells by Peyer's patch dendritic cells

31 March 2020

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LPAM (α4β7 integrin) is an important homing integrin on alloreactive T cells in the development of intestinal graft-versus-host disease

31 March 2020

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Visualizing the generation of memory CD4 T cells in the whole body

31 March 2020

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The infusion of ex vivo activated and expanded CD4(+)CD25(+) immune regulatory cells inhibits graft-versus-host disease lethality

31 March 2020

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Donor-type CD4(+)CD25(+) regulatory T cells suppress lethal acute graft-versus-host disease after allogeneic bone marrow transplantation

31 March 2020

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CD4(+)CD25(+) immunoregulatory T Cells: new therapeutics for graft-versus-host disease

31 March 2020

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Recipient CD4+ T cells that survive irradiation regulate chronic graft-versus-host disease.

31 March 2020

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Post-hematopoietic cell transplantation control of graft-versus-host disease by donor CD425 T cells to allow an effective graft-versus-leukemia response

31 March 2020

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Only the CD62L+ subpopulation of CD4+CD25+ regulatory T cells protects from lethal acute GVHD

31 March 2020

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Critical role for CCR5 in the function of donor CD4+CD25+ regulatory T cells during acute graft-versus-host disease

31 March 2020

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Early CD30 signaling is critical for adoptively transferred CD4+CD25+ regulatory T cells in prevention of acute graft-versus-host disease

31 March 2020

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Host conditioning with total lymphoid irradiation and antithymocyte globulin prevents graft-versus-host disease: the role of CD1-reactive natural killer T cells

31 March 2020

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Predominance of NK1.1+TCR alpha beta+ or DX5+TCR alpha beta+ T cells in mice conditioned with fractionated lymphoid irradiation protects against graft-versus-host disease: "natural suppressor" cells

31 March 2020

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Bone marrow NK1.1(-) and NK1.1(+) T cells reciprocally regulate acute graft versus host disease

31 March 2020

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Protective conditioning for acute graft-versus-host disease

31 March 2020

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Thymus: a direct target tissue in graft-versus-host reaction after allogeneic bone marrow transplantation that results in abrogation of induction of self-tolerance

31 March 2020

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Rituximab for steroid-refractory chronic graft-versus-host disease

31 March 2020

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Antibody responses to H-Y minor histocompatibility antigens correlate with chronic graft-versus-host disease and disease remission

31 March 2020

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Acute graft-versus-host disease without costimulation via CD28

31 March 2020

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LIGHT, a TNF-like molecule, costimulates T cell proliferation and is required for dendritic cell-mediated allogeneic T cell response

31 March 2020

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Modulation of T-cell-mediated immunity in tumor and graft-versus-host disease models through the LIGHT co-stimulatory pathway

31 March 2020

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Blockade of LIGHT/LTbeta and CD40 signaling induces allospecific T cell anergy, preventing graft-versus-host disease

31 March 2020

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Absence of inducible costimulator on alloreactive T cells reduces graft versus host disease and induces Th2 deviation

31 March 2020

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Targeting of inducible costimulator (ICOS) expressed on alloreactive T cells down-regulates graft-versus-host disease (GVHD) and facilitates engraftment of allogeneic bone marrow (BM).

31 March 2020

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Ligation of OX40 (CD134) regulates graft-versus-host disease (GVHD) and graft rejection in allogeneic bone marrow transplant recipients

31 March 2020

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CD30/CD30 ligand (CD153) interaction regulates CD4+ T cell-mediated graft-versus-host disease

31 March 2020

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Blockade of programmed death-1 engagement accelerates graft-versus-host disease lethality by an IFN-gamma-dependent mechanism.

31 March 2020

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31 March 2020

Identifiers

DOI

10.1038/NRI2000

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16 August 2017

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PubMed ID

17438575