Polycomb repressive complex 2 is required for MLL-AF9 leukemia (Q35882496)

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25 January 2020

title

Polycomb repressive complex 2 is required for MLL-AF9 leukemia (English)

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25 January 2020

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1

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25 January 2020

author name string

Amit U Sinha

2

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25 January 2020

Michael J Kluk

3

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25 January 2020

Nan Zhu

4

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25 January 2020

Mohamed H Khattab

5

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25 January 2020

Lauren Stein

6

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25 January 2020

Huafeng Xie

7

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25 January 2020

Stuart H Orkin

8

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25 January 2020

Scott A Armstrong

9

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language of work or name

English

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publication date

6 March 2012

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Proceedings of the National Academy of Sciences of the United States of America

25 January 2020

published in

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volume

109

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25 January 2020

page(s)

5028-5033

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issue

13

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Genetic inactivation of the polycomb repressive complex 2 in T cell acute lymphoblastic leukemia

25 January 2020

cites work

1 reference

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The genetic basis of early T-cell precursor acute lymphoblastic leukaemia

11 July 2018

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Myc regulates the transcription of the PRC2 gene to control the expression of developmental genes in embryonic stem cells

11 July 2018

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Inhibition of BET recruitment to chromatin as an effective treatment for MLL-fusion leukaemia

11 July 2018

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BET bromodomain inhibition as a therapeutic strategy to target c-Myc

11 July 2018

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Mutational spectrum analysis of chronic myelomonocytic leukemia includes genes associated with epigenetic regulation: UTX, EZH2, and DNMT3A.

11 July 2018

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RNAi screen identifies Brd4 as a therapeutic target in acute myeloid leukaemia

11 July 2018

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MLL-rearranged leukemia is dependent on aberrant H3K79 methylation by DOT1L.

11 July 2018

1 reference

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EZH2-mediated concordant repression of Wnt antagonists promotes β-catenin-dependent hepatocarcinogenesis.

11 July 2018

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EZH1 and EZH2 cogovern histone H3K27 trimethylation and are essential for hair follicle homeostasis and wound repair

11 July 2018

1 reference

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Coordinated activities of wild-type plus mutant EZH2 drive tumor-associated hypertrimethylation of lysine 27 on histone H3 (H3K27) in human B-cell lymphomas

11 July 2018

1 reference

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Epigenetic antagonism between polycomb and SWI/SNF complexes during oncogenic transformation

11 July 2018

1 reference

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A Myc network accounts for similarities between embryonic stem and cancer cell transcription programs

11 July 2018

1 reference

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Somatic mutations of the histone methyltransferase gene EZH2 in myelodysplastic syndromes

11 July 2018

1 reference

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Inactivating mutations of the histone methyltransferase gene EZH2 in myeloid disorders

11 July 2018

1 reference

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Polycomb group protein-mediated repression of transcription

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3324004

EZH2 is essential for glioblastoma cancer stem cell maintenance

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3324004

Hierarchical maintenance of MLL myeloid leukemia stem cells employs a transcriptional program shared with embryonic rather than adult stem cells

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3324004

Ezh1 and Ezh2 maintain repressive chromatin through different mechanisms

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3324004

EZH1 mediates methylation on histone H3 lysine 27 and complements EZH2 in maintaining stem cell identity and executing pluripotency

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3324004

H3K79 methylation profiles define murine and human MLL-AF4 leukemias

11 July 2018

1 reference

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The polycomb group protein Suz12 is required for embryonic stem cell differentiation

11 July 2018

1 reference

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Control of developmental regulators by Polycomb in human embryonic stem cells

11 July 2018

1 reference

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Polycomb complexes repress developmental regulators in murine embryonic stem cells

11 July 2018

1 reference

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The Polycomb group gene Ezh2 prevents hematopoietic stem cell exhaustion

11 July 2018

1 reference

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The polycomb group protein enhancer of zeste homolog 2 (EZH 2) is an oncogene that influences myeloma cell growth and the mutant ras phenotype

11 July 2018

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The polycomb group protein EZH2 is involved in progression of prostate cancer

11 July 2018

1 reference

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Role of histone H3 lysine 27 methylation in Polycomb-group silencing

11 July 2018

1 reference

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Self-excising retroviral vectors encoding the Cre recombinase overcome Cre-mediated cellular toxicity

11 July 2018

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Cre reporter strains produced by targeted insertion of EYFP and ECFP into the ROSA26 locus

11 July 2018

1 reference

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EZH2 mutational status predicts poor survival in myelofibrosis.

11 July 2018

1 reference

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Deregulation of H3K27 methylation in cancer

21 January 2018

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Polycomb repressive complex 2 is dispensable for maintenance of embryonic stem cell pluripotency

21 January 2018

1 reference

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Dependency on the polycomb gene Ezh2 distinguishes fetal from adult hematopoietic stem cells.

21 January 2018

1 reference

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21 January 2018

Identifiers

DOI

10.1073/PNAS.1202258109

1 reference

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25 January 2020

0 references

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25 January 2020

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