Transcriptional plasticity promotes primary and acquired resistance to BET inhibition (Q37038076)

17 August 2017

Transcriptional plasticity promotes primary and acquired resistance to BET inhibition (English)

1 reference

17 August 2017

20

1 reference

17 August 2017

Sabine Cerny-Reiterer

8

Sabine Cerny-Reiterer

0 references

Tobias Neumann

Tobias Neumann

3

0 references

Felix Muerdter

Felix Muerdter

4

0 references

Barbara Peter

Barbara Peter

9

0 references

Johannes Zuber

Johannes Zuber

23

0 references

Peter Valent

Peter Valent

19

0 references

Matthias Muhar

Matthias Muhar

6

0 references

Christopher R. Vakoc

22

Christopher R Vakoc

1 reference

17 August 2017

Philipp Rathert

1

1 reference

17 August 2017

Mareike Roth

2

1 reference

17 August 2017

Jae-Seok Roe

5

1 reference

17 August 2017

Sumit Deswal

7

1 reference

17 August 2017

Julian Jude

10

1 reference

17 August 2017

Thomas Hoffmann

11

1 reference

17 August 2017

Łukasz M Boryń

12

1 reference

17 August 2017

Elin Axelsson

13

1 reference

17 August 2017

Norbert Schweifer

14

1 reference

17 August 2017

Ulrike Tontsch-Grunt

15

1 reference

17 August 2017

Lukas E Dow

16

1 reference

17 August 2017

Davide Gianni

17

1 reference

17 August 2017

Mark Pearson

18

1 reference

17 August 2017

Norbert Kraut

21

1 reference

17 August 2017

language of work or name

English

0 references

publication date

14 September 2015

1 reference

17 August 2017

1 reference

17 August 2017

525

1 reference

17 August 2017

543-547

1 reference

17 August 2017

7570

1 reference

https://scigraph.springernature.com/pub.10.1038/nature14898

17 August 2017

0 references

cites work

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BET Bromodomain Inhibition Suppresses the Function of Hematopoietic Transcription Factors in Acute Myeloid Leukemia

29 September 2017

1 reference

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Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2

29 September 2017

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A comprehensive transcriptional portrait of human cancer cell lines

29 September 2017

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HTSeq--a Python framework to work with high-throughput sequencing data

29 September 2017

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Therapeutic targeting of BET bromodomain proteins in castration-resistant prostate cancer

29 September 2017

1 reference

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Disruption of CRAF-mediated MEK activation is required for effective MEK inhibition in KRAS mutant tumors

29 September 2017

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An epigenetic mechanism of resistance to targeted therapy in T cell acute lymphoblastic leukemia

29 September 2017

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An optimized microRNA backbone for effective single-copy RNAi

29 September 2017

1 reference

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Role of SWI/SNF in acute leukemia maintenance and enhancer-mediated Myc regulation

29 September 2017

1 reference

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Transcriptional regulation by Polycomb group proteins

29 September 2017

1 reference

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Selective inhibition of tumor oncogenes by disruption of super-enhancers

29 September 2017

1 reference

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Targeting MYCN in neuroblastoma by BET bromodomain inhibition

29 September 2017

1 reference

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Genome-wide quantitative enhancer activity maps identified by STARR-seq

29 September 2017

1 reference

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Phf19 links methylated Lys36 of histone H3 to regulation of Polycomb activity

29 September 2017

1 reference

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The Polycomb complex PRC2 supports aberrant self-renewal in a mouse model of MLL-AF9;Nras(G12D) acute myeloid leukemia.

29 September 2017

1 reference

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The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity

29 September 2017

1 reference

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Polycomb repressive complex 2 is required for MLL-AF9 leukemia

29 September 2017

1 reference

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Fast gapped-read alignment with Bowtie 2

29 September 2017

1 reference

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A pipeline for the generation of shRNA transgenic mice

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4921058

Inhibition of BET recruitment to chromatin as an effective treatment for MLL-fusion leukaemia

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4921058

BET bromodomain inhibition as a therapeutic strategy to target c-Myc

29 September 2017

1 reference

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An integrated approach to dissecting oncogene addiction implicates a Myb-coordinated self-renewal program as essential for leukemia maintenance

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4921058

RNAi screen identifies Brd4 as a therapeutic target in acute myeloid leukaemia

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4921058

The Brd4 extraterminal domain confers transcription activation independent of pTEFb by recruiting multiple proteins, including NSD3.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4921058

Functional identification of optimized RNAi triggers using a massively parallel sensor assay

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4921058

Toolkit for evaluating genes required for proliferation and survival using tetracycline-regulated RNAi

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4921058

Small-molecule inhibition of Wnt signaling through activation of casein kinase 1α

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4921058

Selective inhibition of BET bromodomains

29 September 2017

1 reference

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Galaxy: a comprehensive approach for supporting accessible, reproducible, and transparent computational research in the life sciences

29 September 2017

1 reference

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BEDTools: a flexible suite of utilities for comparing genomic features

29 September 2017

1 reference

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edgeR: a Bioconductor package for differential expression analysis of digital gene expression data

29 September 2017

1 reference

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Fast and accurate short read alignment with Burrows-Wheeler transform

29 September 2017

1 reference

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The 2008 revision of the World Health Organization (WHO) classification of myeloid neoplasms and acute leukemia: rationale and important changes

29 September 2017

1 reference

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Mouse models of human AML accurately predict chemotherapy response

29 September 2017

1 reference

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TopHat: discovering splice junctions with RNA-Seq

29 September 2017

1 reference

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Ultrafast and memory-efficient alignment of short DNA sequences to the human genome

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4921058

Model-based analysis of ChIP-Seq (MACS)

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4921058

Mapping and quantifying mammalian transcriptomes by RNA-Seq

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4921058

Theoretical basis, experimental design, and computerized simulation of synergism and antagonism in drug combination studies

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4921058

CRD-BP mediates stabilization of betaTrCP1 and c-myc mRNA in response to beta-catenin signalling

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4921058

Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4921058

The bromodomain protein Brd4 is a positive regulatory component of P-TEFb and stimulates RNA polymerase II-dependent transcription

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4921058

A role for Wnt signalling in self-renewal of haematopoietic stem cells

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4921058

Analysis of lung tumor initiation and progression using conditional expression of oncogenic K-ras

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4921058

Identification of c-MYC as a target of the APC pathway

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4921058

Proposed revised criteria for the classification of acute myeloid leukemia. A report of the French-American-British Cooperative Group

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4921058

Proposals for the Classification of the Acute Leukaemias French-American-British (FAB) Co-operative Group

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4921058

PRC2 loss amplifies Ras-driven transcription and confers sensitivity to BRD4-based therapies

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4921058

The Wnt/beta-catenin pathway is required for the development of leukemia stem cells in AML.

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4921058

ITF-2, a downstream target of the Wnt/TCF pathway, is activated in human cancers with beta-catenin defects and promotes neoplastic transformation.

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4921058

Synergistic tumor suppressor activity of BRCA2 and p53 in a conditional mouse model for breast cancer.

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4921058

Cutadapt removes adapter sequences from high-throughput sequencing reads

4 September 2018

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FNATURE14898

21 January 2018

Identifiers

DOI

10.1038/NATURE14898

1 reference

17 August 2017

1 reference

17 August 2017

1 reference