The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta (Q24305136)

PYD and CARD domain containing

1 reference

Caspase 5

1 reference

Caspase 1

1 reference

1 reference

3

Jürg Tschopp

Jürg

Tschopp

1 reference

PubMed

PubMed publication ID

9 December 2023

Fabio Martinon

1

Fabio

Martinon

1 reference

PubMed

PubMed publication ID

12191486

9 December 2023

Kimberly Burns

series ordinal

2

author given names

Kimberly

author last names

Burns

1 reference

PubMed

PubMed publication ID

12191486

Regulation of apoptotic protease activating factor-1 oligomerization and apoptosis by the WD-40 repeat region

9 December 2023

language of work or name

English

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publication date

August 2002

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published in

Molecular Cell

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volume

10

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issue

2

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page(s)

417-26

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cites work

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Caspase activation involves the formation of the aposome, a large (approximately 700 kDa) caspase-activating complex

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Molecular cloning of the interleukin-1 beta converting enzyme

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A novel enhancer of the Apaf1 apoptosome involved in cytochrome c-dependent caspase activation and apoptosis

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Interleukin-1 beta, interleukin-18, and the interleukin-1 beta converting enzyme

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Fever: links with an ancient receptor

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Natural adjuvants: endogenous activators of dendritic cells

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Inhibition of human caspases by peptide-based and macromolecular inhibitors

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Intracellular vs extracellular recognition of pathogens--common concepts in mammals and flies

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Molecular cloning and characterization of DEFCAP-L and -S, two isoforms of a novel member of the mammalian Ced-4 family of apoptosis proteins

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The modular nature of apoptotic signaling proteins

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Mutation of a new gene encoding a putative pyrin-like protein causes familial cold autoinflammatory syndrome and Muckle-Wells syndrome

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The NOD: a signaling module that regulates apoptosis and host defense against pathogens

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Human Nod1 confers responsiveness to bacterial lipopolysaccharides

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Nods: a family of cytosolic proteins that regulate the host response to pathogens

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Innate immune recognition

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ATP-activated oligomerization as a mechanism for apoptosis regulation: fold and mechanism prediction for CED-4.

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The NACHT family - a new group of predicted NTPases implicated in apoptosis and MHC transcription activation

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Identification of a monocyte specific pre-interleukin 1 beta convertase activity

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Altered cytokine export and apoptosis in mice deficient in interleukin-1 beta converting enzyme

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Mice deficient in IL-1 beta-converting enzyme are defective in production of mature IL-1 beta and resistant to endotoxic shock

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Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade

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Expression analysis of the human caspase-1 subfamily reveals specific regulation of the CASP5 gene by lipopolysaccharide and interferon-gamma

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Induction of apoptotic program in cell-free extracts: requirement for dATP and cytochrome c

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PYPAF1, a PYRIN-containing Apaf1-like protein that assembles with ASC and regulates activation of NF-kappa B

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Regulation of inhibitory pathways of the interleukin-1 system

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The pyrin domain: a possible member of the death domain-fold family implicated in apoptosis and inflammation

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ASC, a novel 22-kDa protein, aggregates during apoptosis of human promyelocytic leukemia HL-60 cells

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Expression of apoptosis-associated speck-like protein containing a caspase recruitment domain, a pyrin N-terminal homology domain-containing protein, in normal human tissues

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The danger model: a renewed sense of self

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Identification of Ipaf, a human caspase-1-activating protein related to Apaf-1

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Consequences of cell death: exposure to necrotic tumor cells, but not primary tissue cells or apoptotic cells, induces the maturation of immunostimulatory dendritic cells

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Apoptosome: the cellular engine for the activation of caspase-9.

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The interleukin-1 beta-converting enzyme (ICE) is localized on the external cell surface membranes and in the cytoplasmic ground substance of human monocytes by immuno-electron microscopy

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The PYRIN-CARD protein ASC is an activating adaptor for caspase-1

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Identification of CARDIAK, a RIP-like kinase that associates with caspase-1

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A novel heterodimeric cysteine protease is required for interleukin-1 beta processing in monocytes

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HSP70 as endogenous stimulus of the Toll/interleukin-1 receptor signal pathway

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The NB-ARC domain: a novel signalling motif shared by plant resistance gene products and regulators of cell death in animals

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Murine caspase-11, an ICE-interacting protease, is essential for the activation of ICE.

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Activation of the native 45-kDa precursor form of interleukin-1-converting enzyme

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