Molecular mechanism of β-arrestin-biased agonism at seven-transmembrane receptors (Q36773326)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21942629%20AND%20SRC:MED&resulttype=core&format=json

13 February 2020

review article

1 reference

title

Molecular mechanism of β-arrestin-biased agonism at seven-transmembrane receptors (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21942629%20AND%20SRC:MED&resulttype=core&format=json

13 February 2020

main subject

transmembrane protein

0 references

author

Arun K Shukla

series ordinal

3

1 reference

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13 February 2020

4

Robert J Lefkowitz

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21942629%20AND%20SRC:MED&resulttype=core&format=json

13 February 2020

author name string

Eric Reiter

series ordinal

1

1 reference

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13 February 2020

Seungkirl Ahn

series ordinal

2

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13 February 2020

publication date

19 September 2011

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Annual Review of Pharmacology and Toxicology

13 February 2020

published in

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21942629%20AND%20SRC:MED&resulttype=core&format=json

13 February 2020

volume

52

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13 February 2020

page(s)

179-197

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Multiple ligand-specific conformations of the β2-adrenergic receptor

13 February 2020

cites work

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Quantifying ligand bias at seven-transmembrane receptors.

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The structural basis for agonist and partial agonist action on a β(1)-adrenergic receptor

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Selectively engaging β-arrestins at the angiotensin II type 1 receptor reduces blood pressure and increases cardiac performance.

29 September 2017

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29 September 2017

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29 September 2017

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The complex G protein-coupled receptor kinase 2 (GRK2) interactome unveils new physiopathological targets

29 September 2017

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Teaching old receptors new tricks: biasing seven-transmembrane receptors

29 September 2017

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A beta-arrestin-biased agonist of the parathyroid hormone receptor (PTH1R) promotes bone formation independent of G protein activation.

29 September 2017

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Ligand-specific regulation of the extracellular surface of a G-protein-coupled receptor

29 September 2017

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Site-specific phosphorylation of CXCR4 is dynamically regulated by multiple kinases and results in differential modulation of CXCR4 signaling

29 September 2017

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Selective engagement of G protein coupled receptor kinases (GRKs) encodes distinct functions of biased ligands

29 September 2017

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beta-Arrestin1 mediates nicotinic acid-induced flushing, but not its antilipolytic effect, in mice

29 September 2017

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Identification of two distinct inactive conformations of the beta2-adrenergic receptor reconciles structural and biochemical observations

29 September 2017

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{beta}-Arrestin-2 Mediates Anti-apoptotic Signaling through Regulation of BAD Phosphorylation

29 September 2017

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Fluorescence resonance energy transfer analysis of alpha 2a-adrenergic receptor activation reveals distinct agonist-specific conformational changes.

29 September 2017

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The 2.6 angstrom crystal structure of a human A2A adenosine receptor bound to an antagonist

29 September 2017

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Beta-blockers alprenolol and carvedilol stimulate beta-arrestin-mediated EGFR transactivation.

29 September 2017

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Physical interaction of calmodulin with the 5-hydroxytryptamine2C receptor C-terminus is essential for G protein-independent, arrestin-dependent receptor signaling.

29 September 2017

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Distinct conformational changes in beta-arrestin report biased agonism at seven-transmembrane receptors.

29 September 2017

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Structure of a beta1-adrenergic G-protein-coupled receptor

29 September 2017

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Beta-arrestin-mediated localization of smoothened to the primary cilium

29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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Beta-arrestin-mediated beta1-adrenergic receptor transactivation of the EGFR confers cardioprotection.

29 September 2017

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29 September 2017

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Beta-arrestin-biased ligands at seven-transmembrane receptors

29 September 2017

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Conformational complexity of G-protein-coupled receptors

29 September 2017

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Collateral efficacy in drug discovery: taking advantage of the good (allosteric) nature of 7TM receptors

29 September 2017

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Functional specialization of beta-arrestin interactions revealed by proteomic analysis

29 September 2017

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The active conformation of beta-arrestin1: direct evidence for the phosphate sensor in the N-domain and conformational differences in the active states of beta-arrestins1 and -2

29 September 2017

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Transmembrane signaling by G protein-coupled receptors

29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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beta-Arrestin 1 and Galphaq/11 coordinately activate RhoA and stress fiber formation following receptor stimulation

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29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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Structure and conformational changes in the C-terminal domain of the beta2-adrenoceptor: insights from fluorescence resonance energy transfer studies

27 June 2018

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Dancing with different partners: protein kinase a phosphorylation of seven membrane-spanning receptors regulates their G protein-coupling specificity.

27 June 2018

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Visual arrestin interaction with rhodopsin. Sequential multisite binding ensures strict selectivity toward light-activated phosphorylated rhodopsin.

27 June 2018

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Operational models of pharmacological agonism.

27 June 2018

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Distinct phosphorylation sites on the β(2)-adrenergic receptor establish a barcode that encodes differential functions of β-arrestin.

27 June 2018

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The minor binding pocket: a major player in 7TM receptor activation

5 September 2018

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FRET-based sensors for the human M1-, M3-, and M5-acetylcholine receptors

5 September 2018

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3-(1H-tetrazol-5-yl)-1,4,5,6-tetrahydro-cyclopentapyrazole (MK-0354): a partial agonist of the nicotinic acid receptor, G-protein coupled receptor 109a, with antilipolytic but no vasodilatory activity in mice.

5 September 2018

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Coupling ligand structure to specific conformational switches in the beta2-adrenoceptor

5 September 2018

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Probing the beta2 adrenoceptor binding site with catechol reveals differences in binding and activation by agonists and partial agonists

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5 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3628752

Allosteric Modulation of G Protein–Coupled Receptors

5 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3628752

A phosphorylation cluster of five serine and threonine residues in the C-terminus of the follicle-stimulating hormone receptor is important for desensitization but not for beta-arrestin-mediated ERK activation

5 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21942629

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1146/ANNUREV.PHARMTOX.010909.105800

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21942629%20AND%20SRC:MED&resulttype=core&format=json

13 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21942629%20AND%20SRC:MED&resulttype=core&format=json

13 February 2020

1 reference