Unleashing the therapeutic potential of NOD-like receptors (Q37502679)

20 August 2017

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title

Unleashing the therapeutic potential of NOD-like receptors (English)

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20 August 2017

Kaoru Geddes

1

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PubMed ID

19483708

20 August 2017

João G Magalhães

series ordinal

2

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PubMed ID

19483708

20 August 2017

Stephen E Girardin

series ordinal

3

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20 August 2017

1 June 2009

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Nature Reviews Drug Discovery

20 August 2017

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20 August 2017

8

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20 August 2017

6

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20 August 2017

465-479

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https://scigraph.springernature.com/pub.10.1038/nrd2783

20 August 2017

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cites work

The evolution and genetics of innate immunity

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Toll signaling: the TIReless quest for specificity

31 March 2020

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Pathogen recognition with Toll-like receptors

31 March 2020

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Nod-like proteins in immunity, inflammation and disease

31 March 2020

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TIR, CARD and PYRIN: three domains for an antimicrobial triad

31 March 2020

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The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta

31 March 2020

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Nod-like proteins in inflammation and disease.

31 March 2020

1 reference

Nod2 is a general sensor of peptidoglycan through muramyl dipeptide (MDP) detection

31 March 2020

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Host recognition of bacterial muramyl dipeptide mediated through NOD2. Implications for Crohn's disease

31 March 2020

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Nod1 detects a unique muropeptide from gram-negative bacterial peptidoglycan

31 March 2020

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An essential role for NOD1 in host recognition of bacterial peptidoglycan containing diaminopimelic acid

31 March 2020

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The inflammasome: a danger sensing complex triggering innate immunity

31 March 2020

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The microbial and danger signals that activate Nod-like receptors

31 March 2020

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Innate immune activation through Nalp3 inflammasome sensing of asbestos and silica

31 March 2020

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The NALP3 inflammasome is involved in the innate immune response to amyloid-beta

31 March 2020

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Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization

31 March 2020

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Cytosolic flagellin requires Ipaf for activation of caspase-1 and interleukin 1beta in salmonella-infected macrophages

31 March 2020

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Cytoplasmic flagellin activates caspase-1 and secretion of interleukin 1beta via Ipaf

31 March 2020

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Nalp1b controls mouse macrophage susceptibility to anthrax lethal toxin

31 March 2020

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Intracellular NOD-like receptors in host defense and disease

31 March 2020

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NALP1 in vitiligo-associated multiple autoimmune disease

31 March 2020

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Mutations in NALP12 cause hereditary periodic fever syndromes

31 March 2020

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The 3020insC allele of NOD2 predisposes to early-onset breast cancer

31 March 2020

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Association between early-onset breast and laryngeal cancers.

31 March 2020

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Prevalence of the NOD2 3020insC mutation in aggregations of breast and lung cancer

31 March 2020

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Polymorphisms in innate immunity genes and risk of non-Hodgkin lymphoma

31 March 2020

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NOD2 variants and the risk of malignant melanoma

31 March 2020

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Both donor and recipient NOD2/CARD15 mutations associate with transplant-related mortality and GvHD following allogeneic stem cell transplantation

31 March 2020

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Impact of NOD2/CARD15 haplotypes on the outcome after kidney transplantation

31 March 2020

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Adjuvants--a classification and review of their modes of action

31 March 2020

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Targeting the innate immune response with improved vaccine adjuvants

31 March 2020

1 reference

Immunological concepts of vaccine adjuvant activity

31 March 2020

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Synergistic stimulation of human monocytes and dendritic cells by Toll-like receptor 4 and NOD1- and NOD2-activating agonists

31 March 2020

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Various human epithelial cells express functional Toll-like receptors, NOD1 and NOD2 to produce anti-microbial peptides, but not proinflammatory cytokines

31 March 2020

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Muramyldipeptide and diaminopimelic acid-containing desmuramylpeptides in combination with chemically synthesized Toll-like receptor agonists synergistically induced production of interleukin-8 in a NOD2- and NOD1-dependent manner, respectively, in h

31 March 2020

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Synergistic effect of Nod1 and Nod2 agonists with toll-like receptor agonists on human dendritic cells to generate interleukin-12 and T helper type 1 cells

31 March 2020

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Nod1-Mediated Innate Immune Recognition of Peptidoglycan Contributes to the Onset of Adaptive Immunity

31 March 2020

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Nod2-dependent Th2 polarization of antigen-specific immunity.

31 March 2020

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Nod2-dependent regulation of innate and adaptive immunity in the intestinal tract

31 March 2020

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Crucial role for the Nalp3 inflammasome in the immunostimulatory properties of aluminium adjuvants

31 March 2020

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The Nlrp3 inflammasome is critical for aluminium hydroxide-mediated IL-1beta secretion but dispensable for adjuvant activity

31 March 2020

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Alum adjuvant boosts adaptive immunity by inducing uric acid and activating inflammatory dendritic cells

31 March 2020

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Immunostimulatory combinations: designing the next generation of vaccine adjuvants

31 March 2020

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Immunoactive peptides, FK-156 and FK-565. I. Enhancement of host resistance to microbial infection in mice.

31 March 2020

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Effect of immunostimulant therapy on acute viral myocarditis in an animal model

31 March 2020

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Treatment of coxsackievirus B3 myocarditis by immunoactive peptide in an animal model

31 March 2020

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Antitumor effects of novel immunoactive peptides, FK-156 and its synthetic derivatives

31 March 2020

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Adjuvant activity of monomeric bacterial cell wall peptidoglycans.

31 March 2020

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Effect of stearoyl-N-acetylmuramyl-L-alanyl-D-isoglutamine on host resistance to Corynebacterium kutscheri infection in cortisone-treated mice

31 March 2020

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Glucosaminylmuramyl dipeptide-induced changes in murine macrophage metabolism

31 March 2020

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Minimal structural requirements for adjuvant activity of bacterial peptidoglycan derivatives

31 March 2020

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Distinctive adjuvanticity of synthetic analogs of mycobacterial water-soluble components

31 March 2020

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Combinations of TLR and NOD2 ligands stimulate rat microglial P2X4R expression

31 March 2020

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Impaired dendritic cell function in Crohn's disease patients with NOD2 3020insC mutation

31 March 2020

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Endotoxin and muramyl dipeptide modulate surface receptor expression on human mononuclear cells

31 March 2020

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Selective induction of CD11a,b,c/CD18 and CD54 expression at the cell surface of human leukocytes by muramyl peptides

31 March 2020

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IL-32 synergizes with nucleotide oligomerization domain (NOD) 1 and NOD2 ligands for IL-1beta and IL-6 production through a caspase 1-dependent mechanism

31 March 2020

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Study of the adjuvant activity of new MDP derivatives and purified saponins and their influence on HIV-1 replication in vitro

31 March 2020

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Enhancement of non-specific resistance to viral infection by muramyldipeptide and its analogs

31 March 2020

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Effect of N alpha-acetylmuramyl-L-alanyl-D-isoglutaminyl-N epsilon-stearoyl- L-lysine on resistance to herpes simplex virus type-1 infection in cyclophosphamide-treated mice

31 March 2020

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Muramyl dipeptide inhibits replication of human immunodeficiency virus in vitro

31 March 2020

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Intranasal vaccination with recombinant P6 protein and adamantylamide dipeptide as mucosal adjuvant confers efficient protection against otitis media and lung infection by nontypeable Haemophilus influenzae.

31 March 2020

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Synergistic effects of romurtide and cefmenoxime against experimental Klebsiella pneumonia in mice

31 March 2020

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Eradication of spontaneous metastases and activation of alveolar macrophages by intravenous injection of liposomes containing muramyl dipeptide

31 March 2020

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Therapy for osteosarcoma in dogs with intravenous injection of liposome-encapsulated muramyl tripeptide

31 March 2020

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Muramyl peptides. Variation of somnogenic activity with structure

31 March 2020

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The synthetic immunomodulator murabutide controls human immunodeficiency virus type 1 replication at multiple levels in macrophages and dendritic cells

31 March 2020

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Cryopyrin activates the inflammasome in response to toxins and ATP

31 March 2020

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Identification of bacterial muramyl dipeptide as activator of the NALP3/cryopyrin inflammasome.

31 March 2020

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Critical role for Cryopyrin/Nalp3 in activation of caspase-1 in response to viral infection and double-stranded RNA

31 March 2020

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Bacterial RNA and small antiviral compounds activate caspase-1 through cryopyrin/Nalp3

31 March 2020

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Gout-associated uric acid crystals activate the NALP3 inflammasome

31 March 2020

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Cutting edge: inflammasome activation by alum and alum's adjuvant effect are mediated by NLRP3.

31 March 2020

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The cytolytic P2Z receptor for extracellular ATP identified as a P2X receptor (P2X7)

31 March 2020

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Critical role for NALP3/CIAS1/Cryopyrin in innate and adaptive immunity through its regulation of caspase-1

31 March 2020

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Augmentation of cutaneous immune responses by ATP gamma S: purinergic agonists define a novel class of immunologic adjuvants.

31 March 2020

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MDP-induced interleukin-1beta processing requires Nod2 and CIAS1/NALP3.

31 March 2020

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A NOD2-NALP1 complex mediates caspase-1-dependent IL-1beta secretion in response to Bacillus anthracis infection and muramyl dipeptide

31 March 2020

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Pannexin-1-mediated intracellular delivery of muramyl dipeptide induces caspase-1 activation via cryopyrin/NLRP3 independently of Nod2.

31 March 2020

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Activation of NOD2 in vivo induces IL-1beta production in the eye via caspase-1 but results in ocular inflammation independently of IL-1 signaling

31 March 2020

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Cutting edge: alum adjuvant stimulates inflammatory dendritic cells through activation of the NALP3 inflammasome

31 March 2020

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(How) do aluminium adjuvants work?

31 March 2020

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Activation of dendritic cells and induction of CD4(+) T cell differentiation by aluminum-containing adjuvants

31 March 2020

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The IL-1 receptor 1 is critical for Th2 cell type airway immune responses in a mild but not in a more severe asthma model

31 March 2020

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Interleukin-18 plays a role in both the alum-induced T helper 2 response and the T helper 1 response induced by alum-adsorbed interleukin-12

31 March 2020

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Mutation of a new gene encoding a putative pyrin-like protein causes familial cold autoinflammatory syndrome and Muckle-Wells syndrome

31 March 2020

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Chronic infantile neurological cutaneous and articular syndrome is caused by mutations in CIAS1, a gene highly expressed in polymorphonuclear cells and chondrocytes

31 March 2020

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De novo CIAS1 mutations, cytokine activation, and evidence for genetic heterogeneity in patients with neonatal-onset multisystem inflammatory disease (NOMID): a new member of the expanding family of pyrin-associated autoinflammatory diseases

31 March 2020

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NALP3 forms an IL-1beta-processing inflammasome with increased activity in Muckle-Wells autoinflammatory disorder

31 March 2020

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Cryopyrin-induced interleukin 1beta secretion in monocytic cells: enhanced activity of disease-associated mutants and requirement for ASC

31 March 2020

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New mutations of CIAS1 that are responsible for Muckle-Wells syndrome and familial cold urticaria: a novel mutation underlies both syndromes

31 March 2020

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Interleukin-1-receptor antagonist in the Muckle-Wells syndrome.

31 March 2020

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Anakinra improves sensory deafness in a Japanese patient with Muckle-Wells syndrome, possibly by inhibiting the cryopyrin inflammasome

31 March 2020

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Recovery from deafness in a patient with Muckle-Wells syndrome treated with anakinra.

31 March 2020

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Hearing improvement in a patient with variant Muckle-Wells syndrome in response to interleukin 1 receptor antagonism

31 March 2020

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Successful treatment of acute visual loss in Muckle-Wells syndrome with interleukin 1 receptor antagonist

31 March 2020

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Prevention of cold-associated acute inflammation in familial cold autoinflammatory syndrome by interleukin-1 receptor antagonist

31 March 2020

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Dramatic improvement with anakinra in a case of chronic infantile neurological cutaneous and articular (CINCA) syndrome

31 March 2020

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Colchicine: its mechanism of action and efficacy in crystal-induced inflammation

31 March 2020

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Management of treatment resistant inflammation of acute on chronic tophaceous gout with anakinra

31 March 2020

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A pilot study of IL-1 inhibition by anakinra in acute gout

31 March 2020

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Efficacy and safety of rilonacept (interleukin-1 Trap) in patients with cryopyrin-associated periodic syndromes: results from two sequential placebo-controlled studies

31 March 2020

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A pilot study to evaluate the safety and efficacy of the long-acting interleukin-1 inhibitor rilonacept (interleukin-1 Trap) in patients with familial cold autoinflammatory syndrome

31 March 2020

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Ischemic-reperfusion syndromes: biochemical and immunologic rationale for IL-1 targeted therapy

31 March 2020

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The Nalp3 inflammasome is essential for the development of silicosis

31 March 2020

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Cryopyrin/NALP3 binds ATP/dATP, is an ATPase, and requires ATP binding to mediate inflammatory signaling

31 March 2020

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PYPAF1, a PYRIN-containing Apaf1-like protein that assembles with ASC and regulates activation of NF-kappa B

31 March 2020

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Interaction between pyrin and the apoptotic speck protein (ASC) modulates ASC-induced apoptosis

31 March 2020

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The PYRIN-CARD protein ASC is an activating adaptor for caspase-1

31 March 2020

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A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease

31 March 2020

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Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease

31 March 2020

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A genome-wide association study identifies IL23R as an inflammatory bowel disease gene

31 March 2020

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A genome-wide association scan of nonsynonymous SNPs identifies a susceptibility variant for Crohn disease in ATG16L1

31 March 2020

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Genome-wide association study identifies new susceptibility loci for Crohn disease and implicates autophagy in disease pathogenesis

31 March 2020

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Nod2, a Nod1/Apaf-1 family member that is restricted to monocytes and activates NF-kappaB

31 March 2020

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Induction of Nod2 in Myelomonocytic and Intestinal Epithelial Cells via Nuclear Factor-κB Activation

31 March 2020

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CARD15/NOD2 functions as an antibacterial factor in human intestinal epithelial cells

31 March 2020

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TNF-alpha and IFN-gamma regulate the expression of the NOD2 (CARD15) gene in human intestinal epithelial cells.

31 March 2020

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Card15 gene overexpression in mononuclear and epithelial cells of the inflamed Crohn's disease colon

31 March 2020

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Gene-environment interaction modulated by allelic heterogeneity in inflammatory diseases.

31 March 2020

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Crohn's disease-associated NOD2 variants share a signaling defect in response to lipopolysaccharide and peptidoglycan

31 March 2020

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Regulation of IL-8 and IL-1beta expression in Crohn's disease associated NOD2/CARD15 mutations

31 March 2020

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Synergy between TLR9 and NOD2 innate immune responses is lost in genetic Crohn's disease

31 March 2020

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NOD2 mediates anti-inflammatory signals induced by TLR2 ligands: implications for Crohn's disease

31 March 2020

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Nucleotide-binding oligomerization domain-2 modulates specific TLR pathways for the induction of cytokine release

31 March 2020

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Detection of muramyl dipeptide-sensing pathway defects in patients with Crohnʼs disease

31 March 2020

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Response to infliximab treatment in Crohn's disease is not associated with mutations in the CARD15 (NOD2) gene: an analysis in 534 patients from two multicenter, prospective GCP-level trials

31 March 2020

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NOD2/CARD15 does not influence response to infliximab in Crohn's disease

31 March 2020

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Crohn's disease patients homozygous for the 3020insC NOD2 mutation have a defective NOD2/TLR4 cross-tolerance to intestinal stimuli

31 March 2020

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Chronic stimulation of Nod2 mediates tolerance to bacterial products

31 March 2020

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Nod2 mutation in Crohn's disease potentiates NF-kappaB activity and IL-1beta processing

31 March 2020

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Consequence of functional Nod2 and Tlr4 mutations on gene transcription in Crohn’s disease patients

31 March 2020

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Colonic explant production of IL-1and its receptor antagonist is imbalanced in inflammatory bowel disease (IBD).

31 March 2020

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Imbalance of the interleukin 1 system in colonic mucosa--association with intestinal inflammation and interleukin 1 receptor antagonist [corrected] genotype 2.

31 March 2020

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Colonic mucosal interleukin 1 receptor antagonist in inflammatory bowel disease

31 March 2020

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Common variants in the NLRP3 region contribute to Crohn's disease susceptibility

31 March 2020

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Crohn disease worsened by anakinra administration

31 March 2020

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Sequence variants in IL10, ARPC2 and multiple other loci contribute to ulcerative colitis susceptibility

31 March 2020

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Interleukin-10-based therapy for inflammatory bowel disease

31 March 2020

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Crohn's disease and the NOD2 gene: a role for paneth cells

31 March 2020

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Expression of NOD2 in Paneth cells: a possible link to Crohn's ileitis

31 March 2020

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NOD2/CARD15 and the Paneth cell: another piece in the genetic jigsaw of inflammatory bowel disease

31 March 2020

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NOD2 (CARD15) mutations in Crohn's disease are associated with diminished mucosal alpha-defensin expression

31 March 2020

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Reduced alpha-defensin expression is associated with inflammation and not NOD2 mutation status in ileal Crohn's disease.

31 March 2020

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Absence of mutation in the NOD2/CARD15 gene among 483 Japanese patients with Crohn's disease

31 March 2020

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Lack of common NOD2 variants in Japanese patients with Crohn's disease

31 March 2020

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NOD2/CARD15 gene polymorphisms and Crohn's disease in the Chinese population.

31 March 2020

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NOD2 3020insC frameshift mutation is not associated with inflammatory bowel disease in Chinese patients of Han nationality.

31 March 2020

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A microbial symbiosis factor prevents intestinal inflammatory disease

31 March 2020

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An immunomodulatory molecule of symbiotic bacteria directs maturation of the host immune system

31 March 2020

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A bacterial carbohydrate links innate and adaptive responses through Toll-like receptor 2.

31 March 2020

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Association of NOD1 polymorphisms with atopic eczema and related phenotypes

31 March 2020

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NOD1 variation, immunoglobulin E and asthma.

31 March 2020

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Synergistic enhancement of Toll-like receptor responses by NOD1 activation

31 March 2020

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Nod1, an Apaf-1-like activator of caspase-9 and nuclear factor-kappaB

31 March 2020

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Identification of the critical residues involved in peptidoglycan detection by Nod1.

31 March 2020

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CARD15 mutations in Blau syndrome

31 March 2020

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A new CARD15 mutation in Blau syndrome

31 March 2020

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Presence of a sporadic case of systemic granulomatosis syndrome with a CARD15 mutation.

31 March 2020

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Early-onset sarcoidosis and CARD15 mutations with constitutive nuclear factor-kappaB activation: common genetic etiology with Blau syndrome

31 March 2020

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Favourable effect of TNF-alpha inhibitor (infliximab) on Blau syndrome in monozygotic twins with a de novo CARD15 mutation

31 March 2020

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Evaluation of the anti-inflammatory effect of infliximab in a mouse model of acute asthma

31 March 2020

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Genetic polymorphisms of NOD1 and IL-8, but not polymorphisms of TLR4 genes, are associated with Helicobacter pylori-induced duodenal ulcer and gastritis

31 March 2020

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Influence of polymorphisms in the NOD1/CARD4 and NOD2/CARD15 genes on the clinical outcome of Helicobacter pylori infection

31 March 2020

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Common nonsynonymous polymorphisms in the NOD2 gene are associated with resistance or susceptibility to tuberculosis disease in African Americans

31 March 2020

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Host susceptibility to tuberculosis: CARD15 polymorphisms in a South African population

31 March 2020

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Nod1 responds to peptidoglycan delivered by the Helicobacter pylori cag pathogenicity island

31 March 2020

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Differential regulation of caspase-1 activation, pyroptosis, and autophagy via Ipaf and ASC in Shigella-infected macrophages

31 March 2020

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Regulation of Legionella phagosome maturation and infection through flagellin and host Ipaf.

31 March 2020

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Immune recognition of Pseudomonas aeruginosa mediated by the IPAF/NLRC4 inflammasome.

31 March 2020

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Critical role for Ipaf in Pseudomonas aeruginosa-induced caspase-1 activation

31 March 2020

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Multiple Nod-like receptors activate caspase 1 during Listeria monocytogenes infection

31 March 2020

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NLRX1 is a mitochondrial NOD-like receptor that amplifies NF-kappaB and JNK pathways by inducing reactive oxygen species production

31 March 2020

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The inflammasome recognizes cytosolic microbial and host DNA and triggers an innate immune response

31 March 2020

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NLRX1 is a regulator of mitochondrial antiviral immunity

31 March 2020

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Nod1 signaling overcomes resistance of S. pneumoniae to opsonophagocytic killing

31 March 2020

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Pyogenic bacterial infections in humans with MyD88 deficiency

31 March 2020

1 reference

The effect of paraffin oil and mycobacteria on antibody formation and sensitization; a review

31 March 2020

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Adjuvants--a balance between toxicity and adjuvanticity

31 March 2020

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Glomerulonephritis induced in sheep by injections of heterologous glomerular basement membrane and Freund's complete adjuvant

31 March 2020

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Cell walls of mycobacteria and related organisms; Chemistry and immunostimulant properties

31 March 2020

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Relationship between the degree of antigen adsorption to aluminum hydroxide adjuvant in interstitial fluid and antibody production

31 March 2020

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Potentiation of the immune response to non-adsorbed antigens by aluminum-containing adjuvants

31 March 2020

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Relationship between the strength of antigen adsorption to an aluminum-containing adjuvant and the immune response

31 March 2020

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Immunology: Toll-like receptors and antibody responses

31 March 2020

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Flagellin-deficient Legionella mutants evade caspase-1- and Naip5-mediated macrophage immunity

31 March 2020

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Cytosolic recognition of flagellin by mouse macrophages restricts Legionella pneumophila infection

31 March 2020

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Activation of the NALP3 inflammasome is triggered by low intracellular potassium concentration

31 March 2020

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Complementation cloning of an MHC class II transactivator mutated in hereditary MHC class II deficiency (or bare lymphocyte syndrome)

31 March 2020

1 reference

Genetic susceptibility to multiple sclerosis: detection of polymorphic nucleotides and an intron in the 3' untranslated region of the major histocompatibility complex class II transactivator gene

31 March 2020

1 reference

Single nucleotide polymorphisms in the gene encoding the major histocompatibility complex class II transactivator (CIITA) in systemic lupus erythematosus

31 March 2020

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Polymorphisms in CLEC16A and CIITA at 16p13 are associated with primary adrenal insufficiency

31 March 2020

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Polymorphisms in NACHT-LRR (NLR) genes in atopic dermatitis

31 March 2020

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Autoimmune polyendocrine syndrome type 1 and NALP5, a parathyroid autoantigen

31 March 2020

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Association between a complex insertion/deletion polymorphism in NOD1 (CARD4) and susceptibility to inflammatory bowel disease

31 March 2020

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Susceptibility of mice deficient in the MHC class II transactivator to infection with Mycobacterium tuberculosis

31 March 2020

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Single nucleotide polymorphisms and functional analysis of class II transactivator (CIITA) promoter IV in persistent HBV infection

31 March 2020

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Not polymorphism but methylation of class II transactivator gene promoter IV associated with persistent HBV infection

31 March 2020

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NAIP and Ipaf control Legionella pneumophila replication in human cells.

31 March 2020

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The Nod-like receptor family member Naip5/Birc1e restricts Legionella pneumophila growth independently of caspase-1 activation

31 March 2020

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Restriction of Legionella pneumophila growth in macrophages requires the concerted action of cytokine and Naip5/Ipaf signalling pathways

31 March 2020

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ASC/PYCARD and caspase-1 regulate the IL-18/IFN-gamma axis during Anaplasma phagocytophilum infection

31 March 2020

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Naip5 affects host susceptibility to the intracellular pathogen Legionella pneumophila.

31 March 2020

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Birc1e is the gene within the Lgn1 locus associated with resistance to Legionella pneumophila.

31 March 2020

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Nod1 is an essential signal transducer in intestinal epithelial cells infected with bacteria that avoid recognition by toll-like receptors

31 March 2020

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Nod1 Participates in the Innate Immune Response toPseudomonas aeruginosa

31 March 2020

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Stimulation of the cytosolic receptor for peptidoglycan, Nod1, by infection with Chlamydia trachomatis or Chlamydia muridarum.

31 March 2020

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Nod1-mediated endothelial cell activation by Chlamydophila pneumoniae

31 March 2020

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A major role for intestinal epithelial nucleotide oligomerization domain 1 (NOD1) in eliciting host bactericidal immune responses to Campylobacter jejuni

31 March 2020

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The cytosolic sensors Nod1 and Nod2 are critical for bacterial recognition and host defense after exposure to Toll-like receptor ligands

31 March 2020

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CARD4/Nod1 mediates NF-kappaB and JNK activation by invasive Shigella flexneri.

31 March 2020

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Nucleotide-binding oligomerization domain proteins are innate immune receptors for internalized Streptococcus pneumoniae

31 March 2020

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NOD2 and toll-like receptors are nonredundant recognition systems of Mycobacterium tuberculosis

31 March 2020

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Nucleotide-binding oligomerization domain protein 2-deficient mice control infection with Mycobacterium tuberculosis

31 March 2020

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Mycobacterium paratuberculosis is recognized by Toll-like receptors and NOD2.

31 March 2020

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Nod2 mediates susceptibility to Yersinia pseudotuberculosis in mice

31 March 2020

1 reference

CARD15 variants determine a disturbed early response of monocytes to adherent-invasive Escherichia coli strain LF82 in Crohn's disease

31 March 2020

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Amyloidosis in mice following injections with Freud's adjuvant, its components separately and homologous liver-adjuvant mixture.

31 March 2020

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12 December 2020

Blau syndrome mutation of CARD15/NOD2 in sporadic early onset granulomatous arthritis.

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12 December 2020

Stimulation of nonspecific resistance to infection induced by muramyl dipeptide analogs substituted in the gamma-carboxyl group and evaluation of N alpha-muramyl dipeptide-N epsilon-stearoyllysine

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12 December 2020

Immunoadjuvant activities of cell walls, their water-soluble fractions and peptidoglycan subunits, prepared from various gram-positive bacteria, and of synthetic n-acetylmuramyl peptides

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12 December 2020

Demyelination in the guinea pig in chronic allergic encephalomyelitis produced by injecting guinea pig brain in oil emulsion containing a variant of mycobacterium butyricum.

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12 December 2020

Synthetic immunomodulators and synthetic vaccines

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12 December 2020

Synergistic activation by recombinant mouse interferon-gamma and muramyl dipeptide of tumoricidal properties in mouse macrophages

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12 December 2020

Biological activity of a new synthetic muramyl peptide adjuvant devoid of pyrogenicity

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12 December 2020

Stimulation of host-defense mechanism with synthetic adjuvants and recombinant cytokines against viral infection in mice

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12 December 2020

Peptidoglycan adjuvants: minimal structure required for activity

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12 December 2020

Intracellular NOD-like receptors in innate immunity, infection and disease

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12 December 2020

Selective modulation of lipopolysaccharide-induced death and cytokine production by various muramyl peptides

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12 December 2020

Intrafamilial variable phenotypic expression of a CIAS1 mutation: from Muckle-Wells to chronic infantile neurological cutaneous and articular syndrome

1 reference

12 December 2020

Immunoactive peptides, FK-156 and FK-565. III. Enhancement of host defense mechanisms against infection

1 reference

12 December 2020

Activation of cellular immunity in mice under normal conditions and in tumor growth during treatment with glucosaminyl muramyl dipeptide

1 reference

12 December 2020

Activation of tumoricidal properties in macrophages and inhibition of experimentally-induced murine metastases by a new synthetic acyltripeptide, FK-565.

1 reference

12 December 2020

Effect of quinonyl-N-acetyl muramyl dipeptide on immune responses in tumor-bearing mice

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12 December 2020

Protective effects of immunoactive peptide, FK565 against systemic and local infections with herpes simplex virus and murine cytomegalovirus and respiratory tract infection with influenza virus in mice

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12 December 2020

Macrophage involvement in the antitumor activity of a synthetic acyltripeptide (FK-565) against experimental lung carcinoma metastases

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12 December 2020

Immunostimulant activities of a lipophilic muramyl dipeptide derivative and of desmuramyl peptidolipid analogs.

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12 December 2020

Inhibitory effect of FK-565 alone and in combination with zidovudine on retroviral infection by Friend leukemia virus in mice

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12 December 2020

Immunostimulating and adjuvant activities of a low molecular weight lipopeptide

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12 December 2020

NOD2 3020insC mutation and the pathogenesis of Crohn's disease: impaired IL-1beta production points to a loss-of-function phenotype.

1 reference

12 December 2020

The immunomodulatory property of a novel synthetic compound adamantylamide dipeptide

1 reference

12 December 2020

Adjuvant therapy for melanoma in dogs: results of randomized clinical trials using surgery, liposome-encapsulated muramyl tripeptide, and granulocyte macrophage colony-stimulating factor.

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12 December 2020

Vaccination of rhesus monkeys against Plasmodium knowlesi with aqueous suspension of MDP as an adjuvant

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12 December 2020

Protective effect of muramyl dipeptide analogs in combination with trehalose dimycolate against aerogenic influenza virus and Mycobacterium tuberculosis infections in mice

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12 December 2020

MDP and other muropeptides--direct and synergistic effects on the immune system

1 reference

12 December 2020

Immunoadjuvant activities of synthetic N-acetyl-muramyl-peptides or -amino acids

1 reference

12 December 2020

Synergism between human recombinant gamma-interferon and muramyl dipeptide encapsulated in liposomes for activation of antitumor properties in human blood monocytes

1 reference

12 December 2020

The influence of components of M. tuberculosis and other Mycobacteria upon antibody production to ovalbumin

1 reference

12 December 2020

Identifiers

DOI

10.1038/NRD2783

1 reference

20 August 2017

1 reference

PubMed ID

19483708