Targeting bile-acid signalling for metabolic diseases (Q37231731)

19 August 2017

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title

Targeting bile-acid signalling for metabolic diseases (English)

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19 August 2017

4

Johan Auwerx

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Kristina Schoonjans

series ordinal

5

object named as

Kristina Schoonjans

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Roberto Pellicciari

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2

object named as

Roberto Pellicciari

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19 August 2017

3

Mark Pruzanski

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19 August 2017

Charles Thomas

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19 August 2017

1 August 2008

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Nature Reviews Drug Discovery

19 August 2017

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19 August 2017

7

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19 August 2017

678-693

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19 August 2017

8

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https://scigraph.springernature.com/pub.10.1038/nrd2619

19 August 2017

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cites work

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The metabolism of chenodeoxycholic acid to beta-muricholic acid in rat liver

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Identification of membrane-type receptor for bile acids (M-BAR)

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A G protein-coupled receptor responsive to bile acids

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Identification of a nuclear receptor for bile acids

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Bile acids: natural ligands for an orphan nuclear receptor

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Endogenous bile acids are ligands for the nuclear receptor FXR/BAR

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Identification of a nuclear receptor that is activated by farnesol metabolites

31 March 2020

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Identification of farnesoid X receptor beta as a novel mammalian nuclear receptor sensing lanosterol

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Generation of multiple farnesoid-X-receptor isoforms through the use of alternative promoters

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Natural structural variants of the nuclear receptor farnesoid X receptor affect transcriptional activation

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Peroxisome proliferator-activated receptor-gamma coactivator 1alpha (PGC-1alpha) regulates triglyceride metabolism by activation of the nuclear receptor FXR

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Structural basis for bile acid binding and activation of the nuclear receptor FXR

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A chemical, genetic, and structural analysis of the nuclear bile acid receptor FXR

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The nuclear receptor PXR is a lithocholic acid sensor that protects against liver toxicity

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Coordinate transcriptional regulation of bile acid homeostasis and drug metabolism

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Prevention of cholesterol gallstone disease by FXR agonists in a mouse model.

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The nuclear receptor for bile acids, FXR, transactivates human organic solute transporter-alpha and -beta genes

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FXR regulates organic solute transporters alpha and beta in the adrenal gland, kidney, and intestine

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Definition of a novel growth factor-dependent signal cascade for the suppression of bile acid biosynthesis

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Fibroblast growth factor 15 functions as an enterohepatic signal to regulate bile acid homeostasis

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Bile acids induce energy expenditure by promoting intracellular thyroid hormone activation

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Targeted deletion of Gpbar1 protects mice from cholesterol gallstone formation

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The G-protein coupled bile salt receptor TGR5 is expressed in liver sinusoidal endothelial cells

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Involvement of membrane-type bile acid receptor M-BAR/TGR5 in bile acid-induced activation of epidermal growth factor receptor and mitogen-activated protein kinases in gastric carcinoma cells

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Molecular basis for feedback regulation of bile acid synthesis by nuclear receptors

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A regulatory cascade of the nuclear receptors FXR, SHP-1, and LRH-1 represses bile acid biosynthesis

31 March 2020

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The small heterodimer partner interacts with the liver X receptor alpha and represses its transcriptional activity

31 March 2020

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Compromised intestinal lipid absorption in mice with a liver-specific deficiency of liver receptor homolog 1.

31 March 2020

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Liver receptor homolog-1 regulates bile acid homeostasis but is not essential for feedback regulation of bile acid synthesis.

31 March 2020

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The negative effects of bile acids and tumor necrosis factor-alpha on the transcription of cholesterol 7alpha-hydroxylase gene (CYP7A1) converge to hepatic nuclear factor-4: a novel mechanism of feedback regulation of bile acid synthesis mediated by

31 March 2020

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Transcriptional regulation of the human sterol 12alpha-hydroxylase gene (CYP8B1): roles of heaptocyte nuclear factor 4alpha in mediating bile acid repression

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Regulation of bile acid biosynthesis by hepatocyte nuclear factor 4alpha.

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Identification of a hormonal basis for gallbladder filling.

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Impaired negative feedback suppression of bile acid synthesis in mice lacking betaKlotho

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Molecular insights into the klotho-dependent, endocrine mode of action of fibroblast growth factor 19 subfamily members

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Co-receptor requirements for fibroblast growth factor-19 signaling

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Liver-specific activities of FGF19 require Klotho beta

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Differential regulation of rat and human CYP7A1 by the nuclear oxysterol receptor liver X receptor-alpha

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Chenodiol (chenodeoxycholic acid) for dissolution of gallstones: the National Cooperative Gallstone Study. A controlled trial of efficacy and safety

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Different effects of chenodeoxycholic acid and ursodeoxycholic acid on serum lipoprotein concentrations in patients with radiolucent gallstones

31 March 2020

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Nuclear receptors and the control of metabolism

31 March 2020

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Changes in plasma triglyceride metabolism during withdrawal of bile

31 March 2020

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Prevention and treatment of obesity, insulin resistance, and diabetes by bile acid-binding resin.

31 March 2020

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Triglyceride-lowering effect of chenodeoxycholic acid in patients with endogenous hypertriglyceridaemia

31 March 2020

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Farnesoid X-activated receptor induces apolipoprotein C-II transcription: a molecular mechanism linking plasma triglyceride levels to bile acids

31 March 2020

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The nuclear bile acid receptor FXR is activated by PGC-1alpha in a ligand-dependent manner

31 March 2020

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Regulation of carbohydrate metabolism by the farnesoid X receptor

31 March 2020

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Bile acids lower triglyceride levels via a pathway involving FXR, SHP, and SREBP-1c

31 March 2020

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Activation of the nuclear receptor FXR improves hyperglycemia and hyperlipidemia in diabetic mice

31 March 2020

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Activation of the farnesoid X receptor improves lipid metabolism in combined hyperlipidemic hamsters

31 March 2020

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SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver

31 March 2020

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Insulin selectively increases SREBP-1c mRNA in the livers of rats with streptozotocin-induced diabetes

31 March 2020

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Sterol regulatory element binding protein-1c is a major mediator of insulin action on the hepatic expression of glucokinase and lipogenesis-related genes

31 March 2020

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Role of LXRs in control of lipogenesis

31 March 2020

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Regulation of mouse sterol regulatory element-binding protein-1c gene (SREBP-1c) by oxysterol receptors, LXRalpha and LXRbeta

31 March 2020

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Mutations in the small heterodimer partner gene are associated with mild obesity in Japanese subjects

31 March 2020

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Contribution of variants in the small heterodimer partner gene to birthweight, adiposity, and insulin levels: mutational analysis and association studies in multiple populations

31 March 2020

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Genetic Variation in the Small Heterodimer Partner Gene and Young-Onset Type 2 Diabetes, Obesity, and Birth Weight in U.K. Subjects

31 March 2020

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Redundant pathways for negative feedback regulation of bile acid production

31 March 2020

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Loss of nuclear receptor SHP impairs but does not eliminate negative feedback regulation of bile acid synthesis

31 March 2020

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Targeted disruption of the nuclear receptor FXR/BAR impairs bile acid and lipid homeostasis.

31 March 2020

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FXR signaling in metabolic disease

31 March 2020

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Measurement of mitochondrial calcium in single living cardiomyocytes by selective removal of cytosolic indo 1

31 March 2020

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Anti-hyperglycemic activity of a TGR5 agonist isolated from Olea europaea

31 March 2020

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Transgenic mice expressing human fibroblast growth factor-19 display increased metabolic rate and decreased adiposity

31 March 2020

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The orphan nuclear receptor SHP regulates PGC-1alpha expression and energy production in brown adipocytes

31 March 2020

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Cholestyramine therapy for dyslipidemia in non-insulin-dependent diabetes mellitus. A short-term, double-blind, crossover trial.

31 March 2020

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The farnesoid X receptor modulates hepatic carbohydrate metabolism during the fasting-refeeding transition.

31 March 2020

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Coordinated control of cholesterol catabolism to bile acids and of gluconeogenesis via a novel mechanism of transcription regulation linked to the fasted-to-fed cycle

31 March 2020

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Bile acids regulate gluconeogenic gene expression via small heterodimer partner-mediated repression of hepatocyte nuclear factor 4 and Foxo1.

31 March 2020

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Farnesoid X receptor is essential for normal glucose homeostasis

31 March 2020

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PGC-1 promotes insulin resistance in liver through PPAR-alpha-dependent induction of TRB-3.

31 March 2020

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Transient impairment of the adaptive response to fasting in FXR-deficient mice

31 March 2020

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The farnesoid X receptor modulates adiposity and peripheral insulin sensitivity in mice

31 March 2020

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Bile acids enhance the activity of the insulin receptor and glycogen synthase in primary rodent hepatocytes

31 March 2020

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Bile acids induce mitochondrial ROS, which promote activation of receptor tyrosine kinases and signaling pathways in rat hepatocytes

31 March 2020

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Conjugated bile acids promote ERK1/2 and AKT activation via a pertussis toxin-sensitive mechanism in murine and human hepatocytes

31 March 2020

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Conjugated bile acids regulate hepatocyte glycogen synthase activity in vitro and in vivo via Galphai signaling

31 March 2020

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Improving metabolism by increasing energy expenditure

31 March 2020

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Chemical chaperones reduce ER stress and restore glucose homeostasis in a mouse model of type 2 diabetes

31 March 2020

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Targeting farnesoid X receptor for liver and metabolic disorders.

31 March 2020

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Regulation of antibacterial defense in the small intestine by the nuclear bile acid receptor

31 March 2020

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Farnesoid X receptor modulates renal lipid metabolism, fibrosis, and diabetic nephropathy

31 March 2020

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Identification of a chemical tool for the orphan nuclear receptor FXR.

31 March 2020

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Hepatoprotection by the farnesoid X receptor agonist GW4064 in rat models of intra- and extrahepatic cholestasis

31 March 2020

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Farnesoid X receptor: from structure to potential clinical applications

31 March 2020

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Guggulsterone is a farnesoid X receptor antagonist in coactivator association assays but acts to enhance transcription of bile salt export pump

31 March 2020

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Identification of gene-selective modulators of the bile acid receptor FXR.

31 March 2020

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A natural product that lowers cholesterol as an antagonist ligand for FXR.

31 March 2020

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Guggulipid for the treatment of hypercholesterolemia: a randomized controlled trial

31 March 2020

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Is antagonism of E/Z-guggulsterone at the farnesoid X receptor mediated by a noncanonical binding site? A molecular modeling study

31 March 2020

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Novel potent and selective bile acid derivatives as TGR5 agonists: biological screening, structure-activity relationships, and molecular modeling studies

31 March 2020

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Nongenomic actions of bile acids. Synthesis and preliminary characterization of 23- and 6,23-alkyl-substituted bile acid derivatives as selective modulators for the G-protein coupled receptor TGR5.

31 March 2020

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Effect of colestimide therapy for glycemic control in type 2 diabetes mellitus with hypercholesterolemia.

31 March 2020

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Glucuronidation converting methyl 1-(3,4-dimethoxyphenyl)-3-(3-ethylvaleryl)-4-hydroxy-6,7,8-trimethoxy-2-naphthoate (S-8921) to a potent apical sodium-dependent bile acid transporter inhibitor, resulting in a hypocholesterolemic action

31 March 2020

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Inhibition of ileal bile acid transport lowers plasma cholesterol levels by inactivating hepatic farnesoid X receptor and stimulating cholesterol 7 alpha-hydroxylase

31 March 2020

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SC-435, an ileal apical sodium co-dependent bile acid transporter (ASBT) inhibitor lowers plasma cholesterol and reduces atherosclerosis in guinea pigs

31 March 2020

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An obesity-associated gut microbiome with increased capacity for energy harvest

31 March 2020

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A top-down systems biology view of microbiome-mammalian metabolic interactions in a mouse model

31 March 2020

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Symbiotic gut microbes modulate human metabolic phenotypes

31 March 2020

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Modulation of longevity by environmental sensing.

31 March 2020

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The Physiology of Glucagon-like Peptide 1

31 March 2020

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Nuclear receptor-dependent bile acid signaling is required for normal liver regeneration

31 March 2020

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Identification of ligands for DAF-12 that govern dauer formation and reproduction in C. elegans.

31 March 2020

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A bile acid-like steroid modulates Caenorhabditis elegans lifespan through nuclear receptor signaling

31 March 2020

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Feeding natural hydrophilic bile acids inhibits intestinal cholesterol absorption: studies in the gallstone-susceptible mouse

31 March 2020

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Muscarinic acetylcholine receptors: mutant mice provide new insights for drug development

31 March 2020

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A critical role for beta cell M3 muscarinic acetylcholine receptors in regulating insulin release and blood glucose homeostasis in vivo

31 March 2020

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Formyl-peptide receptors revisited

31 March 2020

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Characterization of chenodeoxycholic acid as an endogenous antagonist of the G-coupled formyl peptide receptors

31 March 2020

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Effect of cholestasis and bile acids on interferon-induced 2',5'-adenylate synthetase and NK cell activities.

31 March 2020

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Pharmacophore model for bile acids recognition by the FPR receptor

31 March 2020

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Bile Acid Regulation of C/EBPβ, CREB, and c-Jun Function, via the Extracellular Signal-Regulated Kinase and c-Jun NH2-Terminal Kinase Pathways, Modulates the Apoptotic Response of Hepatocytes

31 March 2020

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Bile acid-mediated induction of cyclooxygenase-2 and Mcl-1 in hepatic stellate cells

31 March 2020

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Activation and role of mitogen-activated protein kinases in deoxycholic acid-induced apoptosis

31 March 2020

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Down-regulation of cholesterol 7alpha-hydroxylase (CYP7A1) gene expression by bile acids in primary rat hepatocytes is mediated by the c-Jun N-terminal kinase pathway

31 March 2020

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Three hypotheses linking bile to carcinogenesis in the gastrointestinal tract: certain bile salts have properties that may be used to complement chemotherapy

31 March 2020

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Expression of sterol 12alpha-hydroxylase alters bile acid pool composition in primary rat hepatocytes and in vivo

31 March 2020

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Cholic acid mediates negative feedback regulation of bile acid synthesis in mice

31 March 2020

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Molecular cloning and expression of rat liver bile acid CoA ligase

31 March 2020

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Bile acid coenzyme A: amino acid N-acyltransferase in the amino acid conjugation of bile acids

31 March 2020

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Rat liver bile acid CoA:amino acid N-acyltransferase: expression, characterization, and peroxisomal localization

31 March 2020

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31 March 2020

Bile salt transporters

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Bile salt transporters: molecular characterization, function, and regulation

31 March 2020

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The organic solute transporter alpha-beta, Ostalpha-Ostbeta, is essential for intestinal bile acid transport and homeostasis

31 March 2020

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Nuclear bile acid receptor FXR as pharmacological target: are we there yet?

31 March 2020

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6alpha-ethyl-chenodeoxycholic acid (6-ECDCA), a potent and selective FXR agonist endowed with anticholestatic activity.

31 March 2020

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The farnesoid X receptor FXRalpha/NR1H4 acquired ligand specificity for bile salts late in vertebrate evolution.

31 March 2020

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31 March 2020

Identifiers

DOI

10.1038/NRD2619

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PubMed ID

18670431

Dimensions Publication ID

19 August 2017

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PubMed ID

18670431