Inhibiting HIV-1 integrase by shifting its oligomerization equilibrium (Q35850134)

10 August 2017

Inhibiting HIV-1 integrase by shifting its oligomerization equilibrium (English)

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10 August 2017

Joseph Rosenbluh

2

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Dmitry B Veprintsev

object named as

Dmitry Veprintsev

6

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author name string

Zvi Hayouka

1

1 reference

10 August 2017

Aviad Levin

3

1 reference

10 August 2017

Shoshana Loya

4

1 reference

10 August 2017

Mario Lebendiker

5

1 reference

10 August 2017

Moshe Kotler

7

1 reference

10 August 2017

Amnon Hizi

8

1 reference

10 August 2017

Abraham Loyter

9

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10 August 2017

Assaf Friedler

10

1 reference

10 August 2017

language of work or name

English

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publication date

8 May 2007

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10 August 2017

6

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Proceedings of the National Academy of Sciences of the United States of America

inferred from page(s)

published in

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10 August 2017

104

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10 August 2017

8316-8321

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10 August 2017

20

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Overexpression of the lens epithelium-derived growth factor/p75 integrase binding domain inhibits human immunodeficiency virus replication

10 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1895947

An essential role for LEDGF/p75 in HIV integration

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1895947

Structure-based mutagenesis of the integrase-LEDGF/p75 interface uncouples a strict correlation between in vitro protein binding and HIV-1 fitness

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1895947

Dimerization inhibitors of HIV-1 reverse transcriptase, protease and integrase: a single mode of inhibition for the three HIV enzymes?

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1895947

The hunt for HIV-1 integrase inhibitors

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1895947

Allosteric effectors influence the tetramer stability of both R- and T-states of hemoglobin A.

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1895947

Relationship between the oligomeric status of HIV-1 integrase on DNA and enzymatic activity

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1895947

Analysis of human immunodeficiency virus type 1 integration by using a specific, sensitive and quantitative assay based on real-time polymerase chain reaction

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1895947

Structural basis for the recognition between HIV-1 integrase and transcriptional coactivator p75.

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1895947

Peptides derived from the reverse transcriptase of human immunodeficiency virus type 1 as novel inhibitors of the viral integrase

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1895947

The interaction of LEDGF/p75 with integrase is lentivirus-specific and promotes DNA binding

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1895947

Integrase inhibitors to treat HIV/AIDS.

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1895947

HIV-1 integrase crosslinked oligomers are active in vitro

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1895947

Pharmacologic rescue of conformationally-defective proteins: implications for the treatment of human disease

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1895947

Identification of an evolutionarily conserved domain in human lens epithelium-derived growth factor/transcriptional co-activator p75 (LEDGF/p75) that binds HIV-1 integrase

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1895947

Small-molecule inhibitors of protein-protein interactions: progressing towards the dream

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1895947

ON THE NATURE OF ALLOSTERIC TRANSITIONS: A PLAUSIBLE MODEL

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1895947

A contradictory treatment for lysosomal storage disorders: inhibitors enhance mutant enzyme activity

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1895947

A peptide that binds and stabilizes p53 core domain: chaperone strategy for rescue of oncogenic mutants

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1895947

DNA binding induces dissociation of the multimeric form of HIV-1 integrase: a time-resolved fluorescence anisotropy study

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1895947

HIV integrase, a brief overview from chemistry to therapeutics

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1895947

Sensitivity of human immunodeficiency virus type 1 to the fusion inhibitor T-20 is modulated by coreceptor specificity defined by the V3 loop of gp120

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1895947

Oligomeric states of the HIV-1 integrase as measured by time-resolved fluorescence anisotropy

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1895947

Protein misfolding, evolution and disease

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1895947

Controlling signal transduction with synthetic ligands

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1895947

Inhibition of human immunodeficiency virus type 1 reverse transcriptase dimerization using synthetic peptides derived from the connection domain

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1895947

Substituted benzaldehydes designed to increase the oxygen affinity of human haemoglobin and inhibit the sickling of sickle erythrocytes

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1895947

Use of eukaryotic expression technology in the functional analysis of cloned genes

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1895947

Calculation of protein extinction coefficients from amino acid sequence data

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1895947

Complete nucleotide sequence of the AIDS virus, HTLV-III

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1895947

Detection of replication-competent and pseudotyped human immunodeficiency virus with a sensitive cell line on the basis of activation of an integrated beta-galactosidase gene

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1895947

Identification of amino acids in HIV-1 and avian sarcoma virus integrase subsites required for specific recognition of the long terminal repeat Ends

11 July 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0700781104

Integrase inhibitors and cellular immunity suppress retroviral replication in rhesus macaques.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0700781104

Mechanism of HIV-1 integrase inhibition by styrylquinoline derivatives in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0700781104

Global allostery model of hemoglobin. Modulation of O(2) affinity, cooperativity, and Bohr effect by heterotropic allosteric effectors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0700781104

Inhibition of the integrases of human immunodeficiency viruses type 1 and type 2 by reverse transcriptases

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0700781104

A tripartite DNA-binding element, comprised of the nuclear localization signal and two AT-hook motifs, mediates the association of LEDGF/p75 with chromatin in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0700781104

Binding of Rad51 and other peptide sequences to a promiscuous, highly electrostatic binding site in p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0700781104

Stereochemistry of Cooperative Effects in Haemoglobin: Haem–Haem Interaction and the Problem of Allostery

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0700781104

Antiretroviral activity, pharmacokinetics, and tolerability of MK-0518, a novel inhibitor of HIV-1 integrase, dosed as monotherapy for 10 days in treatment-naive HIV-1-infected individuals

21 January 2018

1 reference

12 December 2020

LEDGF binds to heat shock and stress-related element to activate the expression of stress-related genes

1 reference

12 December 2020

The global allostery model of hemoglobin: an allosteric mechanism involving homotropic and heterotropic interactions

1 reference

12 December 2020

HIV-1 DNA integration: Mechanism of viral DNA cleavage and DNA strand transfer

1 reference

12 December 2020

Molecular code for cooperativity in hemoglobin

1 reference

12 December 2020

A soluble active mutant of HIV-1 integrase: involvement of both the core and carboxyl-terminal domains in multimerization

1 reference

12 December 2020

Identifiers

DOI

10.1073/PNAS.0700781104

1 reference

10 August 2017

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1 reference

10 August 2017

1 reference