Transcriptional regulation by Polycomb group proteins (Q38149730)

29 August 2017

Transcriptional regulation by Polycomb group proteins (English)

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29 August 2017

2

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29 August 2017

Luciano Di Croce

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publication date

1 October 2013

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Nature Structural & Molecular Biology

29 August 2017

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29 August 2017

20

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29 August 2017

1147-1155

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29 August 2017

10

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https://scigraph.springernature.com/pub.10.1038/nsmb.2669

29 August 2017

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cites work

Crystal structure of the nucleosome core particle at 2.8 A resolution

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Perceiving the epigenetic landscape through histone readers.

31 March 2020

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A gene complex controlling segmentation in Drosophila

31 March 2020

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A model for transmission of the H3K27me3 epigenetic mark

31 March 2020

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TrxG and PcG proteins but not methylated histones remain associated with DNA through replication

31 March 2020

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Polycomb group proteins: multi-faceted regulators of somatic stem cells and cancer

31 March 2020

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Polycomb complexes in stem cells and embryonic development.

31 March 2020

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Regulation of human epidermal stem cell proliferation and senescence requires polycomb- dependent and -independent functions of Cbx4.

31 March 2020

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Roles of the Polycomb group proteins in stem cells and cancer

31 March 2020

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Polycomb group proteins: navigators of lineage pathways led astray in cancer

31 March 2020

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The core of the polycomb repressive complex is compositionally and functionally conserved in flies and humans

31 March 2020

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Ezh1 and Ezh2 maintain repressive chromatin through different mechanisms

31 March 2020

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EZH1 mediates methylation on histone H3 lysine 27 and complements EZH2 in maintaining stem cell identity and executing pluripotency

31 March 2020

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Role of Bmi-1 and Ring1A in H2A ubiquitylation and Hox gene silencing

31 March 2020

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Role of histone H2A ubiquitination in Polycomb silencing

31 March 2020

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PCGF homologs, CBX proteins, and RYBP define functionally distinct PRC1 family complexes

31 March 2020

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KDM2B links the Polycomb Repressive Complex 1 (PRC1) to recognition of CpG islands.

31 March 2020

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Polycomb group and SCF ubiquitin ligases are found in a novel BCOR complex that is recruited to BCL6 targets

31 March 2020

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dKDM2 couples histone H2A ubiquitylation to histone H3 demethylation during Polycomb group silencing

31 March 2020

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A complex with chromatin modifiers that occupies E2F- and Myc-responsive genes in G0 cells

31 March 2020

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Proteomics analysis of Ring1B/Rnf2 interactors identifies a novel complex with the Fbxl10/Jhdm1B histone demethylase and the Bcl6 interacting corepressor

31 March 2020

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RYBP-PRC1 complexes mediate H2A ubiquitylation at polycomb target sites independently of PRC2 and H3K27me3

31 March 2020

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Fbxl10/Kdm2b recruits polycomb repressive complex 1 to CpG islands and regulates H2A ubiquitylation

31 March 2020

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Nonoverlapping functions of the Polycomb group Cbx family of proteins in embryonic stem cells

31 March 2020

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MicroRNA regulation of Cbx7 mediates a switch of Polycomb orthologs during ESC differentiation

31 March 2020

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RYBP and Cbx7 define specific biological functions of polycomb complexes in mouse embryonic stem cells

31 March 2020

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Ring1B compacts chromatin structure and represses gene expression independent of histone ubiquitination

31 March 2020

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Demethylation of H3K27 regulates polycomb recruitment and H2A ubiquitination

31 March 2020

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Cooperation between EZH2, NSPc1-mediated histone H2A ubiquitination and Dnmt1 in HOX gene silencing

31 March 2020

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A novel repressive E2F6 complex containing the polycomb group protein, EPC1, that interacts with EZH2 in a proliferation-specific manner

31 March 2020

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Homeotic transformations of the axial skeleton that accompany a targeted deletion of E2f6.

31 March 2020

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Histone H2A deubiquitinase activity of the Polycomb repressive complex PR-DUB

31 March 2020

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ASXL1 mutations promote myeloid transformation through loss of PRC2-mediated gene repression

31 March 2020

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Loss of the tumor suppressor BAP1 causes myeloid transformation

31 March 2020

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The nuclear deubiquitinase BAP1 is commonly inactivated by somatic mutations and 3p21.1 losses in malignant pleural mesothelioma

31 March 2020

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The role of mutations in epigenetic regulators in myeloid malignancies

31 March 2020

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Chromatin compaction by a polycomb group protein complex

31 March 2020

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Ezh2 requires PHF1 to efficiently catalyze H3 lysine 27 trimethylation in vivo.

31 March 2020

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Polycomb-dependent regulatory contacts between distant Hox loci in Drosophila.

31 March 2020

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Three-dimensional folding and functional organization principles of the Drosophila genome

31 March 2020

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Polycomb group proteins: repression in 3D.

31 March 2020

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MBD3, a component of the NuRD complex, facilitates chromatin alteration and deposition of epigenetic marks.

31 March 2020

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NuRD-mediated deacetylation of H3K27 facilitates recruitment of Polycomb Repressive Complex 2 to direct gene repression

31 March 2020

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Selective arrangement of ubiquitinated and D1 protein-containing nucleosomes within the drosophila genome

31 March 2020

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Ring1-mediated ubiquitination of H2A restrains poised RNA polymerase II at bivalent genes in mouse ES cells

31 March 2020

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Histone H2A monoubiquitination represses transcription by inhibiting RNA polymerase II transcriptional elongation

31 March 2020

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Deubiquitylation of histone H2A activates transcriptional initiation via trans-histone cross-talk with H3K4 di- and trimethylation

31 March 2020

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Histone H2A mono-ubiquitination is a crucial step to mediate PRC1-dependent repression of developmental genes to maintain ES cell identity

31 March 2020

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Transcriptional activation of polycomb-repressed genes by ZRF1

31 March 2020

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General transcription factors bind promoters repressed by Polycomb group proteins.

31 March 2020

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A Drosophila Polycomb group complex includes Zeste and dTAFII proteins.

31 March 2020

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Selective anchoring of TFIID to nucleosomes by trimethylation of histone H3 lysine 4

31 March 2020

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Polycomb associates genome-wide with a specific RNA polymerase II variant, and regulates metabolic genes in ESCs

31 March 2020

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Short RNAs are transcribed from repressed polycomb target genes and interact with polycomb repressive complex-2.

31 March 2020

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Polycomb complexes repress developmental regulators in murine embryonic stem cells

31 March 2020

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The polycomb-group gene Ezh2 is required for early mouse development

31 March 2020

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Polycomb repressive complex 2 is dispensable for maintenance of embryonic stem cell pluripotency

31 March 2020

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Suz12 is essential for mouse development and for EZH2 histone methyltransferase activity

31 March 2020

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Mammalian polyhomeotic homologues Phc2 and Phc1 act in synergy to mediate polycomb repression of Hox genes

31 March 2020

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Rnf2 (Ring1b) deficiency causes gastrulation arrest and cell cycle inhibition

31 March 2020

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Polycomb group proteins Ring1A/B link ubiquitylation of histone H2A to heritable gene silencing and X inactivation

31 March 2020

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Ubiquitin E3 ligase Ring1b/Rnf2 of polycomb repressive complex 1 contributes to stable maintenance of mouse embryonic stem cells

31 March 2020

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Ring1B is crucial for the regulation of developmental control genes and PRC1 proteins but not X inactivation in embryonic cells

31 March 2020

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Polycomb group proteins Ring1A/B are functionally linked to the core transcriptional regulatory circuitry to maintain ES cell identity

31 March 2020

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Phf19 links methylated Lys36 of histone H3 to regulation of Polycomb activity

31 March 2020

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Polycomb PHF19 binds H3K36me3 and recruits PRC2 and demethylase NO66 to embryonic stem cell genes during differentiation

31 March 2020

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An H3K36 methylation-engaging Tudor motif of polycomb-like proteins mediates PRC2 complex targeting

31 March 2020

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Molecular basis for H3K36me3 recognition by the Tudor domain of PHF1

31 March 2020

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Genome-wide analysis of Polycomb targets in Drosophila melanogaster

31 March 2020

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Genome-wide profiling of PRC1 and PRC2 Polycomb chromatin binding in Drosophila melanogaster

31 March 2020

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Chromosomal distribution of PcG proteins during Drosophila development

31 March 2020

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GC-rich sequence elements recruit PRC2 in mammalian ES cells

31 March 2020

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Genomewide analysis of PRC1 and PRC2 occupancy identifies two classes of bivalent domains

31 March 2020

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Yin Yang 1 extends the Myc-related transcription factors network in embryonic stem cells.

31 March 2020

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Genome-wide mapping of Polycomb target genes unravels their roles in cell fate transitions

31 March 2020

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Control of developmental regulators by Polycomb in human embryonic stem cells

31 March 2020

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REST interacts with Cbx proteins and regulates polycomb repressive complex 1 occupancy at RE1 elements

31 March 2020

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REST-mediated recruitment of polycomb repressor complexes in mammalian cells

31 March 2020

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Direct recruitment of polycomb repressive complex 1 to chromatin by core binding transcription factors.

31 March 2020

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Hyperconserved CpG domains underlie Polycomb-binding sites

31 March 2020

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An interspecies analysis reveals a key role for unmethylated CpG dinucleotides in vertebrate Polycomb complex recruitment

31 March 2020

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AEBP2 as a potential targeting protein for Polycomb Repression Complex PRC2.

31 March 2020

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Jarid2 is a PRC2 component in embryonic stem cells required for multi-lineage differentiation and recruitment of PRC1 and RNA Polymerase II to developmental regulators.

31 March 2020

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Jarid2 and PRC2, partners in regulating gene expression

31 March 2020

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JARID2 regulates binding of the Polycomb repressive complex 2 to target genes in ES cells

31 March 2020

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Jarid2/Jumonji coordinates control of PRC2 enzymatic activity and target gene occupancy in pluripotent cells

31 March 2020

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Jumonji modulates polycomb activity and self-renewal versus differentiation of stem cells

31 March 2020

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Role of the polycomb protein EED in the propagation of repressive histone marks

31 March 2020

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Polycomb-like 3 promotes polycomb repressive complex 2 binding to CpG islands and embryonic stem cell self-renewal

31 March 2020

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Polycomb-like 2 associates with PRC2 and regulates transcriptional networks during mouse embryonic stem cell self-renewal and differentiation

31 March 2020

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Modeling of epigenome dynamics identifies transcription factors that mediate Polycomb targeting

31 March 2020

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The PRC1 Polycomb group complex interacts with PLZF/RARA to mediate leukemic transformation

31 March 2020

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Polycomb complex 2 is required for E-cadherin repression by the Snail1 transcription factor.

31 March 2020

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Role of the polycomb repressive complex 2 in acute promyelocytic leukemia

31 March 2020

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Role of histone H3 lysine 27 methylation in X inactivation

31 March 2020

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Establishment of histone h3 methylation on the inactive X chromosome requires transient recruitment of Eed-Enx1 polycomb group complexes

31 March 2020

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Polycomb proteins targeted by a short repeat RNA to the mouse X chromosome

31 March 2020

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Functional demarcation of active and silent chromatin domains in human HOX loci by noncoding RNAs

31 March 2020

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Kcnq1ot1 antisense noncoding RNA mediates lineage-specific transcriptional silencing through chromatin-level regulation

31 March 2020

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Polycomb group proteins Ezh2 and Rnf2 direct genomic contraction and imprinted repression in early mouse embryos

31 March 2020

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Many human large intergenic noncoding RNAs associate with chromatin-modifying complexes and affect gene expression

31 March 2020

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Genome-wide identification of polycomb-associated RNAs by RIP-seq

31 March 2020

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Noncoding RNA and Polycomb recruitment.

31 March 2020

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Partitioning and plasticity of repressive histone methylation states in mammalian chromatin

31 March 2020

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Quantitative mass spectrometry of histones H3.2 and H3.3 in Suz12-deficient mouse embryonic stem cells reveals distinct, dynamic post-translational modifications at Lys-27 and Lys-36

31 March 2020

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Coordinated activities of wild-type plus mutant EZH2 drive tumor-associated hypertrimethylation of lysine 27 on histone H3 (H3K27) in human B-cell lymphomas

31 March 2020

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A histone mutant reproduces the phenotype caused by loss of histone-modifying factor Polycomb.

31 March 2020

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High-resolution profiling of histone methylations in the human genome

31 March 2020

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Chromatin signatures in multipotent human hematopoietic stem cells indicate the fate of bivalent genes during differentiation

31 March 2020

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Mice doubly deficient for the Polycomb Group genes Mel18 and Bmi1 reveal synergy and requirement for maintenance but not initiation of Hox gene expression

31 March 2020

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24096405

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Involvement of the Polycomb-group gene Ring1B in the specification of the anterior-posterior axis in mice

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24096405

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

The Polycomb-group gene eed is required for normal morphogenetic movements during gastrulation in the mouse embryo.

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24096405

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/NSMB.2669

1 reference

29 August 2017

1 reference

PubMed ID

24096405