In search of small molecules blocking interactions between HIV proteins and intracellular cofactors (Q37350544)

19 August 2017

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title

In search of small molecules blocking interactions between HIV proteins and intracellular cofactors (English)

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19 August 2017

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4

Zeger Debyser

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Frauke Christ

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3

object named as

Frauke Christ

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19 August 2017

Katrien Busschots

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PubMed ID

19081927

19 August 2017

Jan De Rijck

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2

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PubMed ID

19081927

19 August 2017

language of work or name

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16 October 2008

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19 August 2017

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19 August 2017

5

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19 August 2017

1

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19 August 2017

21-31

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Protein-protein interactions in human disease

19 August 2017

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Small-molecule inhibitors of protein-protein interactions: progressing towards the dream

21 January 2018

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Antibody cocktails: next-generation biopharmaceuticals with improved potency

21 January 2018

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Inhibiting protein-protein interactions using designed molecules

21 January 2018

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Potent suppression of HIV-1 replication in humans by T-20, a peptide inhibitor of gp41-mediated virus entry

21 January 2018

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Protein-protein interactions as a target for drugs in proteomics

21 January 2018

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Principles of protein-protein interactions

21 January 2018

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Unraveling hot spots in binding interfaces: progress and challenges

21 January 2018

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Reaching for high-hanging fruit in drug discovery at protein-protein interfaces

21 January 2018

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In vivo activation of the p53 pathway by small-molecule antagonists of MDM2

21 January 2018

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Discovery and cocrystal structure of benzodiazepinedione HDM2 antagonists that activate p53 in cells.

21 January 2018

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Discovery of the first series of inhibitors of human papillomavirus type 11: inhibition of the assembly of the E1-E2-Origin DNA complex

21 January 2018

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Emerging classes of protein-protein interaction inhibitors and new tools for their development

21 January 2018

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Fragment-Based Drug Discovery

21 January 2018

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Discovery of a potent small molecule IL-2 inhibitor through fragment assembly

21 January 2018

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MDM2 inhibitors for cancer therapy

21 January 2018

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Structural details on mdm2-p53 interaction

21 January 2018

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Structure of the MDM2 oncoprotein bound to the p53 tumor suppressor transactivation domain

21 January 2018

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1,4-Benzodiazepine-2,5-diones as small molecule antagonists of the HDM2-p53 interaction: discovery and SAR.

21 January 2018

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Benzodiazepinedione inhibitors of the Hdm2:p53 complex suppress human tumor cell proliferation in vitro and sensitize tumors to doxorubicin in vivo

21 January 2018

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Temporal activation of p53 by a specific MDM2 inhibitor is selectively toxic to tumors and leads to complete tumor growth inhibition

21 January 2018

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Binding of small molecules to an adaptive protein-protein interface

21 January 2018

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Identification of nonpeptidic small-molecule inhibitors of interleukin-2.

21 January 2018

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Hot-spot mimicry of a cytokine receptor by a small molecule

21 January 2018

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An inhibitor of Bcl-2 family proteins induces regression of solid tumours

21 January 2018

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A small-molecule inhibitor of Bcl-XL potentiates the activity of cytotoxic drugs in vitro and in vivo

21 January 2018

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Cellular co-factors of HIV-1 integration

21 January 2018

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New biarsenical ligands and tetracysteine motifs for protein labeling in vitro and in vivo: synthesis and biological applications

21 January 2018

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Maraviroc (UK-427,857), a potent, orally bioavailable, and selective small-molecule inhibitor of chemokine receptor CCR5 with broad-spectrum anti-human immunodeficiency virus type 1 activity

21 January 2018

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Inhibition of HIV-1 replication by cyclosporine A or related compounds correlates with the ability to disrupt the Gag-cyclophilin A interaction

21 January 2018

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Cyclophilin a modulates processing of human immunodeficiency virus type 1 p55Gag: mechanism for antiviral effects of cyclosporin A.

21 January 2018

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Inhibition of human immunodeficiency virus replication by nonimmunosuppressive analogs of cyclosporin A

21 January 2018

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Cyclophilin B is a functional regulator of hepatitis C virus RNA polymerase

21 January 2018

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NIM811, a Cyclophilin Inhibitor, Exhibits Potent In Vitro Activity against Hepatitis C Virus Alone or in Combination with Alpha Interferon

21 January 2018

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Cyclophilin inhibitors in hepatitis C viral infection

21 January 2018

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The cyclophilin inhibitor Debio-025 shows potent anti-hepatitis C effect in patients coinfected with hepatitis C and human immunodeficiency virus.

21 January 2018

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Inhibition of human papillomavirus DNA replication by small molecule antagonists of the E1-E2 protein interaction

21 January 2018

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Crystal structure of the E2 transactivation domain of human papillomavirus type 11 bound to a protein interaction inhibitor

21 January 2018

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Identification of an evolutionarily conserved domain in human lens epithelium-derived growth factor/transcriptional co-activator p75 (LEDGF/p75) that binds HIV-1 integrase

21 January 2018

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Solution structure of the HIV-1 integrase-binding domain in LEDGF/p75

21 January 2018

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Interacting residues in the extracellular region of the common beta subunit of the human granulocyte-macrophage colony-stimulating factor, interleukin (IL)-3, and IL-5 receptors involved in constitutive activation.

21 January 2018

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Identification of the LEDGF/p75 binding site in HIV-1 integrase

21 January 2018

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Structure-based mutagenesis of the integrase-LEDGF/p75 interface uncouples a strict correlation between in vitro protein binding and HIV-1 fitness

21 January 2018

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Virus evolution reveals an exclusive role for LEDGF/p75 in chromosomal tethering of HIV.

21 January 2018

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Identification and characterization of the chromatin-binding domains of the HIV-1 integrase interactor LEDGF/p75.

21 January 2018

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Chromatinized templates reveal the requirement for the LEDGF/p75 PWWP domain during HIV-1 integration in vitro

21 January 2018

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A tripartite DNA-binding element, comprised of the nuclear localization signal and two AT-hook motifs, mediates the association of LEDGF/p75 with chromatin in vivo

21 January 2018

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Identification and characterization of a functional nuclear localization signal in the HIV-1 integrase interactor LEDGF/p75

21 January 2018

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Identification of the LEDGF/p75 HIV-1 integrase-interaction domain and NLS reveals NLS-independent chromatin tethering

21 January 2018

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Lens epithelium-derived growth factor (LEDGF/p75) and p52 are derived from a single gene by alternative splicing

21 January 2018

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Isolation of cDNAs encoding novel transcription coactivators p52 and p75 reveals an alternate regulatory mechanism of transcriptional activation

21 January 2018

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Structural basis for the recognition between HIV-1 integrase and transcriptional coactivator p75.

21 January 2018

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Integrase mutants defective for interaction with LEDGF/p75 are impaired in chromosome tethering and HIV-1 replication

21 January 2018

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LEDGF/p75 is essential for nuclear and chromosomal targeting of HIV-1 integrase in human cells

21 January 2018

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LEDGF/p75 determines cellular trafficking of diverse lentiviral but not murine oncoretroviral integrase proteins and is a component of functional lentiviral preintegration complexes

21 January 2018

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Wild-type levels of human immunodeficiency virus type 1 infectivity in the absence of cellular emerin protein

21 January 2018

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Transient and stable knockdown of the integrase cofactor LEDGF/p75 reveals its role in the replication cycle of human immunodeficiency virus

21 January 2018

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An essential role for LEDGF/p75 in HIV integration

21 January 2018

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Role of PSIP1/LEDGF/p75 in lentiviral infectivity and integration targeting

21 January 2018

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A role for LEDGF/p75 in targeting HIV DNA integration

21 January 2018

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LEDGF/p75 functions downstream from preintegration complex formation to effect gene-specific HIV-1 integration

21 January 2018

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Overexpression of the lens epithelium-derived growth factor/p75 integrase binding domain inhibits human immunodeficiency virus replication

21 January 2018

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Disruption of Ledgf/Psip1 results in perinatal mortality and homeotic skeletal transformations

21 January 2018

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LEDGF, a survival factor, activates stress-related genes.

21 January 2018

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Caspase cleavage of the nuclear autoantigen LEDGF/p75 abrogates its pro-survival function: implications for autoimmunity in atopic disorders

21 January 2018

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Differential interaction of HIV-1 integrase and JPO2 with the C terminus of LEDGF/p75.

21 January 2018

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Transcriptional co-activator p75 binds and tethers the Myc-interacting protein JPO2 to chromatin

21 January 2018

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Identification of a small-molecule binding site at the dimer interface of the HIV integrase catalytic domain

21 January 2018

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Discovery of a small-molecule HIV-1 integrase inhibitor-binding site

21 January 2018

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Inhibitory profile of a LEDGF/p75 peptide against HIV-1 integrase: insight into integrase-DNA complex formation and catalysis

21 January 2018

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Identification of host proteins required for HIV infection through a functional genomic screen

21 January 2018

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Host factors exploited by retroviruses

21 January 2018

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Blocking interactions between HIV-1 integrase and cellular cofactors: an emerging anti-retroviral strategy

21 January 2018

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Identification of a novel human immunodeficiency virus type 1 integrase interactor, Gemin2, that facilitates efficient viral cDNA synthesis in vivo

21 January 2018

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"UnPAKing" human immunodeficiency virus (HIV) replication: using small interfering RNA screening to identify novel cofactors and elucidate the role of group I PAKs in HIV infection

21 January 2018

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Identification of novel therapeutic targets for HIV infection through functional genomic cDNA screening

21 January 2018

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Binding and stimulation of HIV-1 integrase by a human homolog of yeast transcription factor SNF5

21 January 2018

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Isolation of a human gene that inhibits HIV-1 infection and is suppressed by the viral Vif protein

21 January 2018

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Hypermutation of HIV-1 DNA in the Absence of the Vif Protein

21 January 2018

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Broad antiretroviral defence by human APOBEC3G through lethal editing of nascent reverse transcripts

21 January 2018

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The antiretroviral enzyme APOBEC3G is degraded by the proteasome in response to HIV-1 Vif

21 January 2018

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Tetherin inhibits retrovirus release and is antagonized by HIV-1 Vpu

21 January 2018

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Tail-interacting protein TIP47 is a connector between Gag and Env and is required for Env incorporation into HIV-1 virions

21 January 2018

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HIV-1 and Ebola virus encode small peptide motifs that recruit Tsg101 to sites of particle assembly to facilitate egress

21 January 2018

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Overexpression of the N-terminal domain of TSG101 inhibits HIV-1 budding by blocking late domain function

21 January 2018

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Targeting of the human immunodeficiency virus type 1 envelope to the trans-Golgi network through binding to TIP47 is required for env incorporation into virions and infectivity

21 January 2018

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Tsg101, a homologue of ubiquitin-conjugating (E2) enzymes, binds the L domain in HIV type 1 Pr55(Gag)

21 January 2018

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Tsg101 and the vacuolar protein sorting pathway are essential for HIV-1 budding

21 January 2018

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Inhibiting HIV-1 integrase by shifting its oligomerization equilibrium

21 January 2018

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Small molecule inhibitors targeting HIV-1 reverse transcriptase dimerization

21 January 2018

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21 January 2018

Identifiers

DOI

10.1039/B810306B

1 reference

19 August 2017

1 reference

PubMed ID

19081927