Hot-spot mimicry of a cytokine receptor by a small molecule (Q35070688)

6 August 2017

Hot-spot mimicry of a cytokine receptor by a small molecule (English)

1 reference

6 August 2017

2

Warren L DeLano

1 reference

6 August 2017

Christopher D Thanos

1

1 reference

6 August 2017

James A Wells

series ordinal

3

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6 August 2017

language of work or name

English

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publication date

10 October 2006

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Proceedings of the National Academy of Sciences of the United States of America

6 August 2017

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6 August 2017

103

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6 August 2017

15422-15427

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6 August 2017

42

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describes a project that uses

6 August 2017

PyMOL

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/efetch.fcgi?db=pmc&rettype=xml&id=PMC1592646

cites work

Structure of the quaternary complex of interleukin-2 with its alpha, beta, and gammac receptors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1592646

An inhibitor of Bcl-2 family proteins induces regression of solid tumours

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1592646

The CCP4 suite: programs for protein crystallography

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1592646

Ligand efficiency: a useful metric for lead selection

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1592646

Small-molecule inhibitors of protein-protein interactions: progressing towards the dream

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1592646

Interleukin-2 mutants with enhanced alpha-receptor subunit binding affinity

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1592646

In vivo activation of the p53 pathway by small-molecule antagonists of MDM2

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1592646

Potent small-molecule binding to a dynamic hot spot on IL-2

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1592646

Discovery and characterization of cooperative ligand binding in the adaptive region of interleukin-2

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1592646

Binding of small molecules to an adaptive protein-protein interface

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1592646

Unraveling hot spots in binding interfaces: progress and challenges

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1592646

High affinity RNase S-peptide variants obtained by phage display have a novel "hot-spot" of binding energy

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1592646

Electrostatics of nanosystems: application to microtubules and the ribosome

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1592646

Phage display for selection of novel binding peptides

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1592646

High copy display of large proteins on phage for functional selections

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1592646

The maximal affinity of ligands

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1592646

Shared and unique determinants of the erythropoietin (EPO) receptor are important for binding EPO and EPO mimetic peptide

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1592646

The atomic structure of protein-protein recognition sites

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1592646

Selection of heregulin variants having higher affinity for the ErbB3 receptor by monovalent phage display

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1592646

Functional mimicry of a protein hormone by a peptide agonist: the EPO receptor complex at 2.8 A

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1592646

Binding in the growth hormone receptor complex

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1592646

Definition and spatial location of mouse interleukin-2 residues that interact with its heterotrimeric receptor

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1592646

A hot spot of binding energy in a hormone-receptor interface

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1592646

Rapid and efficient site-specific mutagenesis without phenotypic selection

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1592646

High-resolution epitope mapping of hGH-receptor interactions by alanine-scanning mutagenesis

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1592646

Selecting high-affinity binding proteins by monovalent phage display

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1592646

Discovery of a potent small molecule IL-2 inhibitor through fragment assembly

8 July 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0607058103

Integrating fragment assembly and biophysical methods in the chemical advancement of small-molecule antagonists of IL-2: an approach for inhibiting protein-protein interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0607058103

The role of protein dynamics in increasing binding affinity for an engineered protein-protein interaction established by H/D exchange mass spectrometry.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0607058103

Merck molecular force field. I. Basis, form, scope, parameterization, and performance of MMFF94

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0607058103

Protein−Protein Interactions: Interface Structure, Binding Thermodynamics, and Mutational Analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0607058103

The structure of interleukin-2 complexed with its alpha receptor

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/17032757

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1073/PNAS.0607058103

1 reference

6 August 2017

0 references

1 reference

6 August 2017

1 reference