A genome-wide association study identifies IL23R as an inflammatory bowel disease gene (Q28270603)

Dan L Nicolae

22

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Michael Barmada

M Michael Barmada

20

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John D. Rioux

John D Rioux

4

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Jerome I Rotter

21

Jerome I Rotter

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Mark Joseph Daly

6

Mark J Daly

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Peter K. Gregersen

19

Peter K Gregersen

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Kent D Taylor

2

Kent D Taylor

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Stephan R. Targan

14

Stephan Targan

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Steven R. Brant

3

Steven R Brant

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Mark S. Silverberg

5

Mark S Silverberg

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Judy H. Cho

23

Judy H Cho

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Anne M. Griffiths

10

Anne Griffiths

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A Hillary Steinhart

7

A Hillary Steinhart

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Lisa Wu Datta

15

Lisa Wu Datta

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Miguel D Regueiro

9

Miguel Regueiro

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L Philip Schumm

17

L Philip Schumm

0 references

Themistocles Dassopoulos

11

Themistocles Dassopoulos

0 references

Huiying Yang

13

Huiying Yang

0 references

Clara Abraham

8

Clara Abraham

0 references

Emily Kistner-Griffin

16

Emily O Kistner

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Alain Bitton

12

Annette Jassies-van der Lee

Alain Bitton

0 references

18

describes a project that uses

Annette T Lee

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publication date

1 December 2006

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language of work or name

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314

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issue

5804

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page(s)

1461-3

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genome-wide association study

1 reference

on focus list of Wikimedia project

inferred from title

ScienceSource

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cites work

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Human IL-23-producing type 1 macrophages promote but IL-10-producing type 2 macrophages subvert immunity to (myco)bacteria

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A receptor for the heterodimeric cytokine IL-23 is composed of IL-12Rbeta1 and a novel cytokine receptor subunit, IL-23R

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Ubiquitous transgenic expression of the IL-23 subunit p19 induces multiorgan inflammation, runting, infertility, and premature death

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20 March 2017

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Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12

20 March 2017

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IL-23 drives a pathogenic T cell population that induces autoimmune inflammation

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Divergent pro- and antiinflammatory roles for IL-23 and IL-12 in joint autoimmune inflammation

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Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain

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Clinical epidemiology of inflammatory bowel disease: Incidence, prevalence, and environmental influences

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29 September 2017

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PubMed

https://pubmed.ncbi.nlm.nih.gov/17068223

12 December 2020

inferred from PubMed ID database lookup

Cutting edge: IL-23 cross-regulates IL-12 production in T cell-dependent experimental colitis

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/17068223

12 December 2020

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Both IL-12p70 and IL-23 are synthesized during active Crohn's disease and are down-regulated by treatment with anti-IL-12 p40 monoclonal antibody

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/17068223

12 December 2020

inferred from PubMed ID database lookup

Identifiers

DOI

10.1126/SCIENCE.1135245

1 reference

1 reference

1 reference

PubMed publication ID

17068223

1 reference