Bile acids induce mitochondrial ROS, which promote activation of receptor tyrosine kinases and signaling pathways in rat hepatocytes (Q44905065)

7 December 2017

Bile acids induce mitochondrial ROS, which promote activation of receptor tyrosine kinases and signaling pathways in rat hepatocytes (English)

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7 December 2017

8

Paul Dent

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7 December 2017

Youwen Fang

1

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7 December 2017

Song Iy Han

2

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7 December 2017

Clint Mitchell

3

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7 December 2017

Seema Gupta

4

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7 December 2017

Elaine Studer

5

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7 December 2017

Steven Grant

6

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7 December 2017

Phillip B Hylemon

7

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7 December 2017

language of work or name

English

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publication date

1 October 2004

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7 December 2017

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7 December 2017

40

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7 December 2017

4

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7 December 2017

961-971

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Deoxycholic acid (DCA) causes ligand-independent activation of epidermal growth factor receptor (EGFR) and FAS receptor in primary hepatocytes: inhibition of EGFR/mitogen-activated protein kinase-signaling module enhances DCA-induced apoptosis.

7 December 2017

1 reference

https://api.crossref.org/works/10.1002%2FHEP.1840400427

Bile acids activate EGF receptor via a TGF-alpha-dependent mechanism in human cholangiocyte cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FHEP.1840400427

The mitogen-activated protein (MAP) kinase cascade can either stimulate or inhibit DNA synthesis in primary cultures of rat hepatocytes depending upon whether its activation is acute/phasic or chronic.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FHEP.1840400427

Radiation-induced release of transforming growth factor alpha activates the epidermal growth factor receptor and mitogen-activated protein kinase pathway in carcinoma cells, leading to increased proliferation and protection from radiation-induced ce

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FHEP.1840400427

Enterohepatic circulation: physiological, pharmacokinetic and clinical implications

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FHEP.1840400427

7 January 2021

Toxic bile salts induce rodent hepatocyte apoptosis via direct activation of Fas.

1 reference

https://api.crossref.org/works/10.1002%2FHEP.1840400427

7 January 2021

Effect of high concentrations of bile acids on cultured hepatocytes

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https://api.crossref.org/works/10.1002%2FHEP.1840400427

7 January 2021

Chronic cholestatic diseases

1 reference

https://api.crossref.org/works/10.1002%2FHEP.1840400427

7 January 2021

Activation of the Raf-1/MEK/ERK cascade by bile acids occurs via the epidermal growth factor receptor in primary rat hepatocytes

1 reference

https://api.crossref.org/works/10.1002%2FHEP.1840400427

7 January 2021

Inhibition of the MAPK and PI3K pathways enhances UDCA-induced apoptosis in primary rodent hepatocytes

1 reference

https://api.crossref.org/works/10.1002%2FHEP.1840400427

7 January 2021

Protein tyrosine phosphatases and the control of cellular signaling responses

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https://api.crossref.org/works/10.1002%2FHEP.1840400427

7 January 2021

Oxidation state of the active-site cysteine in protein tyrosine phosphatase 1B

1 reference

https://api.crossref.org/works/10.1002%2FHEP.1840400427

7 January 2021

Redox regulation of protein tyrosine phosphatase 1B involves a sulphenyl-amide intermediate

1 reference

https://api.crossref.org/works/10.1002%2FHEP.1840400427

7 January 2021

Deoxycholic acid activates the c-Jun N-terminal kinase pathway via FAS receptor activation in primary hepatocytes. Role of acidic sphingomyelinase-mediated ceramide generation in FAS receptor activation

1 reference

https://api.crossref.org/works/10.1002%2FHEP.1840400427

7 January 2021

Activation and role of mitogen-activated protein kinases in deoxycholic acid-induced apoptosis

1 reference

https://api.crossref.org/works/10.1002%2FHEP.1840400427

7 January 2021

Roles of reactive oxygen species, NF-kappaB, and peroxiredoxins in glycochenodeoxycholic acid-induced rat hepatocytes death.

1 reference

https://api.crossref.org/works/10.1002%2FHEP.1840400427

7 January 2021

Bile acid-induced rat hepatocyte apoptosis is inhibited by antioxidants and blockers of the mitochondrial permeability transition

1 reference

https://api.crossref.org/works/10.1002%2FHEP.1840400427

7 January 2021

Induction and regulation of hepatocyte apoptosis by oxidative stress

1 reference

https://api.crossref.org/works/10.1002%2FHEP.1840400427

7 January 2021

Activation of constitutive nitric-oxide synthase activity is an early signaling event induced by ionizing radiation

1 reference

https://api.crossref.org/works/10.1002%2FHEP.1840400427

7 January 2021

Bile acids enhance the activity of the insulin receptor and glycogen synthase in primary rodent hepatocytes

1 reference

https://api.crossref.org/works/10.1002%2FHEP.1840400427

7 January 2021

Bile acids stimulate cFLIP phosphorylation enhancing TRAIL-mediated apoptosis

1 reference

https://api.crossref.org/works/10.1002%2FHEP.1840400427

7 January 2021

Depletion of mitochondrial DNA alters glucose metabolism in SK-Hep1 cells

1 reference

https://api.crossref.org/works/10.1002%2FHEP.1840400427

7 January 2021

Dichlorodihydrofluorescein and dihydrorhodamine 123 are sensitive indicators of peroxynitrite in vitro: implications for intracellular measurement of reactive nitrogen and oxygen species

1 reference

https://api.crossref.org/works/10.1002%2FHEP.1840400427

7 January 2021

2,7-Dihydrodichlorofluorescein diacetate as a fluorescent marker for peroxynitrite formation

1 reference

https://api.crossref.org/works/10.1002%2FHEP.1840400427

7 January 2021

Association of SH2 domain protein tyrosine phosphatases with the epidermal growth factor receptor in human tumor cells. Phosphatidic acid activates receptor dephosphorylation by PTP1C

1 reference

https://api.crossref.org/works/10.1002%2FHEP.1840400427

7 January 2021

MAPK pathways in radiation responses

1 reference

https://api.crossref.org/works/10.1002%2FHEP.1840400427

7 January 2021

Activation of mitogen-activated protein kinase kinase by v-Raf in NIH 3T3 cells and in vitro

1 reference

https://api.crossref.org/works/10.1002%2FHEP.1840400427

7 January 2021

Serine and tyrosine phosphorylations cooperate in Raf-1, but not B-Raf activation

1 reference

https://api.crossref.org/works/10.1002%2FHEP.1840400427

7 January 2021

Differential abilities of activated Raf oncoproteins to abrogate cytokine dependency, prevent apoptosis and induce autocrine growth factor synthesis in human hematopoietic cells

1 reference

https://api.crossref.org/works/10.1002%2FHEP.1840400427

7 January 2021

Bid activates multiple mitochondrial apoptotic mechanisms in primary hepatocytes after death receptor engagement

1 reference

https://api.crossref.org/works/10.1002%2FHEP.1840400427

7 January 2021

Role of mitochondrial inner membrane permeabilization in necrotic cell death, apoptosis, and autophagy

1 reference

https://api.crossref.org/works/10.1002%2FHEP.1840400427

7 January 2021

Cell permeable BH3-peptides overcome the cytoprotective effect of Bcl-2 and Bcl-X(L).

1 reference

https://api.crossref.org/works/10.1002%2FHEP.1840400427

7 January 2021

Roles of ERBB family receptor tyrosine kinases, and downstream signaling pathways, in the control of cell growth and survival

1 reference

https://api.crossref.org/works/10.1002%2FHEP.1840400427

7 January 2021

Mitogen-activated protein kinases mediate the stimulation of bile acid secretion by tauroursodeoxycholate in rat liver

1 reference

https://api.crossref.org/works/10.1002%2FHEP.1840400427

7 January 2021

Bile acid-induced activation of activator protein-1 requires both extracellular signal-regulated kinase and protein kinase C signaling

1 reference

https://api.crossref.org/works/10.1002%2FHEP.1840400427

7 January 2021

Resistance of mitochondrial DNA-depleted cells against cell death: role of mitochondrial superoxide dismutase

1 reference

https://api.crossref.org/works/10.1002%2FHEP.1840400427

7 January 2021

Mitochondrial state 3 to 4 respiration transition during Fas-mediated apoptosis controls cellular redox balance and rate of cell death.

1 reference

https://api.crossref.org/works/10.1002%2FHEP.1840400427

7 January 2021

CYP2E1 overexpression alters hepatocyte death from menadione and fatty acids by activation of ERK1/2 signaling.

1 reference

https://api.crossref.org/works/10.1002%2FHEP.1840400427

7 January 2021

Ursodeoxycholic acid may inhibit deoxycholic acid-induced apoptosis by modulating mitochondrial transmembrane potential and reactive oxygen species production

1 reference

https://api.crossref.org/works/10.1002%2FHEP.1840400427

7 January 2021

Bile salt-induced hepatocyte apoptosis involves epidermal growth factor receptor-dependent CD95 tyrosine phosphorylation

1 reference

https://api.crossref.org/works/10.1002%2FHEP.1840400427

7 January 2021

Taurolithocholic acid-3 sulfate induces CD95 trafficking and apoptosis in a c-Jun N-terminal kinase-dependent manner

1 reference

https://api.crossref.org/works/10.1002%2FHEP.1840400427

7 January 2021

Insulin-activated Erk-mitogen-activated protein kinases phosphorylate sterol regulatory element-binding Protein-2 at serine residues 432 and 455 in vivo.

1 reference

https://api.crossref.org/works/10.1002%2FHEP.1840400427

7 January 2021

Epidermal Growth Factor Receptor Targeting Prevents Uncoupling of the Grb2-SOS Complex

1 reference

https://api.crossref.org/works/10.1002%2FHEP.1840400427

7 January 2021

Reversal of Raf-1 activation by purified and membrane-associated protein phosphatases

1 reference

https://api.crossref.org/works/10.1002%2FHEP.1840400427

7 January 2021

Differential regulation of Raf-1, A-Raf, and B-Raf by oncogenic ras and tyrosine kinases

1 reference

https://api.crossref.org/works/10.1002%2FHEP.1840400427

7 January 2021

Identification and H2O2 sensitivity of the major constitutive MAPK phosphatase from rat brain

1 reference

https://api.crossref.org/works/10.1002%2FHEP.1840400427

7 January 2021

Inhibition of PTPs by H(2)O(2) regulates the activation of distinct MAPK pathways

1 reference

https://api.crossref.org/works/10.1002%2FHEP.1840400427

7 January 2021

Follicle-stimulating hormone activates extracellular signal-regulated kinase but not extracellular signal-regulated kinase kinase through a 100-kDa phosphotyrosine phosphatase

1 reference

https://api.crossref.org/works/10.1002%2FHEP.1840400427

7 January 2021

Identifiers

DOI

10.1002/HEP.1840400427

1 reference

7 December 2017

1 reference