Back to basics: how natural products can provide the basis for new therapeutics (Q36985862)

17 August 2017

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title

Back to basics: how natural products can provide the basis for new therapeutics (English)

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17 August 2017

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Amit Deorukhkar

1

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17 August 2017

Sunil Krishnan

series ordinal

2

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17 August 2017

Gautam Sethi

series ordinal

3

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17 August 2017

Bharat B Aggarwal

series ordinal

4

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17 August 2017

language of work or name

English

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publication date

1 November 2007

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Expert Opinion on Investigational Drugs

17 August 2017

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17 August 2017

16

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17 August 2017

1753-1773

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17 August 2017

11

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17 August 2017

Cancer statistics, 2007

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21 January 2018

The Hallmarks of Cancer

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Natural products in anticancer therapy.

21 January 2018

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The influence of natural products upon drug discovery

21 January 2018

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Novel aspects of natural and modified vinca alkaloids

21 January 2018

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Marine pharmacology in 2003-2004: anti-tumour and cytotoxic compounds.

21 January 2018

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Marine peptides and related compounds in clinical trial.

21 January 2018

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Cancer chemoprevention with dietary phytochemicals

21 January 2018

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Role of chemopreventive agents in cancer therapy

21 January 2018

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Molecular targets of dietary agents for prevention and therapy of cancer

21 January 2018

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Curcumin: getting back to the roots.

21 January 2018

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Cancer preventive properties of ginger: a brief review

21 January 2018

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Inhibitory effects of [6]-gingerol on PMA-induced COX-2 expression and activation of NF-kappaB and p38 MAPK in mouse skin

21 January 2018

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Capsaicin is a novel blocker of constitutive and interleukin-6-inducible STAT3 activation

21 January 2018

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Capsaicin inhibits in vitro and in vivo angiogenesis

21 January 2018

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Targeting multiple signaling pathways by green tea polyphenol (-)-epigallocatechin-3-gallate.

21 January 2018

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Protein tyrosine kinase inhibitors block tumor necrosis factor-induced activation of nuclear factor-kappaB, degradation of IkappaBalpha, nuclear translocation of p65, and subsequent gene expression

21 January 2018

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The role of genistein and synthetic derivatives of isoflavone in cancer prevention and therapy

21 January 2018

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Flavopiridol inhibits NF-kappaB activation induced by various carcinogens and inflammatory agents through inhibition of IkappaBalpha kinase and p65 phosphorylation: abrogation of cyclin D1, cyclooxygenase-2, and matrix metalloprotease-9.

21 January 2018

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Silybin and silymarin--new and emerging applications in medicine

21 January 2018

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From chemoprevention to chemotherapy: common targets and common goals

21 January 2018

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Mammalian MAP kinase signalling cascades

21 January 2018

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Inhibition of the c-Jun N-terminal kinase (JNK) signaling pathway by curcumin.

21 January 2018

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Inhibition of UVB-induced oxidative stress-mediated phosphorylation of mitogen-activated protein kinase signaling pathways in cultured human epidermal keratinocytes by green tea polyphenol (-)-epigallocatechin-3-gallate

21 January 2018

1 reference

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Resveratrol antagonizes EGFR-dependent Erk1/2 activation in human androgen-independent prostate cancer cells with associated isozyme-selective PKC alpha inhibition

21 January 2018

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Potent antiproliferative effects of resveratrol on human osteosarcoma SJSA1 cells: Novel cellular mechanisms involving the ERKs/p53 cascade

21 January 2018

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Social controls on cell survival and cell death

21 January 2018

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Rules for making human tumor cells

21 January 2018

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Suppression of IL-8 gene transcription by resveratrol in phorbol ester treated human monocytic cells

21 January 2018

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Targeting epidermal growth factor receptor--are we missing the mark?

21 January 2018

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Inhibition of ligand-induced activation of epidermal growth factor receptor tyrosine phosphorylation by curcumin

21 January 2018

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Peroxisome proliferator-activated receptors in tumorigenesis: targets of tumour promotion and treatment

21 January 2018

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Activation of PPAR{gamma} by curcumin inhibits Moser cell growth and mediates suppression of gene expression of cyclin D1 and EGFR.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.11.1753

(-)-Epigallocatechin gallate and polyphenon E inhibit growth and activation of the epidermal growth factor receptor and human epidermal growth factor receptor-2 signaling pathways in human colon cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.11.1753

Epigallocatechin-3-gallate inhibits epidermal growth factor receptor signaling pathway. Evidence for direct inhibition of ERK1/2 and AKT kinases.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.11.1753

Green tea polyphenol epigallocatechin-3-gallate blocks PDGF-induced proliferation and migration of rat pancreatic stellate cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.11.1753

Involvement of PI3K/Akt pathway in cell cycle progression, apoptosis, and neoplastic transformation: a target for cancer chemotherapy.

21 January 2018

1 reference

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NF-kappaB activation by tumour necrosis factor requires the Akt serine-threonine kinase

21 January 2018

1 reference

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Regulation of cell death protease caspase-9 by phosphorylation

21 January 2018

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Relevance of mitogen activated protein kinase (MAPK) and phosphotidylinositol-3-kinase/protein kinase B (PI3K/PKB) pathways to induction of apoptosis by curcumin in breast cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.11.1753

A component of green tea, (-)-epigallocatechin-3-gallate, promotes apoptosis in T24 human bladder cancer cells via modulation of the PI3K/Akt pathway and Bcl-2 family proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.11.1753

Tea polyphenol epigallocatechin 3-gallate impedes the anti-apoptotic effects of low-grade repetitive stress through inhibition of Akt and NFkappaB survival pathways.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.11.1753

Resveratrol-caused apoptosis of human prostate carcinoma LNCaP cells is mediated via modulation of phosphatidylinositol 3'-kinase/Akt pathway and Bcl-2 family proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.11.1753

Resveratrol inhibits proliferation, induces apoptosis, and overcomes chemoresistance through down-regulation of STAT3 and nuclear factor-kappaB-regulated antiapoptotic and cell survival gene products in human multiple myeloma cells.

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543784.16.11.1753

Nuclear factor-kappaB: the enemy within

21 January 2018

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Transcription factor NF-kappaB: a sensor for smoke and stress signals

21 January 2018

1 reference

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Curcumin (diferuloylmethane) down-regulates the constitutive activation of nuclear factor-kappa B and IkappaBalpha kinase in human multiple myeloma cells, leading to suppression of proliferation and induction of apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.11.1753

Capsaicin suppresses phorbol ester-induced activation of NF-kappaB/Rel and AP-1 transcription factors in mouse epidermis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.11.1753

Resveratrol suppresses TNF-induced activation of nuclear transcription factors NF-kappa B, activator protein-1, and apoptosis: potential role of reactive oxygen intermediates and lipid peroxidation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.11.1753

Guggulsterone inhibits NF-kappaB and IkappaBalpha kinase activation, suppresses expression of anti-apoptotic gene products, and enhances apoptosis

21 January 2018

1 reference

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Betulinic acid suppresses carcinogen-induced NF-kappa B activation through inhibition of I kappa B alpha kinase and p65 phosphorylation: abrogation of cyclooxygenase-2 and matrix metalloprotease-9.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.11.1753

Indole-3-carbinol suppresses NF-kappaB and IkappaBalpha kinase activation, causing inhibition of expression of NF-kappaB-regulated antiapoptotic and metastatic gene products and enhancement of apoptosis in myeloid and leukemia cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.11.1753

Anethole blocks both early and late cellular responses transduced by tumor necrosis factor: effect on NF-kappaB, AP-1, JNK, MAPKK and apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.11.1753

Lycopene suppresses the lipopolysaccharide-induced phenotypic and functional maturation of murine dendritic cells through inhibition of mitogen-activated protein kinases and nuclear factor-kappaB.

21 January 2018

1 reference

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Inactivation of NF-kappaB by genistein is mediated via Akt signaling pathway in breast cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.11.1753

Diosgenin inhibits osteoclastogenesis, invasion, and proliferation through the downregulation of Akt, I kappa B kinase activation and NF-kappa B-regulated gene expression

21 January 2018

1 reference

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AP-1 as a regulator of cell life and death

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.11.1753

Shortage of mitogen-activated protein kinase is responsible for resistance to AP-1 transactivation and transformation in mouse JB6 cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.11.1753

Curcumin suppresses activation of NF-kappaB and AP-1 induced by phorbol ester in cultured human promyelocytic leukemia cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.11.1753

Curcumin downregulates cell survival mechanisms in human prostate cancer cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.11.1753

Tracking STAT nuclear traffic

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.11.1753

Targeting signal-transducer-and-activator-of-transcription-3 for prevention and therapy of cancer: modern target but ancient solution

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.11.1753

Green tea inhibits human inducible nitric-oxide synthase expression by down-regulating signal transducer and activator of transcription-1alpha activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.11.1753

Curcumin (Diferuloylmethane) Inhibits Constitutive and IL-6-Inducible STAT3 Phosphorylation in Human Multiple Myeloma Cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.11.1753

The biochemistry of apoptosis

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543784.16.11.1753

Apoptosis: A Basic Biological Phenomenon with Wideranging Implications in Tissue Kinetics

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543784.16.11.1753

Cell death: critical control points

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.11.1753

Induction of apoptosis by cancer chemotherapy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.11.1753

Cellular stress response and apoptosis in cancer therapy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.11.1753

Apoptosis-based therapies

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.11.1753

Resveratrol modulation of signal transduction in apoptosis and cell survival: A mini-review

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.11.1753

Sensitization for tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis by the chemopreventive agent resveratrol

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.11.1753

Epigallocatechin-3-gallate is a potent natural inhibitor of fatty acid synthase in intact cells and selectively induces apoptosis in prostate cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.11.1753

Green tea epigallocatechin gallate shows a pronounced growth inhibitory effect on cancerous cells but not on their normal counterparts.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.11.1753

Inhibition of bladder tumor growth by the green tea derivative epigallocatechin-3-gallate

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.11.1753

Synergistic effect of green tea catechins on cell growth and apoptosis induction in gastric carcinoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.11.1753

Epigallocatechin-3-gallate-induced stress signals in HT-29 human colon adenocarcinoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.11.1753

Inhibition of growth and induction of apoptosis in human cancer cell lines by tea polyphenols

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.11.1753

Induction of apoptosis by curcumin and its implications for cancer therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.11.1753

Curcumin induces apoptosis in human melanoma cells through a Fas receptor/caspase-8 pathway independent of p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.11.1753

Curcumin (diferuloylmethane) inhibits constitutive NF-kappaB activation, induces G1/S arrest, suppresses proliferation, and induces apoptosis in mantle cell lymphoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.11.1753

Silymarin causes caspases activation and apoptosis in K562 leukemia cells through inactivation of Akt pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.11.1753

Mammalian caspases: structure, activation, substrates, and functions during apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.11.1753

Serial killers: ordering caspase activation events in apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.11.1753

Curcumin (diferuloylmethane) induces apoptosis through activation of caspase-8, BID cleavage and cytochrome c release: its suppression by ectopic expression of Bcl-2 and Bcl-xl

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.11.1753

Resveratrol induces apoptosis of human malignant B cells by activation of caspase-3 and p38 MAP kinase pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.11.1753

Caspase-2 triggers Bax-Bak-dependent and -independent cell death in colon cancer cells treated with resveratrol.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.11.1753

The p53 family in differentiation and tumorigenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.11.1753

21 January 2018

Surfing the p53 network

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.11.1753

p53-based cancer therapies: Is defective p53 the Achilles heel of the tumor?

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.11.1753

Curcumin causes the growth arrest and apoptosis of B cell lymphoma by downregulation of egr-1, c-myc, bcl-XL, NF-kappa B, and p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.11.1753

Resveratrol suppresses cell transformation and induces apoptosis through a p53-dependent pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.11.1753

Resveratrol enhances the expression of non-steroidal anti-inflammatory drug-activated gene (NAG-1) by increasing the expression of p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.11.1753

Genistein, a dietary isoflavone, down-regulates the MDM2 oncogene at both transcriptional and posttranslational levels

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.11.1753

Green tea constituent (-)-epigallocatechin-3-gallate inhibits Hep G2 cell proliferation and induces apoptosis through p53-dependent and Fas-mediated pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.11.1753

Tumorigenesis and the angiogenic switch

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.11.1753

Vascular-specific growth factors and blood vessel formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.11.1753

Angiogenesis: from plants to blood vessels

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.11.1753

Resveratrol ameliorates myocardial damage by inducing vascular endothelial growth factor-angiogenesis and tyrosine kinase receptor Flk-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.11.1753

Luteolin inhibits vascular endothelial growth factor-induced angiogenesis; inhibition of endothelial cell survival and proliferation by targeting phosphatidylinositol 3'-kinase activity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.11.1753

Green tea catechin, epigallocatechin-3-gallate, inhibits vascular endothelial growth factor angiogenic signaling by disrupting the formation of a receptor complex.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.11.1753

Angiogenesis inhibited by drinking tea.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.11.1753

Cancer metastasis: building a framework

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.11.1753

Beta-catenin-mediated transactivation and cell-cell adhesion pathways are important in curcumin (diferuylmethane)-induced growth arrest and apoptosis in colon cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.11.1753

Anti-invasive gene expression profile of curcumin in lung adenocarcinoma based on a high throughput microarray analysis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.11.1753

Resveratrol suppresses hepatoma cell invasion independently of its anti-proliferative action

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.11.1753

The cancer chemopreventive agent resveratrol induces tensin, a cell-matrix adhesion protein with signaling and antitumor activities.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.11.1753

Effect of resveratrol on matrix metalloproteinase-2 (MMP-2) and Secreted Protein Acidic and Rich in Cysteine (SPARC) on human cultured glioblastoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.11.1753

Chemosensitization and radiosensitization of tumors by plant polyphenols

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.11.1753

Potentiation of the effect of erlotinib by genistein in pancreatic cancer: the role of Akt and nuclear factor-kappaB.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.11.1753

Curcumin enhances cytotoxicity of chemotherapeutic agents in prostate cancer cells by inducing p21(WAF1/CIP1) and C/EBPbeta expressions and suppressing NF-kappaB activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.11.1753

Emodin enhances arsenic trioxide-induced apoptosis via generation of reactive oxygen species and inhibition of survival signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.11.1753

Transcription factors activated in mammalian cells after clinically relevant doses of ionizing radiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.11.1753

Mechanisms of disease: Radiosensitization by epidermal growth factor receptor inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.11.1753

Genistein inhibits radiation-induced activation of NF-kappaB in prostate cancer cells promoting apoptosis and G2/M cell cycle arrest

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.11.1753

Down-regulation of apurinic/apyrimidinic endonuclease 1/redox factor-1 expression by soy isoflavones enhances prostate cancer radiotherapy in vitro and in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.11.1753

Soy isoflavones enhance radiotherapy in a metastatic prostate cancer model

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.11.1753

Curcumin confers radiosensitizing effect in prostate cancer cell line PC-3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.11.1753

Ras, PI(3)K and mTOR signalling controls tumour cell growth

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.11.1753

Flavopiridol downregulates hypoxia-mediated hypoxia-inducible factor-1alpha expression in human glioma cells by a proteasome-independent pathway: implications for in vivo therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.11.1753

Radiosensitizing and anti-proliferative effects of resveratrol in two human cervical tumor cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.11.1753

Cell Death in Development

21 January 2018

1 reference

5 June 2022

https://opencitations.net/index/coci/api/v1/citations/10.1016/S0092-8674(00)80564-4

Emodin has a cytotoxic activity against human multiple myeloma as a Janus-activated kinase 2 inhibitor

1 reference

12 April 2024

https://opencitations.net/index/api/v1/citations/10.1158/1535-7163.MCT-06-0605

Identifiers

DOI

10.1517/13543784.16.11.1753

1 reference

17 August 2017

1 reference