Structure of the MDM2 oncoprotein bound to the p53 tumor suppressor transactivation domain (Q24314763)

ubiquitin protein ligase binding

GOA release 2020-03-11

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GOA release 2020-03-11

author name string

P H Kussie

1

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S Gorina

2

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V Marechal

3

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B Elenbaas

4

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J Moreau

5

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A J Levine

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N P Pavletich

Protein folding and association: insights from the interfacial and thermodynamic properties of hydrocarbons

7

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publication date

8 November 1996

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language of work or name

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274

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issue

5289

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page(s)

948-53

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cites work

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Wild-type p53 restores cell cycle control and inhibits gene amplification in cells with mutant p53 alleles.

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p53 function and dysfunction

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A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia

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The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation

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p53-dependent apoptosis suppresses tumor growth and progression in vivo

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Modular binding domains in signal transduction proteins

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TBP-TAF complexes: selectivity factors for eukaryotic transcription

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Structure and function of transcriptional activation domains

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Protein-peptide interactions

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Structure of anti-peptide antibody complexes

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Structure of the human class I histocompatibility antigen, HLA-A2

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The p53 tumour suppressor gene

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Amplification of a gene encoding a p53-associated protein in human sarcomas

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Oncoprotein MDM2 conceals the activation domain of tumour suppressor p53

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Three-dimensional structure of the human class II histocompatibility antigen HLA-DR1.

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p53-dependent apoptosis in the absence of transcriptional activation of p53-target genes

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Interaction between the retinoblastoma protein and the oncoprotein MDM2

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Rescue of early embryonic lethality in mdm2-deficient mice by deletion of p53

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Rescue of embryonic lethality in Mdm2-deficient mice by absence of p53

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Definition of a consensus binding site for p53

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Pattern of aromatic and hydrophobic amino acids critical for one of two subdomains of the VP16 transcriptional activator

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A glutamine-rich hydrophobic patch in transcription factor Sp1 contacts the dTAFII110 component of the Drosophila TFIID complex and mediates transcriptional activation

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Sequence-specific transcriptional activation is essential for growth suppression by p53.

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p53 and E2F-1 cooperate to mediate apoptosis

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Human TAFII31 protein is a transcriptional coactivator of the p53 protein

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Transactivation ability of p53 transcriptional activation domain is directly related to the binding affinity to TATA-binding protein

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p53: puzzle and paradigm

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The DNA-binding domain of p53 contains the four conserved regions and the major mutation hot spots

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The p53-mdm-2 autoregulatory feedback loop

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Several hydrophobic amino acids in the p53 amino-terminal domain are required for transcriptional activation, binding to mdm-2 and the adenovirus 5 E1B 55-kD protein

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Essential role for p53-mediated transcription in E1A-induced apoptosis

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Target enzyme recognition by calmodulin: 2.4 A structure of a calmodulin-peptide complex

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Critical structural elements of the VP16 transcriptional activation domain

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Identification of p53 as a sequence-specific DNA-binding protein

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Presence of a potent transcription activating sequence in the p53 protein

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p53 transcriptional activation mediated by coactivators TAFII40 and TAFII60

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A p53-dependent mouse spindle checkpoint

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Crystal structure of a p53 tumor suppressor-DNA complex: understanding tumorigenic mutations

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Mediation of c-Myc-induced apoptosis by p53.

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The mdm-2 oncogene can overcome wild-type p53 suppression of transformed cell growth

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Mapping of the p53 and mdm-2 Interaction Domains

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Mutational analysis of the transcription activation domain of RelA: identification of a highly synergistic minimal acidic activation module

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Reconstitution of transcriptional activation domains by reiteration of short peptide segments reveals the modular organization of a glutamine-rich activation domain

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Biochemistry and structural biology of transcription factor IID (TFIID)

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