Ligand-selective receptor conformations revisited: the promise and the problem (Q35181787)

7 August 2017

title

Ligand-selective receptor conformations revisited: the promise and the problem (English)

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7 August 2017

Terry Kenakin

1

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7 August 2017

publication date

1 July 2003

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Trends in Pharmacological Sciences

7 August 2017

language of work or name

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7 August 2017

volume

24

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7 August 2017

issue

7

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7 August 2017

page(s)

346-354

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publication type of scholarly work

7 August 2017

review article

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Agonist-receptor efficacy. II. Agonist trafficking of receptor signals

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Functionally different agonists induce distinct conformations in the G protein coupling domain of the beta 2 adrenergic receptor

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The use of stimulus-biased assay systems to detect agonist-specific receptor active states: implications for the trafficking of receptor stimulus by agonists

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Differential G-protein activation by alkaloid and peptide opioid agonists in the human neuroblastoma cell line SK-N-BE.

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Protean agonists. Keys to receptor active states?

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The cholecystokininB receptor is coupled to two effector pathways through pertussis toxin-sensitive and -insensitive G proteins

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Fluorescent labeling of purified beta 2 adrenergic receptor. Evidence for ligand-specific conformational changes

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Bombesin and substance P analogues differentially regulate G-protein coupling to the bombesin receptor. Direct evidence for biased agonism

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Amino-terminal modifications of human parathyroid hormone (PTH) selectively alter phospholipase C signaling via the type 1 PTH receptor: implications for design of signal-specific PTH ligands

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Differences in Signal Transduction of Two 5-HT4Receptor Splice Variants: Compound Specificity and Dual Coupling with Gαs- and Gαi/o-Proteins

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Recombinant roulette versus the apparent virtues of 'natural' cell receptor systems: receptor genotypes versus phenotypes

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Further Delineation of the Two Binding Sites (R*n) Associated with Tachykinin Neurokinin-1 Receptors Using [3-Prolinomethionine11]SP Analogues

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Influence of receptor number on functional responses elicited by agonists acting at the human adenosine A(1) receptor: evidence for signaling pathway-dependent changes in agonist potency and relative intrinsic activity

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Agonist trafficking of G(i/o)-mediated alpha(2A)-adrenoceptor responses in HEL 92.1.7 cells

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Effector Pathway-Dependent Relative Efficacy at Serotonin Type 2A and 2C Receptors: Evidence for Agonist-Directed Trafficking of Receptor Stimulus

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7 January 2021

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7 January 2021

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Selective ligand-induced stabilization of active and desensitized parathyroid hormone type 1 receptor conformations

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Agonist-induced phosphorylation of the angiotensin II (AT(1A)) receptor requires generation of a conformation that is distinct from the inositol phosphate-signaling state

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Distinct Differences Between Morphine‐ and [d‐Ala2,N‐MePhe4,Gly‐ol5]‐Enkephalin‐ μ‐Opioid Receptor Complexes Demonstrated by Cyclic AMP‐Dependent Protein Kinase Phosphorylation

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Differential opioid agonist regulation of the mouse mu opioid receptor

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Selection of distinct conformational states of the 5-HT3 receptor by full and partial agonists

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Effects of guanine, inosine, and xanthine nucleotides on beta(2)-adrenergic receptor/G(s) interactions: evidence for multiple receptor conformations

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7 January 2021

10.1016/S0165-6147(03)00167-6

Identifiers

DOI

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7 August 2017

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