The farnesoid X receptor FXRalpha/NR1H4 acquired ligand specificity for bile salts late in vertebrate evolution. (Q47778761)

5 February 2018

title

The farnesoid X receptor FXRalpha/NR1H4 acquired ligand specificity for bile salts late in vertebrate evolution. (English)

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5 February 2018

author name string

Shi-Ying Cai

1

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Liangshi Xiong

2

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5 February 2018

Charles G Wray

3

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Nazzareno Ballatori

4

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James L Boyer

5

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publication date

13 June 2007

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American Journal of Physiology - Regulatory, Integrative and Comparative Physiology

published in

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volume

293

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issue

3

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page(s)

R1400-9

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Parallel Metropolis coupled Markov chain Monte Carlo for Bayesian phylogenetic inference

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Upregulation of a basolateral FXR-dependent bile acid efflux transporter OSTalpha-OSTbeta in cholestasis in humans and rodents

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Nuclear receptors RXRalpha:RARalpha are repressors for human MRP3 expression

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The Farnesoid X receptor: a molecular link between bile acid and lipid and glucose metabolism

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The amino acid residues asparagine 354 and isoleucine 372 of human farnesoid X receptor confer the receptor with high sensitivity to chenodeoxycholate

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Oxysterol 22(R)-hydroxycholesterol induces the expression of the bile salt export pump through nuclear receptor farsenoid X receptor but not liver X receptor

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A chemical, genetic, and structural analysis of the nuclear bile acid receptor FXR

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Ligand binding was acquired during evolution of nuclear receptors

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Identification of a nuclear receptor that is activated by farnesol metabolites

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A regulatory cascade of the nuclear receptors FXR, SHP-1, and LRH-1 represses bile acid biosynthesis

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Identification of a bile acid-responsive element in the human ileal bile acid-binding protein gene. Involvement of the farnesoid X receptor/9-cis-retinoic acid receptor heterodimer

21 January 2018

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9-cis retinoic acid is a high affinity ligand for the retinoid X receptor

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The nuclear receptor for bile acids, FXR, transactivates human organic solute transporter-alpha and -beta genes

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Molecular basis for feedback regulation of bile acid synthesis by nuclear receptors

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Identification of farnesoid X receptor beta as a novel mammalian nuclear receptor sensing lanosterol

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Fatty acid distribution in muscle, liver, and gonads of rays (Dasyatis marmorata, Rhinobatos cemiculus, and Rhinoptera marginata) from the East Tropical Atlantic Ocean

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6alpha-ethyl-chenodeoxycholic acid (6-ECDCA), a potent and selective FXR agonist endowed with anticholestatic activity.

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FOR, a novel orphan nuclear receptor related to farnesoid X receptor

21 January 2018

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Targeted disruption of the nuclear receptor FXR/BAR impairs bile acid and lipid homeostasis.

21 January 2018

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Endogenous bile acids are ligands for the nuclear receptor FXR/BAR

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The nuclear hormone receptor farnesoid X receptor (FXR) is activated by androsterone

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Polyunsaturated fatty acids are FXR ligands and differentially regulate expression of FXR targets

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21 January 2018

Identifiers

DOI

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5 February 2018

PubMed ID

17567710

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5 February 2018